| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50181705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_331786 (CHEMBL864669) |
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| IC50 | 500±n/a nM |
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| Citation |  Powers, JP; Piper, DE; Li, Y; Mayorga, V; Anzola, J; Chen, JM; Jaen, JC; Lee, G; Liu, J; Peterson, MG; Tonn, GR; Ye, Q; Walker, NP; Wang, Z SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase. J Med Chem49:1034-46 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50181705 |
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| n/a |
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| Name | BDBM50181705 |
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| Synonyms: | 5-(3,4-dichlorobenzylidene)-3-(4-chlorobenzenesulfonylamino)-4-oxo-2-thionothiazolidine | CHEMBL372998 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11Cl3N2O3S3 |
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| Mol. Mass. | 481.824 |
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| SMILES | OC1N(NS(=O)(=O)c2ccc(Cl)cc2)C(=S)S\C1=C/c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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