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Compile Data Set for Download or QSAR

Found 83 hits with Last Name = 'de cesco' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.0200n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in Han/Wistar rat brain using Suc-Gly-Pro-AMC substrate incubated for 60 mins


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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0.0600n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrate


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180679
PNG
(CHEMBL3817958)
Show SMILES [H][C@]12CN(Cc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:19|
Show InChI InChI=1S/C21H23N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2/t16-,17-,18+,19-/m0/s1
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0.75n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP by tight binding based Morrison equation analysis


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.920n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP by tight binding based Morrison equation analysis


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.950n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180679
PNG
(CHEMBL3817958)
Show SMILES [H][C@]12CN(Cc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:19|
Show InChI InChI=1S/C21H23N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2/t16-,17-,18+,19-/m0/s1
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1n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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1n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50316818
PNG
(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCSC1 |r|
Show InChI InChI=1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP using Z-Gly-Pro-7-AMC substrate


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508977
PNG
(CHEMBL4451993)
Show SMILES O=C[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H20N2O3/c24-14-17-9-5-11-23(17)20(25)18-10-4-8-16-13-22(21(26)19(16)18)12-15-6-2-1-3-7-15/h1-4,6-8,10,14,17H,5,9,11-13H2/t17-/m0/s1
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3.5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508977
PNG
(CHEMBL4451993)
Show SMILES O=C[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H20N2O3/c24-14-17-9-5-11-23(17)20(25)18-10-4-8-16-13-22(21(26)19(16)18)12-15-6-2-1-3-7-15/h1-4,6-8,10,14,17H,5,9,11-13H2/t17-/m0/s1
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4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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8n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180664
PNG
(CHEMBL3818013)
Show SMILES [H][C@]12CN(OCc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:20|
Show InChI InChI=1S/C21H23N3O3/c22-12-17-9-5-11-23(17)20(25)18-10-4-8-16-13-24(21(26)19(16)18)27-14-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2/t16-,17-,18+,19-/m0/s1
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10n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508977
PNG
(CHEMBL4451993)
Show SMILES O=C[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H20N2O3/c24-14-17-9-5-11-23(17)20(25)18-10-4-8-16-13-22(21(26)19(16)18)12-15-6-2-1-3-7-15/h1-4,6-8,10,14,17H,5,9,11-13H2/t17-/m0/s1
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20n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508979
PNG
(CHEMBL4558566)
Show SMILES [H][C@]12C[C@]([H])(C1(C)C)[C@@]1(C)OB(O[C@@]1([H])C2)[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C30H35BN2O4/c1-29(2)21-15-23(29)30(3)24(16-21)36-31(37-30)25-13-8-14-33(25)27(34)22-12-7-11-20-18-32(28(35)26(20)22)17-19-9-5-4-6-10-19/h4-7,9-12,21,23-25H,8,13-18H2,1-3H3/t21-,23-,24+,25+,30-/m1/s1
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22n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 2 hrs before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50393843
PNG
(CHEMBL2159748)
Show SMILES O=C(N1CCC[C@H]1C#N)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H19N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,10,17H,5,9,11,13-14H2/t17-/m0/s1
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23n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50393843
PNG
(CHEMBL2159748)
Show SMILES O=C(N1CCC[C@H]1C#N)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H19N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,10,17H,5,9,11,13-14H2/t17-/m0/s1
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25n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50393843
PNG
(CHEMBL2159748)
Show SMILES O=C(N1CCC[C@H]1C#N)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H19N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,10,17H,5,9,11,13-14H2/t17-/m0/s1
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25n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508979
PNG
(CHEMBL4558566)
Show SMILES [H][C@]12C[C@]([H])(C1(C)C)[C@@]1(C)OB(O[C@@]1([H])C2)[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C30H35BN2O4/c1-29(2)21-15-23(29)30(3)24(16-21)36-31(37-30)25-13-8-14-33(25)27(34)22-12-7-11-20-18-32(28(35)26(20)22)17-19-9-5-4-6-10-19/h4-7,9-12,21,23-25H,8,13-18H2,1-3H3/t21-,23-,24+,25+,30-/m1/s1
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29n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180669
PNG
(CHEMBL3818020)
Show SMILES [H][C@]12CN(Cc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCCC1 |r,c:19|
Show InChI InChI=1S/C20H24N2O2/c23-19(21-11-4-5-12-21)17-10-6-9-16-14-22(20(24)18(16)17)13-15-7-2-1-3-8-15/h1-3,6-9,16-18H,4-5,10-14H2/t16-,17+,18-/m0/s1
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33n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180678
PNG
(CHEMBL3819136)
Show SMILES [H][C@]12CN(Cc3ccccc3)C(=O)[C@]1([H])[C@@H]([C@@H](C)C=C2)C(=O)N1CCC[C@H]1C#N |r,c:20|
Show InChI InChI=1S/C22H25N3O2/c1-15-9-10-17-14-24(13-16-6-3-2-4-7-16)21(26)20(17)19(15)22(27)25-11-5-8-18(25)12-23/h2-4,6-7,9-10,15,17-20H,5,8,11,13-14H2,1H3/t15-,17-,18-,19+,20-/m0/s1
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46n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508979
PNG
(CHEMBL4558566)
Show SMILES [H][C@]12C[C@]([H])(C1(C)C)[C@@]1(C)OB(O[C@@]1([H])C2)[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C30H35BN2O4/c1-29(2)21-15-23(29)30(3)24(16-21)36-31(37-30)25-13-8-14-33(25)27(34)22-12-7-11-20-18-32(28(35)26(20)22)17-19-9-5-4-6-10-19/h4-7,9-12,21,23-25H,8,13-18H2,1-3H3/t21-,23-,24+,25+,30-/m1/s1
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60n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508979
PNG
(CHEMBL4558566)
Show SMILES [H][C@]12C[C@]([H])(C1(C)C)[C@@]1(C)OB(O[C@@]1([H])C2)[C@@H]1CCCN1C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C30H35BN2O4/c1-29(2)21-15-23(29)30(3)24(16-21)36-31(37-30)25-13-8-14-33(25)27(34)22-12-7-11-20-18-32(28(35)26(20)22)17-19-9-5-4-6-10-19/h4-7,9-12,21,23-25H,8,13-18H2,1-3H3/t21-,23-,24+,25+,30-/m1/s1
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110n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50393842
PNG
(CHEMBL2159749)
Show SMILES O=C(N1CCCC1)c1cccc2CN(Cc3ccccc3)C(=O)c12
Show InChI InChI=1S/C20H20N2O2/c23-19(21-11-4-5-12-21)17-10-6-9-16-14-22(20(24)18(16)17)13-15-7-2-1-3-8-15/h1-3,6-10H,4-5,11-14H2
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160n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508978
PNG
(CHEMBL4462021)
Show SMILES F[C@H]1C[C@@H](C#N)N(C1)C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H18FN3O2/c22-16-9-17(10-23)25(13-16)20(26)18-8-4-7-15-12-24(21(27)19(15)18)11-14-5-2-1-3-6-14/h1-8,16-17H,9,11-13H2/t16-,17-/m0/s1
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170n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508981
PNG
(CHEMBL4437462)
Show SMILES F[C@H]1CCN(C1)C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C20H19FN2O2/c21-16-9-10-22(13-16)19(24)17-8-4-7-15-12-23(20(25)18(15)17)11-14-5-2-1-3-6-14/h1-8,16H,9-13H2/t16-/m0/s1
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290n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508980
PNG
(CHEMBL4584206)
Show SMILES F[C@@H]1CCN(C1)C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C20H19FN2O2/c21-16-9-10-22(13-16)19(24)17-8-4-7-15-12-23(20(25)18(15)17)11-14-5-2-1-3-6-14/h1-8,16H,9-13H2/t16-/m1/s1
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620n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180668
PNG
(CHEMBL3819096)
Show SMILES [H][C@]12CN(Cc3ccccc3)C(=O)[C@]1([H])[C@@H]([C@@H](C)C=C2)C(=O)N1CCCC1 |r,c:20|
Show InChI InChI=1S/C21H26N2O2/c1-15-9-10-17-14-23(13-16-7-3-2-4-8-16)21(25)19(17)18(15)20(24)22-11-5-6-12-22/h2-4,7-10,15,17-19H,5-6,11-14H2,1H3/t15-,17-,18+,19-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180667
PNG
(CHEMBL3818815)
Show SMILES [H][C@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:23|
Show InChI InChI=1S/C22H24N4O4/c23-12-17-9-5-11-25(17)20(27)18-10-4-8-16-13-26(21(28)19(16)18)24-22(29)30-14-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2,(H,24,29)/t16-,17-,18+,19-/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180681
PNG
(CHEMBL3818902)
Show SMILES [H][C@@]12CN(Cc3ccccc3)C(=O)[C@@]1([H])[C@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:19|
Show InChI InChI=1S/C21H23N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2/t16-,17+,18+,19-/m1/s1
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2.10E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508982
PNG
(CHEMBL4474579)
Show SMILES FC1(F)C[C@@H](C#N)N(C1)C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H17F2N3O2/c22-21(23)9-16(10-24)26(13-21)19(27)17-8-4-7-15-12-25(20(28)18(15)17)11-14-5-2-1-3-6-14/h1-8,16H,9,11-13H2/t16-/m0/s1
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3.30E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180665
PNG
(CHEMBL3819346)
Show SMILES [H][C@]12CN(NC(=O)Cc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:22|
Show InChI InChI=1S/C22H24N4O3/c23-13-17-9-5-11-25(17)21(28)18-10-4-8-16-14-26(22(29)20(16)18)24-19(27)12-15-6-2-1-3-7-15/h1-4,6-8,16-18,20H,5,9-12,14H2,(H,24,27)/t16-,17-,18+,20-/m0/s1
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4.00E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180670
PNG
(CHEMBL3819362)
Show SMILES [H][C@]12CN(OCc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCCC1 |r,c:20|
Show InChI InChI=1S/C20H24N2O3/c23-19(21-11-4-5-12-21)17-10-6-9-16-13-22(20(24)18(16)17)25-14-15-7-2-1-3-8-15/h1-3,6-9,16-18H,4-5,10-14H2/t16-,17+,18-/m0/s1
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7.50E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180673
PNG
(CHEMBL3819408)
Show SMILES [H][C@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCCC1 |r,c:23|
Show InChI InChI=1S/C21H25N3O4/c25-19(23-11-4-5-12-23)17-10-6-9-16-13-24(20(26)18(16)17)22-21(27)28-14-15-7-2-1-3-8-15/h1-3,6-9,16-18H,4-5,10-14H2,(H,22,27)/t16-,17+,18-/m0/s1
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1.20E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180680
PNG
(CHEMBL3818446)
Show SMILES [H][C@@]12CN(Cc3ccccc3)C(=O)[C@@]1([H])[C@H]([C@H](C)C=C2)C(=O)N1CCC[C@H]1C#N |r,c:20|
Show InChI InChI=1S/C22H25N3O2/c1-15-9-10-17-14-24(13-16-6-3-2-4-7-16)21(26)20(17)19(15)22(27)25-11-5-8-18(25)12-23/h2-4,6-7,9-10,15,17-20H,5,8,11,13-14H2,1H3/t15-,17-,18+,19+,20-/m1/s1
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6.20E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180666
PNG
(CHEMBL3818472)
Show SMILES [H][C@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@]1([H])[C@@H]([C@@H](C)C=C2)C(=O)N1CCC[C@H]1C#N |r,c:24|
Show InChI InChI=1S/C23H26N4O4/c1-15-9-10-17-13-27(25-23(30)31-14-16-6-3-2-4-7-16)22(29)20(17)19(15)21(28)26-11-5-8-18(26)12-24/h2-4,6-7,9-10,15,17-20H,5,8,11,13-14H2,1H3,(H,25,30)/t15-,17-,18-,19+,20-/m0/s1
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6.25E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180671
PNG
(CHEMBL3819072)
Show SMILES [H][C@]12CN(NC(=O)Cc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C(=O)N1CCCC1 |r,c:22|
Show InChI InChI=1S/C21H25N3O3/c25-18(13-15-7-2-1-3-8-15)22-24-14-16-9-6-10-17(19(16)21(24)27)20(26)23-11-4-5-12-23/h1-3,6-9,16-17,19H,4-5,10-14H2,(H,22,25)/t16-,17+,19-/m0/s1
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6.50E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180672
PNG
(CHEMBL3818541)
Show SMILES [H][C@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@]1([H])[C@@H]([C@@H](C)C=C2)C(=O)N1CCCC1 |r,c:24|
Show InChI InChI=1S/C22H27N3O4/c1-15-9-10-17-13-25(23-22(28)29-14-16-7-3-2-4-8-16)21(27)19(17)18(15)20(26)24-11-5-6-12-24/h2-4,7-10,15,17-19H,5-6,11-14H2,1H3,(H,23,28)/t15-,17-,18+,19-/m0/s1
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6.70E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180677
PNG
(CHEMBL3818999)
Show SMILES [H][C@@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@@]1([H])[C@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:23|
Show InChI InChI=1S/C22H24N4O4/c23-12-17-9-5-11-25(17)20(27)18-10-4-8-16-13-26(21(28)19(16)18)24-22(29)30-14-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2,(H,24,29)/t16-,17+,18+,19-/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508984
PNG
(CHEMBL4453293)
Show SMILES F[C@@H]1C[C@@H](C#N)N(C1)C(=O)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H18FN3O2/c22-16-9-17(10-23)25(13-16)20(26)18-8-4-7-15-12-24(21(27)19(15)18)11-14-5-2-1-3-6-14/h1-8,16-17H,9,11-13H2/t16-,17+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180676
PNG
(CHEMBL3818703)
Show SMILES [H][C@@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@@]1([H])[C@H]([C@H](C)C=C2)C(=O)N1CCC[C@H]1C#N |r,c:24|
Show InChI InChI=1S/C23H26N4O4/c1-15-9-10-17-13-27(25-23(30)31-14-16-6-3-2-4-7-16)22(29)20(17)19(15)21(28)26-11-5-8-18(26)12-24/h2-4,6-7,9-10,15,17-20H,5,8,11,13-14H2,1H3,(H,25,30)/t15-,17-,18+,19+,20-/m1/s1
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>1.50E+5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180674
PNG
(CHEMBL3818697)
Show SMILES [H][C@]12CN(NC(=O)OCc3ccccc3)C(=O)[C@]1([H])[C@@H](CC=C2)C#N |r,c:23|
Show InChI InChI=1S/C17H17N3O3/c18-9-13-7-4-8-14-10-20(16(21)15(13)14)19-17(22)23-11-12-5-2-1-3-6-12/h1-6,8,13-15H,7,10-11H2,(H,19,22)/t13-,14-,15+/m0/s1
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>1.50E+5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180682
PNG
(CHEMBL3819233)
Show SMILES [H][C@@]12CN(OCc3ccccc3)C(=O)[C@@]1([H])[C@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:20|
Show InChI InChI=1S/C21H23N3O3/c22-12-17-9-5-11-23(17)20(25)18-10-4-8-16-13-24(21(26)19(16)18)27-14-15-6-2-1-3-7-15/h1-4,6-8,16-19H,5,9-11,13-14H2/t16-,17+,18+,19-/m1/s1
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>1.50E+5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50180675
PNG
(CHEMBL3819297)
Show SMILES [H][C@@]12CN(NC(=O)Cc3ccccc3)C(=O)[C@@]1([H])[C@H](CC=C2)C(=O)N1CCC[C@H]1C#N |r,c:22|
Show InChI InChI=1S/C22H24N4O3/c23-13-17-9-5-11-25(17)21(28)18-10-4-8-16-14-26(22(29)20(16)18)24-19(27)12-15-6-2-1-3-7-15/h1-4,6-8,16-18,20H,5,9-12,14H2,(H,24,27)/t16-,17+,18+,20-/m1/s1
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>1.50E+5n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition


J Med Chem 59: 4221-34 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01296
BindingDB Entry DOI: 10.7270/Q2Z89FBB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50508983
PNG
(CHEMBL4464623)
Show SMILES CC(C)[C@H](NC(=O)c1ccncc1)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C15H22BN3O4/c1-10(2)13(18-14(20)11-5-7-17-8-6-11)15(21)19-9-3-4-12(19)16(22)23/h5-8,10,12-13,22-23H,3-4,9H2,1-2H3,(H,18,20)/t12-,13-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP (unknown origin)


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Acyl-protein thioesterase 1


(Rattus norvegicus)
BDBM50326390
PNG
((2S,4S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-...)
Show SMILES F[C@H]1C[C@@H](C#N)N(C1)C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1 |r|
Show InChI InChI=1S/C20H21FN4O3/c21-15-7-16(8-22)25(11-15)20(28)17-5-14(19(27)23-17)6-18(26)24-9-12-3-1-2-4-13(12)10-24/h1-4,14-17H,5-7,9-11H2,(H,23,27)/t14-,15-,16-,17-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of FAP (unknown origin)


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Acyl-protein thioesterase 1


(Rattus norvegicus)
BDBM50431242
PNG
(CHEMBL2333026)
Show SMILES C[C@@H](NC(=O)c1ccncc1)C(=O)N1CCC[C@H]1B(O)O |r|
Show InChI InChI=1S/C13H18BN3O4/c1-9(16-12(18)10-4-6-15-7-5-10)13(19)17-8-2-3-11(17)14(20)21/h4-7,9,11,20-21H,2-3,8H2,1H3,(H,16,18)/t9-,11+/m1/s1
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n/an/a>36n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of FAP (unknown origin)


J Med Chem 62: 7874-7884 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00642
BindingDB Entry DOI: 10.7270/Q2FB5682
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50393843
PNG
(CHEMBL2159748)
Show SMILES O=C(N1CCC[C@H]1C#N)c1cccc2CN(Cc3ccccc3)C(=O)c12 |r|
Show InChI InChI=1S/C21H19N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,10,17H,5,9,11,13-14H2/t17-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in human LN229 cell extracts using Cbz-Gly-Pro-AMC substrate incubated for 30 mins by fluorimetric assay


J Med Chem 55: 6306-15 (2012)


Article DOI: 10.1021/jm3002839
BindingDB Entry DOI: 10.7270/Q2D79CHF
More data for this
Ligand-Target Pair
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