Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50259542![]() (2-(3-Trifluoromethylphenyl)-4(5)-(3-trifluoromethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50259490![]() (2-Phenyl-4(5)-(4-trifluoromethylphenyl)imidazole |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50259388![]() (2-(4-Chlorophenyl)-4(5)-phenylimidazole | CHEMBL50...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50365938![]() (CHEMBL1958460) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.7 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50365939![]() (CHEMBL1958461) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.7 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50259541![]() (2-(4-Nitrophenyl)-4(5)-(3-trifluoromethylphenyl)-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50365940![]() (CHEMBL1958462) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.7 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50145044![]() (2-Phenyl-4(5)-(3-trifluoromethylphenyl)imidazole |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50365940![]() (CHEMBL1958462) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.5 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50365938![]() (CHEMBL1958460) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.5 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50365939![]() (CHEMBL1958461) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.5 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50133778![]() (2,4(5)-Diphenylimidazole | 2,4-diphenyl-1H-imidazo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50003655![]() (Phenytoin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50003655![]() (Phenytoin) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.5 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50259540![]() (2-(4-Chlorophenyl)-4(5)-(3-trifluoromethylphenyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50003655![]() (Phenytoin) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of human voltage-gated sodium channel 1.7 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy... | Bioorg Med Chem 20: 2180-8 (2012) Article DOI: 10.1016/j.bmc.2011.08.061 BindingDB Entry DOI: 10.7270/Q2377961 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50031299![]() (6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method | Bioorg Med Chem 17: 3642-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.067 BindingDB Entry DOI: 10.7270/Q2GQ6XN5 | |||||||||||
More data for this Ligand-Target Pair |