Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24855 (4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24848 (5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24853 (1-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24847 (5-chloro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24846 (1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24852 (1-{5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24849 (1'-methyl-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12.7 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24845 (5-chloro-4-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24841 (N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 151 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24842 (N-[4-chloro-2-(5-methyl-4H-1,2,4-triazol-3-yl)phen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 171 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24837 (N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24844 (5-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-3H,4H,5H,6H,7H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 294 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24840 (5-chloro-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 318 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24839 (5-methyl-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 425 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24854 (1-{5-benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24850 (1-(5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.79E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24851 (5-fluoro-1'-methanesulfonyl-1-{7H-pyrrolo[2,3-d]py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24843 (N-[5-chloro-2-(5-methyl-4H-1,2,4-triazol-3-yl)phen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24838 (7-methyl-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP... | Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC | |||||||||||
More data for this Ligand-Target Pair |