Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398510 ((rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317578 (US9624198, 3 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317585 (US9624198, 10 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317586 (US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317584 (US9624198, 9 | [4-(6-Methoxy-3,4-dihydroisoquinoli...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317577 (US9624198, 2 | [4-(7-Fluoro-3,4-dihydroisoquinolin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398515 (US10323020, Example 9 | [4-(7-Fluoro-3,4-dihydrois...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398511 ((rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317586 (US9624198, 11 | US9624198, 12 | [4-(3,4-Dihydroiso...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317582 (US9624198, 7 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317576 ( [4-(3,4-Dihydroisoquinolin-2-(1H)-yl)piperidin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317589 (US9624198, 14 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398514 (US10323020, Example 8 | [4-(3,4-Dihydroisoquinolin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398519 (US10323020, Example 13 | US10323020, Example 14 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317579 (US9624198, 4 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398508 ((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398518 (US10323020, Example 12 | [4-(3,4-Dihydroisoquinoli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398508 ((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317581 (1-(5-{[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398516 (US10323020, Example 10 | [4-(6-Methoxy-3,4-dihydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398512 ((rac)-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398519 (US10323020, Example 13 | US10323020, Example 14 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317590 (US9624198, 15 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317588 (US9624198, 13 | [4-(3,4-Dihydroisoquinolin-2(1H)-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317583 (US9624198, 8 | [4-(6-Fluoro-3,4-dihydroisoquinolin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM317580 (US9624198, 5 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | US Patent US9624198 (2017) BindingDB Entry DOI: 10.7270/Q2377BS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398513 ((rac)-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398521 (US10323020, Example 15 | [4-(3,4-Dihydroisoquinoli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398507 (US10323020, Example 1 | [4-(3,4-Dihydroisoquinolin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM398517 (1-(5-{[4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina... | Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C8 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2C8 using amodiaquine as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2C9 using diclofenac as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2C19 using S-mephenytoin as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP3A4 using midazolam as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP3A4 using midazolam as substrate preincubated with compound followed by substrate addition | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2A6 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2A6 using coumarin as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP1A2 using phenacetin as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP3A4 using testosterone as substrate preincubated with compound followed by substrate addition | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2D6 using dextromethorphan as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP2B6 using bupropion as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50239781 (CHEMBL4066936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL | Assay Description Inhibition of human liver microsomes CYP3A4 using testosterone as substrate | J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281735 (US10023528, Example 12 | US10259776, Example 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 17 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281736 (US10023528, Example 13 | US10259776, Example 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 14 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281737 (US10023528, Example 14 | US10259776, Example 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 8.40 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281738 ((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 68 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281739 (US10023528, Example 25 | US10259776, Example 25) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 220 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281740 (US10023528, Example 27 | US10259776, Example 27) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 68 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281741 (3-(4-Chloro-3-{[(3R)-2-chlorophenyl)-4,4,4-trifluo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 640 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281742 ((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 11 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281743 (US10023528, Example 35 | US10259776, Example 35) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 11 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair |
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