Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR7 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of imid... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 5 (Homo sapiens) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR5 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of flag... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR4 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of LPS-... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 3 (Homo sapiens) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR3 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of poly... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 2 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR2 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as inhibition of Pam2CS-induced N... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TLR9 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of ODN2... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit alpha (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK2alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type 1G (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK1gamma using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type 1D (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK1delta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type 1B (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK1beta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric ho... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type 1 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK1alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit beta (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK2beta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric ho... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type IV (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK4 using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric hotspo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit gamma (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK2gamma using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild-type human CAMK2delta using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TLR8 in human CD14-positive monocytes cells in presence of TLR7 stimulus | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TLR8 in human CD14-positive monocytes cells in presence of TLR4 stimulus | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced TNFalpha production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL-6 production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL-8 production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IFNgamma production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced MCP1 production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563780 (CHEMBL4795714) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL12 p40 production incubated for 16 hrs by immunoassay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124215 (CHEMBL3622866) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50330062 (1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50330063 (1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124216 (CHEMBL3622865) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 621 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124217 (CHEMBL3622863) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124218 (CHEMBL3622862) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124219 (CHEMBL3622861) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124220 (CHEMBL3622860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124221 (CHEMBL3622859) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 519 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124222 (CHEMBL3622858) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 727 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124223 (CHEMBL3622857) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.86E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124224 (CHEMBL3622856) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.18E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124225 (CHEMBL3622855) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124340 (CHEMBL3622854) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124341 (CHEMBL3622853) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124342 (CHEMBL3622852) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 91 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124343 (CHEMBL3622851) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 699 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124344 (CHEMBL3622847) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124345 (CHEMBL3622846) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124346 (CHEMBL3622844) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124347 (CHEMBL3622842) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124348 (CHEMBL3622841) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124349 (CHEMBL3622840) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50124350 (CHEMBL3622839) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay | J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563742 (CHEMBL4795284) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.84E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563743 (CHEMBL4783434) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.48E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50563744 (CHEMBL4780126) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00023 BindingDB Entry DOI: 10.7270/Q2CR5Z3F | |||||||||||
More data for this Ligand-Target Pair |
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