BDBM50434371 AZURE A::Azure A (12)
SMILES: C[N+](C)=c1ccc2nc3ccc(N)cc3sc2c1
InChI Key: InChIKey=HMYISFASHDWPMO-UHFFFAOYSA-O
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Microtubule-associated protein tau (TAU)(2N4R) (Homo sapiens (Human)) | BDBM50434371 (AZURE A | Azure A (12)) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Ohio State University | Assay Description The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek... | J Biol Chem 288: 32599-611 (2013) Article DOI: 10.1074/jbc.M113.503474 BindingDB Entry DOI: 10.7270/Q2R49PMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tau (Homo sapiens (Human)) | BDBM50434371 (AZURE A | Azure A (12)) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Humboldt-Universit£t zu Berlin Curated by ChEMBL | Assay Description Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic... | J Med Chem 56: 4135-55 (2013) Article DOI: 10.1021/jm3017317 BindingDB Entry DOI: 10.7270/Q2HT2QQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tau (Homo sapiens (Human)) | BDBM50434371 (AZURE A | Azure A (12)) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Humboldt-Universit£t zu Berlin Curated by ChEMBL | Assay Description Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis | J Med Chem 56: 4135-55 (2013) Article DOI: 10.1021/jm3017317 BindingDB Entry DOI: 10.7270/Q2HT2QQD | |||||||||||
More data for this Ligand-Target Pair |