Compile Data Set for Download or QSAR

Found 91 hits with Last Name = 'love' and Initial = 'pl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50429650 (CHEMBL2334981) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H25N5OS/c1-13(2)18-6-5-7-20(25-18)21-22(15-8-9-19-16(11-15)12-29(4)27-19)28-31-24(21)26-23(30)17-10-14(17)3/h5-9,11-14,17H,10H2,1-4H3,(H,26,30)/t14-,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity to 5HT2B receptor (unknown origin)				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427184 (CHEMBL2324479) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(OC)cc(cc2C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C24H33F6N3O4S/c1-3-13-38(35,36)33-11-9-32(10-12-33)22(7-5-4-6-8-22)16-31-21(34)20-18(24(28,29)30)14-17(23(25,26)27)15-19(20)37-2/h14-15H,3-13,16H2,1-2H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427183 (CHEMBL2324480) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(OC)cc(F)cc2SC)CCCCC1 Show InChI InChI=1S/C23H36FN3O4S2/c1-4-14-33(29,30)27-12-10-26(11-13-27)23(8-6-5-7-9-23)17-25-22(28)21-19(31-2)15-18(24)16-20(21)32-3/h15-16H,4-14,17H2,1-3H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427181 (CHEMBL2324483) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(N)cccc2Cl)CCCCCC1 Show InChI InChI=1S/C22H35ClN4O3S/c1-2-16-31(29,30)27-14-12-26(13-15-27)22(10-5-3-4-6-11-22)17-25-21(28)20-18(23)8-7-9-19(20)24/h7-9H,2-6,10-17,24H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50379862 (CHEMBL2011870) Show SMILES COc1ccc(cc1)-c1nsc(NC(=O)[C@@H]2C[C@H]2C)c1C |r| Show InChI InChI=1S/C16H18N2O2S/c1-9-8-13(9)15(19)17-16-10(2)14(18-21-16)11-4-6-12(20-3)7-5-11/h4-7,9,13H,8H2,1-3H3,(H,17,19)/t9-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429655 (CHEMBL2334976) Show SMILES CCc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C23H23N5OS/c1-4-16-6-5-7-19(24-16)20-21(14-8-9-18-15(11-14)12-28(3)26-18)27-30-23(20)25-22(29)17-10-13(17)2/h5-9,11-13,17H,4,10H2,1-3H3,(H,25,29)/t13-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427185 (CHEMBL2324478) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(Cl)cccc2Cl)CCCCC1 Show InChI InChI=1S/C21H31Cl2N3O3S/c1-2-15-30(28,29)26-13-11-25(12-14-26)21(9-4-3-5-10-21)16-24-20(27)19-17(22)7-6-8-18(19)23/h6-8H,2-5,9-16H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427198 (CHEMBL2324158) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(N)cccc2Cl)CCCCC1 Show InChI InChI=1S/C21H33ClN4O3S/c1-2-15-30(28,29)26-13-11-25(12-14-26)21(9-4-3-5-10-21)16-24-20(27)19-17(22)7-6-8-18(19)23/h6-8H,2-5,9-16,23H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427190 (CHEMBL2324166) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(OC)cc2F)CCCCC1 Show InChI InChI=1S/C22H34FN3O4S/c1-3-15-31(28,29)26-13-11-25(12-14-26)22(9-5-4-6-10-22)17-24-21(27)19-8-7-18(30-2)16-20(19)23/h7-8,16H,3-6,9-15,17H2,1-2H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429650 (CHEMBL2334981) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H25N5OS/c1-13(2)18-6-5-7-20(25-18)21-22(15-8-9-19-16(11-15)12-29(4)27-19)28-31-24(21)26-23(30)17-10-14(17)3/h5-9,11-14,17H,10H2,1-4H3,(H,26,30)/t14-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429652 (CHEMBL2334979) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)N(C)C)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C23H24N6OS/c1-13-10-16(13)22(30)25-23-20(18-6-5-7-19(24-18)28(2)3)21(27-31-23)14-8-9-17-15(11-14)12-29(4)26-17/h5-9,11-13,16H,10H2,1-4H3,(H,25,30)/t13-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429651 (CHEMBL2334980) Show SMILES CCCc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H25N5OS/c1-4-6-17-7-5-8-20(25-17)21-22(15-9-10-19-16(12-15)13-29(3)27-19)28-31-24(21)26-23(30)18-11-14(18)2/h5,7-10,12-14,18H,4,6,11H2,1-3H3,(H,26,30)/t14-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427195 (CHEMBL2324161) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccccc2OC(F)(F)F)CCCCC1 Show InChI InChI=1S/C22H32F3N3O4S/c1-2-16-33(30,31)28-14-12-27(13-15-28)21(10-6-3-7-11-21)17-26-20(29)18-8-4-5-9-19(18)32-22(23,24)25/h4-5,8-9H,2-3,6-7,10-17H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427189 (CHEMBL2324167) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(Cl)cc2Cl)CCCCC1 Show InChI InChI=1S/C21H31Cl2N3O3S/c1-2-14-30(28,29)26-12-10-25(11-13-26)21(8-4-3-5-9-21)16-24-20(27)18-7-6-17(22)15-19(18)23/h6-7,15H,2-5,8-14,16H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427186 (CHEMBL2324477) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)CCCCC1 Show InChI InChI=1S/C21H31F2N3O3S/c1-2-15-30(28,29)26-13-11-25(12-14-26)21(9-4-3-5-10-21)16-24-20(27)19-17(22)7-6-8-18(19)23/h6-8H,2-5,9-16H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429647 (CHEMBL2334984) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)C1CCCC1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C26H27N5OS/c1-15-12-19(15)25(32)28-26-23(22-9-5-8-20(27-22)16-6-3-4-7-16)24(30-33-26)17-10-11-21-18(13-17)14-31(2)29-21/h5,8-11,13-16,19H,3-4,6-7,12H2,1-2H3,(H,28,32)/t15-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427188 (CHEMBL2324168) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(F)cc2C)CCCCC1 Show InChI InChI=1S/C22H34FN3O3S/c1-3-15-30(28,29)26-13-11-25(12-14-26)22(9-5-4-6-10-22)17-24-21(27)20-8-7-19(23)16-18(20)2/h7-8,16H,3-6,9-15,17H2,1-2H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429659 (CHEMBL2334972) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1ccccn1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C21H19N5OS/c1-12-9-15(12)20(27)23-21-18(17-5-3-4-8-22-17)19(25-28-21)13-6-7-16-14(10-13)11-26(2)24-16/h3-8,10-12,15H,9H2,1-2H3,(H,23,27)/t12-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429649 (CHEMBL2334982) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)C1CC1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H23N5OS/c1-13-10-17(13)23(30)26-24-21(20-5-3-4-18(25-20)14-6-7-14)22(28-31-24)15-8-9-19-16(11-15)12-29(2)27-19/h3-5,8-9,11-14,17H,6-7,10H2,1-2H3,(H,26,30)/t13-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429646 (CHEMBL2334985) Show SMILES CC[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)N(C)C)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H26N6OS/c1-5-14-12-17(14)23(31)26-24-21(19-7-6-8-20(25-19)29(2)3)22(28-32-24)15-9-10-18-16(11-15)13-30(4)27-18/h6-11,13-14,17H,5,12H2,1-4H3,(H,26,31)/t14-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429654 (CHEMBL2334977) Show SMILES COc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H21N5O2S/c1-12-9-15(12)21(28)24-22-19(17-5-4-6-18(23-17)29-3)20(26-30-22)13-7-8-16-14(10-13)11-27(2)25-16/h4-8,10-12,15H,9H2,1-3H3,(H,24,28)/t12-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429645 (CHEMBL2334986) Show SMILES CCc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2n[nH]cc2c1 |r| Show InChI InChI=1S/C22H21N5OS/c1-3-15-5-4-6-18(24-15)19-20(13-7-8-17-14(10-13)11-23-26-17)27-29-22(19)25-21(28)16-9-12(16)2/h4-8,10-12,16H,3,9H2,1-2H3,(H,23,26)(H,25,28)/t12-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429642 (CHEMBL2334989) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)C2CC2)snc1-c1ccc2nn(C)cc2c1 Show InChI InChI=1S/C23H23N5OS/c1-13(2)17-5-4-6-19(24-17)20-21(27-30-23(20)25-22(29)14-7-8-14)15-9-10-18-16(11-15)12-28(3)26-18/h4-6,9-14H,7-8H2,1-3H3,(H,25,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429658 (CHEMBL2334973) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(C)n1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H21N5OS/c1-12-9-16(12)21(28)24-22-19(18-6-4-5-13(2)23-18)20(26-29-22)14-7-8-17-15(10-14)11-27(3)25-17/h4-8,10-12,16H,9H2,1-3H3,(H,24,28)/t12-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429644 (CHEMBL2334987) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2n[nH]cc2c1 |r| Show InChI InChI=1S/C23H23N5OS/c1-12(2)17-5-4-6-19(25-17)20-21(14-7-8-18-15(10-14)11-24-27-18)28-30-23(20)26-22(29)16-9-13(16)3/h4-8,10-13,16H,9H2,1-3H3,(H,24,27)(H,26,29)/t13-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429643 (CHEMBL2334988) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)N(C)C)-c1ccc2n[nH]cc2c1 |r| Show InChI InChI=1S/C22H22N6OS/c1-12-9-15(12)21(29)25-22-19(17-5-4-6-18(24-17)28(2)3)20(27-30-22)13-7-8-16-14(10-13)11-23-26-16/h4-8,10-12,15H,9H2,1-3H3,(H,23,26)(H,25,29)/t12-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427196 (CHEMBL2324160) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccccc2C(F)(F)F)CCCCC1 Show InChI InChI=1S/C22H32F3N3O3S/c1-2-16-32(30,31)28-14-12-27(13-15-28)21(10-6-3-7-11-21)17-26-20(29)18-8-4-5-9-19(18)22(23,24)25/h4-5,8-9H,2-3,6-7,10-17H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429657 (CHEMBL2334974) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(CF)n1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H20FN5OS/c1-12-8-16(12)21(29)25-22-19(18-5-3-4-15(10-23)24-18)20(27-30-22)13-6-7-17-14(9-13)11-28(2)26-17/h3-7,9,11-12,16H,8,10H2,1-2H3,(H,25,29)/t12-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429648 (CHEMBL2334983) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)C1CCC1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C25H25N5OS/c1-14-11-18(14)24(31)27-25-22(21-8-4-7-19(26-21)15-5-3-6-15)23(29-32-25)16-9-10-20-17(12-16)13-30(2)28-20/h4,7-10,12-15,18H,3,5-6,11H2,1-2H3,(H,27,31)/t14-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429653 (CHEMBL2334978) Show SMILES CNc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H22N6OS/c1-12-9-15(12)21(29)25-22-19(17-5-4-6-18(23-2)24-17)20(27-30-22)13-7-8-16-14(10-13)11-28(3)26-16/h4-8,10-12,15H,9H2,1-3H3,(H,23,24)(H,25,29)/t12-,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427173 (CHEMBL2324491) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)CCC(F)(F)CC1 Show InChI InChI=1S/C21H29F4N3O3S/c1-2-14-32(30,31)28-12-10-27(11-13-28)20(6-8-21(24,25)9-7-20)15-26-19(29)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427191 (CHEMBL2324165) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2cccc(c2Cl)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C22H31ClF3N3O3S/c1-2-15-33(31,32)29-13-11-28(12-14-29)21(9-4-3-5-10-21)16-27-20(30)17-7-6-8-18(19(17)23)22(24,25)26/h6-8H,2-5,9-16H2,1H3,(H,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427176 (CHEMBL2324488) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(Cl)cc2Cl)CCOCC1 Show InChI InChI=1S/C20H29Cl2N3O4S/c1-2-13-30(27,28)25-9-7-24(8-10-25)20(5-11-29-12-6-20)15-23-19(26)17-4-3-16(21)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50429656 (CHEMBL2334975) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1cccc(n1)C(F)F)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H19F2N5OS/c1-11-8-14(11)21(30)26-22-18(16-4-3-5-17(25-16)20(23)24)19(28-31-22)12-6-7-15-13(9-12)10-29(2)27-15/h3-7,9-11,14,20H,8H2,1-2H3,(H,26,30)/t11-,14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427193 (CHEMBL2324163) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1 Show InChI InChI=1S/C22H32F3N3O4S/c1-2-16-33(30,31)28-14-12-27(13-15-28)21(10-4-3-5-11-21)17-26-20(29)18-6-8-19(9-7-18)32-22(23,24)25/h6-9H,2-5,10-17H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50379862 (CHEMBL2011870) Show SMILES COc1ccc(cc1)-c1nsc(NC(=O)[C@@H]2C[C@H]2C)c1C |r| Show InChI InChI=1S/C16H18N2O2S/c1-9-8-13(9)15(19)17-16-10(2)14(18-21-16)11-4-6-12(20-3)7-5-11/h4-7,9,13H,8H2,1-3H3,(H,17,19)/t9-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427177 (CHEMBL2324487) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)CCC2(CC2)CC1 Show InChI InChI=1S/C23H33F2N3O3S/c1-2-16-32(30,31)28-14-12-27(13-15-28)23(10-8-22(6-7-22)9-11-23)17-26-21(29)20-18(24)4-3-5-19(20)25/h3-5H,2,6-17H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50429650 (CHEMBL2334981) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H25N5OS/c1-13(2)18-6-5-7-20(25-18)21-22(15-8-9-19-16(11-15)12-29(4)27-19)28-31-24(21)26-23(30)17-10-14(17)3/h5-9,11-14,17H,10H2,1-4H3,(H,26,30)/t14-,17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu5 receptor				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427194 (CHEMBL2324162) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(Cl)cc2)CCCCC1 Show InChI InChI=1S/C21H32ClN3O3S/c1-2-16-29(27,28)25-14-12-24(13-15-25)21(10-4-3-5-11-21)17-23-20(26)18-6-8-19(22)9-7-18/h6-9H,2-5,10-17H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427182 (CHEMBL2324482) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(N)cccc2Cl)CCCC1 Show InChI InChI=1S/C20H31ClN4O3S/c1-2-14-29(27,28)25-12-10-24(11-13-25)20(8-3-4-9-20)15-23-19(26)18-16(21)6-5-7-17(18)22/h5-7H,2-4,8-15,22H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50429654 (CHEMBL2334977) Show SMILES COc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C22H21N5O2S/c1-12-9-15(12)21(28)24-22-19(17-5-4-6-18(23-17)29-3)20(26-30-22)13-7-8-16-14(10-13)11-27(2)25-16/h4-8,10-12,15H,9H2,1-3H3,(H,24,28)/t12-,15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50429659 (CHEMBL2334972) Show SMILES C[C@@H]1C[C@H]1C(=O)Nc1snc(c1-c1ccccn1)-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C21H19N5OS/c1-12-9-15(12)20(27)23-21-18(17-5-3-4-8-22-17)19(25-28-21)13-6-7-16-14(10-13)11-26(2)24-16/h3-8,10-12,15H,9H2,1-2H3,(H,23,27)/t12-,15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427174 (CHEMBL2324490) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)CCCOCC1 Show InChI InChI=1S/C21H31F2N3O4S/c1-2-15-31(28,29)26-11-9-25(10-12-26)21(7-4-13-30-14-8-21)16-24-20(27)19-17(22)5-3-6-18(19)23/h3,5-6H,2,4,7-16H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427187 (CHEMBL2324476) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2ccc(Cl)c(Cl)c2)CCCCC1 Show InChI InChI=1S/C21H31Cl2N3O3S/c1-2-14-30(28,29)26-12-10-25(11-13-26)21(8-4-3-5-9-21)16-24-20(27)17-6-7-18(22)19(23)15-17/h6-7,15H,2-5,8-14,16H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50429655 (CHEMBL2334976) Show SMILES CCc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C23H23N5OS/c1-4-16-6-5-7-19(24-16)20-21(14-8-9-18-15(11-14)12-28(3)26-18)27-30-23(20)25-22(29)17-10-13(17)2/h5-9,11-13,17H,4,10H2,1-3H3,(H,25,29)/t13-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	279	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50429642 (CHEMBL2334989) Show SMILES CC(C)c1cccc(n1)-c1c(NC(=O)C2CC2)snc1-c1ccc2nn(C)cc2c1 Show InChI InChI=1S/C23H23N5OS/c1-13(2)17-5-4-6-19(24-17)20-21(27-30-23(20)25-22(29)14-7-8-14)15-9-10-18-16(11-15)12-28(3)26-18/h4-6,9-14H,7-8H2,1-3H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	397	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50429651 (CHEMBL2334980) Show SMILES CCCc1cccc(n1)-c1c(NC(=O)[C@@H]2C[C@H]2C)snc1-c1ccc2nn(C)cc2c1 |r| Show InChI InChI=1S/C24H25N5OS/c1-4-6-17-7-5-8-20(25-17)21-22(15-9-10-19-16(12-15)13-29(3)27-19)28-31-24(21)26-23(30)18-11-14(18)2/h5,7-10,12-14,18H,4,6,11H2,1-3H3,(H,26,30)/t14-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	409	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in...				Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427175 (CHEMBL2324489) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(N)cccc2Cl)CCN(C)CC1 Show InChI InChI=1S/C21H34ClN5O3S/c1-3-15-31(29,30)27-13-11-26(12-14-27)21(7-9-25(2)10-8-21)16-24-20(28)19-17(22)5-4-6-18(19)23/h4-6H,3,7-16,23H2,1-2H3,(H,24,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427192 (CHEMBL2324164) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2cccc(OC(F)(F)F)c2)CCCCC1 Show InChI InChI=1S/C22H32F3N3O4S/c1-2-15-33(30,31)28-13-11-27(12-14-28)21(9-4-3-5-10-21)17-26-20(29)18-7-6-8-19(16-18)32-22(23,24)25/h6-8,16H,2-5,9-15,17H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	523	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50427178 (CHEMBL2324486) Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)C[C@@H]2C[C@@H]2C1 |r| Show InChI InChI=1S/C21H29F2N3O3S/c1-2-10-30(28,29)26-8-6-25(7-9-26)21(12-15-11-16(15)13-21)14-24-20(27)19-17(22)4-3-5-18(19)23/h3-5,15-16H,2,6-14H2,1H3,(H,24,27)/t15-,16+,21?	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	621	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay				Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6
					More data for this Ligand-Target Pair

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