Compile Data Set for Download or QSAR

Found 440 hits with Last Name = 'imajo' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM134267 (US8846660, 41) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C30H29ClF2N4O6/c1-17(19-5-3-18(4-6-19)9-28(38)39)35-30(41)37-16-27(36-43-25-13-23(32)12-24(33)14-25)34-15-21(29(37)40)10-20-11-22(31)7-8-26(20)42-2/h3-8,11-14,17,21H,9-10,15-16H2,1-2H3,(H,34,36)(H,35,41)(H,38,39)/t17-,21?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134262 (US8846660, 30) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C29H28ClF2N5O6/c1-15(16-3-5-23(28(39)40)24(33)9-16)35-29(41)37-14-26(36-43-22-11-20(31)10-21(32)12-22)34-13-18(27(37)38)7-17-8-19(30)4-6-25(17)42-2/h3-6,8-12,15,18H,7,13-14,33H2,1-2H3,(H,34,36)(H,35,41)(H,39,40)/t15-,18?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134278 (US8846660, 96) Show SMILES CCC[C@@H](NC(=O)N1CC2=NOCC(=O)N2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r,t:9| Show InChI InChI=1S/C27H30ClN5O7/c1-3-4-21(15-5-7-19(26(36)37)20(29)11-15)30-27(38)33-13-23-31-40-14-24(34)32(23)12-17(25(33)35)9-16-10-18(28)6-8-22(16)39-2/h5-8,10-11,17,21H,3-4,9,12-14,29H2,1-2H3,(H,30,38)(H,36,37)/t17?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50452609 (CHEMBL4206099) Show SMILES CC[C@@H](NC(=O)N1C\C(NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C30H32ClN5O6/c1-3-25(18-9-11-23(29(38)39)24(32)15-18)34-30(40)36-17-27(35-42-22-7-5-4-6-8-22)33-16-20(28(36)37)13-19-14-21(31)10-12-26(19)41-2/h4-12,14-15,20,25H,3,13,16-17,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t20-,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...				Bioorg Med Chem Lett 28: 188-192 (2018) Article DOI: 10.1016/j.bmcl.2017.11.031 BindingDB Entry DOI: 10.7270/Q2T72M14
					More data for this Ligand-Target Pair				3D Structure (crystal)
Chymase (Homo sapiens (Human))	BDBM134276 (US8846660, 76) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C30H32ClN5O6/c1-3-25(18-9-11-23(29(38)39)24(32)15-18)34-30(40)36-17-27(35-42-22-7-5-4-6-8-22)33-16-20(28(36)37)13-19-14-21(31)10-12-26(19)41-2/h4-12,14-15,20,25H,3,13,16-17,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t20?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134263 (US8846660, 31) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1ccccn1 |r| Show InChI InChI=1S/C28H29ClN6O6/c1-16(17-6-8-21(27(37)38)22(30)13-17)33-28(39)35-15-24(34-41-25-5-3-4-10-31-25)32-14-19(26(35)36)11-18-12-20(29)7-9-23(18)40-2/h3-10,12-13,16,19H,11,14-15,30H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t16-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134261 (US8846660, 29) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C29H29ClFN5O6/c1-16(17-3-9-23(28(38)39)24(32)13-17)34-29(40)36-15-26(35-42-22-7-5-21(31)6-8-22)33-14-19(27(36)37)11-18-12-20(30)4-10-25(18)41-2/h3-10,12-13,16,19H,11,14-15,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134266 (US8846660, 40) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C30H30ClFN4O6/c1-18(20-5-3-19(4-6-20)13-28(37)38)34-30(40)36-17-27(35-42-25-10-8-24(32)9-11-25)33-16-22(29(36)39)14-21-15-23(31)7-12-26(21)41-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t18-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210107 (7-chloro-3-(4-chlorophenylsulfonyl)quinazoline-2,4...) Show SMILES Clc1ccc(cc1)S(=O)(=O)n1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C14H8Cl2N2O4S/c15-8-1-4-10(5-2-8)23(21,22)18-13(19)11-6-3-9(16)7-12(11)17-14(18)20/h1-7H,(H,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058973 (3-(3,4-Dichloro-benzenesulfonyl)-1-phenyl-imidazol...) Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C15H10Cl2N2O4S/c16-12-7-6-11(8-13(12)17)24(22,23)19-14(20)9-18(15(19)21)10-4-2-1-3-5-10/h1-8H,9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100749 (US8507714, 214) Show SMILES COC(=O)C[C@H]1N(C(=O)[C@@H](Cc2cc(F)ccc2OC)CNC1=O)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C22H22ClFN2O7S/c1-32-19-8-5-16(24)10-13(19)9-14-12-25-21(28)18(11-20(27)33-2)26(22(14)29)34(30,31)17-6-3-15(23)4-7-17/h3-8,10,14,18H,9,11-12H2,1-2H3,(H,25,28)/t14-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...				US Patent US8507714 (2013) BindingDB Entry DOI: 10.7270/Q2H130N8
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100743 (US8507714, 67) Show SMILES COc1cc(Cl)c(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17Cl2FN2O5S/c1-29-17-8-15(21)16(22)7-11(17)6-12-9-23-18(25)10-24(19(12)26)30(27,28)14-4-2-13(20)3-5-14/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...				US Patent US8507714 (2013) BindingDB Entry DOI: 10.7270/Q2H130N8
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134253 (US8846660, 103 | US8846660, 12) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O6/c1-4-6-22(16-7-9-20(26(35)36)21(29)13-16)31-27(37)33-15-24(32-39-5-2)30-14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,4-6,11,14-15,29H2,1-3H3,(H,30,32)(H,31,37)(H,35,36)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134256 (US8846660, 18) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCCO)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O7/c1-3-4-22(16-5-7-20(26(36)37)21(29)13-16)31-27(38)33-15-24(32-40-10-9-34)30-14-18(25(33)35)11-17-12-19(28)6-8-23(17)39-2/h5-8,12-13,18,22,34H,3-4,9-11,14-15,29H2,1-2H3,(H,30,32)(H,31,38)(H,36,37)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058984 (3-(3,4-Dichloro-benzenesulfonyl)-1-(3,4-dimethyl-p...) Show SMILES Cc1ccc(cc1C)N1CC(=O)N(C1=O)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H14Cl2N2O4S/c1-10-3-4-12(7-11(10)2)20-9-16(22)21(17(20)23)26(24,25)13-5-6-14(18)15(19)8-13/h3-8H,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134272 (US8846660, 58) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)C(=O)Nc1nnn[nH]1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134260 (US8846660, 27) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(cc2)C(O)=O)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C29H27ClF2N4O6/c1-16(17-3-5-18(6-4-17)28(38)39)34-29(40)36-15-26(35-42-24-12-22(31)11-23(32)13-24)33-14-20(27(36)37)9-19-10-21(30)7-8-25(19)41-2/h3-8,10-13,16,20H,9,14-15H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,20?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134269 (US8846660, 44) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1cc(F)cc(F)c1)c1ccc(C(O)=O)c(O)c1 |r| Show InChI InChI=1S/C30H29ClF2N4O7/c1-3-24(16-4-6-23(29(40)41)25(38)10-16)35-30(42)37-15-27(36-44-22-12-20(32)11-21(33)13-22)34-14-18(28(37)39)8-17-9-19(31)5-7-26(17)43-2/h4-7,9-13,18,24,38H,3,8,14-15H2,1-2H3,(H,34,36)(H,35,42)(H,40,41)/t18?,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134268 (US8846660, 42) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccccn1 |r| Show InChI InChI=1S/C29H30ClN5O6/c1-18(20-8-6-19(7-9-20)13-27(36)37)33-29(39)35-17-25(34-41-26-5-3-4-12-31-26)32-16-22(28(35)38)14-21-15-23(30)10-11-24(21)40-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,36,37)/t18-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058990 (3-(3,4-Dimethoxy-benzenesulfonyl)-1-(3,4-dimethyl-...) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N1C(=O)CN(C1=O)c1ccc(C)c(C)c1 Show InChI InChI=1S/C19H20N2O6S/c1-12-5-6-14(9-13(12)2)20-11-18(22)21(19(20)23)28(24,25)15-7-8-16(26-3)17(10-15)27-4/h5-10H,11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210098 (6-(4,5-dichloro-2-methoxybenzyl)-4-(4-chlorophenyl...) Show SMILES COc1cc(Cl)c(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17Cl3N2O5S/c1-29-17-8-16(22)15(21)7-11(17)6-12-9-23-18(25)10-24(19(12)26)30(27,28)14-4-2-13(20)3-5-14/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058996 (3-(4-Chloro-benzenesulfonyl)-1-(3,4-dichloro-pheny...) Show SMILES Clc1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C15H9Cl3N2O4S/c16-9-1-4-11(5-2-9)25(23,24)20-14(21)8-19(15(20)22)10-3-6-12(17)13(18)7-10/h1-7H,8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100752 (US8507714, 269) Show SMILES COC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H20Cl2N2O7S/c1-31-20(27)12-32-18-7-4-16(23)9-13(18)8-14-10-24-19(26)11-25(21(14)28)33(29,30)17-5-2-15(22)3-6-17/h2-7,9,14H,8,10-12H2,1H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...				US Patent US8507714 (2013) BindingDB Entry DOI: 10.7270/Q2H130N8
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210116 (6-(5-fluoro-2-methoxybenzyl)-4-(4-chlorophenylsulf...) Show SMILES COc1ccc(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18ClFN2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210120 ((S)-6-(5-chloro-2-methoxybenzyl)-4-(4-chlorophenyl...) Show SMILES COc1ccc(Cl)cc1C[C@H]1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210094 (3-((1-(4-chlorophenylsulfonyl)-3,7-dioxo-1,4-diaze...) Show SMILES COc1ccc(cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1)C#N Show InChI InChI=1S/C20H18ClN3O5S/c1-29-18-7-2-13(10-22)8-14(18)9-15-11-23-19(25)12-24(20(15)26)30(27,28)17-5-3-16(21)4-6-17/h2-8,15H,9,11-12H2,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50059007 (4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-be...) Show SMILES COC(=O)c1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C17H14N2O6S/c1-25-16(21)12-7-9-14(10-8-12)26(23,24)19-15(20)11-18(17(19)22)13-5-3-2-4-6-13/h2-10H,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134252 (US8846660, 3) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccn1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C29H30ClN5O6/c1-3-23(18-7-9-19(10-8-18)28(37)38)33-29(39)35-17-25(34-41-26-6-4-5-13-31-26)32-16-21(27(35)36)14-20-15-22(30)11-12-24(20)40-2/h4-13,15,21,23H,3,14,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t21?,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134275 (US8846660, 73) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1cccc(c1)C(O)=O |r| Show InChI InChI=1S/C30H31ClN4O6/c1-3-25(19-8-7-9-20(14-19)29(37)38)33-30(39)35-18-27(34-41-24-10-5-4-6-11-24)32-17-22(28(35)36)15-21-16-23(31)12-13-26(21)40-2/h4-14,16,22,25H,3,15,17-18H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t22?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134264 (US8846660, 34) Show SMILES CCC[C@@H](NC(=O)N1C\C(=N\OC)N(C)CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O6/c1-5-6-22(16-7-9-20(26(35)36)21(29)13-16)30-27(37)33-15-24(31-39-4)32(2)14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,5-6,11,14-15,29H2,1-4H3,(H,30,37)(H,35,36)/b31-24-/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134273 (US8846660, 64) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(CC(O)=O)cc1 |r| Show InChI InChI=1S/C31H33ClN4O6/c1-3-26(21-11-9-20(10-12-21)15-29(37)38)34-31(40)36-19-28(35-42-25-7-5-4-6-8-25)33-18-23(30(36)39)16-22-17-24(32)13-14-27(22)41-2/h4-14,17,23,26H,3,15-16,18-19H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t23?,26-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134270 (US8846660, 49) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1cncc(c1)C(O)=O |r| Show InChI InChI=1S/C29H30ClN5O6/c1-3-24(19-12-21(28(37)38)15-31-14-19)33-29(39)35-17-26(34-41-23-7-5-4-6-8-23)32-16-20(27(35)36)11-18-13-22(30)9-10-25(18)40-2/h4-10,12-15,20,24H,3,11,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t20?,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058964 (3-(3,4-Dimethyl-benzenesulfonyl)-1-phenyl-imidazol...) Show SMILES Cc1ccc(cc1C)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C17H16N2O4S/c1-12-8-9-15(10-13(12)2)24(22,23)19-16(20)11-18(17(19)21)14-6-4-3-5-7-14/h3-10H,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134254 (US8846660, 14) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\O)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C25H30ClN5O6/c1-3-4-20(14-5-7-18(24(33)34)19(27)11-14)29-25(35)31-13-22(30-36)28-12-16(23(31)32)9-15-10-17(26)6-8-21(15)37-2/h5-8,10-11,16,20,36H,3-4,9,12-13,27H2,1-2H3,(H,28,30)(H,29,35)(H,33,34)/t16?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134255 (US8846660, 15) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OC(C)C)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C28H36ClN5O6/c1-5-6-23(17-7-9-21(27(36)37)22(30)13-17)32-28(38)34-15-25(33-40-16(2)3)31-14-19(26(34)35)11-18-12-20(29)8-10-24(18)39-4/h7-10,12-13,16,19,23H,5-6,11,14-15,30H2,1-4H3,(H,31,33)(H,32,38)(H,36,37)/t19?,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134257 (US8846660, 20) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCC(F)(F)F)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H31ClF3N5O6/c1-3-4-21(15-5-7-19(25(38)39)20(32)11-15)34-26(40)36-13-23(35-42-14-27(29,30)31)33-12-17(24(36)37)9-16-10-18(28)6-8-22(16)41-2/h5-8,10-11,17,21H,3-4,9,12-14,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t17?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134280 (US8846660, 108) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(F)ccc2OC)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34FN5O6/c1-4-6-22(16-7-9-20(26(35)36)21(29)13-16)31-27(37)33-15-24(32-39-5-2)30-14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,4-6,11,14-15,29H2,1-3H3,(H,30,32)(H,31,37)(H,35,36)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210743 (6-(4-chloro-2-methoxybenzyl)-4-(4-chlorophenylsulf...) Show SMILES COc1cc(Cl)ccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-9-15(21)3-2-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-6-4-14(20)5-7-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3435-9 (2007) Article DOI: 10.1016/j.bmcl.2007.03.085 BindingDB Entry DOI: 10.7270/Q2MK6CKH
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100740 (CHEMBL391608 | US8507714, 29) Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100740 (CHEMBL391608 | US8507714, 29) Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...				US Patent US8507714 (2013) BindingDB Entry DOI: 10.7270/Q2H130N8
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058969 (3-(4-Chloro-benzenesulfonyl)-1-(3,4-dimethyl-pheny...) Show SMILES Cc1ccc(cc1C)N1CC(=O)N(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15ClN2O4S/c1-11-3-6-14(9-12(11)2)19-10-16(21)20(17(19)22)25(23,24)15-7-4-13(18)5-8-15/h3-9H,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210099 (CHEMBL246964 | rac-2q) Show SMILES OC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H18Cl2N2O7S/c21-14-1-4-16(5-2-14)32(29,30)24-10-18(25)23-9-13(20(24)28)7-12-8-15(22)3-6-17(12)31-11-19(26)27/h1-6,8,13H,7,9-11H2,(H,23,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50058972 (4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-be...) Show SMILES O=C1CN(C(=O)N1S(=O)(=O)c1ccc(cc1)C#N)c1ccccc1 Show InChI InChI=1S/C16H11N3O4S/c17-10-12-6-8-14(9-7-12)24(22,23)19-15(20)11-18(16(19)21)13-4-2-1-3-5-13/h1-9H,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134271 (US8846660, 53) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)NCc2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1 Show InChI InChI=1S/C28H26ClF2N5O6/c1-41-24-5-3-18(29)8-16(24)7-17-13-33-25(35-42-21-10-19(30)9-20(31)11-21)14-36(26(17)37)28(40)34-12-15-2-4-22(27(38)39)23(32)6-15/h2-6,8-11,17H,7,12-14,32H2,1H3,(H,33,35)(H,34,40)(H,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134258 (US8846660, 22) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\N(C)C)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H35ClN6O5/c1-5-6-22(16-7-9-20(26(36)37)21(29)13-16)31-27(38)34-15-24(32-33(2)3)30-14-18(25(34)35)11-17-12-19(28)8-10-23(17)39-4/h7-10,12-13,18,22H,5-6,11,14-15,29H2,1-4H3,(H,30,32)(H,31,38)(H,36,37)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134281 (US8846660, 113) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2F)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C26H31ClFN5O5/c1-3-5-22(15-6-8-19(25(35)36)21(29)12-15)31-26(37)33-14-23(32-38-4-2)30-13-17(24(33)34)10-16-11-18(27)7-9-20(16)28/h6-9,11-12,17,22H,3-5,10,13-14,29H2,1-2H3,(H,30,32)(H,31,37)(H,35,36)/t17?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50210096 (2-(4-chloro-2-((1-(4-chlorophenylsulfonyl)-3,7-dio...) Show SMILES CNC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H21Cl2N3O6S/c1-24-20(28)12-32-18-7-4-16(23)9-13(18)8-14-10-25-19(27)11-26(21(14)29)33(30,31)17-5-2-15(22)3-6-17/h2-7,9,14H,8,10-12H2,1H3,(H,24,28)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM87059 (CHEMBL247767 | Chymostatin) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCNC(N)=N1)C(=O)N[C@@H](Cc1ccccc1)C=O |c:30| Show InChI InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair
Kallikrein-7 (Homo sapiens (Human))	BDBM50460879 (CHEMBL4228441) Show SMILES CCC[C@H](N1C\C(NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)=N\N(C)C)C(=O)Nc1cccc(c1)-c1cnn(C)c1 |r| Show InChI InChI=1S/C30H38ClN7O3/c1-6-8-26(29(39)34-25-10-7-9-20(15-25)23-17-33-37(4)18-23)38-19-28(35-36(2)3)32-16-22(30(38)40)13-21-14-24(31)11-12-27(21)41-5/h7,9-12,14-15,17-18,22,26H,6,8,13,16,19H2,1-5H3,(H,32,35)(H,34,39)/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human KLK7 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by s...				Bioorg Med Chem Lett 28: 1371-1375 (2018) Article DOI: 10.1016/j.bmcl.2018.03.011 BindingDB Entry DOI: 10.7270/Q2222XD7
					More data for this Ligand-Target Pair
Chymotrypsinogen A (Bos taurus (bovine))	BDBM50058977 (3-Benzoyl-1-phenyl-imidazolidine-2,4-dione | CHEMB...) Show SMILES Oc1cn(-c2ccccc2)c(=O)n1C(=O)c1ccccc1 Show InChI InChI=1S/C16H12N2O3/c19-14-11-17(13-9-5-2-6-10-13)16(21)18(14)15(20)12-7-3-1-4-8-12/h1-11,19H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against bovine pancreas alpha-chymotrypsin in vitro				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair

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