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Compile Data Set for Download or QSAR

Found 42 hits with Last Name = 'dotsey' and Initial = 'ey'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514172
PNG
(CHEMBL4536072)
Show SMILES O=c1n(NCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C19H20N4O2S2/c24-18-14-8-2-4-10-16(14)26-22(18)20-12-6-1-7-13-21-23-19(25)15-9-3-5-11-17(15)27-23/h2-5,8-11,20-21H,1,6-7,12-13H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514166
PNG
(CHEMBL4448448)
Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514173
PNG
(CHEMBL4463191)
Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514167
PNG
(CHEMBL4560077)
Show SMILES O=c1n(CCc2cccc3ccccc23)sc2ccccc12
Show InChI InChI=1S/C19H15NOS/c21-19-17-10-3-4-11-18(17)22-20(19)13-12-15-8-5-7-14-6-1-2-9-16(14)15/h1-11H,12-13H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514173
PNG
(CHEMBL4463191)
Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514170
PNG
(CHEMBL4515209)
Show SMILES O=c1n(CCc2ccc3ccccc3c2)sc2ccccc12
Show InChI InChI=1S/C19H15NOS/c21-19-17-7-3-4-8-18(17)22-20(19)12-11-14-9-10-15-5-1-2-6-16(15)13-14/h1-10,13H,11-12H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514173
PNG
(CHEMBL4463191)
Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514182
PNG
(CHEMBL3219170)
Show SMILES O=c1n(sc2ccccc12)C1CCCCC1
Show InChI InChI=1S/C13H15NOS/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50359050
PNG
(CHEMBL1922513)
Show SMILES CCCCCCCCn1sc2ccccc2c1=O
Show InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM61908
PNG
(2-methyl-1,2-benzothiazol-3-one | KUC103657N | acs...)
Show SMILES Cn1sc2ccccc2c1=O
Show InChI InChI=1S/C8H7NOS/c1-9-8(10)6-4-2-3-5-7(6)11-9/h2-5H,1H3
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514166
PNG
(CHEMBL4448448)
Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM81363
PNG
(Pristimerin)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=c5c(cc(O)c(O)c5=C)[C@]4(C)CC[C@@]3(C)C2C1 |r,c:16,t:14|
Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,31-32H,1,10-15,17H2,2-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 93n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514180
PNG
(CHEMBL4439900)
Show SMILES COC(=O)c1ccc(CNn2sc3ccccc3c2=O)cc1
Show InChI InChI=1S/C16H14N2O3S/c1-21-16(20)12-8-6-11(7-9-12)10-17-18-15(19)13-4-2-3-5-14(13)22-18/h2-9,17H,10H2,1H3
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514166
PNG
(CHEMBL4448448)
Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514179
PNG
(CHEMBL4558017)
Show SMILES Oc1ccc2sn(CCc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C15H13NO2S/c17-12-6-7-14-13(10-12)15(18)16(19-14)9-8-11-4-2-1-3-5-11/h1-7,10,17H,8-9H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514183
PNG
(CHEMBL4445264)
Show SMILES [O-][N+](=O)c1ccc2sn(CCc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C15H12N2O3S/c18-15-13-10-12(17(19)20)6-7-14(13)21-16(15)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514174
PNG
(CHEMBL4514686)
Show SMILES CN(Cc1ccccc1)n1sc2ccccc2c1=O
Show InChI InChI=1S/C15H14N2OS/c1-16(11-12-7-3-2-4-8-12)17-15(18)13-9-5-6-10-14(13)19-17/h2-10H,11H2,1H3
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514171
PNG
(CHEMBL4450432)
Show SMILES O=c1n(CCCCCCN2CCCCC2)sc2ccccc12
Show InChI InChI=1S/C18H26N2OS/c21-18-16-10-4-5-11-17(16)22-20(18)15-9-2-1-6-12-19-13-7-3-8-14-19/h4-5,10-11H,1-3,6-9,12-15H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514172
PNG
(CHEMBL4536072)
Show SMILES O=c1n(NCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C19H20N4O2S2/c24-18-14-8-2-4-10-16(14)26-22(18)20-12-6-1-7-13-21-23-19(25)15-9-3-5-11-17(15)27-23/h2-5,8-11,20-21H,1,6-7,12-13H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514172
PNG
(CHEMBL4536072)
Show SMILES O=c1n(NCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C19H20N4O2S2/c24-18-14-8-2-4-10-16(14)26-22(18)20-12-6-1-7-13-21-23-19(25)15-9-3-5-11-17(15)27-23/h2-5,8-11,20-21H,1,6-7,12-13H2
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Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514178
PNG
(CHEMBL4544505)
Show SMILES [O-][N+](=O)c1ccc2c(c1)sn(CCc1ccccc1)c2=O
Show InChI InChI=1S/C15H12N2O3S/c18-15-13-7-6-12(17(19)20)10-14(13)21-16(15)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2
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n/an/a 238n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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n/an/a 243n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514176
PNG
(CHEMBL4449771)
Show SMILES OC(=O)c1ccc(CNn2sc3ccccc3c2=O)cc1
Show InChI InChI=1S/C15H12N2O3S/c18-14-12-3-1-2-4-13(12)21-17(14)16-9-10-5-7-11(8-6-10)15(19)20/h1-8,16H,9H2,(H,19,20)
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n/an/a 278n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM46658
PNG
(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Show SMILES O=c1[nH]sc2ccccc12
Show InChI InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
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n/an/a 307n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514175
PNG
(CHEMBL4553365)
Show SMILES O=c1n(NCc2ccc(cc2)-c2ccccc2)sc2ccccc12
Show InChI InChI=1S/C20H16N2OS/c23-20-18-8-4-5-9-19(18)24-22(20)21-14-15-10-12-17(13-11-15)16-6-2-1-3-7-16/h1-13,21H,14H2
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n/an/a 322n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514177
PNG
(CHEMBL4530292)
Show SMILES COc1ccc2c(c1)sn(CCc1ccccc1)c2=O
Show InChI InChI=1S/C16H15NO2S/c1-19-13-7-8-14-15(11-13)20-17(16(14)18)10-9-12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3
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n/an/a 512n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514181
PNG
(CHEMBL4438540)
Show SMILES COc1ccc2sn(CCc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C16H15NO2S/c1-19-13-7-8-15-14(11-13)16(18)17(20-15)10-9-12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3
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n/an/a 568n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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n/an/a 605n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins follo...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514169
PNG
(CHEMBL4576162)
Show SMILES O=c1ccsn1CCc1ccccc1
Show InChI InChI=1S/C11H11NOS/c13-11-7-9-14-12(11)8-6-10-4-2-1-3-5-10/h1-5,7,9H,6,8H2
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n/an/a 759n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514173
PNG
(CHEMBL4463191)
Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2
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n/an/a 782n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins follo...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514172
PNG
(CHEMBL4536072)
Show SMILES O=c1n(NCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C19H20N4O2S2/c24-18-14-8-2-4-10-16(14)26-22(18)20-12-6-1-7-13-21-23-19(25)15-9-3-5-11-17(15)27-23/h2-5,8-11,20-21H,1,6-7,12-13H2
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n/an/a 1.46E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins follo...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50071058
PNG
((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...)
Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17|
Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514166
PNG
(CHEMBL4448448)
Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12
Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2
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n/an/a 2.08E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins follo...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514184
PNG
(CHEMBL4548018)
Show SMILES Oc1ccc2c(c1)sn(CCc1ccccc1)c2=O
Show InChI InChI=1S/C15H13NO2S/c17-12-6-7-13-14(10-12)19-16(15(13)18)9-8-11-4-2-1-3-5-11/h1-7,10,17H,8-9H2
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n/an/a 2.55E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Mus musculus (mouse))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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n/an/a 3.58E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of mouse ABHD6 expressed in HEK293 cells using 2-AG as substrate


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM81364
PNG
(Pristimerol)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1 |r,t:14|
Show InChI InChI=1S/C30H42O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h9,16,23,31-32H,8,10-15,17H2,1-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50435396
PNG
(CHEMBL2391916)
Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12
Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
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MMDB

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B.MOAD
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n/an/a 9.38E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain homogenates using [3H]anandamide as substrate measured after 30 mins by liquid scintillation counting method


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM50514168
PNG
(CHEMBL4545305)
Show SMILES Cc1cccc2c1sn(CCc1ccccc1)c2=O
Show InChI InChI=1S/C16H15NOS/c1-12-6-5-9-14-15(12)19-17(16(14)18)11-10-13-7-3-2-4-8-13/h2-9H,10-11H2,1H3
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n/an/a 1.31E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...


J Med Chem 63: 1261-1280 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01679
BindingDB Entry DOI: 10.7270/Q2377D2G
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM81366
PNG
(Dihydrocelastryl diacetate)
Show SMILES CC(=O)Oc1cc2c(CC=C3[C@@]2(C)CC[C@@]2(C)[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@]32C)C(O)=O)c(C)c1OC(C)=O |r,c:9|
Show InChI InChI=1S/C33H44O6/c1-19-22-9-10-25-31(6,23(22)17-24(38-20(2)34)27(19)39-21(3)35)14-16-33(8)26-18-30(5,28(36)37)12-11-29(26,4)13-15-32(25,33)7/h10,17,26H,9,11-16,18H2,1-8H3,(H,36,37)/t26-,29-,30-,31+,32-,33+/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Rattus norvegicus (Rat))
BDBM81365
PNG
(Dihydrocelastrol)
Show SMILES Cc1c(O)c(O)cc2c1CC=C1[C@@]2(C)CC[C@@]2(C)C3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:11|
Show InChI InChI=1S/C29H40O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h8,15,22,30-31H,7,9-14,16H2,1-6H3,(H,32,33)/t22?,25-,26-,27+,28-,29+/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Chem Biol 16: 1045-52 (2009)


Article DOI: 10.1016/j.chembiol.2009.09.012
BindingDB Entry DOI: 10.7270/Q2HH6HJ3
More data for this
Ligand-Target Pair