BDBM85550 Ang IV::CAS_12676-15-2::CHEMBL261120::cid_123814
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI Key: InChIKey=QSBGWDDCOJYQGY-KOQODJNWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Angiotensin IV (BOVINE) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University Curated by PDSP Ki Database | J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin IV (BOVINE) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University Curated by PDSP Ki Database | J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin IV (BOVINE) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University Curated by PDSP Ki Database | J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin IV (BOVINE) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington State University Curated by PDSP Ki Database | J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucyl-cystinyl aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125I]Angiotensin 4 from human recombinant IRAP expressed in CHOK1 cells | Bioorg Med Chem 16: 6924-35 (2008) Article DOI: 10.1016/j.bmc.2008.05.046 BindingDB Entry DOI: 10.7270/Q2B857XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Inhibition of human recombinant IRAP expressed in HEK293 cells | J Med Chem 51: 2291-6 (2008) Article DOI: 10.1021/jm701490g BindingDB Entry DOI: 10.7270/Q25M68HP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 56.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Inhibition of catalytic activity of human aminopeptidase N transfected in HEK293 cells assessed as formation of p-nitroaniline | J Med Chem 52: 5612-8 (2009) Article DOI: 10.1021/jm900651p BindingDB Entry DOI: 10.7270/Q2TB185F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucyl-cystinyl aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of human recombinant IRAP expressed in HEK293 cells | Bioorg Med Chem 16: 6924-35 (2008) Article DOI: 10.1016/j.bmc.2008.05.046 BindingDB Entry DOI: 10.7270/Q2B857XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucyl-cystinyl aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 62.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili... | J Med Chem 54: 3779-92 (2011) Article DOI: 10.1021/jm200036n BindingDB Entry DOI: 10.7270/Q2348KPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cells | J Med Chem 51: 2291-6 (2008) Article DOI: 10.1021/jm701490g BindingDB Entry DOI: 10.7270/Q25M68HP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting | J Med Chem 52: 5612-8 (2009) Article DOI: 10.1021/jm900651p BindingDB Entry DOI: 10.7270/Q2TB185F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of human recombinant APN expressed in HEK293 cells | Bioorg Med Chem 16: 6924-35 (2008) Article DOI: 10.1016/j.bmc.2008.05.046 BindingDB Entry DOI: 10.7270/Q2B857XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucyl-cystinyl aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 832 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Inhibition of catalytic activity of human IRAP transfected in HEK293 cells assessed as formation of p-nitroaniline | J Med Chem 52: 5612-8 (2009) Article DOI: 10.1021/jm900651p BindingDB Entry DOI: 10.7270/Q2TB185F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 841 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of catalytic activity of recombinant human AP-N transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili... | J Med Chem 54: 3779-92 (2011) Article DOI: 10.1021/jm200036n BindingDB Entry DOI: 10.7270/Q2348KPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.00E+14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel Curated by ChEMBL | Assay Description Inhibition of human recombinant APN expressed in HEK293 cells | J Med Chem 51: 2291-6 (2008) Article DOI: 10.1021/jm701490g BindingDB Entry DOI: 10.7270/Q25M68HP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 receptor antagonist protein (Homo sapiens) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Scientific Research Demokritos Curated by ChEMBL | Assay Description Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Leu-AMC as substrate incubated for 2 hrs by fluorescence based assay | ACS Med Chem Lett 11: 1429-1434 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Scientific Research Demokritos Curated by ChEMBL | Assay Description Inhibition of ERAP2 (unknown origin) using Arg-AMC as substrate by fluorescence based assay | ACS Med Chem Lett 11: 1429-1434 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase (Homo sapiens (Human)) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Scientific Research Demokritos Curated by ChEMBL | Assay Description Inhibition of ERAP1 (unknown origin) using Leu-AMC as substrate by fluorescence based assay | ACS Med Chem Lett 11: 1429-1434 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
leucine aminopeptidase (Plasmodium falciparum 3D7) | BDBM85550 (Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q27W69N8 | |||||||||||
More data for this Ligand-Target Pair |