Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141376 (US8916600, 10 | US9738632, Example 10) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.647 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141385 (US8916600, 19 | US9738632, Example 19) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.663 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141378 (US8916600, 12 | US9738632, Example 12) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.767 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141373 (US8916600, 7 | US9738632, Example 8) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.796 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141379 (US8916600, 13 | US9738632, Example 13) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.817 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141372 (US8916600, 6 | US9738632, Example 6) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 0.913 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141383 (US8916600, 17 | US9738632, Example 17) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.996 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141371 (US8916600, 5 | US9738632, Example 5) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.08 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141375 (US8916600, 9 | US9738632, Example 9) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.09 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141373 (US8916600, 7 | US9738632, Example 8) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141367 (US8916600, 1 | US8916600, 4 | US9738632, Example 1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.32 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141368 (US8916600, 2 | US8916600, 3 | US9738632, Example 2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM335727 (US9738632, Example 4) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM335726 (US9738632, Example 3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141380 (US8916600, 14 | US9738632, Example 14) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141386 (US8916600, 20 | US9738632, Example 20) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.96 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141377 (US8916600, 11 | US9738632, Example 11) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.15 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489174 ((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488661 ((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488662 ((R)-N-(3-(2-(2-fluoro-3- (methylsulfonyl)phenyl am...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488663 ((R)-N-(3-(2-(3- (ethylsulfonyl)-2- fluorophenylami...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488667 ((R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488685 ((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488689 ((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488710 ((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488719 ((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488735 ((S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488758 ((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488777 ((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488779 ((R)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488809 ((R)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489047 ((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489073 ((R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfony...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489165 ((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489168 ((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489170 ((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489172 ((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489179 ((R)-3-ethoxy-N-(3-(2- ((2-fluoro-3- (methylsulfony...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488811 ((R)-N-(3-(5-fluoro-2 ((2-fluoro-3- (methylsulfonyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488674 ((R)-2-((3S,5S)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141384 (US8916600, 18 | US9738632, Example 18) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.44 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488690 ((R)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141381 (US8916600, 15 | US8916600, 16 | US9738632, Example...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.64 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM489046 ((R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfony...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.95 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488713 ((R)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM141381 (US8916600, 15 | US8916600, 16 | US9738632, Example...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.27 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Bayer Pharma Aktiengesellschaft US Patent | Assay Description In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _... | US Patent US9738632 (2017) BindingDB Entry DOI: 10.7270/Q2057J12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM50503287 (ABT-494 | Rinvoq | US10961228, Example ABT-494 | U...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488668 ((R)-N-(3-(5-chloro-2- ((2-fluoro-3- methylsulfonyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488763 ((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM488672 ((R)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci... | US Patent US10961228 (2021) BindingDB Entry DOI: 10.7270/Q20G3P8F | |||||||||||
More data for this Ligand-Target Pair |
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