Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Evaluated for binding activity against [3H]ketanserin as radioligand for 5-hydroxytryptamine 2 receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (RAT) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]-WB- 4101 as radioligand for alpha-1 adrenergic receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 164 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]-haloperidol as radioligand for Dopamine receptor D2 | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A/1B/1D/1F (RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 4.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]haloperidol as radioligand for Dopamine receptor D2 | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127246![]() (8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127246![]() (8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I at 10 uM | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.562 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Evaluated for binding activity against [3H]ketanserin as radioligand for 5-hydroxytryptamine 2 receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136383![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136383![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50126335![]() (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | MMDB PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM14434![]() (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Janssen Research Foundation | Assay Description Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid... | Cancer Res 61: 131-7 (2001) BindingDB Entry DOI: 10.7270/Q20C4T2R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50126335![]() (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | MMDB PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50126335![]() (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | MMDB PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127248![]() (6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136377![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136375![]() (6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136385![]() (C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-1-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127252![]() (8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127254![]() (9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136379![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (RAT) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136376![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136389![]() (C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-[1,2,4]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127255![]() (6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127247![]() (1-(3-Chloro-phenyl)-9-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136378![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136380![]() (4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136382![]() (4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136386![]() (C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136381![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127257![]() (6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127249![]() (6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127250![]() (6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136387![]() (C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM14434![]() (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Janssen Research Foundation | Assay Description Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid... | Cancer Res 61: 131-7 (2001) BindingDB Entry DOI: 10.7270/Q20C4T2R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136383![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide at 10 uM | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127256![]() (7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of farnesyl transferase at 0.1 uM | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136374![]() (4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127258![]() (2-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50127251![]() (7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of farnesyl transferase at 0.1 uM | Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]GGPP into biotinYRASNRSCAIL peptide at 10 uM | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136384![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]GGPP into biotinYRASNRSCAIL peptide | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50025124![]() (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for binding activity against [3H]haloperidol as radioligand for Dopamine receptor D2 | J Med Chem 29: 1663-8 (1986) BindingDB Entry DOI: 10.7270/Q2RX9B3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50136383![]() ((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 461 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase | Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5 | |||||||||||
More data for this Ligand-Target Pair |
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