BindingDB PrimarySearch

BDBM84950 CAS_183782::NSC_183782::RS 67333

SMILES: CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1

InChI Key: InChIKey=JBHLYIVFFLNISJ-UHFFFAOYSA-N

Data: 19 KI 2 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 84950
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR4 (GUINEA PIG)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR4 (GUINEA PIG)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	9.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CERMN Curated by ChEMBL					Assay Description Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay				J Med Chem 58: 3172-87 (2015) Article DOI: 10.1021/acs.jmedchem.5b00115 BindingDB Entry DOI: 10.7270/Q2HQ41MH
CERMN Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	9.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Displacement of [3H]-GR113808 from recombinant human 5-HT4BR expressed in membranes after 60 mins				Eur J Med Chem 162: 234-248 (2019) Article DOI: 10.1016/j.ejmech.2018.10.064
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Rattus norvegicus)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
DRD2 (GUINEA PIG)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
DRD1 (GUINEA PIG)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Rattus norvegicus (Rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (NEONATAL RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Rattus norvegicus (rat))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 1387-92 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16628.x BindingDB Entry DOI: 10.7270/Q23B5XP1
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Suven Life Sciences Ltd. Curated by ChEMBL					Assay Description Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay				Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST
Suven Life Sciences Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (RAT)	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.70	n/a	n/a	n/a	n/a
Suven Life Sciences Ltd. Curated by ChEMBL					Assay Description Agonist activity at 5-HT4 receptor in Sprague-Dawley rat oesophagus assessed as relaxation of carbachol precontracted oesophagus				Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST
Suven Life Sciences Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	403	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every 1 min for ...				Eur J Med Chem 158: 463-477 (2018) Article DOI: 10.1016/j.ejmech.2018.09.031 BindingDB Entry DOI: 10.7270/Q26H4M3Z
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM84950 (CAS_183782 \| NSC_183782 \| RS 67333) Show SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	403	n/a	n/a	n/a	n/a	n/a	n/a
CERMN Curated by ChEMBL					Assay Description Inhibition of human erythrocyte AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate by Ellman' method				J Med Chem 58: 3172-87 (2015) Article DOI: 10.1021/acs.jmedchem.5b00115 BindingDB Entry DOI: 10.7270/Q2HQ41MH
CERMN Curated by ChEMBL					More data for this Ligand-Target Pair