Compile Data Set for Download or QSAR

Found 57 hits with Last Name = 'dickman' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase delta (Homo sapiens (Human))	BDBM50475863 (CHEMBL209054) Show SMILES Cn1c(nc2ccc(cc12)C(=O)NC(O)COc1ccc(F)cc1)C(F)(F)c1nc2c(F)cc(F)cc2[nH]1 Show InChI InChI=1S/C25H18F5N5O3/c1-35-19-8-12(22(37)33-20(36)11-38-15-5-3-13(26)4-6-15)2-7-17(19)32-24(35)25(29,30)23-31-18-10-14(27)9-16(28)21(18)34-23/h2-10,20,36H,11H2,1H3,(H,31,34)(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Tryptase delta (Homo sapiens (Human))	BDBM50475860 (CHEMBL424699) Show SMILES Cn1c(nc2ccc(cc12)C(=O)NCCOc1ccc(F)cc1)C(F)(F)c1nc2c(F)cc(F)c(O)c2[nH]1 Show InChI InChI=1S/C25H18F5N5O3/c1-35-18-10-12(22(37)31-8-9-38-14-5-3-13(26)4-6-14)2-7-17(18)32-24(35)25(29,30)23-33-19-15(27)11-16(28)21(36)20(19)34-23/h2-7,10-11,36H,8-9H2,1H3,(H,31,37)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Tryptase delta (Homo sapiens (Human))	BDBM50475861 (CHEMBL211733) Show SMILES Cn1c(nc2ccc(cc12)C(=O)NCCOc1ccc(F)cc1)C(F)(F)c1nc2c(F)cc(F)cc2[nH]1 Show InChI InChI=1S/C25H18F5N5O2/c1-35-20-10-13(22(36)31-8-9-37-16-5-3-14(26)4-6-16)2-7-18(20)33-24(35)25(29,30)23-32-19-12-15(27)11-17(28)21(19)34-23/h2-7,10-12H,8-9H2,1H3,(H,31,36)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Tryptase delta (Homo sapiens (Human))	BDBM50475865 (CHEMBL212765) Show SMILES Cn1c(nc2ccc(cc12)C(=O)NCCOc1ccc(F)cc1)C(F)(F)c1nc2c(F)c(O)c(F)cc2[nH]1 Show InChI InChI=1S/C25H18F5N5O3/c1-35-18-10-12(22(37)31-8-9-38-14-5-3-13(26)4-6-14)2-7-16(18)33-24(35)25(29,30)23-32-17-11-15(27)21(36)19(28)20(17)34-23/h2-7,10-11,36H,8-9H2,1H3,(H,31,37)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Tryptase delta (Homo sapiens (Human))	BDBM50475864 (CHEMBL378085) Show SMILES Cn1c(nc2ccc(cc12)C(N)=O)C(F)(F)c1nc2c(F)cc(F)cc2[nH]1 Show InChI InChI=1S/C17H11F4N5O/c1-26-12-4-7(14(22)27)2-3-10(12)24-16(26)17(20,21)15-23-11-6-8(18)5-9(19)13(11)25-15/h2-6H,1H3,(H2,22,27)(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Tryptase delta (Homo sapiens (Human))	BDBM50475862 (CHEMBL379076) Show SMILES Cn1c(nc2ccc(cc12)C(=O)NCCO)C(F)(F)c1nc2c(F)cc(F)cc2[nH]1 Show InChI InChI=1S/C19H15F4N5O2/c1-28-14-6-9(16(30)24-4-5-29)2-3-12(14)26-18(28)19(22,23)17-25-13-8-10(20)7-11(21)15(13)27-17/h2-3,6-8,29H,4-5H2,1H3,(H,24,30)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Genomics Curated by ChEMBL					Assay Description Inhibition of mast cell tryptase				Bioorg Med Chem Lett 16: 4053-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.003 BindingDB Entry DOI: 10.7270/Q26H4M69
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50067563 ((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50067584 ((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...) Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076811 (CHEMBL10877 | Lithium; (S)-2-({5-[5-(4-chloro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(Cl)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30ClNO5S/c1-20-5-3-4-6-25(20)27-17-21(7-13-26(27)30(34)33-28(31(35)36)15-16-39-2)18-37-19-24-12-14-29(38-24)22-8-10-23(32)11-9-22/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076809 (CHEMBL417606 | Lithium; (S)-2-({5-[5-(4-formyl-phe...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(C=O)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H31NO6S/c1-21-5-3-4-6-26(21)28-17-23(9-13-27(28)31(35)33-29(32(36)37)15-16-40-2)19-38-20-25-12-14-30(39-25)24-10-7-22(18-34)8-11-24/h3-14,17-18,29H,15-16,19-20H2,1-2H3,(H,33,35)(H,36,37)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076798 (CHEMBL273697 | Lithium; (S)-2-({5-[5-(4-fluoro-phe...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(F)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-5-3-4-6-25(20)27-17-21(7-13-26(27)30(34)33-28(31(35)36)15-16-39-2)18-37-19-24-12-14-29(38-24)22-8-10-23(32)11-9-22/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human))	BDBM50068561 ((16E,24E,26E,28E)-1,18-Dihydroxy-12-[2-(4-hydroxy-...) Show SMILES CO[C@@H]1C[C@H](CC(C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@H]3O[C@](O)([C@H](C)C[C@@H]3OC)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31| Show InChI InChI=1S/C52H81NO14/c1-30-17-13-12-14-18-31(2)41(62-8)29-45-44(64-10)26-36(7)52(61,67-45)49(58)50(59)53-22-16-15-19-38(53)51(60)66-42(33(4)25-37-20-21-39(54)43(27-37)63-9)28-40(55)32(3)24-35(6)47(57)48(65-11)46(56)34(5)23-30/h12-14,17-18,24,30,32-34,36-39,41-45,47-48,54,57,61H,15-16,19-23,25-29H2,1-11H3/b14-12+,17-13+,31-18+,35-24+/t30-,32-,33?,34-,36-,37+,38+,39-,41+,42+,43-,44+,45-,47+,48+,52-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	MMDB PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The compound was tested for binding afifnity to FK506 binding protein 12 with an ascomycin conjugate of alkaline phosphatase in a competition binding...				Bioorg Med Chem Lett 10: 1405-8 (2000) BindingDB Entry DOI: 10.7270/Q2CV4GZH
					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human))	BDBM50089437 (CHEMBL437064 | Rapamycin analogue) Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)N(O)C(=O)Oc2ccccc2)CC[C@H]1O |c:14,33,t:29,31| Show InChI InChI=1S/C57H82N2O15/c1-34-18-12-10-13-19-35(2)45(59(69)56(67)72-42-20-14-11-15-21-42)32-43-25-23-40(7)57(68,74-43)53(64)54(65)58-27-17-16-22-44(58)55(66)73-48(37(4)30-41-24-26-46(60)49(31-41)70-8)33-47(61)36(3)29-39(6)51(63)52(71-9)50(62)38(5)28-34/h10-15,18-21,29,34,36-38,40-41,43-46,48-49,51-52,60,63,68-69H,16-17,22-28,30-33H2,1-9H3/b13-10+,18-12+,35-19+,39-29+/t34-,36-,37-,38-,40-,41+,43+,44+,45+,46-,48+,49-,51-,52+,57-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The compound was tested for binding afifnity to FK506 binding protein 12 using Rapamycin as control, with an ascomycin conjugate of alkaline phosphat...				Bioorg Med Chem Lett 10: 1405-8 (2000) BindingDB Entry DOI: 10.7270/Q2CV4GZH
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076802 (CHEMBL10912 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccncc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H30N2O5S/c1-20-5-3-4-6-24(20)26-17-21(7-9-25(26)29(33)32-27(30(34)35)13-16-38-2)18-36-19-23-8-10-28(37-23)22-11-14-31-15-12-22/h3-12,14-15,17,27H,13,16,18-19H2,1-2H3,(H,32,33)(H,34,35)/p-1/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076795 (CHEMBL11210 | Lithium; (S)-2-({5-[5-(4-dimethylami...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)N(C)C)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C33H36N2O5S/c1-22-7-5-6-8-27(22)29-19-23(9-15-28(29)32(36)34-30(33(37)38)17-18-41-4)20-39-21-26-14-16-31(40-26)24-10-12-25(13-11-24)35(2)3/h5-16,19,30H,17-18,20-21H2,1-4H3,(H,34,36)(H,37,38)/p-1/t30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076791 (CHEMBL10990 | Lithium; (S)-4-methylsulfanyl-2-{[2'...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(C)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H33NO5S/c1-21-8-11-24(12-9-21)30-15-13-25(38-30)20-37-19-23-10-14-27(28(18-23)26-7-5-4-6-22(26)2)31(34)33-29(32(35)36)16-17-39-3/h4-15,18,29H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076794 (CHEMBL276602 | Lithium; (S)-2-({5-[5-(4-isopropyl-...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)C(C)C)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C34H37NO5S/c1-22(2)25-10-12-26(13-11-25)32-16-14-27(40-32)21-39-20-24-9-15-29(30(19-24)28-8-6-5-7-23(28)3)33(36)35-31(34(37)38)17-18-41-4/h5-16,19,22,31H,17-18,20-21H2,1-4H3,(H,35,36)(H,37,38)/p-1/t31-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076810 (CHEMBL428001 | Lithium; (S)-4-methylsulfanyl-2-({2...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)C(F)(F)F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H30F3NO5S/c1-20-5-3-4-6-25(20)27-17-21(7-13-26(27)30(37)36-28(31(38)39)15-16-42-2)18-40-19-24-12-14-29(41-24)22-8-10-23(11-9-22)32(33,34)35/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,36,37)(H,38,39)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076799 ((S)-2-{[5-(5-Bromo-furan-2-ylmethoxymethyl)-2'-met...) Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1ccc(COCc2ccc(Br)o2)cc1-c1ccccc1C Show InChI InChI=1S/C26H28BrNO5S/c1-17-6-4-5-7-20(17)22-14-18(15-32-16-19-9-11-24(27)33-19)8-10-21(22)25(29)28-23(12-13-34-3)26(30)31-2/h4-11,14,23H,12-13,15-16H2,1-3H3,(H,28,29)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076792 (CHEMBL10812 | Lithium; (S)-2-({5-[5-(4-chloro-3-fl...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(Cl)c(F)c2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H29ClFNO5S/c1-19-5-3-4-6-23(19)25-15-20(7-10-24(25)30(35)34-28(31(36)37)13-14-40-2)17-38-18-22-9-12-29(39-22)21-8-11-26(32)27(33)16-21/h3-12,15-16,28H,13-14,17-18H2,1-2H3,(H,34,35)(H,36,37)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076801 (CHEMBL430096 | Lithium; (S)-2-({2'-methyl-5-[5-(3-...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2cccc(c2)[N+]([O-])=O)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30N2O7S/c1-20-6-3-4-9-25(20)27-16-21(10-12-26(27)30(34)32-28(31(35)36)14-15-41-2)18-39-19-24-11-13-29(40-24)22-7-5-8-23(17-22)33(37)38/h3-13,16-17,28H,14-15,18-19H2,1-2H3,(H,32,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076797 (CHEMBL10955 | Lithium; (S)-2-{[2'-methyl-5-(5-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H31NO5S/c1-21-8-6-7-11-25(21)27-18-22(12-14-26(27)30(33)32-28(31(34)35)16-17-38-2)19-36-20-24-13-15-29(37-24)23-9-4-3-5-10-23/h3-15,18,28H,16-17,19-20H2,1-2H3,(H,32,33)(H,34,35)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076793 (CHEMBL11003 | Lithium; (S)-2-({2'-methyl-5-[5-(4-m...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(SC)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H33NO5S2/c1-21-6-4-5-7-26(21)28-18-22(8-14-27(28)31(34)33-29(32(35)36)16-17-39-2)19-37-20-24-11-15-30(38-24)23-9-12-25(40-3)13-10-23/h4-15,18,29H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076803 (CHEMBL10970 | Lithium; (S)-2-({5-[5-(2-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-7-3-4-8-23(20)26-17-21(11-13-24(26)30(34)33-28(31(35)36)15-16-39-2)18-37-19-22-12-14-29(38-22)25-9-5-6-10-27(25)32/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076790 (CHEMBL10902 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2cccnc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H30N2O5S/c1-20-6-3-4-8-24(20)26-16-21(9-11-25(26)29(33)32-27(30(34)35)13-15-38-2)18-36-19-23-10-12-28(37-23)22-7-5-14-31-17-22/h3-12,14,16-17,27H,13,15,18-19H2,1-2H3,(H,32,33)(H,34,35)/p-1/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076800 (CHEMBL430307 | Lithium; (S)-2-({5-[5-(4-acetyl-phe...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)C(C)=O)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C33H33NO6S/c1-21-6-4-5-7-27(21)29-18-23(8-14-28(29)32(36)34-30(33(37)38)16-17-41-3)19-39-20-26-13-15-31(40-26)25-11-9-24(10-12-25)22(2)35/h4-15,18,30H,16-17,19-20H2,1-3H3,(H,34,36)(H,37,38)/p-1/t30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076788 (CHEMBL11195 | Lithium; (S)-2-({5-[5-(3-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2cccc(F)c2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-6-3-4-9-25(20)27-16-21(10-12-26(27)30(34)33-28(31(35)36)14-15-39-2)18-37-19-24-11-13-29(38-24)22-7-5-8-23(32)17-22/h3-13,16-17,28H,14-15,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076806 (CHEMBL273265 | Lithium; (S)-2-({5-[5-(4-methoxy-ph...) Show SMILES COc1ccc(cc1)-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-6-4-5-7-26(21)28-18-22(8-14-27(28)31(34)33-29(32(35)36)16-17-40-3)19-38-20-25-13-15-30(39-25)23-9-11-24(37-2)12-10-23/h4-15,18,29H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076804 (CHEMBL273507 | Lithium; (S)-4-methylsulfanyl-2-({2...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2cccc(c2)C(F)(F)F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H30F3NO5S/c1-20-6-3-4-9-25(20)27-16-21(10-12-26(27)30(37)36-28(31(38)39)14-15-42-2)18-40-19-24-11-13-29(41-24)22-7-5-8-23(17-22)32(33,34)35/h3-13,16-17,28H,14-15,18-19H2,1-2H3,(H,36,37)(H,38,39)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076789 (CHEMBL274672 | Lithium; (S)-4-methylsulfanyl-2-({2...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2C(F)(F)F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H30F3NO5S/c1-20-7-3-4-8-23(20)26-17-21(11-13-24(26)30(37)36-28(31(38)39)15-16-42-2)18-40-19-22-12-14-29(41-22)25-9-5-6-10-27(25)32(33,34)35/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,36,37)(H,38,39)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076807 (CHEMBL273721 | Lithium; (S)-2-({5-[5-(3-methoxy-ph...) Show SMILES COc1cccc(c1)-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-7-4-5-10-26(21)28-17-22(11-13-27(28)31(34)33-29(32(35)36)15-16-40-3)19-38-20-25-12-14-30(39-25)23-8-6-9-24(18-23)37-2/h4-14,17-18,29H,15-16,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human))	BDBM50089447 (CHEMBL281297 | Rapamycin analogue) Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](O)C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)CC[C@H]1O |c:14,33,t:29,31| Show InChI InChI=1S/C50H77NO13/c1-29-15-11-10-12-16-30(2)40(53)27-37-20-18-35(7)50(60,64-37)47(57)48(58)51-22-14-13-17-38(51)49(59)63-42(32(4)25-36-19-21-39(52)43(26-36)61-8)28-41(54)31(3)24-34(6)45(56)46(62-9)44(55)33(5)23-29/h10-12,15-16,24,29,31-33,35-40,42-43,45-46,52-53,56,60H,13-14,17-23,25-28H2,1-9H3/b12-10+,15-11+,30-16+,34-24+/t29-,31-,32-,33-,35-,36+,37+,38+,39-,40-,42+,43-,45-,46+,50-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The compound was tested for binding afifnity to FK506 binding protein 12 using Rapamycin as control, with an ascomycin conjugate of alkaline phosphat...				Bioorg Med Chem Lett 10: 1405-8 (2000) BindingDB Entry DOI: 10.7270/Q2CV4GZH
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076808 (CHEMBL10762 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccn2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H30N2O5S/c1-20-7-3-4-8-23(20)25-17-21(10-12-24(25)29(33)32-27(30(34)35)14-16-38-2)18-36-19-22-11-13-28(37-22)26-9-5-6-15-31-26/h3-13,15,17,27H,14,16,18-19H2,1-2H3,(H,32,33)(H,34,35)/p-1/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076813 (CHEMBL10687 | Lithium; (S)-2-({5-[5-(2-methoxy-phe...) Show SMILES COc1ccccc1-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-8-4-5-9-24(21)27-18-22(12-14-25(27)31(34)33-28(32(35)36)16-17-40-3)19-38-20-23-13-15-30(39-23)26-10-6-7-11-29(26)37-2/h4-15,18,28H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076812 ((S)-2-[(5-{[(Furan-2-ylmethyl)-amino]-methyl}-biph...) Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCc2ccco2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C24H26N2O4S/c1-31-13-11-22(24(28)29)26-23(27)20-10-9-17(15-25-16-19-8-5-12-30-19)14-21(20)18-6-3-2-4-7-18/h2-10,12,14,22,25H,11,13,15-16H2,1H3,(H,26,27)(H,28,29)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human))	BDBM50089429 (4-[2-(1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,2...) Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)CCCC\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OC(=O)N1CCOCC1 |c:14,33| Show InChI InChI=1S/C56H90N2O15/c1-34-16-12-11-13-17-35(2)46(67-8)32-42-21-19-40(7)56(66,73-42)52(62)53(63)58-23-15-14-18-43(58)54(64)71-47(33-44(59)36(3)29-39(6)50(61)51(69-10)49(60)38(5)28-34)37(4)30-41-20-22-45(48(31-41)68-9)72-55(65)57-24-26-70-27-25-57/h17,29,34,36-38,40-43,45-48,50-51,61,66H,11-16,18-28,30-33H2,1-10H3/b35-17+,39-29+/t34-,36-,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,56-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The compound was tested for binding afifnity to FK506 binding protein 12 using Rapamycin as control, with an ascomycin conjugate of alkaline phosphat...				Bioorg Med Chem Lett 10: 1405-8 (2000) BindingDB Entry DOI: 10.7270/Q2CV4GZH
					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human))	BDBM50089432 (1,18-dihydroxy-19,30-dimethoxy-12-{2-[3-methoxy-4-...) Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)CCCC\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OC(=O)N(C)OC |c:14,33| Show InChI InChI=1S/C54H88N2O15/c1-32-18-14-13-15-19-33(2)44(65-9)30-40-23-21-38(7)54(64,71-40)50(60)51(61)56-25-17-16-20-41(56)52(62)69-45(31-42(57)34(3)27-37(6)48(59)49(67-11)47(58)36(5)26-32)35(4)28-39-22-24-43(46(29-39)66-10)70-53(63)55(8)68-12/h19,27,32,34-36,38-41,43-46,48-49,59,64H,13-18,20-26,28-31H2,1-12H3/b33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,54-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The compound was tested for binding afifnity to FK506 binding protein 12 using Rapamycin as control, with an ascomycin conjugate of alkaline phosphat...				Bioorg Med Chem Lett 10: 1405-8 (2000) BindingDB Entry DOI: 10.7270/Q2CV4GZH
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076805 ((S)-4-Methylsulfanyl-2-[(5-phenoxymethyl-biphenyl-...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2ccccc2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H25NO4S/c1-31-15-14-23(25(28)29)26-24(27)21-13-12-18(17-30-20-10-6-3-7-11-20)16-22(21)19-8-4-2-5-9-19/h2-13,16,23H,14-15,17H2,1H3,(H,26,27)(H,28,29)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076793 (CHEMBL11003 | Lithium; (S)-2-({2'-methyl-5-[5-(4-m...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(SC)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H33NO5S2/c1-21-6-4-5-7-26(21)28-18-22(8-14-27(28)31(34)33-29(32(35)36)16-17-39-2)19-37-20-24-11-15-30(38-24)23-9-12-25(40-3)13-10-23/h4-15,18,29H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076794 (CHEMBL276602 | Lithium; (S)-2-({5-[5-(4-isopropyl-...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)C(C)C)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C34H37NO5S/c1-22(2)25-10-12-26(13-11-25)32-16-14-27(40-32)21-39-20-24-9-15-29(30(19-24)28-8-6-5-7-23(28)3)33(36)35-31(34(37)38)17-18-41-4/h5-16,19,22,31H,17-18,20-21H2,1-4H3,(H,35,36)(H,37,38)/p-1/t31-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	0.780	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076788 (CHEMBL11195 | Lithium; (S)-2-({5-[5-(3-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2cccc(F)c2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-6-3-4-9-25(20)27-16-21(10-12-26(27)30(34)33-28(31(35)36)14-15-39-2)18-37-19-24-11-13-29(38-24)22-7-5-8-23(32)17-22/h3-13,16-17,28H,14-15,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076798 (CHEMBL273697 | Lithium; (S)-2-({5-[5-(4-fluoro-phe...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(F)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-5-3-4-6-25(20)27-17-21(7-13-26(27)30(34)33-28(31(35)36)15-16-39-2)18-37-19-24-12-14-29(38-24)22-8-10-23(32)11-9-22/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076809 (CHEMBL417606 | Lithium; (S)-2-({5-[5-(4-formyl-phe...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(C=O)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H31NO6S/c1-21-5-3-4-6-26(21)28-17-23(9-13-27(28)31(35)33-29(32(36)37)15-16-40-2)19-38-20-25-12-14-30(39-25)24-10-7-22(18-34)8-11-24/h3-14,17-18,29H,15-16,19-20H2,1-2H3,(H,33,35)(H,36,37)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076803 (CHEMBL10970 | Lithium; (S)-2-({5-[5-(2-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-7-3-4-8-23(20)26-17-21(11-13-24(26)30(34)33-28(31(35)36)15-16-39-2)18-37-19-22-12-14-29(38-22)25-9-5-6-10-27(25)32/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076791 (CHEMBL10990 | Lithium; (S)-4-methylsulfanyl-2-{[2'...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(C)cc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H33NO5S/c1-21-8-11-24(12-9-21)30-15-13-25(38-30)20-37-19-23-10-14-27(28(18-23)26-7-5-4-6-22(26)2)31(34)33-29(32(35)36)16-17-39-3/h4-15,18,29H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.80	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076813 (CHEMBL10687 | Lithium; (S)-2-({5-[5-(2-methoxy-phe...) Show SMILES COc1ccccc1-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-8-4-5-9-24(21)27-18-22(12-14-25(27)31(34)33-28(32(35)36)16-17-40-3)19-38-20-23-13-15-30(39-23)26-10-6-7-11-29(26)37-2/h4-15,18,28H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076807 (CHEMBL273721 | Lithium; (S)-2-({5-[5-(3-methoxy-ph...) Show SMILES COc1cccc(c1)-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-7-4-5-10-26(21)28-17-22(11-13-27(28)31(34)33-29(32(35)36)15-16-40-3)19-38-20-25-12-14-30(39-25)23-8-6-9-24(18-23)37-2/h4-14,17-18,29H,15-16,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076808 (CHEMBL10762 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccn2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H30N2O5S/c1-20-7-3-4-8-23(20)25-17-21(10-12-24(25)29(33)32-27(30(34)35)14-16-38-2)18-36-19-22-11-13-28(37-22)26-9-5-6-15-31-26/h3-13,15,17,27H,14,16,18-19H2,1-2H3,(H,32,33)(H,34,35)/p-1/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>0.300	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076810 (CHEMBL428001 | Lithium; (S)-4-methylsulfanyl-2-({2...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccc(cc2)C(F)(F)F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C32H30F3NO5S/c1-20-5-3-4-6-25(20)27-17-21(7-13-26(27)30(37)36-28(31(38)39)15-16-42-2)18-40-19-24-12-14-29(41-24)22-8-10-23(11-9-22)32(33,34)35/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,36,37)(H,38,39)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076802 (CHEMBL10912 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccncc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H30N2O5S/c1-20-5-3-4-6-24(20)26-17-21(7-9-25(26)29(33)32-27(30(34)35)13-16-38-2)18-36-19-23-8-10-28(37-23)22-11-14-31-15-12-22/h3-12,14-15,17,27H,13,16,18-19H2,1-2H3,(H,32,33)(H,34,35)/p-1/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>0.300	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair

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