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TargetRNA-directed RNA polymerase
LigandBDBM50181689
Substrate/Competitorn/a
Meas. Tech.ChEMBL_331786 (CHEMBL864669)
IC50 3000±n/a nM
Citation Powers, JPPiper, DELi, YMayorga, VAnzola, JChen, JMJaen, JCLee, GLiu, JPeterson, MGTonn, GRYe, QWalker, NPWang, Z SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase. J Med Chem49:1034-46 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181689
n/a
NameBDBM50181689
Synonyms:5-(2,4-difluorobenzylidene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | CHEMBL200986
TypeSmall organic molecule
Emp. Form.C16H10F2N2O3S3
Mol. Mass.412.454
SMILESFc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c(F)c1 |w:5.4|
Structure
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