Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575344 (CHEMBL4854822) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (658 to 1072) (unknown origin) by HTRF assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575348 (CHEMBL4853155) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (658 to 1072) (unknown origin) by HTRF assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575350 (CHEMBL4877264) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (658 to 1072) (unknown origin) by HTRF assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538514 (CHEMBL4644274) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538516 (CHEMBL4643578) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575345 (CHEMBL4848347) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (658 to 1072) (unknown origin) by HTRF assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50538514 (CHEMBL4644274) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538515 (CHEMBL4636056) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50538517 (CHEMBL4639022) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538517 (CHEMBL4639022) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of FGFR2 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575347 (CHEMBL4855562) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (658 to 1072) (unknown origin) by HTRF assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50538509 (CHEMBL4636995) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of PDGFRalpha (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of FGFR1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575351 (CHEMBL4874648) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50538516 (CHEMBL4643578) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50538515 (CHEMBL4636056) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of PDGFRalpha (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET V804M mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs b... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575352 (CHEMBL4857808) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIT (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575353 (CHEMBL4859681) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of PDGFRbeta (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of FGFR2 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell prolifera... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538512 (CHEMBL4638840) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50575351 (CHEMBL4874648) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 4 (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of FGFR4 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538507 (CHEMBL4640601) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50538509 (CHEMBL4636995) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of PDGFRbeta (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ROS (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIT (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIT (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell prolife... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575350 (CHEMBL4877264) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50575350 (CHEMBL4877264) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50575353 (CHEMBL4859681) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50538512 (CHEMBL4638840) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50538513 (CHEMBL4636800) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell prolife... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KDR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LCK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50575343 (CHEMBL4858720) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SRC (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00450 BindingDB Entry DOI: 10.7270/Q23R0XP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM50538508 (CHEMBL4634073) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of LYN (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer... | ACS Med Chem Lett 11: 558-565 (2020) Article DOI: 10.1021/acsmedchemlett.0c00015 BindingDB Entry DOI: 10.7270/Q29S1VJ7 | |||||||||||
More data for this Ligand-Target Pair |
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