Compile Data Set for Download or QSAR

Found 76 hits with Last Name = 'anzola' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317611 (4-(3,5-dichloropyridin-4-ylamino)-8-(3-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCN(C)C Show InChI InChI=1S/C20H21Cl2N3O4/c1-25(2)7-4-8-28-20-16(27-3)6-5-12-15(9-17(26)29-19(12)20)24-18-13(21)10-23-11-14(18)22/h5-6,9-11H,4,7-8H2,1-3H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317610 (9-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCCC(O)=O Show InChI InChI=1S/C24H26Cl2N2O6/c1-32-19-10-9-15-18(28-22-16(25)13-27-14-17(22)26)12-21(31)34-23(15)24(19)33-11-7-5-3-2-4-6-8-20(29)30/h9-10,12-14H,2-8,11H2,1H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317609 (8-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCC(O)=O Show InChI InChI=1S/C23H24Cl2N2O6/c1-31-18-9-8-14-17(27-21-15(24)12-26-13-16(21)25)11-20(30)33-22(14)23(18)32-10-6-4-2-3-5-7-19(28)29/h8-9,11-13H,2-7,10H2,1H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317616 (4-(3,5-dichloropyridin-4-ylamino)-8-(8-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCCN(C)C Show InChI InChI=1S/C25H31Cl2N3O4/c1-30(2)12-8-6-4-5-7-9-13-33-25-21(32-3)11-10-17-20(14-22(31)34-24(17)25)29-23-18(26)15-28-16-19(23)27/h10-11,14-16H,4-9,12-13H2,1-3H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317615 (4-(3,5-dichloropyridin-4-ylamino)-8-(7-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCN(C)C Show InChI InChI=1S/C24H29Cl2N3O4/c1-29(2)11-7-5-4-6-8-12-32-24-20(31-3)10-9-16-19(13-21(30)33-23(16)24)28-22-17(25)14-27-15-18(22)26/h9-10,13-15H,4-8,11-12H2,1-3H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317614 (4-(3,5-dichloropyridin-4-ylamino)-8-(6-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCN(C)C Show InChI InChI=1S/C23H27Cl2N3O4/c1-28(2)10-6-4-5-7-11-31-23-19(30-3)9-8-15-18(12-20(29)32-22(15)23)27-21-16(24)13-26-14-17(21)25/h8-9,12-14H,4-7,10-11H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317603 (8-(cyclopentyloxy)-4-(3,5-dichloropyridin-4-ylamin...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OC1CCCC1 Show InChI InChI=1S/C20H18Cl2N2O4/c1-26-16-7-6-12-15(24-18-13(21)9-23-10-14(18)22)8-17(25)28-19(12)20(16)27-11-4-2-3-5-11/h6-11H,2-5H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317604 (2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCC(O)=O Show InChI InChI=1S/C17H12Cl2N2O6/c1-25-12-3-2-8-11(21-15-9(18)5-20-6-10(15)19)4-14(24)27-16(8)17(12)26-7-13(22)23/h2-6H,7H2,1H3,(H,20,21)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317608 (7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCC(O)=O Show InChI InChI=1S/C22H22Cl2N2O6/c1-30-17-8-7-13-16(26-20-14(23)11-25-12-15(20)24)10-19(29)32-21(13)22(17)31-9-5-3-2-4-6-18(27)28/h7-8,10-12H,2-6,9H2,1H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317613 (4-(3,5-dichloropyridin-4-ylamino)-8-(5-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCN(C)C Show InChI InChI=1S/C22H25Cl2N3O4/c1-27(2)9-5-4-6-10-30-22-18(29-3)8-7-14-17(11-19(28)31-21(14)22)26-20-15(23)12-25-13-16(20)24/h7-8,11-13H,4-6,9-10H2,1-3H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317607 (6-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCC(O)=O Show InChI InChI=1S/C21H20Cl2N2O6/c1-29-16-7-6-12-15(25-19-13(22)10-24-11-14(19)23)9-18(28)31-20(12)21(16)30-8-4-2-3-5-17(26)27/h6-7,9-11H,2-5,8H2,1H3,(H,24,25)(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317612 (4-(3,5-dichloropyridin-4-ylamino)-8-(4-(dimethylam...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCN(C)C Show InChI InChI=1S/C21H23Cl2N3O4/c1-26(2)8-4-5-9-29-21-17(28-3)7-6-13-16(10-18(27)30-20(13)21)25-19-14(22)11-24-12-15(19)23/h6-7,10-12H,4-5,8-9H2,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317606 (5-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCC(O)=O Show InChI InChI=1S/C20H18Cl2N2O6/c1-28-15-6-5-11-14(24-18-12(21)9-23-10-13(18)22)8-17(27)30-19(11)20(15)29-7-3-2-4-16(25)26/h5-6,8-10H,2-4,7H2,1H3,(H,23,24)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181735 (5-(5-[2-chloro-5-(trifluoromethyl)phenyl]-furan-2-...) Show SMILES FC(F)(F)c1ccc(Cl)c(c1)-c1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)o1 |w:15.15| Show InChI InChI=1S/C21H12ClF3N2O4S3/c22-16-8-6-12(21(23,24)25)10-15(16)17-9-7-13(31-17)11-18-19(28)27(20(32)33-18)26-34(29,30)14-4-2-1-3-5-14/h1-11,26H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181696 (5-(2,4,5-trifluorobenzylidene)-3-(benzenesulfonyla...) Show SMILES Fc1cc(F)c(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1F |w:6.5| Show InChI InChI=1S/C16H9F3N2O3S3/c17-11-8-13(19)12(18)6-9(11)7-14-15(22)21(16(25)26-14)20-27(23,24)10-4-2-1-3-5-10/h1-8,20H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181693 (5-(3,4-dichlorobenzylidene)-3-(2-fluorobenzenesulf...) Show SMILES OC1N(NS(=O)(=O)c2ccccc2F)C(=S)S\C1=C/c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H11Cl2FN2O3S3/c17-10-6-5-9(7-11(10)18)8-13-15(22)21(16(25)26-13)20-27(23,24)14-4-2-1-3-12(14)19/h1-8,15,20,22H/b13-8-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181692 (5-(3,4-dichlorobenzylidene)-3-(2-thiophenesulfonyl...) Show SMILES Clc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3cccs3)C2=O)cc1Cl |w:5.4| Show InChI InChI=1S/C14H8Cl2N2O3S4/c15-9-4-3-8(6-10(9)16)7-11-13(19)18(14(22)24-11)17-25(20,21)12-2-1-5-23-12/h1-7,17H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181685 (CHEMBL202580 | N-(5-(3,4-dichlorobenzylidene)-4-ox...) Show SMILES Clc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1Cl |w:5.4| Show InChI InChI=1S/C16H10Cl2N2O3S3/c17-12-7-6-10(8-13(12)18)9-14-15(21)20(16(24)25-14)19-26(22,23)11-4-2-1-3-5-11/h1-9,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181684 (5-(2-methyl-3-phenyl-allylidene)-3-(benzenesulfony...) Show SMILES CC(C=C1SC(=S)N(NS(=O)(=O)c2ccccc2)C1=O)=Cc1ccccc1 |w:2.1,20.22| Show InChI InChI=1S/C19H16N2O3S3/c1-14(12-15-8-4-2-5-9-15)13-17-18(22)21(19(25)26-17)20-27(23,24)16-10-6-3-7-11-16/h2-13,20H,1H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181720 (5-(3,4-dibromobenzylidene)-3-(benzenesulfonylamino...) Show SMILES Brc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1Br |w:5.4| Show InChI InChI=1S/C16H10Br2N2O3S3/c17-12-7-6-10(8-13(12)18)9-14-15(21)20(16(24)25-14)19-26(22,23)11-4-2-1-3-5-11/h1-9,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50092350 ((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)nncc2c1OC1CCCC1 Show InChI InChI=1S/C19H18Cl2N4O2/c1-26-16-7-6-12-13(18(16)27-11-4-2-3-5-11)8-23-25-19(12)24-17-14(20)9-22-10-15(17)21/h6-11H,2-5H2,1H3,(H,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181705 (5-(3,4-dichlorobenzylidene)-3-(4-chlorobenzenesulf...) Show SMILES OC1N(NS(=O)(=O)c2ccc(Cl)cc2)C(=S)S\C1=C/c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H11Cl3N2O3S3/c17-10-2-4-11(5-3-10)27(23,24)20-21-15(22)14(26-16(21)25)8-9-1-6-12(18)13(19)7-9/h1-8,15,20,22H/b14-8-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317599 (5-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-6-...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)nccc2c1OC1CCCC1 Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-17-7-6-14-13(19(17)27-12-4-2-3-5-12)8-9-24-20(14)25-18-15(21)10-23-11-16(18)22/h6-12H,2-5H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181726 (5-(3,4-dichlorophenyl-1-ethylene)-3-(benzenesulfon...) Show SMILES Oc1c(sc(=S)n1NS(=O)(=O)c1ccccc1)C(=C)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H12Cl2N2O3S3/c1-10(11-7-8-13(18)14(19)9-11)15-16(22)21(17(25)26-15)20-27(23,24)12-5-3-2-4-6-12/h2-9,20,22H,1H2	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181701 (5-(3,4-dichlorobenzylidene)-3-(4-methylbenzenesulf...) Show SMILES Cc1ccc(cc1)S(=O)(=O)NN1C(O)\C(SC1=S)=C\c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H14Cl2N2O3S3/c1-10-2-5-12(6-3-10)27(23,24)20-21-16(22)15(26-17(21)25)9-11-4-7-13(18)14(19)8-11/h2-9,16,20,22H,1H3/b15-9-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181700 (5-(3,4-dichlorobenzylidene)-3-(4-fluorobenzenesulf...) Show SMILES OC1N(NS(=O)(=O)c2ccc(F)cc2)C(=S)S\C1=C/c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H11Cl2FN2O3S3/c17-12-6-1-9(7-13(12)18)8-14-15(22)21(16(25)26-14)20-27(23,24)11-4-2-10(19)3-5-11/h1-8,15,20,22H/b14-8-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181722 (5-(4-bromobenzylidene)-3-(benzenesulfonylamino)-4-...) Show SMILES Brc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:5.4| Show InChI InChI=1S/C16H11BrN2O3S3/c17-12-8-6-11(7-9-12)10-14-15(20)19(16(23)24-14)18-25(21,22)13-4-2-1-3-5-13/h1-10,18H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181713 (5-(3,4-dichlorobenzylidene)-3-(butylsulfonylamino)...) Show SMILES CCCCS(=O)(=O)NN1C(=S)SC(=Cc2ccc(Cl)c(Cl)c2)C1=O |w:13.13| Show InChI InChI=1S/C14H14Cl2N2O3S3/c1-2-3-6-24(20,21)17-18-13(19)12(23-14(18)22)8-9-4-5-10(15)11(16)7-9/h4-5,7-8,17H,2-3,6H2,1H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181725 (5-(3,4-dichlorobenzylidene)-3-(3-methoxybenzenesul...) Show SMILES COc1cccc(c1)S(=O)(=O)NN1C(O)\C(SC1=S)=C\c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H14Cl2N2O4S3/c1-25-11-3-2-4-12(9-11)28(23,24)20-21-16(22)15(27-17(21)26)8-10-5-6-13(18)14(19)7-10/h2-9,16,20,22H,1H3/b15-8-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181686 (5-(4-cyanobenzylidene)-3-(benzenesulfonylamino)-4-...) Show SMILES O=C1N(NS(=O)(=O)c2ccccc2)C(=S)SC1=Cc1ccc(cc1)C#N |w:17.19| Show InChI InChI=1S/C17H11N3O3S3/c18-11-13-8-6-12(7-9-13)10-15-16(21)20(17(24)25-15)19-26(22,23)14-4-2-1-3-5-14/h1-10,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181717 (5-(3,4,5-trifluorobenzylidene)-3-(benzenesulfonyla...) Show SMILES Fc1cc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc(F)c1F |w:4.3| Show InChI InChI=1S/C16H9F3N2O3S3/c17-11-6-9(7-12(18)14(11)19)8-13-15(22)21(16(25)26-13)20-27(23,24)10-4-2-1-3-5-10/h1-8,20H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181695 (5-(4-nitrobenzylidene)-3-amino-4-oxo-2-thionothiaz...) Show SMILES NN1C(=S)S\C(=C/c2ccc(cc2)[N+]([O-])=O)C1=O Show InChI InChI=1S/C10H7N3O3S2/c11-12-9(14)8(18-10(12)17)5-6-1-3-7(4-2-6)13(15)16/h1-5H,11H2/b8-5-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181714 (5-(4-trifluoromethylbenzylidene)-3-(benzenesulfony...) Show SMILES FC(F)(F)c1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:8.7| Show InChI InChI=1S/C17H11F3N2O3S3/c18-17(19,20)12-8-6-11(7-9-12)10-14-15(23)22(16(26)27-14)21-28(24,25)13-4-2-1-3-5-13/h1-10,21H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181694 (5-(4-chloro-3-fluorobenzylidene)-3-(benzenesulfony...) Show SMILES Fc1cc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)ccc1Cl |w:4.3| Show InChI InChI=1S/C16H10ClFN2O3S3/c17-12-7-6-10(8-13(12)18)9-14-15(21)20(16(24)25-14)19-26(22,23)11-4-2-1-3-5-11/h1-9,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181699 (5-(4-fluorobenzylidene)-3-(benzenesulfonylamino)-4...) Show SMILES Fc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:5.4| Show InChI InChI=1S/C16H11FN2O3S3/c17-12-8-6-11(7-9-12)10-14-15(20)19(16(23)24-14)18-25(21,22)13-4-2-1-3-5-13/h1-10,18H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317605 (4-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-o...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCC(O)=O Show InChI InChI=1S/C19H16Cl2N2O6/c1-27-14-5-4-10-13(23-17-11(20)8-22-9-12(17)21)7-16(26)29-18(10)19(14)28-6-2-3-15(24)25/h4-5,7-9H,2-3,6H2,1H3,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181687 (5-(4-chlorobenzylidene)-3-(benzenesulfonylamino)-4...) Show SMILES Clc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:5.4| Show InChI InChI=1S/C16H11ClN2O3S3/c17-12-8-6-11(7-9-12)10-14-15(20)19(16(23)24-14)18-25(21,22)13-4-2-1-3-5-13/h1-10,18H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181690 (5-(2,5-difluorobenzylidene)-3-(benzenesulfonylamin...) Show SMILES Fc1ccc(F)c(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c1 |w:7.6| Show InChI InChI=1S/C16H10F2N2O3S3/c17-11-6-7-13(18)10(8-11)9-14-15(21)20(16(24)25-14)19-26(22,23)12-4-2-1-3-5-12/h1-9,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181704 (5-(2,3,4-trifluorobenzylidene)-3-(benzenesulfonyla...) Show SMILES Fc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c(F)c1F |w:5.4| Show InChI InChI=1S/C16H9F3N2O3S3/c17-11-7-6-9(13(18)14(11)19)8-12-15(22)21(16(25)26-12)20-27(23,24)10-4-2-1-3-5-10/h1-8,20H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181706 (5-(4-nitrobenzylidene)-3-(benzenesulfonylamino)-4-...) Show SMILES [O-][N+](=O)c1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:7.6| Show InChI InChI=1S/C16H11N3O5S3/c20-15-14(10-11-6-8-12(9-7-11)19(21)22)26-16(25)18(15)17-27(23,24)13-4-2-1-3-5-13/h1-10,17H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181710 (5-(3,4-dichlorobenzylidene)-3-(methanesulfonylamin...) Show SMILES CS(=O)(=O)NN1C(=S)SC(=Cc2ccc(Cl)c(Cl)c2)C1=O |w:10.10| Show InChI InChI=1S/C11H8Cl2N2O3S3/c1-21(17,18)14-15-10(16)9(20-11(15)19)5-6-2-3-7(12)8(13)4-6/h2-5,14H,1H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317600 (8-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-7-...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)ncnc2c1OC1CCCC1 Show InChI InChI=1S/C19H18Cl2N4O2/c1-26-15-7-6-12-16(18(15)27-11-4-2-3-5-11)23-10-24-19(12)25-17-13(20)8-22-9-14(17)21/h6-11H,2-5H2,1H3,(H,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181707 (5-(2-naphthylmethylene)-3-(benzenesulfonylamino)-4...) Show SMILES O=C1N(NS(=O)(=O)c2ccccc2)C(=S)SC1=Cc1ccc2ccccc2c1 |w:17.19| Show InChI InChI=1S/C20H14N2O3S3/c23-19-18(13-14-10-11-15-6-4-5-7-16(15)12-14)27-20(26)22(19)21-28(24,25)17-8-2-1-3-9-17/h1-13,21H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181689 (5-(2,4-difluorobenzylidene)-3-(benzenesulfonylamin...) Show SMILES Fc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c(F)c1 |w:5.4| Show InChI InChI=1S/C16H10F2N2O3S3/c17-11-7-6-10(13(18)9-11)8-14-15(21)20(16(24)25-14)19-26(22,23)12-4-2-1-3-5-12/h1-9,19H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50317598 (8-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-7-...) Show SMILES COc1ccc2c(Nc3c(Cl)cncc3Cl)ccnc2c1OC1CCCC1 Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-17-7-6-13-16(25-19-14(21)10-23-11-15(19)22)8-9-24-18(13)20(17)27-12-4-2-3-5-12/h6-12H,2-5H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kalypsys, Inc. Curated by ChEMBL					Assay Description Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr				Bioorg Med Chem Lett 20: 2928-32 (2010) Article DOI: 10.1016/j.bmcl.2010.03.023 BindingDB Entry DOI: 10.7270/Q2VD6ZMF
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181697 (5-(4-methoxybenzylidene)-3-(benzenesulfonylamino)-...) Show SMILES COc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:6.5| Show InChI InChI=1S/C17H14N2O4S3/c1-23-13-9-7-12(8-10-13)11-15-16(20)19(17(24)25-15)18-26(21,22)14-5-3-2-4-6-14/h2-11,18H,1H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181708 (5-(3-methoxybenzylidene)-3-(benzenesulfonylamino)-...) Show SMILES COc1cccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c1 |w:7.6| Show InChI InChI=1S/C17H14N2O4S3/c1-23-13-7-5-6-12(10-13)11-15-16(20)19(17(24)25-15)18-26(21,22)14-8-3-2-4-9-14/h2-11,18H,1H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181715 (5-(3,4-dichlorobenzylidene)-3-(4-methoxybenzenesul...) Show SMILES COc1ccc(cc1)S(=O)(=O)NN1C(O)\C(SC1=S)=C\c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H14Cl2N2O4S3/c1-25-11-3-5-12(6-4-11)28(23,24)20-21-16(22)15(27-17(21)26)9-10-2-7-13(18)14(19)8-10/h2-9,16,20,22H,1H3/b15-9-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50181691 (5-(2-fluorobenzylidene)-3-(benzenesulfonylamino)-4...) Show SMILES Fc1ccccc1C=C1SC(=S)N(NS(=O)(=O)c2ccccc2)C1=O |w:7.7| Show InChI InChI=1S/C16H11FN2O3S3/c17-13-9-5-4-6-11(13)10-14-15(20)19(16(23)24-14)18-25(21,22)12-7-2-1-3-8-12/h1-10,18H	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against HCV delta 21 NS5b RNA polymerase				J Med Chem 49: 1034-46 (2006) Article DOI: 10.1021/jm050859x BindingDB Entry DOI: 10.7270/Q2CJ8D3W
					More data for this Ligand-Target Pair

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