BindingDB PrimarySearch

BDBM50366826 DR-3355::Floxacin::Iquix::LEVOFLOXACIN::Levaquin

SMILES: C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O

InChI Key: InChIKey=GSDSWSVVBLHKDQ-JTQLQIEISA-N

Data: 2 KI 34 IC50 1 EC50

PDB links: 8 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50366826
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kansas University Curated by ChEMBL					Assay Description Binding affinity against sigma receptor				J Med Chem 30: 2283-6 (1987) BindingDB Entry DOI: 10.7270/Q2R78HFX
Kansas University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	9.96E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kansas University Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2283-6 (1987) BindingDB Entry DOI: 10.7270/Q2R78HFX
Kansas University Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Rattus norvegicus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...				Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Escherichia coli (strain K12))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Wakunaga Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DNA gyrase preincubated for 5 mins at 37 degC before addition of relaxed pBR322 as substrate by supercoiling assay				Eur J Med Chem 103: 354-60 (2015) BindingDB Entry DOI: 10.7270/Q22B90V9
Wakunaga Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	9.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd Curated by ChEMBL					Assay Description Inhibition of human Potassium channel HERG expressed in mammalian cells				Bioorg Med Chem Lett 13: 2773-5 (2003) BindingDB Entry DOI: 10.7270/Q2QZ2BGZ
Gedeon Richter Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug and toxin extrusion protein 1 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay				J Med Chem 56: 781-95 (2013) Article DOI: 10.1021/jm301302s BindingDB Entry DOI: 10.7270/Q2F76DWZ
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sterling-Winthrop Research Institute Curated by ChEMBL					Assay Description Gyrase inhibitory activity against Escherichia coli				J Med Chem 31: 1694-7 (1988) BindingDB Entry DOI: 10.7270/Q2RX9F84
Sterling-Winthrop Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
Reverse proteomics research institute Curated by ChEMBL					Assay Description Inhibitory concentration against potassium channel HERG				Bioorg Med Chem Lett 15: 2886-90 (2005) Article DOI: 10.1016/j.bmcl.2005.03.080 BindingDB Entry DOI: 10.7270/Q29S1S7C
Reverse proteomics research institute Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique				Bioorg Med Chem 16: 6252-60 (2008) Article DOI: 10.1016/j.bmc.2008.04.028 BindingDB Entry DOI: 10.7270/Q25D8T25
Hoffmann-La Roche Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	3.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Procter& Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against quinolone resistant gyrase in Escherichia coli				Bioorg Med Chem Lett 13: 2373-5 (2003) BindingDB Entry DOI: 10.7270/Q2862JN2
Procter& Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	8.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
Procter& Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against wild type gyrase in Escherichia coli				Bioorg Med Chem Lett 13: 2373-5 (2003) BindingDB Entry DOI: 10.7270/Q2862JN2
Procter& Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.66E+6	n/a	n/a	n/a	n/a	n/a	n/a
Procter& Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against mammalian DNA topoisomerase II				Bioorg Med Chem Lett 13: 2373-5 (2003) BindingDB Entry DOI: 10.7270/Q2862JN2
Procter& Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars		n/a	n/a	n/a	n/a	>2.80E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation method				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6SNT
TBA					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11A1 (Rattus norvegicus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 hrs by broth microdilution method				J Nat Prod 77: 1021-30 (2014) Article DOI: 10.1021/np5000457 BindingDB Entry DOI: 10.7270/Q2280BKR
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11A1 (Rattus norvegicus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Antibacterial activity against vancomycin-sensitive Enterococcus faecalis 12-5 after 18 hrs by broth microdilution method				J Nat Prod 77: 1021-30 (2014) Article DOI: 10.1021/np5000457 BindingDB Entry DOI: 10.7270/Q2280BKR
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11A1 (Rattus norvegicus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.28E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Antibacterial activity against vancomycin-resistant Enterococcus faecalis 09-9 after 18 hrs by broth microdilution method				J Nat Prod 77: 1021-30 (2014) Article DOI: 10.1021/np5000457 BindingDB Entry DOI: 10.7270/Q2280BKR
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11A1 (Rattus norvegicus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 after 18 hrs by broth microdilution method				J Nat Prod 77: 1021-30 (2014) Article DOI: 10.1021/np5000457 BindingDB Entry DOI: 10.7270/Q2280BKR
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human ERG current by patch clamp assay				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by pa...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.10E+6	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...				Bioorg Med Chem Lett 23: 3848-51 (2013) Article DOI: 10.1016/j.bmcl.2013.04.074 BindingDB Entry DOI: 10.7270/Q25B05D2
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase Subunit A (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.41E+6	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant				Bioorg Med Chem 17: 6879-89 (2009) Article DOI: 10.1016/j.bmc.2009.08.026 BindingDB Entry DOI: 10.7270/Q2M90CHK
Daiichi Sankyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus wild type DNA gyrase				Bioorg Med Chem 17: 6879-89 (2009) Article DOI: 10.1016/j.bmc.2009.08.026 BindingDB Entry DOI: 10.7270/Q2M90CHK
Daiichi Sankyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co Ltd Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus MS5935 wild type DNA gyrase-mediated supercoiling activity				J Med Chem 51: 3238-49 (2008) Article DOI: 10.1021/jm701428b BindingDB Entry DOI: 10.7270/Q2KP84XK
Kyorin Pharmaceutical Co Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.13E+6	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co Ltd Curated by ChEMBL					Assay Description Inhibition of quinoline-resistant Staphylococcus aureus MS5935 DNA gyrase-mediated supercoiling activity				J Med Chem 51: 3238-49 (2008) Article DOI: 10.1021/jm701428b BindingDB Entry DOI: 10.7270/Q2KP84XK
Kyorin Pharmaceutical Co Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza University of Rome Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase S84L mutant				Eur J Med Chem 178: 500-514 (2019) Article DOI: 10.1016/j.ejmech.2019.05.087
Sapienza University of Rome Curated by ChEMBL					More data for this Ligand-Target Pair
Topoisomerase IV (Staphylococcus aureus)	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza University of Rome Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus topoisomerase-4 expressed in Escherichia coli assessed as relaxation of pBR322 substrate measured after 4 hrs by ...				Eur J Med Chem 178: 500-514 (2019) Article DOI: 10.1016/j.ejmech.2019.05.087
Sapienza University of Rome Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Ba DnaG) (Bacillus anthracis (Firmicutes))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	8.8	n/a
University of Michigan					Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP...				Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ
University of Michigan					More data for this Ligand-Target Pair
Bile salt export pump (BSEP) (Homo sapiens (Human))	BDBM50366826 (DR-3355 \| Floxacin \| Iquix \| LEVOFLOXACIN \| Levaqu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake				Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair