Found 162 hits with Last Name = 'smith' and Initial = 'dr' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403846
(CHEMBL356021)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCCc2ccc(Br)cc12 Show InChI InChI=1S/C20H24BrN3O3S/c1-27-20-7-6-17(14-19(20)23-11-8-22-9-12-23)28(25,26)24-10-2-3-15-4-5-16(21)13-18(15)24/h4-7,13-14,22H,2-3,8-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50403827
(CHEMBL414628)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2ccc(I)cc12 Show InChI InChI=1S/C19H22IN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-5,12-13,21H,6-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n... |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403827
(CHEMBL414628)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2ccc(I)cc12 Show InChI InChI=1S/C19H22IN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-5,12-13,21H,6-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403839
(CHEMBL155717)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Br)c1 Show InChI InChI=1S/C17H19Br2N3O3S/c1-25-17-3-2-15(11-16(17)22-6-4-20-5-7-22)26(23,24)21-14-9-12(18)8-13(19)10-14/h2-3,8-11,20-21H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403850
(CHEMBL157454)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2c(Cl)ccc(Cl)c2C1 Show InChI InChI=1S/C20H23Cl2N3O3S/c1-28-20-5-2-14(12-19(20)24-10-7-23-8-11-24)29(26,27)25-9-6-15-16(13-25)18(22)4-3-17(15)21/h2-5,12,23H,6-11,13H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403851
(CHEMBL346338)Show InChI InChI=1S/C17H20IN3O3S/c1-24-17-6-5-15(12-16(17)21-9-7-19-8-10-21)25(22,23)20-14-4-2-3-13(18)11-14/h2-6,11-12,19-20H,7-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50130286
(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 Show InChI InChI=1S/C21H24ClN3O3S2/c1-14-17-12-15(22)4-7-20(17)29-21(14)30(26,27)23-16-5-6-19(28-3)18(13-16)25-10-8-24(2)9-11-25/h4-7,12-13,23H,8-11H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]5-LSD as radioligand; n... |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403840
(CHEMBL345110)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C17H19Cl2N3O3S/c1-25-17-3-2-15(11-16(17)22-6-4-20-5-7-22)26(23,24)21-14-9-12(18)8-13(19)10-14/h2-3,8-11,20-21H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50130270
(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 Show InChI InChI=1S/C23H26ClN3O3S2/c1-15-19-12-16(24)5-8-22(19)31-23(15)32(28,29)25-17-6-7-21(30-2)20(13-17)27-11-10-26-9-3-4-18(26)14-27/h5-8,12-13,18,25H,3-4,9-11,14H2,1-2H3/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]5-LSD as radioligand; n... |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403861
(CHEMBL151998)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCCc2c(Cl)cc(Cl)cc12 Show InChI InChI=1S/C20H23Cl2N3O3S/c1-28-20-5-4-15(13-19(20)24-9-6-23-7-10-24)29(26,27)25-8-2-3-16-17(22)11-14(21)12-18(16)25/h4-5,11-13,23H,2-3,6-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50001824
(CHEMBL282971)Show SMILES [H][C@]12CCCN1CCN(C2)c1cc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)ccc1OC Show InChI InChI=1S/C23H26ClN3O3S2/c1-15-19-12-16(24)5-8-22(19)31-23(15)32(28,29)25-17-6-7-21(30-2)20(13-17)27-11-10-26-9-3-4-18(26)14-27/h5-8,12-13,18,25H,3-4,9-11,14H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]5-LSD as radioligand; n... |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403843
(CHEMBL151295)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1c2ccccc2CC1(C)C Show InChI InChI=1S/C21H27N3O3S/c1-21(2)15-16-6-4-5-7-18(16)24(21)28(25,26)17-8-9-20(27-3)19(14-17)23-12-10-22-11-13-23/h4-9,14,22H,10-13,15H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403845
(CHEMBL154089)Show InChI InChI=1S/C18H22IN3O3S/c1-13-3-4-14(19)11-16(13)21-26(23,24)15-5-6-18(25-2)17(12-15)22-9-7-20-8-10-22/h3-6,11-12,20-21H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50403826
(CHEMBL154274)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)ccc1Br Show InChI InChI=1S/C17H19Br2N3O3S/c1-25-17-5-3-13(11-16(17)22-8-6-20-7-9-22)26(23,24)21-15-10-12(18)2-4-14(15)19/h2-5,10-11,20-21H,6-9H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=... |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403826
(CHEMBL154274)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)ccc1Br Show InChI InChI=1S/C17H19Br2N3O3S/c1-25-17-5-3-13(11-16(17)22-8-6-20-7-9-22)26(23,24)21-15-10-12(18)2-4-14(15)19/h2-5,10-11,20-21H,6-9H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403842
(CHEMBL154675)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1ccccc1C(C)C Show InChI InChI=1S/C20H27N3O3S/c1-15(2)17-6-4-5-7-18(17)22-27(24,25)16-8-9-20(26-3)19(14-16)23-12-10-21-11-13-23/h4-9,14-15,21-22H,10-13H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM28583
(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1 Show InChI InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]LSD as radioligand; n=3 |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403863
(CHEMBL157173)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2cccc(Cl)c2C1 Show InChI InChI=1S/C20H24ClN3O3S/c1-27-20-6-5-16(13-19(20)23-11-8-22-9-12-23)28(25,26)24-10-7-15-3-2-4-18(21)17(15)14-24/h2-6,13,22H,7-12,14H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403859
(CHEMBL348870)Show InChI InChI=1S/C17H20ClN3O3S/c1-24-17-6-5-15(12-16(17)21-9-7-19-8-10-21)25(22,23)20-14-4-2-3-13(18)11-14/h2-6,11-12,19-20H,7-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403838
(CHEMBL154273)Show SMILES COc1ccc(Cl)cc1NS(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C18H22ClN3O4S/c1-25-17-5-3-13(19)11-15(17)21-27(23,24)14-4-6-18(26-2)16(12-14)22-9-7-20-8-10-22/h3-6,11-12,20-21H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403837
(CHEMBL154367)Show InChI InChI=1S/C17H20BrN3O3S/c1-24-17-6-5-15(12-16(17)21-9-7-19-8-10-21)25(22,23)20-14-4-2-3-13(18)11-14/h2-6,11-12,19-20H,7-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403847
(CHEMBL157338)Show SMILES COc1ccc(OC)c2CN(CCc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C22H29N3O5S/c1-28-20-6-7-21(29-2)18-15-25(11-8-17(18)20)31(26,27)16-4-5-22(30-3)19(14-16)24-12-9-23-10-13-24/h4-7,14,23H,8-13,15H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403849
(CHEMBL155106)Show InChI InChI=1S/C17H20BrN3O3S/c1-24-17-7-6-13(12-16(17)21-10-8-19-9-11-21)25(22,23)20-15-5-3-2-4-14(15)18/h2-7,12,19-20H,8-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403835
(CHEMBL157103)Show InChI InChI=1S/C17H20IN3O3S/c1-24-17-7-6-15(12-16(17)21-10-8-19-9-11-21)25(22,23)20-14-4-2-13(18)3-5-14/h2-7,12,19-20H,8-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403828
(CHEMBL156130)Show SMILES COc1cc(Cl)c(C)cc1NS(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C19H24ClN3O4S/c1-13-10-16(19(27-3)12-15(13)20)22-28(24,25)14-4-5-18(26-2)17(11-14)23-8-6-21-7-9-23/h4-5,10-12,21-22H,6-9H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403848
(CHEMBL346990)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Br)c1Cl Show InChI InChI=1S/C17H18BrCl2N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(19)8-13(18)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50403833
(CHEMBL157910)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1Cl Show InChI InChI=1S/C17H18Cl3N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n... |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403833
(CHEMBL157910)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1Cl Show InChI InChI=1S/C17H18Cl3N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403857
(CHEMBL154525)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H19Cl2N3O3S/c1-25-17-5-3-13(11-16(17)22-8-6-20-7-9-22)26(23,24)21-12-2-4-14(18)15(19)10-12/h2-5,10-11,20-21H,6-9H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403841
(CHEMBL154641)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Br)c1Br Show InChI InChI=1S/C17H18Br3N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403830
(CHEMBL154720)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Br)c1Cl Show InChI InChI=1S/C17H18Br2ClN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403853
(CHEMBL348364)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Br)c1F Show InChI InChI=1S/C17H18Br2FN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403864
(CHEMBL154842)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1Br Show InChI InChI=1S/C17H18BrCl2N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(19)8-13(20)17(14)18/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403862
(CHEMBL154534)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(F)c1Cl Show InChI InChI=1S/C17H18BrClFN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50130268
(CHEMBL329383 | N-(2,5-Dibromo-3-fluoro-phenyl)-4-m...)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(F)c1Br Show InChI InChI=1S/C17H18Br2FN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403856
(CHEMBL152806)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCCc2cc(Br)ccc12 Show InChI InChI=1S/C20H24BrN3O3S/c1-27-20-7-5-17(14-19(20)23-11-8-22-9-12-23)28(25,26)24-10-2-3-15-13-16(21)4-6-18(15)24/h4-7,13-14,22H,2-3,8-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403832
(CHEMBL153918)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Cl)c1Br Show InChI InChI=1S/C17H18Br2ClN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403829
(CHEMBL155234)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2cc(C)c(cc12)C(F)(F)F Show InChI InChI=1S/C21H24F3N3O3S/c1-14-11-15-5-8-27(18(15)13-17(14)21(22,23)24)31(28,29)16-3-4-20(30-2)19(12-16)26-9-6-25-7-10-26/h3-4,11-13,25H,5-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403831
(CHEMBL157285)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2cc(I)ccc12 Show InChI InChI=1S/C19H22IN3O3S/c1-26-19-5-3-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-12-15(20)2-4-17(14)23/h2-5,12-13,21H,6-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403860
(CHEMBL350022)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(Cl)c1Cl Show InChI InChI=1S/C17H18BrCl2N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(19)17(14)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403852
(CHEMBL156610)Show SMILES COc1ccc(cc1NS(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1)C(F)(F)F Show InChI InChI=1S/C19H22F3N3O4S/c1-28-17-5-3-13(19(20,21)22)11-15(17)24-30(26,27)14-4-6-18(29-2)16(12-14)25-9-7-23-8-10-25/h3-6,11-12,23-24H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50219439
(CHEMBL29410)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1 Show InChI InChI=1S/C24H28ClN3O3S2/c1-16-20-13-17(25)6-9-23(20)32-24(16)33(29,30)26-18-7-8-22(31-2)21(14-18)28-12-11-27-10-4-3-5-19(27)15-28/h6-9,13-14,19,26H,3-5,10-12,15H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Similars
| PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]5-LSD as radioligand; n... |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403834
(CHEMBL157175)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cl Show InChI InChI=1S/C17H18Cl3N3O3S/c1-26-17-3-2-11(8-16(17)23-6-4-21-5-7-23)27(24,25)22-15-10-13(19)12(18)9-14(15)20/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403854
(CHEMBL350026)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1ccc(C)cc1Br Show InChI InChI=1S/C18H22BrN3O3S/c1-13-3-5-16(15(19)11-13)21-26(23,24)14-4-6-18(25-2)17(12-14)22-9-7-20-8-10-22/h3-6,11-12,20-21H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403844
(CHEMBL154186)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H22N4O5S/c1-13-3-4-14(22(23)24)11-16(13)20-28(25,26)15-5-6-18(27-2)17(12-15)21-9-7-19-8-10-21/h3-6,11-12,19-20H,7-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403855
(CHEMBL346227)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1ccc(Cl)cc1C(F)(F)F Show InChI InChI=1S/C18H19ClF3N3O3S/c1-28-17-5-3-13(11-16(17)25-8-6-23-7-9-25)29(26,27)24-15-4-2-12(19)10-14(15)18(20,21)22/h2-5,10-11,23-24H,6-9H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50403836
(CHEMBL158094)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(F)cc(F)c1Cl Show InChI InChI=1S/C17H18ClF2N3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(19)8-13(20)17(14)18/h2-3,8-10,21-22H,4-7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity against human 5-hydroxytryptamine 6 receptor |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50130270
(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 Show InChI InChI=1S/C23H26ClN3O3S2/c1-15-19-12-16(24)5-8-22(19)31-23(15)32(28,29)25-17-6-7-21(30-2)20(13-17)27-11-10-26-9-3-4-18(26)14-27/h5-8,12-13,18,25H,3-4,9-11,14H2,1-2H3/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50130270
(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 Show InChI InChI=1S/C23H26ClN3O3S2/c1-15-19-12-16(24)5-8-22(19)31-23(15)32(28,29)25-17-6-7-21(30-2)20(13-17)27-11-10-26-9-3-4-18(26)14-27/h5-8,12-13,18,25H,3-4,9-11,14H2,1-2H3/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1A receptor in HEK293 cells, using [3H]8-OH-DPAT as radioli... |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50001824
(CHEMBL282971)Show SMILES [H][C@]12CCCN1CCN(C2)c1cc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)ccc1OC Show InChI InChI=1S/C23H26ClN3O3S2/c1-15-19-12-16(24)5-8-22(19)31-23(15)32(28,29)25-17-6-7-21(30-2)20(13-17)27-11-10-26-9-3-4-18(26)14-27/h5-8,12-13,18,25H,3-4,9-11,14H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand |
Bioorg Med Chem Lett 12: 1357-60 (2002)
BindingDB Entry DOI: 10.7270/Q2NK3H7V |
More data for this Ligand-Target Pair | |