Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50001922 (2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097712 (CHEMBL3590203) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097711 (CHEMBL3588902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50004923 ((+/-)-SKF-38393 | 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097721 (CHEMBL1879790 | EN300-11843) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097708 (CHEMBL3588903) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 537 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097722 (CHEMBL129399) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50421231 (CHEMBL2087646) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | 646 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097707 (CHEMBL3588904) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50307216 (1-(3-Bromobenzyl)-1H-imidazole | CHEMBL598391) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50106345 (4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097719 (CHEMBL3588905) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097718 (CHEMBL3588906) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 7.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097717 (CHEMBL3588907) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097716 (CHEMBL3588908) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097720 (CHEMBL3588912) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50051838 (CHEMBL1327) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 1.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097714 (CHEMBL3588910) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097715 (CHEMBL3588909) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50097713 (CHEMBL3588911) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary. Curated by ChEMBL | Assay Description Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun... | Bioorg Med Chem 23: 3991-9 (2015) Article DOI: 10.1016/j.bmc.2015.01.013 BindingDB Entry DOI: 10.7270/Q2GM892T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17217 (2,6-quinolinyl derivative, 39 | 2-[(2-chloro-4-met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17216 (2,6-quinolinyl derivative, 38 | 2-[(2-chloro-6-met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17203 (2,6-quinolinyl derivative, 25 | 3-[2-(2-chloro-6-n...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17220 (2,6-quinolinyl derivative, 42 | 2-{[1-(4-chlorophe...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17207 (2,6-quinolinyl derivative, 29 | 2-[(2,6-dichloroph...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human)) | BDBM50112347 (CHEMBL3609327 | FRAX597) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma... | J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17197 (2,6-quinolinyl derivative, 19 | 2-[(2,6-dichloroph...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17218 (2,6-quinolinyl derivative, 40 | 2-[(2,4-dichloro-6...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17210 (2,6-quinolinyl derivative, 32 | 2-[(2,6-dichloroph...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235240 (CHEMBL4065169) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235240 (CHEMBL4065169) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology method | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235250 (CHEMBL4104525) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology method | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human)) | BDBM50112347 (CHEMBL3609327 | FRAX597) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 12.8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma... | J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17221 (2,6-quinolinyl derivative, 43 | 2-{[(2S)-1-benzyl-...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15.3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 3 (Homo sapiens (Human)) | BDBM50112347 (CHEMBL3609327 | FRAX597) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 19.3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma... | J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human)) | BDBM213235 (FRAX414) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma... | J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17198 (2,6-quinolinyl derivative, 20 | 2-[(2,6-dichloroph...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17202 (2,6-quinolinyl derivative, 24 | 3-[2-(2-chloro-6-f...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235255 (CHEMBL4085436) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235259 (CHEMBL4105245) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235250 (CHEMBL4104525) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235275 (CHEMBL4062996) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Tested for irreversible inhibitory activity against AdoMet-DC (S-adenosyl-methionine decarboxylase-) isolated from Escherichia coli | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50315563 (CHEMBL1088844 | {[(1S,2S,5R)-5-methyl-2-(propan-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay | Bioorg Med Chem Lett 20: 2493-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.005 BindingDB Entry DOI: 10.7270/Q2T153SV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235253 (CHEMBL4075394) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50194539 (4-(3-(2-fluorophenyl)propanamido)-N,N-diisopropyl-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 | Bioorg Med Chem Lett 16: 5897-901 (2006) Article DOI: 10.1016/j.bmcl.2006.08.054 BindingDB Entry DOI: 10.7270/Q2Z60NP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17214 (2,6-quinolinyl derivative, 36 | 3-[2-(2,6-dichloro...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37.2 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235254 (CHEMBL4095750) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17213 (2,6-quinolinyl derivative, 35 | 3-[2-(2,6-dichloro...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 53.7 | n/a | n/a | n/a | n/a | 7.4 | 22 |
UCB | Assay Description The VLA-4 expressing U937 cells were plated in 96-well microtiter plates, precoated with soluble human recombinant VCAM-1, in the presence of test co... | Bioorg Med Chem Lett 17: 142-6 (2007) Article DOI: 10.1016/j.bmcl.2006.09.069 BindingDB Entry DOI: 10.7270/Q2W957FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50235260 (CHEMBL4088894) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Kv1.5 (unknown origin) | Bioorg Med Chem Lett 27: 1062-1069 (2017) Article DOI: 10.1016/j.bmcl.2016.12.054 BindingDB Entry DOI: 10.7270/Q2DV1N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily A member 5 (Homo sapiens (Human)) | BDBM50199068 (3-cyano-N-(2-hydroxyethyl)-6-methoxy-4-phenylisoqu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at human Kv1.5 channel expressed in CHO cell membrane by HT clamp assay | J Med Chem 49: 6954-7 (2006) Article DOI: 10.1021/jm060927v BindingDB Entry DOI: 10.7270/Q2ST7PG7 | |||||||||||
More data for this Ligand-Target Pair |
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