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Compile Data Set for Download or QSAR

Found 169 hits with Last Name = 'pais' and Initial = 'gc'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103243
PNG
(4-{2-[2-(2-Acetylamino-3-carboxy-propionylamino)-p...)
Show SMILES CC(C)CC(NC(=O)[C@H](Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(C)=O)C(N)=O
Show InChI InChI=1S/C34H48F2N7O16P/c1-15(2)11-21(28(37)51)41-32(55)22(12-18-5-7-19(8-6-18)34(35,36)60(57,58)59)43-30(53)20(9-10-25(45)46)40-33(56)24(14-27(49)50)42-29(52)16(3)38-31(54)23(13-26(47)48)39-17(4)44/h5-8,15-16,20-24H,9-14H2,1-4H3,(H2,37,51)(H,38,54)(H,39,44)(H,40,56)(H,41,55)(H,42,52)(H,43,53)(H,45,46)(H,47,48)(H,49,50)(H2,57,58,59)/t16?,20?,21?,22-,23?,24?/m0/s1
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 200n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103235
PNG
(5-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Show SMILES CC(C)CC(NC(=O)[C@H](Cc1ccc(OCC(O)=O)c(c1)C(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(C)=O)C(N)=O
Show InChI InChI=1S/C36H49N7O18/c1-15(2)9-21(30(37)53)41-34(57)22(11-18-5-7-25(61-14-29(51)52)19(10-18)36(59)60)43-32(55)20(6-8-26(45)46)40-35(58)24(13-28(49)50)42-31(54)16(3)38-33(56)23(12-27(47)48)39-17(4)44/h5,7,10,15-16,20-24H,6,8-9,11-14H2,1-4H3,(H2,37,53)(H,38,56)(H,39,44)(H,40,58)(H,41,57)(H,42,54)(H,43,55)(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,59,60)/t16?,20?,21?,22-,23?,24?/m0/s1
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 3.60E+3n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103240
PNG
(4-Carbamoyl-4-{[6-(difluoro-phosphono-methyl)-naph...)
Show SMILES NC(=O)[C@@H](CCC(O)=O)NC(=O)c1ccc2cc(ccc2c1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C17H17F2N2O7P/c18-17(19,29(26,27)28)12-4-3-9-7-11(2-1-10(9)8-12)16(25)21-13(15(20)24)5-6-14(22)23/h1-4,7-8,13H,5-6H2,(H2,20,24)(H,21,25)(H,22,23)(H2,26,27,28)/t13-/m1/s1
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 1.20E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103227
PNG
(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Show SMILES OC(=O)c1ccc2cc(ccc2c1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C12H9F2O5P/c13-12(14,20(17,18)19)10-4-3-7-5-9(11(15)16)2-1-8(7)6-10/h1-6H,(H,15,16)(H2,17,18,19)
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 2.20E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103238
PNG
(3-Carboxymethoxy-naphthalene-2,7-dicarboxylic acid...)
Show SMILES OC(=O)COc1cc2ccc(cc2cc1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H10O7/c15-12(16)6-21-11-5-7-1-2-8(13(17)18)3-9(7)4-10(11)14(19)20/h1-5H,6H2,(H,15,16)(H,17,18)(H,19,20)
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 2.50E+5n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103234
PNG
(2-Carboxymethoxy-naphthalene-1,6-dicarboxylic acid...)
Show SMILES OC(=O)COc1ccc2cc(ccc2c1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H10O7/c15-11(16)6-21-10-4-2-7-5-8(13(17)18)1-3-9(7)12(10)14(19)20/h1-5H,6H2,(H,15,16)(H,17,18)(H,19,20)
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 9.00E+5n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103231
PNG
(CHEMBL98615 | Naphthalene-2,7-dicarboxylic acid)
Show SMILES OC(=O)c1ccc2ccc(cc2c1)C(O)=O
Show InChI InChI=1S/C12H8O4/c13-11(14)8-3-1-7-2-4-9(12(15)16)6-10(7)5-8/h1-6H,(H,13,14)(H,15,16)
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>3.20E+6n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50103242
PNG
(CHEMBL316894 | Naphthalene trisulfonate (NTS) | na...)
Show SMILES [O-]S(=O)(=O)c1ccc2c(cc(cc2c1)S([O-])(=O)=O)S([O-])(=O)=O
Show InChI InChI=1S/C10H8O9S3/c11-20(12,13)7-1-2-9-6(3-7)4-8(21(14,15)16)5-10(9)22(17,18)19/h1-5H,(H,11,12,13)(H,14,15,16)(H,17,18,19)/p-3
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>4.00E+6n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)

J Med Chem 44: 2869-78 (2001)


BindingDB Entry DOI: 10.7270/Q237781C
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125697
PNG
(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc(CN=[N+]=[N-])c(CN=[N+]=[N-])c1
Show InChI InChI=1S/C12H10N6O4/c13-17-15-5-8-2-1-7(3-9(8)6-16-18-14)10(19)4-11(20)12(21)22/h1-3H,4-6H2,(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125697
PNG
(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc(CN=[N+]=[N-])c(CN=[N+]=[N-])c1
Show InChI InChI=1S/C12H10N6O4/c13-17-15-5-8-2-1-7(3-9(8)6-16-18-14)10(19)4-11(20)12(21)22/h1-3H,4-6H2,(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (3'processing)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125701
PNG
(4-(5,8-Diazido-5,6,7,8-tetrahydro-naphthalen-2-yl)...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc2C(CCC(N=[N+]=[N-])c2c1)N=[N+]=[N-]
Show InChI InChI=1S/C14H12N6O4/c15-19-17-10-3-4-11(18-20-16)9-5-7(1-2-8(9)10)12(21)6-13(22)14(23)24/h1-2,5,10-11H,3-4,6H2,(H,23,24)
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n/an/a 320n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115572
PNG
((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C17H14O5/c18-15(10-16(19)17(20)21)13-7-4-8-14(9-13)22-11-12-5-2-1-3-6-12/h1-9H,10-11H2,(H,20,21)
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n/an/a 350n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115572
PNG
((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C17H14O5/c18-15(10-16(19)17(20)21)13-7-4-8-14(9-13)22-11-12-5-2-1-3-6-12/h1-9H,10-11H2,(H,20,21)
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n/an/a 350n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125699
PNG
(4-(1,3-Diazido-indan-5-yl)-2,4-dioxo-butyric acid ...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc2C(CC(N=[N+]=[N-])c2c1)N=[N+]=[N-]
Show InChI InChI=1S/C13H10N6O4/c14-18-16-9-4-10(17-19-15)8-3-6(1-2-7(8)9)11(20)5-12(21)13(22)23/h1-3,9-10H,4-5H2,(H,22,23)
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n/an/a 360n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM107681
PNG
((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Show SMILES OC(=O)C(=O)CC(=O)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H20O6/c25-22(14-23(26)24(27)28)19-11-20(29-15-17-7-3-1-4-8-17)13-21(12-19)30-16-18-9-5-2-6-10-18/h1-13H,14-16H2,(H,27,28)
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n/an/a 480n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM107681
PNG
((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Show SMILES OC(=O)C(=O)CC(=O)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H20O6/c25-22(14-23(26)24(27)28)19-11-20(29-15-17-7-3-1-4-8-17)13-21(12-19)30-16-18-9-5-2-6-10-18/h1-13H,14-16H2,(H,27,28)
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n/an/a 480n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM107693
PNG
((2Z)-4-(5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxobut...)
Show SMILES OC(=O)C(=O)CC(=O)c1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C12H8ClNO4/c13-6-1-2-9-7(3-6)8(5-14-9)10(15)4-11(16)12(17)18/h1-3,5,14H,4H2,(H,17,18)
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n/an/a 520n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50093435
PNG
((Z)-1-(5-Chloro-1H-indol-3-yl)-3-hydroxy-3-(1H-tet...)
Show SMILES Clc1ccc2[nH]cc(C(=O)CC(=O)c3nnn[nH]3)c2c1
Show InChI InChI=1S/C12H8ClN5O2/c13-6-1-2-9-7(3-6)8(5-14-9)10(19)4-11(20)12-15-17-18-16-12/h1-3,5,14H,4H2,(H,15,16,17,18)
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n/an/a 650n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50330327
PNG
((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Show SMILES COc1c(N2CC[C@H](C2)C(C)(C)N)c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O |r|
Show InChI InChI=1S/C21H25FN4O3S/c1-21(2,23)10-6-7-25(9-10)16-13(22)8-12-15(18(16)29-3)26(11-4-5-11)20-14(17(12)27)19(28)24-30-20/h8,10-11H,4-7,9,23H2,1-3H3,(H,24,28)/t10-/m1/s1
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n/an/a 680n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50483850
PNG
(CHEMBL1774147)
Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)N |r|
Show InChI InChI=1S/C20H23FN4O3S/c1-9(22)10-5-6-24(8-10)16-13(21)7-12-15(18(16)28-2)25(11-3-4-11)20-14(17(12)26)19(27)23-29-20/h7,9-11H,3-6,8,22H2,1-2H3,(H,23,27)/t9-,10+/m0/s1
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n/an/a 680n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056891
PNG
(2-Hydroxy-benzoic acid N'-(2-hydroxy-benzoyl)-hydr...)
Show SMILES Oc1ccccc1C(=O)NNC(=O)c1ccccc1O
Show InChI InChI=1S/C14H12N2O4/c17-11-7-3-1-5-9(11)13(19)15-16-14(20)10-6-2-4-8-12(10)18/h1-8,17-18H,(H,15,19)(H,16,20)
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n/an/a 700n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50370120
PNG
(CHEMBL611459)
Show SMILES OC(=O)C(=O)CC(=O)C1=CC=CC1 |c:10,t:8|
Show InChI InChI=1S/C9H8O4/c10-7(5-8(11)9(12)13)6-3-1-2-4-6/h1-3H,4-5H2,(H,12,13)
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n/an/a 810n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50483849
PNG
(CHEMBL1774153)
Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)NC |r|
Show InChI InChI=1S/C21H25FN4O3S/c1-10(23-2)11-6-7-25(9-11)17-14(22)8-13-16(19(17)29-3)26(12-4-5-12)21-15(18(13)27)20(28)24-30-21/h8,10-12,23H,4-7,9H2,1-3H3,(H,24,28)/t10-,11+/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115582
PNG
((Z)-4-[4-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc(cc1)C(=O)CC(=O)C(O)=O
Show InChI InChI=1S/C14H10O8/c15-9(5-11(17)13(19)20)7-1-2-8(4-3-7)10(16)6-12(18)14(21)22/h1-4H,5-6H2,(H,19,20)(H,21,22)
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n/an/a 1.28E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50483851
PNG
(CHEMBL1774264)
Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)NCCF |r|
Show InChI InChI=1S/C22H26F2N4O3S/c1-11(25-7-6-23)12-5-8-27(10-12)18-15(24)9-14-17(20(18)31-2)28(13-3-4-13)22-16(19(14)29)21(30)26-32-22/h9,11-13,25H,3-8,10H2,1-2H3,(H,26,30)/t11-,12+/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115570
PNG
((Z)-2-Hydroxy-4-(1H-indol-3-yl)-4-oxo-but-2-enoic ...)
Show SMILES OC(=O)C(=O)CC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C12H9NO4/c14-10(5-11(15)12(16)17)8-6-13-9-4-2-1-3-7(8)9/h1-4,6,13H,5H2,(H,16,17)
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n/an/a 1.43E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125705
PNG
(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(CCC#N)c1
Show InChI InChI=1S/C13H11NO4/c14-6-2-4-9-3-1-5-10(7-9)11(15)8-12(16)13(17)18/h1,3,5,7H,2,4,8H2,(H,17,18)
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n/an/a 1.50E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125704
PNG
(4-(3-Azidomethyl-phenyl)-2,4-dioxo-butyric acid | ...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(CN=[N+]=[N-])c1
Show InChI InChI=1S/C11H9N3O4/c12-14-13-6-7-2-1-3-8(4-7)9(15)5-10(16)11(17)18/h1-4H,5-6H2,(H,17,18)
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n/an/a 1.53E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50476068
PNG
(CHEMBL219534)
Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccnc(C)c1
Show InChI InChI=1S/C20H16FN3O3S/c1-9-7-10(5-6-22-9)14-13(21)8-12-16(18(14)27-2)24(11-3-4-11)20-15(17(12)25)19(26)23-28-20/h5-8,11H,3-4H2,1-2H3,(H,23,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay

J Med Chem 50: 199-210 (2007)


Article DOI: 10.1021/jm060844e
BindingDB Entry DOI: 10.7270/Q2R78J0H
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115575
PNG
(1-(5-Fluoro-1H-indol-3-yl)-3-hydroxy-3-(1H-tetrazo...)
Show SMILES Fc1ccc2[nH]cc(C(=O)CC(=O)c3nnn[nH]3)c2c1
Show InChI InChI=1S/C12H8FN5O2/c13-6-1-2-9-7(3-6)8(5-14-9)10(19)4-11(20)12-15-17-18-16-12/h1-3,5,14H,4H2,(H,15,16,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125705
PNG
(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(CCC#N)c1
Show InChI InChI=1S/C13H11NO4/c14-6-2-4-9-3-1-5-10(7-9)11(15)8-12(16)13(17)18/h1,3,5,7H,2,4,8H2,(H,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115580
PNG
((Z)-4-[3-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(c1)C(=O)CC(=O)C(O)=O
Show InChI InChI=1S/C14H10O8/c15-9(5-11(17)13(19)20)7-2-1-3-8(4-7)10(16)6-12(18)14(21)22/h1-4H,5-6H2,(H,19,20)(H,21,22)
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n/an/a 1.83E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115573
PNG
(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Show SMILES O=C(CC(=O)c1c[nH]c2ccccc12)c1nnn[nH]1
Show InChI InChI=1S/C12H9N5O2/c18-10(5-11(19)12-14-16-17-15-12)8-6-13-9-4-2-1-3-7(8)9/h1-4,6,13H,5H2,(H,14,15,16,17)
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n/an/a 1.90E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056891
PNG
(2-Hydroxy-benzoic acid N'-(2-hydroxy-benzoyl)-hydr...)
Show SMILES Oc1ccccc1C(=O)NNC(=O)c1ccccc1O
Show InChI InChI=1S/C14H12N2O4/c17-11-7-3-1-5-9(11)13(19)15-16-14(20)10-6-2-4-8-12(10)18/h1-8,17-18H,(H,15,19)(H,16,20)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125702
PNG
(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Show SMILES OC(=O)C(=O)CC(=O)c1cc(CN=[N+]=[N-])cc(CN=[N+]=[N-])c1
Show InChI InChI=1S/C12H10N6O4/c13-17-15-5-7-1-8(6-16-18-14)3-9(2-7)10(19)4-11(20)12(21)22/h1-3H,4-6H2,(H,21,22)
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n/an/a 2.00E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50083953
PNG
((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C10H7BrO4/c11-7-3-1-2-6(4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
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n/an/a 2.00E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50115573
PNG
(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Show SMILES O=C(CC(=O)c1c[nH]c2ccccc12)c1nnn[nH]1
Show InChI InChI=1S/C12H9N5O2/c18-10(5-11(19)12-14-16-17-15-12)8-6-13-9-4-2-1-3-7(8)9/h1-4,6,13H,5H2,(H,14,15,16,17)
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n/an/a 2.00E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50476067
PNG
(CHEMBL219216)
Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccc2CNCc2c1
Show InChI InChI=1S/C22H18FN3O3S/c1-29-20-16(10-2-3-11-8-24-9-12(11)6-10)15(23)7-14-18(20)26(13-4-5-13)22-17(19(14)27)21(28)25-30-22/h2-3,6-7,13,24H,4-5,8-9H2,1H3,(H,25,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay

J Med Chem 50: 199-210 (2007)


Article DOI: 10.1021/jm060844e
BindingDB Entry DOI: 10.7270/Q2R78J0H
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50476066
PNG
(CHEMBL436512)
Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccc2[C@@H](C)NCc2c1 |r|
Show InChI InChI=1S/C23H20FN3O3S/c1-10-14-6-3-11(7-12(14)9-25-10)17-16(24)8-15-19(21(17)30-2)27(13-4-5-13)23-18(20(15)28)22(29)26-31-23/h3,6-8,10,13,25H,4-5,9H2,1-2H3,(H,26,29)/t10-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay

J Med Chem 50: 199-210 (2007)


Article DOI: 10.1021/jm060844e
BindingDB Entry DOI: 10.7270/Q2R78J0H
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121970
PNG
(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Show SMILES O=C1NNC(=O)c2ccccc2SSc2ccccc2C(=O)NNC(=O)c2ccccc2SSc2ccccc12
Show InChI InChI=1S/C28H20N4O4S4/c33-25-17-9-1-5-13-21(17)37-38-22-14-6-2-10-18(22)27(35)31-32-28(36)20-12-4-8-16-24(20)40-39-23-15-7-3-11-19(23)26(34)30-29-25/h1-16H,(H,29,33)(H,30,34)(H,31,35)(H,32,36)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50125702
PNG
(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Show SMILES OC(=O)C(=O)CC(=O)c1cc(CN=[N+]=[N-])cc(CN=[N+]=[N-])c1
Show InChI InChI=1S/C12H10N6O4/c13-17-15-5-7-1-8(6-16-18-14)3-9(2-7)10(19)4-11(20)12(21)22/h1-3H,4-6H2,(H,21,22)
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n/an/a 2.80E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)

Bioorg Med Chem Lett 13: 1215-9 (2003)


BindingDB Entry DOI: 10.7270/Q23J3CB7
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50083953
PNG
((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C10H7BrO4/c11-7-3-1-2-6(4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
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n/an/a 3.00E+3n/an/an/an/an/an/a



National Cancer Institute/NIH

Curated by ChEMBL


Assay Description
Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2

J Med Chem 45: 3184-94 (2002)


BindingDB Entry DOI: 10.7270/Q26D5TPD
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121972
PNG
(CHEMBL157373 | Compound 3)
Show SMILES Sc1ccccc1C(=O)NNC(=O)c1ccccc1SSc1ccccc1C(=O)NNC(=O)c1ccccc1S
Show InChI InChI=1S/C28H22N4O4S4/c33-25(17-9-1-5-13-21(17)37)29-31-27(35)19-11-3-7-15-23(19)39-40-24-16-8-4-12-20(24)28(36)32-30-26(34)18-10-2-6-14-22(18)38/h1-16,37-38H,(H,29,33)(H,30,34)(H,31,35)(H,32,36)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
DNA gyrase subunit A


(Staphylococcus aureus)		BDBM50483850
PNG
(CHEMBL1774147)
Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)N |r|
Show InChI InChI=1S/C20H23FN4O3S/c1-9(22)10-5-6-24(8-10)16-13(21)7-12-15(18(16)28-2)25(11-3-4-11)20-14(17(12)26)19(27)23-29-20/h7,9-11H,3-6,8,22H2,1-2H3,(H,23,27)/t9-,10+/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
DNA gyrase subunit A/B


(Staphylococcus aureus)		BDBM50476065
PNG
(CHEMBL220656)
Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C21H18FN3O3S/c1-9-6-11(7-10(2)23-9)15-14(22)8-13-17(19(15)28-3)25(12-4-5-12)21-16(18(13)26)20(27)24-29-21/h6-8,12H,4-5H2,1-3H3,(H,24,27)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay

J Med Chem 50: 199-210 (2007)


Article DOI: 10.1021/jm060844e
BindingDB Entry DOI: 10.7270/Q2R78J0H
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121972
PNG
(CHEMBL157373 | Compound 3)
Show SMILES Sc1ccccc1C(=O)NNC(=O)c1ccccc1SSc1ccccc1C(=O)NNC(=O)c1ccccc1S
Show InChI InChI=1S/C28H22N4O4S4/c33-25(17-9-1-5-13-21(17)37)29-31-27(35)19-11-3-7-15-23(19)39-40-24-16-8-4-12-20(24)28(36)32-30-26(34)18-10-2-6-14-22(18)38/h1-16,37-38H,(H,29,33)(H,30,34)(H,31,35)(H,32,36)
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
DNA gyrase subunit A


(Staphylococcus aureus)		BDBM50330327
PNG
((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Show SMILES COc1c(N2CC[C@H](C2)C(C)(C)N)c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O |r|
Show InChI InChI=1S/C21H25FN4O3S/c1-21(2,23)10-6-7-25(9-10)16-13(22)8-12-15(18(16)29-3)26(11-4-5-11)20-14(17(12)27)19(28)24-30-20/h8,10-11H,4-7,9,23H2,1-3H3,(H,24,28)/t10-/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...

J Med Chem 54: 3268-82 (2011)


Article DOI: 10.1021/jm101604v
BindingDB Entry DOI: 10.7270/Q28S4SRX
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121971
PNG
(2-Mercapto-benzoic acid N'-(2-mercapto-benzoyl)-hy...)
Show SMILES Sc1ccccc1C(=O)NNC(=O)c1ccccc1S
Show InChI InChI=1S/C14H12N2O2S2/c17-13(9-5-1-3-7-11(9)19)15-16-14(18)10-6-2-4-8-12(10)20/h1-8,19-20H,(H,15,17)(H,16,18)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassemble

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121970
PNG
(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Show SMILES O=C1NNC(=O)c2ccccc2SSc2ccccc2C(=O)NNC(=O)c2ccccc2SSc2ccccc12
Show InChI InChI=1S/C28H20N4O4S4/c33-25-17-9-1-5-13-21(17)37-38-22-14-6-2-10-18(22)27(35)31-32-28(36)20-12-4-8-16-24(20)40-39-23-15-7-3-11-19(23)26(34)30-29-25/h1-16H,(H,29,33)(H,30,34)(H,31,35)(H,32,36)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and DNA on ice for 15 min followed by drug for 1h) in strand transfer of postass...

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50121970
PNG
(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Show SMILES O=C1NNC(=O)c2ccccc2SSc2ccccc2C(=O)NNC(=O)c2ccccc2SSc2ccccc12
Show InChI InChI=1S/C28H20N4O4S4/c33-25-17-9-1-5-13-21(17)37-38-22-14-6-2-10-18(22)27(35)31-32-28(36)20-12-4-8-16-24(20)40-39-23-15-7-3-11-19(23)26(34)30-29-25/h1-16H,(H,29,33)(H,30,34)(H,31,35)(H,32,36)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and DNA on ice for 15 min followed by drug for 1h) in 3'' processing of postasse...

J Med Chem 45: 5661-70 (2002)


BindingDB Entry DOI: 10.7270/Q2M61JMB
More data for this
Ligand-Target Pair
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