BDBM50295525 CHEMBL551590::N-(4-Bromophenyl)-3-[3-(3-methoxybenzyl)-5-methyl-2-oxo-2H-pyridazin-1-yl]-propionamide

SMILES: COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1

InChI Key: InChIKey=PPOLUASKGNFIRB-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50295525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295525 (CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...) Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair