Found 388 hits with Last Name = 'wang' and Initial = 'hj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM138204
![PNG](/data/jpeg/tenK13/BindingDB_138204.png) (US8871778, 161)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)nc(Cl)c3c2)n1 Show InChI InChI=1S/C20H21ClN8O/c1-12-13(8-28-10-15(30)11-28)9-29(25-12)18-5-6-22-20(24-18)23-14-3-4-17-16(7-14)19(21)26-27(17)2/h3-7,9,15,30H,8,10-11H2,1-2H3,(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM138201
![PNG](/data/jpeg/tenK13/BindingDB_138201.png) (US8871778, 144)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)cc(Cl)c3c2)n1 Show InChI InChI=1S/C21H22ClN7O/c1-13-14(8-28-10-16(30)11-28)9-29(26-13)20-5-6-23-21(25-20)24-15-3-4-19-17(7-15)18(22)12-27(19)2/h3-7,9,12,16,30H,8,10-11H2,1-2H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM138200
![PNG](/data/jpeg/tenK13/BindingDB_138200.png) (US8871778, 141)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C22H24ClN7O/c1-13-15(9-29-11-17(31)12-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM138210
![PNG](/data/jpeg/tenK13/BindingDB_138210.png) (US8871778, 189)Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C23H26ClN7O/c1-14-16(11-30-9-7-18(32)13-30)12-31(28-14)21-6-8-25-23(27-21)26-17-4-5-20-19(10-17)22(24)15(2)29(20)3/h4-6,8,10,12,18,32H,7,9,11,13H2,1-3H3,(H,25,26,27)/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124868
![PNG](/data/jpeg/tenK5012/BindingDB_50124868.png) (CHEMBL3622958)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(C)c3c2)n1 Show InChI InChI=1S/C23H27N7O/c1-14-16(3)28(4)21-6-5-18(9-20(14)21)25-23-24-8-7-22(26-23)30-11-17(15(2)27-30)10-29-12-19(31)13-29/h5-9,11,19,31H,10,12-13H2,1-4H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124761
![PNG](/data/jpeg/tenK5012/BindingDB_50124761.png) (CHEMBL3622935)Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2cc(CN3CC(O)C3)c(c2)C2CC2)c1 Show InChI InChI=1S/C23H27N5O/c1-15-7-16(2)9-19(8-15)25-23-24-6-5-22(26-23)28-11-18(10-27-12-20(29)13-27)21(14-28)17-3-4-17/h5-9,11,14,17,20,29H,3-4,10,12-13H2,1-2H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124705
![PNG](/data/jpeg/tenK5012/BindingDB_50124705.png) (CHEMBL3622924)Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C22H27N5O/c1-15-8-16(2)10-19(9-15)24-22-23-6-4-21(25-22)27-11-17(3)18(13-27)12-26-7-5-20(28)14-26/h4,6,8-11,13,20,28H,5,7,12,14H2,1-3H3,(H,23,24,25)/t20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Histone deacetylase 4
(Homo sapiens (Human)) | BDBM162846
![PNG](/data/jpeg/tenK16/BindingDB_162846.png) (US9056843, 137)Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01149 BindingDB Entry DOI: 10.7270/Q2CC14PT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124709
![PNG](/data/jpeg/tenK5012/BindingDB_50124709.png) (CHEMBL3622928)Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C21H26N6O/c1-14-8-15(2)10-18(9-14)23-21-22-6-4-20(24-21)27-12-17(16(3)25-27)11-26-7-5-19(28)13-26/h4,6,8-10,12,19,28H,5,7,11,13H2,1-3H3,(H,22,23,24)/t19-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124756
![PNG](/data/jpeg/tenK5012/BindingDB_50124756.png) (CHEMBL3622934)Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2cc(CN3CC[C@@H](O)C3)c(c2)C2CC2)c1 |r| Show InChI InChI=1S/C24H29N5O/c1-16-9-17(2)11-20(10-16)26-24-25-7-5-23(27-24)29-13-19(22(15-29)18-3-4-18)12-28-8-6-21(30)14-28/h5,7,9-11,13,15,18,21,30H,3-4,6,8,12,14H2,1-2H3,(H,25,26,27)/t21-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Histone deacetylase 5
(Homo sapiens (Human)) | BDBM162846
![PNG](/data/jpeg/tenK16/BindingDB_162846.png) (US9056843, 137)Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01149 BindingDB Entry DOI: 10.7270/Q2CC14PT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124765
![PNG](/data/jpeg/tenK5012/BindingDB_50124765.png) (CHEMBL3622938)Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCO)c(C)c2)n1 Show InChI InChI=1S/C23H29N5O3/c1-15-8-19(9-16(2)22(15)31-7-6-29)25-23-24-5-4-21(26-23)28-10-17(3)18(12-28)11-27-13-20(30)14-27/h4-5,8-10,12,20,29-30H,6-7,11,13-14H2,1-3H3,(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124707
![PNG](/data/jpeg/tenK5012/BindingDB_50124707.png) (CHEMBL3622926)Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C21H25N5O/c1-14-6-15(2)8-18(7-14)23-21-22-5-4-20(24-21)26-9-16(3)17(11-26)10-25-12-19(27)13-25/h4-9,11,19,27H,10,12-13H2,1-3H3,(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124807
![PNG](/data/jpeg/tenK5012/BindingDB_50124807.png) (CHEMBL3622944)Show SMILES COc1c(C)cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc1C Show InChI InChI=1S/C22H27N5O2/c1-14-7-18(8-15(2)21(14)29-4)24-22-23-6-5-20(25-22)27-9-16(3)17(11-27)10-26-12-19(28)13-26/h5-9,11,19,28H,10,12-13H2,1-4H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124711
![PNG](/data/jpeg/tenK5012/BindingDB_50124711.png) (CHEMBL3622930)Show InChI InChI=1S/C20H25N5/c1-14-8-15(2)10-18(9-14)22-20-21-7-6-19(23-20)25-11-16(3)17(13-25)12-24(4)5/h6-11,13H,12H2,1-5H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124816
![PNG](/data/jpeg/tenK5012/BindingDB_50124816.png) (CHEMBL3622945)Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OS(C)(=O)=O)c(C)c2)n1 Show InChI InChI=1S/C22H27N5O4S/c1-14-7-18(8-15(2)21(14)31-32(4,29)30)24-22-23-6-5-20(25-22)27-9-16(3)17(11-27)10-26-12-19(28)13-26/h5-9,11,19,28H,10,12-13H2,1-4H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124771
![PNG](/data/jpeg/tenK5012/BindingDB_50124771.png) (CHEMBL3622940)Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C27H34N6O3/c1-18-10-22(11-19(2)26(18)36-17-25(35)32-8-4-5-9-32)29-27-28-7-6-24(30-27)33-12-20(3)21(14-33)13-31-15-23(34)16-31/h6-7,10-12,14,23,34H,4-5,8-9,13,15-17H2,1-3H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124710
![PNG](/data/jpeg/tenK5012/BindingDB_50124710.png) (CHEMBL3622929)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C20H24N6O/c1-13-6-14(2)8-17(7-13)22-20-21-5-4-19(23-20)26-10-16(15(3)24-26)9-25-11-18(27)12-25/h4-8,10,18,27H,9,11-12H2,1-3H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124839
![PNG](/data/jpeg/tenK5012/BindingDB_50124839.png) (CHEMBL3622946)Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OS(C)(=O)=O)c(C)c2)n1 |r| Show InChI InChI=1S/C23H29N5O4S/c1-15-9-19(10-16(2)22(15)32-33(4,30)31)25-23-24-7-5-21(26-23)28-11-17(3)18(13-28)12-27-8-6-20(29)14-27/h5,7,9-11,13,20,29H,6,8,12,14H2,1-4H3,(H,24,25,26)/t20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124869
![PNG](/data/jpeg/tenK5012/BindingDB_50124869.png) (CHEMBL3622960)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(ncc3c2)C2CC2)n1 Show InChI InChI=1S/C22H24N8O/c1-14-16(10-28-12-19(31)13-28)11-29(27-14)21-6-7-23-22(26-21)25-17-2-5-20-15(8-17)9-24-30(20)18-3-4-18/h2,5-9,11,18-19,31H,3-4,10,12-13H2,1H3,(H,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124806
![PNG](/data/jpeg/tenK5012/BindingDB_50124806.png) (CHEMBL3622943)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCN3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C26H35N7O2/c1-18-12-22(13-19(2)25(18)35-11-10-31-8-4-5-9-31)28-26-27-7-6-24(29-26)33-15-21(20(3)30-33)14-32-16-23(34)17-32/h6-7,12-13,15,23,34H,4-5,8-11,14,16-17H2,1-3H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124866
![PNG](/data/jpeg/tenK5012/BindingDB_50124866.png) (CHEMBL3622953)Show SMILES CCn1ccc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(n3)C3CC3)ccc12 Show InChI InChI=1S/C24H27N7O/c1-2-30-10-8-17-11-19(5-6-21(17)30)26-24-25-9-7-22(27-24)31-13-18(12-29-14-20(32)15-29)23(28-31)16-3-4-16/h5-11,13,16,20,32H,2-4,12,14-15H2,1H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124781
![PNG](/data/jpeg/tenK5012/BindingDB_50124781.png) (CHEMBL3622942)Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCN3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C27H36N6O2/c1-19-12-23(13-20(2)26(19)35-11-10-31-8-4-5-9-31)29-27-28-7-6-25(30-27)33-14-21(3)22(16-33)15-32-17-24(34)18-32/h6-7,12-14,16,24,34H,4-5,8-11,15,17-18H2,1-3H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Histone deacetylase 9
(Homo sapiens (Human)) | BDBM162846
![PNG](/data/jpeg/tenK16/BindingDB_162846.png) (US9056843, 137)Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01149 BindingDB Entry DOI: 10.7270/Q2CC14PT |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50005782
![PNG](/data/jpeg/tenK5000/BindingDB_50005782.png) (ATI-13387X | ONALESPIB)Show SMILES CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O Show InChI InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
| PDB PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Histone deacetylase 7
(Homo sapiens (Human)) | BDBM162846
![PNG](/data/jpeg/tenK16/BindingDB_162846.png) (US9056843, 137)Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01149 BindingDB Entry DOI: 10.7270/Q2CC14PT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124763
![PNG](/data/jpeg/tenK5012/BindingDB_50124763.png) (CHEMBL3622936)Show SMILES Cc1cn(cc1CN1CC[C@@H](N)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C22H28N6/c1-15-8-16(2)10-20(9-15)25-22-24-6-4-21(26-22)28-11-17(3)18(13-28)12-27-7-5-19(23)14-27/h4,6,8-11,13,19H,5,7,12,14,23H2,1-3H3,(H,24,25,26)/t19-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124778
![PNG](/data/jpeg/tenK5012/BindingDB_50124778.png) (CHEMBL3622941)Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1 |r| Show InChI InChI=1S/C28H36N6O3/c1-19-12-23(13-20(2)27(19)37-18-26(36)33-9-4-5-10-33)30-28-29-8-6-25(31-28)34-14-21(3)22(16-34)15-32-11-7-24(35)17-32/h6,8,12-14,16,24,35H,4-5,7,9-11,15,17-18H2,1-3H3,(H,29,30,31)/t24-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555456
![PNG](/data/jpeg/tenK5055/BindingDB_50555456.png) (CHEMBL4779990)Show SMILES COCCOc1nc2CCN(Cc2c(n1)N(C)C)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124769
![PNG](/data/jpeg/tenK5012/BindingDB_50124769.png) (CHEMBL3622939)Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OCCO)c(C)c2)n1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-10-20(11-17(2)23(16)32-9-8-30)26-24-25-6-4-22(27-24)29-12-18(3)19(14-29)13-28-7-5-21(31)15-28/h4,6,10-12,14,21,30-31H,5,7-9,13,15H2,1-3H3,(H,25,26,27)/t21-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555451
![PNG](/data/jpeg/tenK5055/BindingDB_50555451.png) (CHEMBL4782374)Show SMILES CNc1nc(OCCOC)nc2CCN(Cc12)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124764
![PNG](/data/jpeg/tenK5012/BindingDB_50124764.png) (CHEMBL3622937)Show SMILES Cc1cn(cc1CN1CC[C@@H](C1)C(O)=O)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-15-8-16(2)10-20(9-15)25-23-24-6-4-21(26-23)28-11-17(3)19(14-28)13-27-7-5-18(12-27)22(29)30/h4,6,8-11,14,18H,5,7,12-13H2,1-3H3,(H,29,30)(H,24,25,26)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555440
![PNG](/data/jpeg/tenK5055/BindingDB_50555440.png) (CHEMBL4797602)Show SMILES COCCOc1ncc2CN(CCc2n1)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555455
![PNG](/data/jpeg/tenK5055/BindingDB_50555455.png) (CHEMBL4753741)Show SMILES COCCOc1nc2CCN(Cc2c(NC2CC2)n1)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50193253
![PNG](/data/jpeg/tenK5019/BindingDB_50193253.png) (CHEMBL3961676)Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-; | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation
Curated by ChEMBL
| Assay Description Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERalpha (unknown origin) after 1 hr by TR-FRET assay |
Eur J Med Chem 120: 338-52 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2 |
More data for this Ligand-Target Pair | |
Estrogen-related receptor gamma
(Homo sapiens (Human)) | BDBM485047
![PNG](/data/jpeg/tenK48/BindingDB_485047.png) (US10934303, Cmpd No. 6g | US10934303, Example 10 |...)Show SMILES CN1CCCC1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C30H35NO3/c1-31-20-5-9-26(31)19-22-34-28-17-13-25(14-18-28)30(24-11-15-27(33)16-12-24)29(10-6-21-32)23-7-3-2-4-8-23/h2-4,7-8,11-18,26,32-33H,5-6,9-10,19-22H2,1H3/b30-29- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q23X8B8M |
More data for this Ligand-Target Pair | |
Estrogen-related receptor gamma
(Homo sapiens (Human)) | BDBM50193253
![PNG](/data/jpeg/tenK5019/BindingDB_50193253.png) (CHEMBL3961676)Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-; | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation
Curated by ChEMBL
| Assay Description Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay |
Eur J Med Chem 120: 338-52 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM138203
![PNG](/data/jpeg/tenK13/BindingDB_138203.png) (US8871778, 160)Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)ncc3c2)n1 Show InChI InChI=1S/C20H22N8O/c1-13-15(9-27-11-17(29)12-27)10-28(25-13)19-5-6-21-20(24-19)23-16-3-4-18-14(7-16)8-22-26(18)2/h3-8,10,17,29H,9,11-12H2,1-2H3,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124865
![PNG](/data/jpeg/tenK5012/BindingDB_50124865.png) (CHEMBL3622951)Show SMILES CN1CCc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C21H25N7O/c1-14-16(10-27-12-18(29)13-27)11-28(25-14)20-5-7-22-21(24-20)23-17-3-4-19-15(9-17)6-8-26(19)2/h3-5,7,9,11,18,29H,6,8,10,12-13H2,1-2H3,(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Endoplasmin
(Homo sapiens (Human)) | BDBM50005782
![PNG](/data/jpeg/tenK5000/BindingDB_50005782.png) (ATI-13387X | ONALESPIB)Show SMILES CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O Show InChI InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal GRP94 (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50124867
![PNG](/data/jpeg/tenK5012/BindingDB_50124867.png) (CHEMBL3622954)Show SMILES CCn1ccc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C22H25N7O/c1-3-28-9-7-16-10-18(4-5-20(16)28)24-22-23-8-6-21(25-22)29-12-17(15(2)26-29)11-27-13-19(30)14-27/h4-10,12,19,30H,3,11,13-14H2,1-2H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | 25 |
Kangwon National University
Curated by ChEMBL
| Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1... |
Bioorg Med Chem Lett 25: 4441-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN |
More data for this Ligand-Target Pair | |
Estrogen-related receptor gamma
(Homo sapiens (Human)) | BDBM50550304
![PNG](/data/jpeg/tenK5055/BindingDB_50550304.png) (CHEMBL4744529)Show SMILES Cl.Cl.CN1CCC[C@@H]1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q23X8B8M |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555448
![PNG](/data/jpeg/tenK5055/BindingDB_50555448.png) (CHEMBL4793342)Show SMILES CCOc1nc(OCCOC)nc2CCN(Cc12)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555416
![PNG](/data/jpeg/tenK5055/BindingDB_50555416.png) (CHEMBL4781723) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555446
![PNG](/data/jpeg/tenK5055/BindingDB_50555446.png) (CHEMBL4759029)Show SMILES CC(C)c1cc(C(=O)N2CCc3nc(OCCN4CCOCC4)ncc3C2)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555452
![PNG](/data/jpeg/tenK5055/BindingDB_50555452.png) (CHEMBL4797252)Show SMILES CCNc1nc(OCCOC)nc2CCN(Cc12)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555444
![PNG](/data/jpeg/tenK5055/BindingDB_50555444.png) (CHEMBL4746663)Show SMILES CC(C)c1cc(C(=O)N2CCc3nc(OCCN4CCCC4)ncc3C2)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555454
![PNG](/data/jpeg/tenK5055/BindingDB_50555454.png) (CHEMBL4753338)Show SMILES COCCOc1nc2CCN(Cc2c(NC(C)C)n1)C(=O)c1cc(C(C)C)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |
Estrogen-related receptor gamma
(Homo sapiens (Human)) | BDBM50550294
![PNG](/data/jpeg/tenK5055/BindingDB_50550294.png) (CHEMBL4791981)Show SMILES Cl.CN1CCC[C@H]1COc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q23X8B8M |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50555441
![PNG](/data/jpeg/tenK5055/BindingDB_50555441.png) (CHEMBL4744192)Show SMILES CC(C)c1cc(C(=O)N2CCc3nc(OCCN(C)C)ncc3C2)c(O)cc1O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of FITC-geldanamycin from N-terminal HSP90alpha (unknown origin) after 30 mins by fluorescence polarization competitive binding assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ72FH |
More data for this Ligand-Target Pair | |