Compile Data Set for Download or QSAR

Found 565 hits with Last Name = 'engler' and Initial = 'ta'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50474994 (Bisarylmaleimide 1) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cccnn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H25N7O3/c35-25-22(23(26(36)30-25)20-14-28-21-8-5-9-29-34(20)21)19-16-32-12-13-33(27(37)31-10-2-1-3-11-31)15-17-6-4-7-18(19)24(17)32/h4-9,14,16H,1-3,10-13,15H2,(H,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cells				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150699 (3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...) Show SMILES Fc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c4cnc5ccccn45)c(c1)c23)C(=O)N1CCCCC1 |t:11| Show InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475025 (CHEMBL181339) Show SMILES O=C(C1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H25N5O4/c34-26-23(24(27(35)30-26)21-14-29-22-6-1-2-9-33(21)22)20-16-31-10-11-32(28(36)17-7-12-37-13-8-17)15-18-4-3-5-19(20)25(18)31/h1-6,9,14,16-17H,7-8,10-13,15H2,(H,30,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475007 (Bisarylmaleimide 2) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H23N5O5/c33-25-21(19-13-28-12-16-4-9-37-24(16)19)22(26(34)29-25)20-15-31-5-6-32(27(35)30-7-10-36-11-8-30)14-17-2-1-3-18(20)23(17)31/h1-4,9,12-13,15H,5-8,10-11,14H2,(H,29,33,34)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475024 (CHEMBL181371) Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:9| Show InChI InChI=1S/C24H18N4O4/c1-13(29)27-6-7-28-12-18(16-4-2-3-15(11-27)21(16)28)20-19(23(30)26-24(20)31)17-10-25-9-14-5-8-32-22(14)17/h2-5,8-10,12H,6-7,11H2,1H3,(H,26,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475018 (CHEMBL181518) Show SMILES CCC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:10| Show InChI InChI=1S/C25H20N4O4/c1-2-19(30)28-7-8-29-13-18(16-5-3-4-15(12-28)22(16)29)21-20(24(31)27-25(21)32)17-11-26-10-14-6-9-33-23(14)17/h3-6,9-11,13H,2,7-8,12H2,1H3,(H,27,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150699 (3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...) Show SMILES Fc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c4cnc5ccccn45)c(c1)c23)C(=O)N1CCCCC1 |t:11| Show InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475031 (CHEMBL359871) Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4CCOc34)c3cccc(C1)c23 |t:9| Show InChI InChI=1S/C25H21N3O4/c1-14(29)27-9-10-28-13-19(17-6-3-5-16(12-27)22(17)28)21-20(24(30)26-25(21)31)18-7-2-4-15-8-11-32-23(15)18/h2-7,13H,8-12H2,1H3,(H,26,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475029 (CHEMBL180779) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C25H21N5O4/c1-28(2)25(33)30-8-7-29-13-18(16-5-3-4-15(12-30)21(16)29)20-19(23(31)27-24(20)32)17-11-26-10-14-6-9-34-22(14)17/h3-6,9-11,13H,7-8,12H2,1-2H3,(H,27,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475008 (CHEMBL369090) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3ccn4ncccc34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H24N6O4/c34-25-22(19-6-8-33-21(19)5-2-7-28-33)23(26(35)29-25)20-16-31-9-10-32(27(36)30-11-13-37-14-12-30)15-17-3-1-4-18(20)24(17)31/h1-8,16H,9-15H2,(H,29,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150700 (7-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-2,5-dihy...) Show SMILES CC(C)OC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:12| Show InChI InChI=1S/C26H23N5O4/c1-15(2)35-26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475022 (CHEMBL361765) Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4ccoc34)c3cccc(C1)c23 |t:9| Show InChI InChI=1S/C25H19N3O4/c1-14(29)27-9-10-28-13-19(17-6-3-5-16(12-27)22(17)28)21-20(24(30)26-25(21)31)18-7-2-4-15-8-11-32-23(15)18/h2-8,11,13H,9-10,12H2,1H3,(H,26,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150702 (3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cells				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150702 (3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50474994 (Bisarylmaleimide 1) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cccnn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H25N7O3/c35-25-22(23(26(36)30-25)20-14-28-21-8-5-9-29-34(20)21)19-16-32-12-13-33(27(37)31-10-2-1-3-11-31)15-17-6-4-7-18(19)24(17)32/h4-9,14,16H,1-3,10-13,15H2,(H,30,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150701 (7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-11-10-29-14-17(16-7-5-6-15(13-30)22(16)29)20-21(24(33)27-23(20)32)18-12-26-19-8-3-4-9-31(18)19/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50150701 (7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-11-10-29-14-17(16-7-5-6-15(13-30)22(16)29)20-21(24(33)27-23(20)32)18-12-26-19-8-3-4-9-31(18)19/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475010 (CHEMBL369316) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ncccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C26H23N7O4/c34-23-20(21(24(35)29-23)19-13-28-25-27-5-2-6-33(19)25)18-15-31-7-8-32(26(36)30-9-11-37-12-10-30)14-16-3-1-4-17(18)22(16)31/h1-6,13,15H,7-12,14H2,(H,29,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475001 (CHEMBL368246) Show SMILES CC(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C26H23N5O3/c1-15(2)26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475014 (CHEMBL361948) Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:9| Show InChI InChI=1S/C24H19N5O3/c1-14(30)27-9-10-28-13-17(16-6-4-5-15(12-27)22(16)28)20-21(24(32)26-23(20)31)18-11-25-19-7-2-3-8-29(18)19/h2-8,11,13H,9-10,12H2,1H3,(H,26,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475004 (CHEMBL369572) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ncccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H25N7O3/c35-24-21(22(25(36)30-24)20-14-29-26-28-8-5-11-34(20)26)19-16-32-12-13-33(27(37)31-9-2-1-3-10-31)15-17-6-4-7-18(19)23(17)32/h4-8,11,14,16H,1-3,9-10,12-13,15H2,(H,30,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6811 (18,23-dimethyl-3,13,18-triazahexacyclo[14.7.0.0^{2...) Show SMILES Cc1cc2ccn(C)c2c2c3C(=O)NC(=O)c3c3c4ccccc4[nH]c3c12 Show InChI InChI=1S/C22H15N3O2/c1-10-9-11-7-8-25(2)20(11)16-14(10)19-15(12-5-3-4-6-13(12)23-19)17-18(16)22(27)24-21(17)26/h3-9,23H,1-2H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6745 (1,7-Annulated indolocarbazole deriv. 13Ab | 7-fluo...) Show SMILES OCC1CCc2cccc3c4c5C(=O)NC(=O)c5c5c6ccc(F)cc6[nH]c5c4n1c23 Show InChI InChI=1S/C24H16FN3O3/c25-11-5-7-13-15(8-11)26-20-16(13)18-19(24(31)27-23(18)30)17-14-3-1-2-10-4-6-12(9-29)28(21(10)14)22(17)20/h1-3,5,7-8,12,26,29H,4,6,9H2,(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	22
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 14: 3057-61 (2004) Article DOI: 10.1016/j.bmcl.2004.04.033 BindingDB Entry DOI: 10.7270/Q2KD1W3H
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150702 (3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50150702 (3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475006 (CHEMBL178851) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cnccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H25N7O3/c35-25-22(23(26(36)30-25)20-13-29-21-14-28-7-10-34(20)21)19-16-32-11-12-33(27(37)31-8-2-1-3-9-31)15-17-5-4-6-18(19)24(17)32/h4-7,10,13-14,16H,1-3,8-9,11-12,15H2,(H,30,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50474996 (CHEMBL178646) Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C28H25N5O4/c34-26-22(20-14-29-13-17-7-12-37-25(17)20)23(27(35)30-26)21-16-32-10-11-33(28(36)31-8-2-1-3-9-31)15-18-5-4-6-19(21)24(18)32/h4-7,12-14,16H,1-3,8-11,15H2,(H,30,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475000 (CHEMBL181296) Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4OCOc34)c3cccc(C1)c23 |t:9| Show InChI InChI=1S/C24H19N3O5/c1-13(28)26-8-9-27-11-17(15-5-2-4-14(10-26)21(15)27)20-19(23(29)25-24(20)30)16-6-3-7-18-22(16)32-12-31-18/h2-7,11H,8-10,12H2,1H3,(H,25,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cells				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475011 (CHEMBL178850) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4ccoc34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C26H22N4O4/c1-28(2)26(33)30-11-10-29-14-19(17-7-4-6-16(13-30)22(17)29)21-20(24(31)27-25(21)32)18-8-3-5-15-9-12-34-23(15)18/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475009 (CHEMBL361635) Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cncc2ccoc12 |c:5| Show InChI InChI=1S/C22H16N4O3/c27-21-17(15-10-24-9-13-4-7-29-20(13)15)18(22(28)25-21)16-11-26-6-5-23-8-12-2-1-3-14(16)19(12)26/h1-4,7,9-11,23H,5-6,8H2,(H,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475016 (CHEMBL361007) Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cnccn34)c3cccc(C1)c23 |t:15| Show InChI InChI=1S/C26H23N7O4/c34-24-21(22(25(35)29-24)19-12-28-20-13-27-4-5-33(19)20)18-15-31-6-7-32(26(36)30-8-10-37-11-9-30)14-16-2-1-3-17(18)23(16)31/h1-5,12-13,15H,6-11,14H2,(H,29,34,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475021 (CHEMBL445649) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4OCOc34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C25H22N4O5/c1-27(2)25(32)29-10-9-28-12-17(15-6-3-5-14(11-29)21(15)28)20-19(23(30)26-24(20)31)16-7-4-8-18-22(16)34-13-33-18/h3-8,12H,9-11,13H2,1-2H3,(H,26,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475005 (CHEMBL178820) Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cccc2CCOc12 |c:5| Show InChI InChI=1S/C23H19N3O3/c27-22-18(16-6-1-3-13-7-10-29-21(13)16)19(23(28)25-22)17-12-26-9-8-24-11-14-4-2-5-15(17)20(14)26/h1-6,12,24H,7-11H2,(H,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50474993 (CHEMBL361996) Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cccc2ccoc12 |c:5| Show InChI InChI=1S/C23H17N3O3/c27-22-18(16-6-1-3-13-7-10-29-21(13)16)19(23(28)25-22)17-12-26-9-8-24-11-14-4-2-5-15(17)20(14)26/h1-7,10,12,24H,8-9,11H2,(H,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475028 (CHEMBL179725) Show SMILES CC(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)C3=CN=[N+]4C=CC=CC34)c3cccc(C1)c23 |c:23,25,t:11,19,21| Show InChI InChI=1S/C26H23N5O3/c1-15(2)26(34)30-11-10-29-14-19(17-7-5-6-16(13-30)23(17)29)22-21(24(32)28-25(22)33)18-12-27-31-9-4-3-8-20(18)31/h3-9,12,14-15,20H,10-11,13H2,1-2H3/p+1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6832 (3-[3-(4-hydroxypiperidin-1-yl)propyl]-6-methoxy-18...) Show SMILES COc1ccc2c(c1)n(CCCN1CCC(O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12 Show InChI InChI=1S/C30H30N4O4/c1-32-13-8-17-4-6-21-24(27(17)32)26-25(29(36)31-30(26)37)23-20-7-5-19(38-2)16-22(20)34(28(21)23)12-3-11-33-14-9-18(35)10-15-33/h4-8,13,16,18,35H,3,9-12,14-15H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475020 (CHEMBL181464) Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3ccn4ncccc34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-12-11-29-14-18(16-6-3-5-15(13-30)22(16)29)21-20(23(32)27-24(21)33)17-8-10-31-19(17)7-4-9-26-31/h3-10,14H,11-13H2,1-2H3,(H,27,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50475027 (CHEMBL359537) Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cnc2cccnn12 |c:5| Show InChI InChI=1S/C21H16N6O2/c28-20-17(14-11-26-8-7-22-9-12-3-1-4-13(14)19(12)26)18(21(29)25-20)15-10-23-16-5-2-6-24-27(15)16/h1-6,10-11,22H,7-9H2,(H,25,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6838 (1-(2-{18-methyl-12,14-dioxo-3,13,18-triazahexacycl...) Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN6CCC(CC6)C(N)=O)cccc5c4c4C(=O)NC(=O)c4c3c12 Show InChI InChI=1S/C29H27N5O3/c1-33-11-7-16-5-6-19-21(26(16)33)23-22(28(36)32-29(23)37)20-18-4-2-3-15(24(18)31-25(19)20)8-12-34-13-9-17(10-14-34)27(30)35/h2-7,11,17,31H,8-10,12-14H2,1H3,(H2,30,35)(H,32,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50475001 (CHEMBL368246) Show SMILES CC(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11| Show InChI InChI=1S/C26H23N5O3/c1-15(2)26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cells				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6846 (5-{2-[(4-hydroxycyclohexyl)amino]ethyl}-18-methyl-...) Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCN[C@H]6CC[C@H](O)CC6)cccc5c4c4C(=O)NC(=O)c4c3c12 |r,wU:18.18,wD:15.14,(3.5,4.11,;3.82,2.6,;5.23,1.97,;5.06,.44,;3.56,.12,;2.79,-1.21,;1.25,-1.21,;.48,.12,;-1.06,.12,;-2.09,-1.02,;-3.5,-.4,;-4.91,-1.02,;-5.07,-2.55,;-6.44,-3.25,;-6.52,-4.79,;-7.89,-5.49,;-9.23,-4.72,;-10.56,-5.49,;-10.56,-7.03,;-11.89,-7.8,;-9.23,-7.8,;-7.89,-7.03,;-6.15,-.12,;-5.99,1.42,;-4.58,2.04,;-3.34,1.14,;-1.83,1.46,;-1.06,2.79,;-1.54,4.25,;-3,4.73,;-.29,5.16,;.95,4.25,;2.42,4.73,;.48,2.79,;1.25,1.46,;2.79,1.46,)| Show InChI InChI=1S/C29H28N4O3/c1-33-14-12-16-5-10-20-22(27(16)33)24-23(28(35)32-29(24)36)21-19-4-2-3-15(25(19)31-26(20)21)11-13-30-17-6-8-18(34)9-7-17/h2-5,10,12,14,17-18,30-31,34H,6-9,11,13H2,1H3,(H,32,35,36)/t17-,18-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150697 (3-Imidazo[1,2-a]pyridin-3-yl-4-[9-methyl-2-(piperi...) Show SMILES Cc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c4cnc5ccccn45)c(c1)c23)C(=O)N1CCCCC1 |t:11| Show InChI InChI=1S/C29H28N6O3/c1-18-13-19-16-34(29(38)32-8-4-2-5-9-32)12-11-33-17-21(20(14-18)26(19)33)24-25(28(37)31-27(24)36)22-15-30-23-7-3-6-10-35(22)23/h3,6-7,10,13-15,17H,2,4-5,8-9,11-12,16H2,1H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM6800 (6-hydroxy-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....) Show SMILES Oc1ccc2c(c1)[nH]c1c2c2C(=O)NC(=O)c2c2c3[nH]ccc3ccc12 Show InChI InChI=1S/C20H11N3O3/c24-9-2-4-10-12(7-9)22-18-11-3-1-8-5-6-21-17(8)14(11)16-15(13(10)18)19(25)23-20(16)26/h1-7,21-22,24H,(H,23,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6803 (6-methoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0...) Show SMILES COc1ccc2c(c1)[nH]c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12 Show InChI InChI=1S/C22H15N3O3/c1-25-8-7-10-3-5-13-16(20(10)25)18-17(21(26)24-22(18)27)15-12-6-4-11(28-2)9-14(12)23-19(13)15/h3-9,23H,1-2H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6815 (6-fluoro-18,23-dimethyl-3,13,18-triazahexacyclo[14...) Show SMILES Cc1cc2ccn(C)c2c2c3C(=O)NC(=O)c3c3c4ccc(F)cc4[nH]c3c12 Show InChI InChI=1S/C22H14FN3O2/c1-9-7-10-5-6-26(2)20(10)16-14(9)19-15(17-18(16)22(28)25-21(17)27)12-4-3-11(23)8-13(12)24-19/h3-8,24H,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 13: 2261-7 (2003) Article DOI: 10.1016/s0960-894x(03)00461-x BindingDB Entry DOI: 10.7270/Q29W0CPW
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318008 (2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Cl)CC1 Show InChI InChI=1S/C18H23ClN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.25	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair

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