Compile Data Set for Download or QSAR

Found 78 hits with Last Name = 'toop' and Initial = 'h'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448544 (N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)19-3-4-22(33-13-11-32(12-14-33)17-20-2-1-15-35-20)21(16-19)31-25(34)24-6-5-23(36-24)18-7-9-30-10-8-18/h1-10,15-16H,11-14,17H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448683 (N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-26-17)29-9-7-28(8-10-29)13-16-12-25-14-31-16/h1-6,11-12,14H,7-10,13H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448727 (5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-5- y...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)15-19-14-29-16-36-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13-14,16-17H,5-12,15H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448695 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C26H28F3N3O4/c27-26(28,29)20-1-2-22(32-10-8-31(9-11-32)16-18-5-12-35-17-18)21(15-20)30-25(33)24-4-3-23(36-24)19-6-13-34-14-7-19/h1-5,12,15,17,19H,6-11,13-14,16H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448663 (N-(2-(4-(oxazol-5-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-35-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448673 (N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1-yl)...) Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H23ClN4O3/c26-19-3-4-22(30-13-11-29(12-14-30)17-20-2-1-15-32-20)21(16-19)28-25(31)24-6-5-23(33-24)18-7-9-27-10-8-18/h1-10,15-16H,11-14,17H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448662 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-35-16-30-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448675 (N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-20(19(14-16)27-21(30)18-5-1-2-8-26-18)29-11-9-28(10-12-29)15-17-4-3-13-31-17/h1-8,13-14H,9-12,15H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448664 (5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-4- y...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)14-19-15-36-16-29-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13,15-17H,5-12,14H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448697 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccoc2)CC1)C(F)(F)F Show InChI InChI=1S/C22H22F3N3O3/c1-15-2-5-20(31-15)21(29)26-18-12-17(22(23,24)25)3-4-19(18)28-9-7-27(8-10-28)13-16-6-11-30-14-16/h2-6,11-12,14H,7-10,13H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448726 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-13-11-32(12-14-33)16-19-7-10-30-36-19)20(15-18)31-24(34)23-4-3-22(35-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448715 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(13-15)27-20(30)17-3-1-2-7-25-17)29-11-9-28(10-12-29)14-16-6-8-26-31-16/h1-8,13H,9-12,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448647 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H28F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)16-19-5-8-29-31-19)20(15-18)30-24(34)23-4-3-22(36-23)17-6-13-35-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,29,31)(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448696 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)C2CCOCC2)C(F)(F)F)o1 Show InChI InChI=1S/C27H30F3N3O4/c1-18-2-4-21(36-18)17-32-10-12-33(13-11-32)23-5-3-20(27(28,29)30)16-22(23)31-26(34)25-7-6-24(37-25)19-8-14-35-15-9-19/h2-7,16,19H,8-15,17H2,1H3,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448661 (N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-20(33-12-10-32(11-13-33)16-23-30-9-14-35-23)19(15-18)31-24(34)22-4-3-21(36-22)17-5-7-29-8-6-17/h1-9,14-15H,10-13,16H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448729 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-4-5-20(19(13-17)27-21(30)18-3-1-2-7-26-18)29-10-8-28(9-11-29)14-16-6-12-31-15-16/h1-7,12-13,15H,8-11,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448717 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)18-1-2-21(32-11-9-31(10-12-32)16-19-5-8-29-36-19)20(15-18)30-24(33)23-4-3-22(35-23)17-6-13-34-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM221074 (SPHINX31 | US9695160, 12 | US9796707, Compound 12) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	7.5	30
Exonate Ltd					Assay Description A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair				3D Structure (crystal)
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM221074 (SPHINX31 | US9695160, 12 | US9796707, Compound 12) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	30
Exonate Ltd					Assay Description A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair				3D Structure (crystal)
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448682 (N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448674 (N-(5-chloro-2-(4-(oxazol-4-ylmethyl)piperazin-1-yl...) Show SMILES Clc1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-1-2-21(30-11-9-29(10-12-30)14-19-15-32-16-27-19)20(13-18)28-24(31)23-4-3-22(33-23)17-5-7-26-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448723 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)16-4-5-19(18(11-16)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)13-15-12-26-31-14-15/h1-6,11-12,14H,7-10,13H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448718 (US10696661, Compound 65) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)19-1-2-21(32-9-7-31(8-10-32)15-17-14-29-35-16-17)20(13-19)30-24(33)23-4-3-22(36-23)18-5-11-34-12-6-18/h1-4,13-14,16,18H,5-12,15H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448698 (5-methyl-N-(2-(4-((5-methylfuran-2-yl)methyl)piper...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)o1 Show InChI InChI=1S/C23H24F3N3O3/c1-15-3-6-18(31-15)14-28-9-11-29(12-10-28)20-7-5-17(23(24,25)26)13-19(20)27-22(30)21-8-4-16(2)32-21/h3-8,13H,9-12,14H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448670 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)18-1-2-21(34-13-11-33(12-14-34)16-19-7-10-30-32-19)20(15-18)31-24(35)23-4-3-22(36-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,30,32)(H,31,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448672 (N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...) Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)n1 Show InChI InChI=1S/C26H25F3N6O2/c1-33-11-8-20(32-33)17-34-12-14-35(15-13-34)22-3-2-19(26(27,28)29)16-21(22)31-25(36)24-5-4-23(37-24)18-6-9-30-10-7-18/h2-11,16H,12-15,17H2,1H3,(H,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448684 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(13-15)27-20(31)17-3-1-2-7-25-17)30-11-9-29(10-12-30)14-16-6-8-26-28-16/h1-8,13H,9-12,14H2,(H,26,28)(H,27,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448667 (5-(pyridin-4-yl)-N-(2-(4-(thiazol-4-ylmethyl)piper...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-36-16-30-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448681 (N-(2-(4-(thiazol-2-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-18(17(13-15)27-20(30)16-3-1-2-6-25-16)29-10-8-28(9-11-29)14-19-26-7-12-31-19/h1-7,12-13H,8-11,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.1	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448548 (5-methyl-N-(2-(4-((furan-2-yl)methyl)piperazin-1-y...) Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccco2)CC1)C(F)(F)F Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-7-20(31-15)21(29)26-18-13-16(22(23,24)25)5-6-19(18)28-10-8-27(9-11-28)14-17-3-2-12-30-17/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM221072 (SPHINX scaffold, 2) Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F Show InChI InChI=1S/C22H21F3N4O2/c1-28-10-12-29(13-11-28)18-3-2-16(22(23,24)25)14-17(18)27-21(30)20-5-4-19(31-20)15-6-8-26-9-7-15/h2-9,14H,10-13H2,1H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	30
Exonate Ltd					Assay Description A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448704 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc3ccccc3o2)c1 Show InChI InChI=1S/C24H21F3N4O3/c25-24(26,27)17-5-6-20(31-9-7-30(8-10-31)13-18-14-33-15-28-18)19(12-17)29-23(32)22-11-16-3-1-2-4-21(16)34-22/h1-6,11-12,14-15H,7-10,13H2,(H,29,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448657 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)o1 Show InChI InChI=1S/C27H25F3N4O3/c1-18-2-4-21(36-18)17-33-12-14-34(15-13-33)23-5-3-20(27(28,29)30)16-22(23)32-26(35)25-7-6-24(37-25)19-8-10-31-11-9-19/h2-11,16H,12-15,17H2,1H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.4	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448687 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448699 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)16-3-4-18(17(12-16)25-20(28)19-2-1-10-30-19)27-8-6-26(7-9-27)13-15-5-11-29-14-15/h1-5,10-12,14H,6-9,13H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448685 (N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...) Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccccn2)C(F)(F)F)n1 Show InChI InChI=1S/C22H23F3N6O/c1-29-9-7-17(28-29)15-30-10-12-31(13-11-30)20-6-5-16(22(23,24)25)14-19(20)27-21(32)18-4-2-3-8-26-18/h2-9,14H,10-13,15H2,1H3,(H,27,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448680 (N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1- yl...) Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21ClN4O2/c22-16-6-7-20(19(14-16)24-21(27)18-5-1-2-8-23-18)26-11-9-25(10-12-26)15-17-4-3-13-28-17/h1-8,13-14H,9-12,15H2,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448668 (5-(pyridin-4-yl)-N-(2-(5-(thiazol-2-ylmethyl)piper...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-36-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448693 (N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448693 (N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM221071 (SPHINX scaffold, 1) Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(C)o1)C(F)(F)F Show InChI InChI=1S/C18H20F3N3O2/c1-12-3-6-16(26-12)17(25)22-14-11-13(18(19,20)21)4-5-15(14)24-9-7-23(2)8-10-24/h3-6,11H,7-10H2,1-2H3,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.5	30
Exonate Ltd					Assay Description A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair				3D Structure (crystal)
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448690 (N-(2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)-5- ...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C26H24F3N5O/c27-26(28,29)19-8-9-24(23(15-19)32-25(35)22-7-3-4-10-30-22)34-13-11-33(12-14-34)17-18-16-31-21-6-2-1-5-20(18)21/h1-10,15-16,31H,11-14,17H2,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448700 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccco2)C(F)(F)F)o1 Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-6-17(31-15)14-27-8-10-28(11-9-27)19-7-5-16(22(23,24)25)13-18(19)26-21(29)20-3-2-12-30-20/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448722 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)15-3-4-17(16(10-15)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-14-11-24-30-13-14/h1-4,9-11,13H,5-8,12H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448725 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5- (t...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)19-1-2-21(33-11-9-32(10-12-33)15-17-14-30-35-16-17)20(13-19)31-24(34)23-4-3-22(36-23)18-5-7-29-8-6-18/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM221073 (SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...) Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	7.45	37
Exonate Ltd					Assay Description Whole cell patch clamp recordings of hERG current (IhERG) were made at 37 °C from human embryonic kidney cells (HEK 293) cells stably expressing ...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448621 (N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-15-11-24-13-30-15/h1-4,9-11,13H,5-8,12H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM221073 (SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...) Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	7.5	30
Exonate Ltd					Assay Description A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...				ACS Chem Biol 12: 825-832 (2017) Article DOI: 10.1021/acschembio.6b01048 BindingDB Entry DOI: 10.7270/Q2K64GXC
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448691 (US10696661, Compound 39) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-30-18)27-7-5-26(6-8-27)11-15-12-29-13-24-15/h1-4,9-10,12-13H,5-8,11H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448574 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H20F3N5O2/c21-20(22,23)14-3-4-17(16(12-14)25-19(29)18-2-1-11-30-18)28-9-7-27(8-10-28)13-15-5-6-24-26-15/h1-6,11-12H,7-10,13H2,(H,24,26)(H,25,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62.4	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair

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