BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 45 hits with Last Name = 'da silva' and Initial = 'eb'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568077
PNG
(CHEMBL4865195)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC1=C(C#N)C(=O)c2ccccc2C1=O)C(O)=O |r,c:18|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
0.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Trypanosoma brucei rhodesain


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50518231
PNG
(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Show SMILES C(Nc1nc(Nc2ccccc2)nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C21H18N4/c1-3-9-16(10-4-1)15-22-20-18-13-7-8-14-19(18)24-21(25-20)23-17-11-5-2-6-12-17/h1-14H,15H2,(H2,22,23,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
1.40E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546138
PNG
(CHEMBL4793916)
Show SMILES Cl.Cl.Clc1cc(Br)ccc1-c1ccc(CNCC2CCNCC2)o1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
3.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50546136
PNG
(CHEMBL531738)
Show SMILES Cn1c2ccc(CNCCNc3ccnc4cc(Cl)ccc34)cc2n(C)c1=O
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Mixed inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50233289
PNG
(CHEMBL1241726)
Show SMILES Clc1ccc2c(NCCCN3CCOCC3)ccnc2c1
Show InChI InChI=1S/C16H20ClN3O/c17-13-2-3-14-15(4-6-19-16(14)12-13)18-5-1-7-20-8-10-21-11-9-20/h2-4,6,12H,1,5,7-11H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.21E+4n/an/an/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant Trypanosoma cruzi cruzain in presence of varying levels of Z-phe-Arg-amidomethylcoumarin substrate by Lineweave...


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058809
PNG
(CHEMBL3329524)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccc2ccccc2c1)c1ccccn1
Show InChI InChI=1S/C20H16N4S/c1-14(18-8-4-5-11-21-18)23-24-20-22-19(13-25-20)17-10-9-15-6-2-3-7-16(15)12-17/h2-13H,1H3,(H,22,24)/b23-14+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058806
PNG
(CHEMBL3329519)
Show SMILES COc1ccc(cc1)-c1csc(N\N=C(/C)c2ccccn2)n1
Show InChI InChI=1S/C17H16N4OS/c1-12(15-5-3-4-10-18-15)20-21-17-19-16(11-23-17)13-6-8-14(22-2)9-7-13/h3-11H,1-2H3,(H,19,21)/b20-12+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058805
PNG
(CHEMBL3329518)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccc(F)cc1)c1ccccn1
Show InChI InChI=1S/C16H13FN4S/c1-11(14-4-2-3-9-18-14)20-21-16-19-15(10-22-16)12-5-7-13(17)8-6-12/h2-10H,1H3,(H,19,21)/b20-11+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058808
PNG
(CHEMBL3329521)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1)c1ccccn1
Show InChI InChI=1S/C16H12Cl2N4S/c1-10(14-4-2-3-7-19-14)21-22-16-20-15(9-23-16)11-5-6-12(17)13(18)8-11/h2-9H,1H3,(H,20,22)/b21-10+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058804
PNG
(CHEMBL3329515)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccc(C)cc1)c1ccccn1
Show InChI InChI=1S/C17H16N4S/c1-12-6-8-14(9-7-12)16-11-22-17(19-16)21-20-13(2)15-5-3-4-10-18-15/h3-11H,1-2H3,(H,19,21)/b20-13+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058802
PNG
(CHEMBL3329513)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(N\N=C\c2ccccn2)n1
Show InChI InChI=1S/C15H11N5O2S/c21-20(22)13-6-3-4-11(8-13)14-10-23-15(18-14)19-17-9-12-5-1-2-7-16-12/h1-10H,(H,18,19)/b17-9+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058803
PNG
(CHEMBL2409542)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccccc1)c1ccccn1
Show InChI InChI=1S/C16H14N4S/c1-12(14-9-5-6-10-17-14)19-20-16-18-15(11-21-16)13-7-3-2-4-8-13/h2-11H,1H3,(H,18,20)/b19-12+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568076
PNG
(CHEMBL4877896)
Show SMILES O=C1C=C(Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)C(=O)c2ccccc12 |t:2|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546137
PNG
(CHEMBL582420 | MMV019202 | TCMDC-123752)
Show SMILES CCOc1cccc(c1)C(=O)Nc1ccc(cc1)-c1nc2ccccc2[nH]1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058807
PNG
(CHEMBL3329520)
Show SMILES C\C(=N/Nc1nc(cs1)-c1ccc(Cl)cc1Cl)c1ccccn1
Show InChI InChI=1S/C16H12Cl2N4S/c1-10(14-4-2-3-7-19-14)21-22-16-20-15(9-23-16)12-6-5-11(17)8-13(12)18/h2-9H,1H3,(H,20,22)/b21-10+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.80E+3n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546139
PNG
(CHEMBL533921 | MMV666072 | TCMDC-124653)
Show SMILES COCCNC(=O)c1ccc(OC2CCN(Cc3ccc(F)c(F)c3)CC2)c(Cl)c1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50568076
PNG
(CHEMBL4877896)
Show SMILES O=C1C=C(Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)C(=O)c2ccccc12 |t:2|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50546139
PNG
(CHEMBL533921 | MMV666072 | TCMDC-124653)
Show SMILES COCCNC(=O)c1ccc(OC2CCN(Cc3ccc(F)c(F)c3)CC2)c(Cl)c1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate preincubated for 10 mins followed by ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50518231
PNG
(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Show SMILES C(Nc1nc(Nc2ccccc2)nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C21H18N4/c1-3-9-16(10-4-1)15-22-20-18-13-7-8-14-19(18)24-21(25-20)23-17-11-5-2-6-12-17/h1-14H,15H2,(H2,22,23,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50058801
PNG
(CHEMBL3329506)
Show SMILES Brc1ccc(cc1)-c1csc(N\N=C\c2ccccn2)n1
Show InChI InChI=1S/C15H11BrN4S/c16-12-6-4-11(5-7-12)14-10-21-15(19-14)20-18-9-13-3-1-2-8-17-13/h1-10H,(H,19,20)/b18-9+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.50E+3n/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...


Eur J Med Chem 86: 48-59 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.012
BindingDB Entry DOI: 10.7270/Q2W097M2
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50322743
PNG
(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Show SMILES Clc1ccc2[nH]c3c(NCCCN4CCOCC4)ncnc3c2c1
Show InChI InChI=1S/C17H20ClN5O/c18-12-2-3-14-13(10-12)15-16(22-14)17(21-11-20-15)19-4-1-5-23-6-8-24-9-7-23/h2-3,10-11,22H,1,4-9H2,(H,19,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50233289
PNG
(CHEMBL1241726)
Show SMILES Clc1ccc2c(NCCCN3CCOCC3)ccnc2c1
Show InChI InChI=1S/C16H20ClN3O/c17-13-2-3-14-15(4-6-19-16(14)12-13)18-5-1-7-20-8-10-21-11-9-20/h2-4,6,12H,1,5,7-11H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568075
PNG
(CHEMBL4845877)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](=O)-c2ccncc2)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546138
PNG
(CHEMBL4793916)
Show SMILES Cl.Cl.Clc1cc(Br)ccc1-c1ccc(CNCC2CCNCC2)o1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50233288
PNG
(CHEMBL460418)
Show SMILES OCCCNc1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C12H13ClN2O/c13-9-2-3-10-11(14-5-1-7-16)4-6-15-12(10)8-9/h2-4,6,8,16H,1,5,7H2,(H,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568074
PNG
(CHEMBL4859457)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](-[#7])=S)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568075
PNG
(CHEMBL4845877)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](=O)-c2ccncc2)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568076
PNG
(CHEMBL4877896)
Show SMILES O=C1C=C(Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)C(=O)c2ccccc12 |t:2|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50518231
PNG
(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Show SMILES C(Nc1nc(Nc2ccccc2)nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C21H18N4/c1-3-9-16(10-4-1)15-22-20-18-13-7-8-14-19(18)24-21(25-20)23-17-11-5-2-6-12-17/h1-14H,15H2,(H2,22,23,24,25)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate and measured at 12 sec interval for 5...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50568075
PNG
(CHEMBL4845877)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](=O)-c2ccncc2)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50049066
PNG
(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Show SMILES OC1=CC(=O)c2ccccc2C1=O |t:1|
Show InChI InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50568074
PNG
(CHEMBL4859457)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](-[#7])=S)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50546136
PNG
(CHEMBL531738)
Show SMILES Cn1c2ccc(CNCCNc3ccnc4cc(Cl)ccc34)cc2n(C)c1=O
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate preincubated for 10 mins followed by ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50120739
PNG
((7-Chloro-quinolin-4-yl)-(2-morpholin-4-yl-ethyl)-...)
Show SMILES Clc1ccc2c(NCCN3CCOCC3)ccnc2c1
Show InChI InChI=1S/C15H18ClN3O/c16-12-1-2-13-14(3-4-17-15(13)11-12)18-5-6-19-7-9-20-10-8-19/h1-4,11H,5-10H2,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50233286
PNG
(CHEMBL528696 | TCMDC-125506)
Show SMILES Clc1ccc2c(NCc3ccccc3)ccnc2c1
Show InChI InChI=1S/C16H13ClN2/c17-13-6-7-14-15(8-9-18-16(14)10-13)19-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.40E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546136
PNG
(CHEMBL531738)
Show SMILES Cn1c2ccc(CNCCNc3ccnc4cc(Cl)ccc34)cc2n(C)c1=O
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50546138
PNG
(CHEMBL4793916)
Show SMILES Cl.Cl.Clc1cc(Br)ccc1-c1ccc(CNCC2CCNCC2)o1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate and measured at 12 sec interval for 5...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50384788
PNG
(LAPACHOL)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-1-[#6](=O)-[#6](=O)-c2ccccc2-[#6]-1=O
Show InChI InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,12H,8H2,1-2H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50233287
PNG
(CHEMBL31000)
Show SMILES OCCNc1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C11H11ClN2O/c12-8-1-2-9-10(14-5-6-15)3-4-13-11(9)7-8/h1-4,7,15H,5-6H2,(H,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.20E+4n/an/an/an/an/an/a



Universidade Federal de Minas Gerais

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method


Bioorg Med Chem 25: 1889-1900 (2017)


Article DOI: 10.1016/j.bmc.2017.02.009
BindingDB Entry DOI: 10.7270/Q21838R0
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50568074
PNG
(CHEMBL4859457)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6](-[#8])-c2ccccc2\[#6](=[#7]\[#7]-[#6](-[#7])=S)-[#6]-1=O |c:5|
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.60E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50384788
PNG
(LAPACHOL)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-1-[#6](=O)-[#6](=O)-c2ccccc2-[#6]-1=O
Show InChI InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,12H,8H2,1-2H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cysteine protease


(Trypanosoma brucei rhodesiense)
BDBM50049066
PNG
(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Show SMILES OC1=CC(=O)c2ccccc2C1=O |t:1|
Show InChI InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116213
BindingDB Entry DOI: 10.7270/Q2183B90
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50546136
PNG
(CHEMBL531738)
Show SMILES Cn1c2ccc(CNCCNc3ccnc4cc(Cl)ccc34)cc2n(C)c1=O
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.45E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...


Citation and Details

Article DOI: 10.1016/j.ejmech.2019.06.062
BindingDB Entry DOI: 10.7270/Q2HM5D27
More data for this
Ligand-Target Pair