Compile Data Set for Download or QSAR

Found 231 hits with Last Name = 'realini' and Initial = 'n'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acid ceramidase (Homo sapiens (Human))	BDBM29080 (CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA...) Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCO Show InChI InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of acid ceramidase (unknown origin)				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367209 (2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1 Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367209 (2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1 Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367226 (4-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES Fc1cccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c12 Show InChI InChI=1S/C18H17FN2O3/c19-14-10-6-11-15-16(14)21(18(23)24-15)17(22)20-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50511300 (CHEMBL4580541) Show SMILES O=C(NCCCCc1ccccc1)n1c2ccncc2oc1=O Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-9-11-18-12-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...				J Med Chem 63: 3634-3664 (2020) Article DOI: 10.1021/acs.jmedchem.9b02004 BindingDB Entry DOI: 10.7270/Q20C503N
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367194 (5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367194 (5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367195 (6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367195 (6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431244 (CHEMBL2333064) Show SMILES CCCCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O Show InChI InChI=1S/C15H22FN3O5/c1-3-4-5-6-7-8-9-17-13(21)18-10-11(16)12(20)19(14(18)22)15(23)24-2/h10H,3-9H2,1-2H3,(H,17,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50556798 (CHEMBL4742096) Show SMILES Clc1ccc(cc1)-c1coc(=O)n1C(=O)NCCCCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50511282 (CHEMBL4592427) Show SMILES O=C(NCCCCc1ccccc1)n1c2cnccc2oc1=O Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-12-18-11-9-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...				J Med Chem 63: 3634-3664 (2020) Article DOI: 10.1021/acs.jmedchem.9b02004 BindingDB Entry DOI: 10.7270/Q20C503N
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431255 (CHEMBL2333053) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O Show InChI InChI=1S/C13H18FN3O5/c1-3-4-5-6-7-15-11(19)16-8-9(14)10(18)17(12(16)20)13(21)22-2/h8H,3-7H2,1-2H3,(H,15,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431246 (CHEMBL2333062 | US9428465, 32) Show SMILES CCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F Show InChI InChI=1S/C14H20F3N3O3/c1-2-3-4-5-6-7-8-18-12(22)20-9-10(14(15,16)17)11(21)19-13(20)23/h9H,2-8H2,1H3,(H,18,22)(H,19,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	4.5	n/a
Fondazione Istituto Italiano Di Technologia US Patent					Assay Description r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...				US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431246 (CHEMBL2333062 | US9428465, 32) Show SMILES CCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F Show InChI InChI=1S/C14H20F3N3O3/c1-2-3-4-5-6-7-8-18-12(22)20-9-10(14(15,16)17)11(21)19-13(20)23/h9H,2-8H2,1H3,(H,18,22)(H,19,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50431253 (CHEMBL2333055) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O Show InChI InChI=1S/C16H24FN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367187 (5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES Clc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17ClN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367186 (6-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES Fc1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C18H17FN2O3/c19-14-9-10-15-16(12-14)24-18(23)21(15)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431271 (CHEMBL2333033 | US9428465, 4) Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	4.5	n/a
Fondazione Istituto Italiano Di Technologia US Patent					Assay Description r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...				US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367196 (2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...) Show SMILES FC(F)(F)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)14-9-10-16-15(12-14)24(18(26)27-16)17(25)23-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367198 (5-cyano-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES O=C(NCCCCc1ccccc1)n1c2cc(ccc2oc1=O)C#N Show InChI InChI=1S/C19H17N3O3/c20-13-15-9-10-17-16(12-15)22(19(24)25-17)18(23)21-11-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431271 (CHEMBL2333033 | US9428465, 4) Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat acid ceramidase				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367185 (5-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES Fc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17FN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431271 (CHEMBL2333033 | US9428465, 4) Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431254 (CHEMBL2333054) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC)c1=O Show InChI InChI=1S/C14H20FN3O5/c1-3-5-6-7-8-16-12(20)17-9-10(15)11(19)18(13(17)21)14(22)23-4-2/h9H,3-8H2,1-2H3,(H,16,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50556790 (CHEMBL4777626) Show SMILES CCCCCCNC(=O)n1cc(Cl)c(=O)n(C(=O)OCC(C)C)c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431260 (CHEMBL2333048) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C)c1=O Show InChI InChI=1S/C12H18FN3O3/c1-3-4-5-6-7-14-11(18)16-8-9(13)10(17)15(2)12(16)19/h8H,3-7H2,1-2H3,(H,14,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM241946 (US9428465, 24) Show SMILES CCCCCCNC(=O)n1cc(Br)c(=O)n(C(=O)OCC(C)C)c1=O Show InChI InChI=1S/C16H24BrN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	4.5	n/a
Fondazione Istituto Italiano Di Technologia US Patent					Assay Description A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ...				US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367214 (6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...) Show SMILES Clc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C25H21ClN2O4/c26-20-12-9-18(10-13-20)23(29)19-11-14-21-22(16-19)32-25(31)28(21)24(30)27-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50556791 (CHEMBL4754069) Show SMILES CCCCCCNC(=O)n1nc(C)cc1C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367214 (6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...) Show SMILES Clc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C25H21ClN2O4/c26-20-12-9-18(10-13-20)23(29)19-11-14-21-22(16-19)32-25(31)28(21)24(30)27-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367187 (5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...) Show SMILES Clc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17ClN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431253 (CHEMBL2333055) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O Show InChI InChI=1S/C16H24FN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367212 (2-oxo-N-(4-phenylbutyl)-6- propanoyl-1,3-benzoxazo...) Show SMILES CCC(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C21H22N2O4/c1-2-18(24)16-11-12-17-19(14-16)27-21(26)23(17)20(25)22-13-7-6-10-15-8-4-3-5-9-15/h3-5,8-9,11-12,14H,2,6-7,10,13H2,1H3,(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431253 (CHEMBL2333055) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O Show InChI InChI=1S/C16H24FN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat acid ceramidase				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367201 (7-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES Brc1cccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc12 Show InChI InChI=1S/C18H17BrN2O3/c19-14-10-6-11-15-16(14)24-18(23)21(15)17(22)20-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367199 (5,6-dichloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxa...) Show SMILES Clc1cc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2cc1Cl Show InChI InChI=1S/C18H16Cl2N2O3/c19-13-10-15-16(11-14(13)20)25-18(24)22(15)17(23)21-9-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,10-11H,4-5,8-9H2,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367196 (2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...) Show SMILES FC(F)(F)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)14-9-10-16-15(12-14)24(18(26)27-16)17(25)23-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50556813 (CHEMBL4777275) Show SMILES O=C(NCCCCc1ccccc1)n1cc(oc1=O)-c1ccncc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431258 (CHEMBL2333050) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(CC)c1=O Show InChI InChI=1S/C13H20FN3O3/c1-3-5-6-7-8-15-12(19)17-9-10(14)11(18)16(4-2)13(17)20/h9H,3-8H2,1-2H3,(H,15,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367199 (5,6-dichloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxa...) Show SMILES Clc1cc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2cc1Cl Show InChI InChI=1S/C18H16Cl2N2O3/c19-13-10-15-16(11-14(13)20)25-18(24)22(15)17(23)21-9-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,10-11H,4-5,8-9H2,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367201 (7-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES Brc1cccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc12 Show InChI InChI=1S/C18H17BrN2O3/c19-14-10-6-11-15-16(14)24-18(23)21(15)17(22)20-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367217 (2-oxo-N-[(4- propylphenyl)methyl]-1,3- benzoxazole...) Show SMILES CCCc1ccc(CNC(=O)n2c3ccccc3oc2=O)cc1 Show InChI InChI=1S/C18H18N2O3/c1-2-5-13-8-10-14(11-9-13)12-19-17(21)20-15-6-3-4-7-16(15)23-18(20)22/h3-4,6-11H,2,5,12H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367217 (2-oxo-N-[(4- propylphenyl)methyl]-1,3- benzoxazole...) Show SMILES CCCc1ccc(CNC(=O)n2c3ccccc3oc2=O)cc1 Show InChI InChI=1S/C18H18N2O3/c1-2-5-13-8-10-14(11-9-13)12-19-17(21)20-15-6-3-4-7-16(15)23-18(20)22/h3-4,6-11H,2,5,12H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431252 (CHEMBL2333056) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)c2ccccc2)c1=O Show InChI InChI=1S/C18H20FN3O4/c1-2-3-4-8-11-20-17(25)21-12-14(19)16(24)22(18(21)26)15(23)13-9-6-5-7-10-13/h5-7,9-10,12H,2-4,8,11H2,1H3,(H,20,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367197 (2-oxo-N-(4-phenylbutyl)-6- (trifluoromethyl)-1,3- ...) Show SMILES FC(F)(F)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)14-9-10-15-16(12-14)27-18(26)24(15)17(25)23-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367197 (2-oxo-N-(4-phenylbutyl)-6- (trifluoromethyl)-1,3- ...) Show SMILES FC(F)(F)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1 Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)14-9-10-15-16(12-14)27-18(26)24(15)17(25)23-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair
Acid ceramidase (Rattus norvegicus (Rat))	BDBM50431256 (CHEMBL2333052) Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)C(C)C)c1=O Show InChI InChI=1S/C15H22FN3O4/c1-4-5-6-7-8-17-14(22)18-9-11(16)13(21)19(15(18)23)12(20)10(2)3/h9-10H,4-8H2,1-3H3,(H,17,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...				J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367189 (5-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES Brc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17BrN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec					Assay Description The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...				J Med Chem 50: 2767-78 (2007) BindingDB Entry DOI: 10.7270/Q23T9KH0
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM367189 (5-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...) Show SMILES Brc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C18H17BrN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...				J Med Chem 58: 9258-72 (2015) Article DOI: 10.1021/acs.jmedchem.5b01188 BindingDB Entry DOI: 10.7270/Q2CF9T36
					More data for this Ligand-Target Pair

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