Compile Data Set for Download or QSAR

Found 693 hits with Last Name = 'marciniak' and Initial = 'g'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Pharmacologie (UA 589 CNRS) Curated by ChEMBL					Assay Description Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation				J Med Chem 32: 1402-7 (1989) BindingDB Entry DOI: 10.7270/Q2SQ92M9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178284 (US9120812, 69) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:9:31:34.35:38| Show InChI InChI=1S/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-14-20-8-9-21(15-35)38-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM135582 (US8846654, 111) Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(F)F)cc3c2=O)cc1OC Show InChI InChI=1S/C24H25F2N3O6/c1-33-20-6-3-15(11-21(20)34-2)13-28-22(31)18-12-17(35-23(25)26)4-5-19(18)29(24(28)32)16-7-9-27(14-30)10-8-16/h3-6,11-12,14,16,23H,7-10,13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...				US Patent US8846654 (2014) BindingDB Entry DOI: 10.7270/Q21V5CPZ
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50013515 ((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...) Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Pharmacologie (UA 589 CNRS) Curated by ChEMBL					Assay Description Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation				J Med Chem 32: 1402-7 (1989) BindingDB Entry DOI: 10.7270/Q2SQ92M9
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM31046 (3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...) Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10| Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Pharmacologie (UA 589 CNRS) Curated by ChEMBL					Assay Description Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation				J Med Chem 32: 1402-7 (1989) BindingDB Entry DOI: 10.7270/Q2SQ92M9
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM31046 (3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...) Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10| Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Pharmacologie (UA 589 CNRS) Curated by ChEMBL					Assay Description Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation				J Med Chem 32: 1402-7 (1989) BindingDB Entry DOI: 10.7270/Q2SQ92M9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178350 (US9120812, 135) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C27H30FN7O5/c1-4-34-14-27(2,3)40-23-21(24(34)36)22(31-25(32-23)35-12-16-6-7-17(13-35)39-16)15-5-8-19(18(28)11-15)29-26(37)30-20-9-10-38-33-20/h5,8-11,16-17H,4,6-7,12-14H2,1-3H3,(H2,29,30,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178395 (US9120812, 180) Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C27H33N7O6/c1-17-15-38-14-11-34(17)25-30-22(18-5-7-19(8-6-18)28-26(36)29-20-9-12-39-32-20)21-23(31-25)40-27(2,3)16-33(24(21)35)10-13-37-4/h5-9,12,17H,10-11,13-16H2,1-4H3,(H2,28,29,32,36)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178388 (US9120812, 173) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-12-11-21(39-5)15-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178230 (US9120812, 15) Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C4CCOCC4)C(=O)c23)N2CC3CCC(C2)O3)no1 |THB:16:34:41:37.38| Show InChI InChI=1S/C31H37N7O6/c1-18-14-24(36-44-18)33-30(40)32-20-6-4-19(5-7-20)26-25-27(35-29(34-26)37-15-22-8-9-23(16-37)42-22)43-31(2,3)17-38(28(25)39)21-10-12-41-13-11-21/h4-7,14,21-23H,8-13,15-17H2,1-3H3,(H2,32,33,36,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178399 (US9120812, 184) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)ccn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-15-21(39-5)11-12-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178283 (US9120812, 68) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1C2CCC1COC2 Show InChI InChI=1S/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-20-8-9-21(35)15-38-14-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178341 (US9120812, 126) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(32-26(33-24)36-14-20-10-11-21(15-36)39-20)17-6-8-18(9-7-17)30-27(38)31-19-12-29-34(4)13-19/h6-9,12-13,20-21H,5,10-11,14-16H2,1-4H3,(H2,30,31,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178226 (US9120812, 11) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)cc3F)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C24H31FN6O4/c1-6-30-13-24(3,4)35-20-18(21(30)32)19(28-22(29-20)31-9-10-34-12-14(31)2)16-8-7-15(11-17(16)25)27-23(33)26-5/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,26,27,33)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178436 (US9120812, 221) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C28H33N7O4/c1-5-34-17-28(3,4)39-24-22(25(34)36)23(32-26(33-24)35-14-15-38-16-18(35)2)19-9-11-20(12-10-19)30-27(37)31-21-8-6-7-13-29-21/h6-13,18H,5,14-17H2,1-4H3,(H2,29,30,31,37)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human))	BDBM135584 (US8846654, 294) Show SMILES FCC(CF)Oc1ccc2n(C3CCN(CC3)C=O)c(=O)n(Cc3ccc(-c4ccccc4)c(c3)C#N)c(=O)c2c1 Show InChI InChI=1S/C31H28F2N4O4/c32-16-26(17-33)41-25-7-9-29-28(15-25)30(39)36(31(40)37(29)24-10-12-35(20-38)13-11-24)19-21-6-8-27(23(14-21)18-34)22-4-2-1-3-5-22/h1-9,14-15,20,24,26H,10-13,16-17,19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...				US Patent US8846654 (2014) BindingDB Entry DOI: 10.7270/Q21V5CPZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178236 (US9120812, 21) Show SMILES COc1ccnc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C)C(=O)c23)N2CC3CCC(C2)O3)c1 |TLB:19:32:35.36:39| Show InChI InChI=1S/C29H33N7O5/c1-29(2)16-35(3)26(37)23-24(33-27(34-25(23)41-29)36-14-20-9-10-21(15-36)40-20)17-5-7-18(8-6-17)31-28(38)32-22-13-19(39-4)11-12-30-22/h5-8,11-13,20-21H,9-10,14-16H2,1-4H3,(H2,30,31,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178282 (US9120812, 67) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1C2CCC1COC2 Show InChI InChI=1S/C29H32FN7O4/c1-16-5-7-18(12-31-16)32-28(39)33-22-10-6-17(11-21(22)30)24-23-25(41-29(2,3)15-36(4)26(23)38)35-27(34-24)37-19-8-9-20(37)14-40-13-19/h5-7,10-12,19-20H,8-9,13-15H2,1-4H3,(H2,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM135578 (US8846654, 16) Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OCC(F)F)cc3c2=O)cc1OC Show InChI InChI=1S/C25H27F2N3O6/c1-34-21-6-3-16(11-22(21)35-2)13-29-24(32)19-12-18(36-14-23(26)27)4-5-20(19)30(25(29)33)17-7-9-28(15-31)10-8-17/h3-6,11-12,15,17,23H,7-10,13-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...				US Patent US8846654 (2014) BindingDB Entry DOI: 10.7270/Q21V5CPZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178342 (US9120812, 127) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC)c4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:34:37.38:41| Show InChI InChI=1S/C31H36N6O5/c1-5-36-18-31(2,3)42-27-25(28(36)38)26(34-29(35-27)37-16-23-13-14-24(17-37)41-23)19-9-11-20(12-10-19)32-30(39)33-21-7-6-8-22(15-21)40-4/h6-12,15,23-24H,5,13-14,16-18H2,1-4H3,(H2,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178281 (US9120812, 66) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |THB:9:33:40:36.37| Show InChI InChI=1S/C29H32FN7O4/c1-16-5-7-18(12-31-16)32-28(39)33-22-10-6-17(11-21(22)30)24-23-25(41-29(2,3)15-36(4)26(23)38)35-27(34-24)37-13-19-8-9-20(14-37)40-19/h5-7,10-12,19-20H,8-9,13-15H2,1-4H3,(H2,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178446 (US9120812, 231) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)18-6-7-21(20(29)14-18)32-27(38)31-19-8-10-30-11-9-19/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178340 (US9120812, 125) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnccn4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C28H32N8O4/c1-4-35-16-28(2,3)40-24-22(25(35)37)23(33-26(34-24)36-14-19-9-10-20(15-36)39-19)17-5-7-18(8-6-17)31-27(38)32-21-13-29-11-12-30-21/h5-8,11-13,19-20H,4,9-10,14-16H2,1-3H3,(H2,30,31,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178227 (US9120812, 12) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)20-7-6-19(14-21(20)29)32-27(38)31-18-8-10-30-11-9-18/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178222 (US9120812, 7) Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(CCC(O)=O)C(=O)c12)N1CC2CCC(C1)O2 |THB:14:31:38:34.35| Show InChI InChI=1S/C27H34N6O6/c1-4-28-26(37)29-17-7-5-16(6-8-17)22-21-23(31-25(30-22)33-13-18-9-10-19(14-33)38-18)39-27(2,3)15-32(24(21)36)12-11-20(34)35/h5-8,18-19H,4,9-15H2,1-3H3,(H,34,35)(H2,28,29,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178383 (US9120812, 168 | US9120812, 169) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178422 (US9120812, 207) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1C2CCC1COC2 |TLB:10:28:34.35.33:30.31| Show InChI InChI=1S/C25H31FN6O4/c1-5-31-13-25(2,3)36-21-19(22(31)33)20(14-6-9-18(17(26)10-14)28-24(34)27-4)29-23(30-21)32-15-7-8-16(32)12-35-11-15/h6,9-10,15-16H,5,7-8,11-13H2,1-4H3,(H2,27,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178267 (US9120812, 52) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CC11CC1O2 Show InChI InChI=1S/C29H30FN7O4/c1-4-36-15-28(2,3)41-24-22(25(36)38)23(34-26(35-24)37-14-18-12-29(37)13-21(29)40-18)16-5-6-20(19(30)11-16)33-27(39)32-17-7-9-31-10-8-17/h5-11,18,21H,4,12-15H2,1-3H3,(H2,31,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178218 (US9120812, 3) Show SMILES CCNC(=O)Nc1ccc(cc1F)-c1nc(nc2OC(C)(C)CN(CC)C(=O)c12)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C25H33FN6O4/c1-6-27-24(34)28-18-9-8-16(12-17(18)26)20-19-21(36-25(4,5)14-31(7-2)22(19)33)30-23(29-20)32-10-11-35-13-15(32)3/h8-9,12,15H,6-7,10-11,13-14H2,1-5H3,(H2,27,28,34)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178374 (US9120812, 159) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C26H30FN7O5/c1-5-33-14-26(3,4)39-22-20(23(33)35)21(30-24(31-22)34-9-11-37-13-15(34)2)16-6-7-18(17(27)12-16)28-25(36)29-19-8-10-38-32-19/h6-8,10,12,15H,5,9,11,13-14H2,1-4H3,(H2,28,29,32,36)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178358 (US9120812, 143) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:33:36.37:40| Show InChI InChI=1S/C28H33FN8O4/c1-5-36-15-28(2,3)41-24-22(25(36)38)23(33-26(34-24)37-13-18-7-8-19(14-37)40-18)16-6-9-21(20(29)10-16)32-27(39)31-17-11-30-35(4)12-17/h6,9-12,18-19H,5,7-8,13-15H2,1-4H3,(H2,31,32,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178337 (US9120812, 122) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(31-26(32-24)36-14-19-10-11-20(15-36)39-19)17-6-8-18(9-7-17)29-27(38)30-21-12-13-34(4)33-21/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,29,30,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178417 (US9120812, 202) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C29H33FN6O4/c1-5-35-17-29(3,4)40-25-23(26(35)37)24(33-27(34-25)36-14-15-39-16-18(36)2)19-10-12-20(13-11-19)31-28(38)32-22-9-7-6-8-21(22)30/h6-13,18H,5,14-17H2,1-4H3,(H2,31,32,38)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178231 (US9120812, 16) Show SMILES Cn1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C4CCOCC4)C(=O)c23)N2CC3CCC(C2)O3)n1 |THB:17:35:42:38.39| Show InChI InChI=1S/C31H38N8O5/c1-31(2)18-39(21-11-14-42-15-12-21)28(40)25-26(34-29(35-27(25)44-31)38-16-22-8-9-23(17-38)43-22)19-4-6-20(7-5-19)32-30(41)33-24-10-13-37(3)36-24/h4-7,10,13,21-23H,8-9,11-12,14-18H2,1-3H3,(H2,32,33,36,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178387 (US9120812, 172) Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CC2CCC(C1)O2 |THB:12:33:40:36.37| Show InChI InChI=1S/C28H33N7O6/c1-28(2)16-34(11-13-38-3)25(36)22-23(17-4-6-18(7-5-17)29-27(37)30-21-10-12-39-33-21)31-26(32-24(22)41-28)35-14-19-8-9-20(15-35)40-19/h4-7,10,12,19-20H,8-9,11,13-16H2,1-3H3,(H2,29,30,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178339 (US9120812, 124) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:35:38.39:42| Show InChI InChI=1S/C30H34FN7O5/c1-5-37-16-30(2,3)43-26-24(27(37)39)25(35-28(36-26)38-14-19-8-9-20(15-38)42-19)17-6-10-22(21(31)12-17)34-29(40)33-18-7-11-23(41-4)32-13-18/h6-7,10-13,19-20H,5,8-9,14-16H2,1-4H3,(H2,33,34,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178438 (US9120812, 223) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccnc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:33:36.37:40| Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-19-8-9-20(15-37)40-19)17-7-10-22(21(30)12-17)33-28(39)32-18-6-5-11-31-13-18/h5-7,10-13,19-20H,4,8-9,14-16H2,1-3H3,(H2,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178266 (US9120812, 51) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1C2CCC1COC2 |TLB:10:33:39.40.38:35.36| Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-19-6-7-20(37)15-40-14-19)17-5-8-22(21(30)13-17)33-28(39)32-18-9-11-31-12-10-18/h5,8-13,19-20H,4,6-7,14-16H2,1-3H3,(H2,31,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178298 (US9120812, 83) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |THB:9:32:39:35.36| Show InChI InChI=1S/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-13-18-5-6-19(14-36)39-18)16-4-7-21(20(29)12-16)32-27(38)31-17-8-10-30-11-9-17/h4,7-12,18-19H,5-6,13-15H2,1-3H3,(H2,30,31,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178327 (US9120812, 112) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39| Show InChI InChI=1S/C29H33N7O4/c1-4-35-17-29(2,3)40-25-23(26(35)37)24(33-27(34-25)36-15-21-11-12-22(16-36)39-21)18-7-9-19(10-8-18)31-28(38)32-20-6-5-13-30-14-20/h5-10,13-14,21-22H,4,11-12,15-17H2,1-3H3,(H2,31,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178286 (US9120812, 71) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O)N1CC2CCC(C1)O2 Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-19-6-7-20(15-37)40-19)21-8-5-18(13-22(21)30)33-28(39)32-17-9-11-31-12-10-17/h5,8-13,19-20H,4,6-7,14-16H2,1-3H3,(H2,31,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178297 (US9120812, 82) Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1C2CCC1COC2 Show InChI InChI=1S/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-18-5-6-19(36)14-39-13-18)16-4-7-21(20(29)12-16)32-27(38)31-17-8-10-30-11-9-17/h4,7-12,18-19H,5-6,13-15H2,1-3H3,(H2,30,31,32,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178245 (US9120812, 30) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOC[C@H]4C)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |r,TLB:10:40:43.44:47| Show InChI InChI=1S/C34H41FN8O5/c1-5-41-19-34(3,4)48-30-28(31(41)44)29(39-32(40-30)42-16-23-8-9-24(17-42)47-23)21-6-10-26(25(35)14-21)38-33(45)37-22-7-11-27(36-15-22)43-12-13-46-18-20(43)2/h6-7,10-11,14-15,20,23-24H,5,8-9,12-13,16-19H2,1-4H3,(H2,37,38,45)/t20-,23?,24?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178217 (US9120812, 2) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C24H31FN6O4/c1-6-30-13-24(3,4)35-20-18(21(30)32)19(28-22(29-20)31-9-10-34-12-14(31)2)15-7-8-17(16(25)11-15)27-23(33)26-5/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,26,27,33)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178389 (US9120812, 174) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C33H43N9O4/c1-6-40-21-33(3,4)46-29-27(30(40)43)28(37-31(38-29)42-17-18-45-20-22(42)2)23-7-9-24(10-8-23)35-32(44)36-25-11-12-26(34-19-25)41-15-13-39(5)14-16-41/h7-12,19,22H,6,13-18,20-21H2,1-5H3,(H2,35,36,44)/t22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178253 (US9120812, 38) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(C)C(=O)c12)N1CC2CCC(C1)O2 |TLB:13:26:29.30:33| Show InChI InChI=1S/C24H30N6O4/c1-24(2)13-29(4)21(31)18-19(14-5-7-15(8-6-14)26-23(32)25-3)27-22(28-20(18)34-24)30-11-16-9-10-17(12-30)33-16/h5-8,16-17H,9-13H2,1-4H3,(H2,25,26,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178338 (US9120812, 123) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NCCF)cc3)c2C1=O)N1CC2CCC(C1)O2 Show InChI InChI=1S/C26H33FN6O4/c1-4-32-15-26(2,3)37-22-20(23(32)34)21(16-5-7-17(8-6-16)29-25(35)28-12-11-27)30-24(31-22)33-13-18-9-10-19(14-33)36-18/h5-8,18-19H,4,9-15H2,1-3H3,(H2,28,29,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178299 (US9120812, 84) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3F)c2C1=O)N1CC2CCC(C1)O2 Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-18-9-10-19(15-37)40-18)20-11-8-17(13-21(20)30)32-28(39)33-22-7-5-6-12-31-22/h5-8,11-13,18-19H,4,9-10,14-16H2,1-3H3,(H2,31,32,33,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178216 (US9120812, 1) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 Show InChI InChI=1S/C25H31FN6O4/c1-5-31-13-25(2,3)36-21-19(22(31)33)20(14-6-9-18(17(26)10-14)28-24(34)27-4)29-23(30-21)32-11-15-7-8-16(12-32)35-15/h6,9-10,15-16H,5,7-8,11-13H2,1-4H3,(H2,27,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM178287 (US9120812, 72) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cn4)N4CCC(O)C4)cc3)c2C1=O)N1CC2CCC(C1)O2 |THB:10:38:45:41.42| Show InChI InChI=1S/C33H40N8O5/c1-4-39-19-33(2,3)46-29-27(30(39)43)28(37-31(38-29)41-17-24-10-11-25(18-41)45-24)20-5-7-21(8-6-20)35-32(44)36-26-12-9-22(15-34-26)40-14-13-23(42)16-40/h5-9,12,15,23-25,42H,4,10-11,13-14,16-19H2,1-3H3,(H2,34,35,36,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	25
Sanofi US Patent					Assay Description The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair

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