Found 534 hits with Last Name = 'born' and Initial = 'r' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343152
(CHEMBL1773196 | N-(3-(3-((R)-3-(diisopropylamino)-...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)Cc2cccc(CC(C)(C)NC[C@H](O)c3ccc(O)c(CO)c3)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C45H61N3O5/c1-31(2)48(32(3)4)23-21-39(36-15-8-7-9-16-36)40-25-33(17-19-42(40)51)14-11-22-46-44(53)26-34-12-10-13-35(24-34)28-45(5,6)47-29-43(52)37-18-20-41(50)38(27-37)30-49/h7-10,12-13,15-20,24-25,27,31-32,39,43,47,49-52H,11,14,21-23,26,28-30H2,1-6H3,(H,46,53)/t39-,43+/m1/s1 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343153
(CHEMBL1773197 | N-(3-(3-((R)-3-(diisopropylamino)-...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)Cc2cccc(CC(C)(C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C45H62N4O6S/c1-31(2)49(32(3)4)24-22-38(36-16-9-8-10-17-36)39-26-33(18-20-41(39)50)15-12-23-46-44(53)27-34-13-11-14-35(25-34)29-45(5,6)47-30-43(52)37-19-21-42(51)40(28-37)48-56(7,54)55/h8-11,13-14,16-21,25-26,28,31-32,38,43,47-48,50-52H,12,15,22-24,27,29-30H2,1-7H3,(H,46,53)/t38-,43+/m1/s1 | PDB
Reactome pathway
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| CHEMBL
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| Article
PubMed
| 0.276 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343161
(5-((R)-2-(4-(4-(3-((R)-3-(diisopropylamino)-1-phen...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCOc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)ccc1O)C(C)C |r| Show InChI InChI=1S/C44H55N3O5/c1-30(2)47(31(3)4)26-24-36(34-11-6-5-7-12-34)39-28-33(15-20-40(39)48)10-8-9-27-52-35-16-13-32(14-17-35)23-25-45-29-42(50)37-18-21-41(49)44-38(37)19-22-43(51)46-44/h5-7,11-22,28,30-31,36,42,45,48-50H,8-10,23-27,29H2,1-4H3,(H,46,51)/t36-,42+/m1/s1 | PDB
Reactome pathway
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PubMed
| 0.305 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343154
(2-(3-((R)-2-((R)-2-(3,5-dihydroxyphenyl)-2-hydroxy...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3cc(O)cc(O)c3)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C43H57N3O5/c1-29(2)46(30(3)4)20-18-39(35-14-7-6-8-15-35)40-23-32(16-17-41(40)49)13-10-19-44-43(51)24-34-12-9-11-33(22-34)21-31(5)45-28-42(50)36-25-37(47)27-38(48)26-36/h6-9,11-12,14-17,22-23,25-27,29-31,39,42,45,47-50H,10,13,18-21,24,28H2,1-5H3,(H,44,51)/t31-,39-,42+/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 0.397 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343157
(CHEMBL1773264 | N-(5-((R)-2-(4-(4-(3-((R)-3-(diiso...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCOc2ccc(CCNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)cc2)ccc1O)C(C)C |r| Show InChI InChI=1S/C42H57N3O6S/c1-30(2)45(31(3)4)25-23-37(34-12-7-6-8-13-34)38-27-33(16-20-40(38)46)11-9-10-26-51-36-18-14-32(15-19-36)22-24-43-29-42(48)35-17-21-41(47)39(28-35)44-52(5,49)50/h6-8,12-21,27-28,30-31,37,42-44,46-48H,9-11,22-26,29H2,1-5H3/t37-,42+/m1/s1 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
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| Article
PubMed
| 0.634 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343158
(2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(4-(...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCOc2ccc(CCNC[C@H](O)c3ccc(O)c(CO)c3)cc2)ccc1O)C(C)C |r| Show InChI InChI=1S/C42H56N2O5/c1-30(2)44(31(3)4)24-22-38(34-11-6-5-7-12-34)39-26-33(15-19-41(39)47)10-8-9-25-49-37-17-13-32(14-18-37)21-23-43-28-42(48)35-16-20-40(46)36(27-35)29-45/h5-7,11-20,26-27,30-31,38,42-43,45-48H,8-10,21-25,28-29H2,1-4H3/t38-,42+/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 0.765 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343160
(CHEMBL1773266 | N-(5-((R)-2-(6-(4-(3-((R)-3-(diiso...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C40H61N3O6S/c1-30(2)43(31(3)4)24-22-35(33-16-9-8-10-17-33)36-27-32(18-20-38(36)44)15-11-14-26-49-25-13-7-6-12-23-41-29-40(46)34-19-21-39(45)37(28-34)42-50(5,47)48/h8-10,16-21,27-28,30-31,35,40-42,44-46H,6-7,11-15,22-26,29H2,1-5H3/t35-,40+/m1/s1 | PDB
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| Article
PubMed
| 0.990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343156
(CHEMBL1773263 | N-(3-(3-((R)-3-(diisopropylamino)-...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)CCCCCCCCCCNC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C44H68N4O6S/c1-33(2)48(34(3)4)29-26-38(36-19-13-12-14-20-36)39-30-35(22-24-41(39)49)18-17-28-46-44(52)21-15-10-8-6-7-9-11-16-27-45-32-43(51)37-23-25-42(50)40(31-37)47-55(5,53)54/h12-14,19-20,22-25,30-31,33-34,38,43,45,47,49-51H,6-11,15-18,21,26-29,32H2,1-5H3,(H,46,52)/t38-,43+/m1/s1 | PDB
Reactome pathway
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| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50354566
(CHEMBL1836647)Show SMILES O[C@@H](CNCCCCCCCCCN1CCC(CC1)Oc1nn(c2CCCCc12)-c1c(O)cccc1F)c1ccc(O)c2[nH]c(=O)ccc12 |r,wU:1.0,(-3.94,-14.4,;-3.93,-15.94,;-2.6,-16.71,;-1.27,-15.93,;.07,-16.7,;1.4,-15.92,;2.74,-16.69,;4.07,-15.91,;5.41,-16.68,;6.74,-15.9,;8.07,-16.67,;9.4,-15.89,;10.74,-16.66,;12.07,-15.88,;13.4,-16.65,;14.72,-15.88,;14.73,-14.34,;13.39,-13.57,;12.05,-14.35,;16.06,-13.57,;16.06,-12.03,;14.64,-11.42,;14.79,-9.89,;16.3,-9.56,;17.05,-8.23,;18.58,-8.22,;19.36,-9.55,;18.6,-10.88,;17.07,-10.88,;13.45,-9.14,;12.14,-9.94,;12.18,-11.48,;10.79,-9.2,;10.76,-7.66,;12.08,-6.86,;13.43,-7.61,;14.75,-6.82,;-5.26,-16.72,;-6.6,-15.95,;-7.93,-16.72,;-7.93,-18.27,;-9.26,-19.04,;-6.59,-19.03,;-6.59,-20.56,;-5.26,-21.34,;-5.26,-22.88,;-3.93,-20.57,;-3.93,-19.03,;-5.26,-18.27,)| Show InChI InChI=1S/C38H50FN5O5/c39-30-12-10-14-33(46)37(30)44-31-13-7-6-11-29(31)38(42-44)49-26-19-23-43(24-20-26)22-9-5-3-1-2-4-8-21-40-25-34(47)27-15-17-32(45)36-28(27)16-18-35(48)41-36/h10,12,14-18,26,34,40,45-47H,1-9,11,13,19-25H2,(H,41,48)/t34-/m0/s1 | PDB
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| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methylscopolamine from human M3 receptor |
J Med Chem 54: 6998-7002 (2011)
Article DOI: 10.1021/jm2007535
BindingDB Entry DOI: 10.7270/Q2SJ1M03 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50354569
(CHEMBL1836646)Show SMILES Oc1cccc(F)c1-n1nc(OC2CCNCC2)c2CCCCc12 |(36.87,1.24,;36.09,2.57,;36.85,3.91,;36.07,5.24,;34.52,5.22,;33.77,3.88,;32.23,3.86,;34.56,2.56,;33.8,1.22,;34.71,-.02,;33.8,-1.27,;34.59,-2.59,;36.13,-2.57,;36.91,-3.9,;38.44,-3.88,;39.2,-2.54,;38.41,-1.22,;36.87,-1.23,;32.33,-.8,;31,-1.58,;29.67,-.81,;29.67,.74,;31,1.51,;32.33,.75,)| Show InChI InChI=1S/C18H22FN3O2/c19-14-5-3-7-16(23)17(14)22-15-6-2-1-4-13(15)18(21-22)24-12-8-10-20-11-9-12/h3,5,7,12,20,23H,1-2,4,6,8-11H2 | PDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methylscopolamine from human M3 receptor |
J Med Chem 54: 6998-7002 (2011)
Article DOI: 10.1021/jm2007535
BindingDB Entry DOI: 10.7270/Q2SJ1M03 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50165008
((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)Show InChI InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 | PDB
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| DrugBank
Article
PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methylscopolamine from human M3 receptor |
J Med Chem 54: 6998-7002 (2011)
Article DOI: 10.1021/jm2007535
BindingDB Entry DOI: 10.7270/Q2SJ1M03 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50165008
((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)Show InChI InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 | PDB
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| DrugBank
Article
PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343159
(4-((R)-2-(4-(4-(3-((R)-3-(diisopropylamino)-1-phen...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCCOc2ccc(CCNC[C@H](O)c3ccc(O)c(O)c3)cc2)ccc1O)C(C)C |r| Show InChI InChI=1S/C41H54N2O5/c1-29(2)43(30(3)4)24-22-36(33-11-6-5-7-12-33)37-26-32(15-19-38(37)44)10-8-9-25-48-35-17-13-31(14-18-35)21-23-42-28-41(47)34-16-20-39(45)40(46)27-34/h5-7,11-20,26-27,29-30,36,41-42,44-47H,8-10,21-25,28H2,1-4H3/t36-,41+/m1/s1 | PDB
Reactome pathway
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PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474703
(CHEMBL1269)Show SMILES Fc1ccc(cc1)C(=O)CCC[n+]1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H18ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-12,14-15H,1-2,13H2/q+1 | PDB
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| <6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474703
(CHEMBL1269)Show SMILES Fc1ccc(cc1)C(=O)CCC[n+]1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H18ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-12,14-15H,1-2,13H2/q+1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| <6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474703
(CHEMBL1269)Show SMILES Fc1ccc(cc1)C(=O)CCC[n+]1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H18ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-12,14-15H,1-2,13H2/q+1 | PDB
Reactome pathway
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UniChem
| Article
PubMed
| <6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50343155
(CHEMBL1773262 | N-(5-((R)-2-(3-((R)-3-(diisopropyl...)Show SMILES CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)ccc1O)C(C)C |r| Show InChI InChI=1S/C32H45N3O5S/c1-22(2)35(23(3)4)18-16-27(25-9-7-6-8-10-25)28-19-24(11-13-30(28)36)15-17-33-21-32(38)26-12-14-31(37)29(20-26)34-41(5,39)40/h6-14,19-20,22-23,27,32-34,36-38H,15-18,21H2,1-5H3/t27-,32+/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 2759-63 (2011)
Article DOI: 10.1016/j.bmcl.2010.10.132
BindingDB Entry DOI: 10.7270/Q2G73F1B |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
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| Article
PubMed
| 6.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50185474
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2 | PDB
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UniChem
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PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474702
(CHEMBL358190)Show SMILES OCCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(12-15-26)11-14-25(16-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
Reactome pathway
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| Article
PubMed
| 6.71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474706
(CHEMBL148626)Show InChI InChI=1S/C21H25ClFNO2/c1-24(14-2-4-20(25)16-6-10-18(22)11-7-16)15-3-5-21(26)17-8-12-19(23)13-9-17/h6-13,20,25H,2-5,14-15H2,1H3 | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 6.72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474708
(CHEMBL149877)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(15-25)11-13-24(14-21)12-1-2-20(26)16-3-9-19(23)10-4-16/h3-10,25H,1-2,11-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 6.78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474706
(CHEMBL148626)Show InChI InChI=1S/C21H25ClFNO2/c1-24(14-2-4-20(25)16-6-10-18(22)11-7-16)15-3-5-21(26)17-8-12-19(23)13-9-17/h6-13,20,25H,2-5,14-15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 6.79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50354567
(CHEMBL1836644)Show SMILES Fc1cccc(F)c1-n1nc(OC2CCNCC2)c2ccccc12 |(8.15,4.15,;9.69,4.17,;10.44,5.51,;11.99,5.53,;12.77,4.2,;12.01,2.86,;12.79,1.54,;10.47,2.86,;9.71,1.52,;10.62,.27,;9.72,-.98,;10.51,-2.3,;12.04,-2.28,;12.82,-3.6,;14.36,-3.59,;15.11,-2.25,;14.33,-.92,;12.78,-.94,;8.25,-.5,;6.92,-1.28,;5.58,-.51,;5.59,1.03,;6.91,1.8,;8.25,1.04,)| Show InChI InChI=1S/C18H17F2N3O/c19-14-5-3-6-15(20)17(14)23-16-7-2-1-4-13(16)18(22-23)24-12-8-10-21-11-9-12/h1-7,12,21H,8-11H2 | Reactome pathway
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PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human NET receptor |
J Med Chem 54: 6998-7002 (2011)
Article DOI: 10.1021/jm2007535
BindingDB Entry DOI: 10.7270/Q2SJ1M03 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22566
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3 | PDB
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PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human histamine H4 receptor by functional assay |
Bioorg Med Chem Lett 21: 6591-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.114
BindingDB Entry DOI: 10.7270/Q2DF6RNQ |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
Reactome pathway
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| DrugBank
Article
PubMed
| 6.87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474705
(CHEMBL357956)Show SMILES OC(C1CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-3-17(4-8-19)22(27)18-11-14-25(15-12-18)13-1-2-21(26)16-5-9-20(24)10-6-16/h3-10,18,22,27H,1-2,11-15H2 | PDB
Reactome pathway
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| PC cid
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| Article
PubMed
| 6.91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474700
(CHEMBL149721)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(16-26)11-14-25(15-12-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
UniProtKB/SwissProt
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| PC cid
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| Article
PubMed
| 6.96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474700
(CHEMBL149721)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(16-26)11-14-25(15-12-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| 7.11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474705
(CHEMBL357956)Show SMILES OC(C1CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-3-17(4-8-19)22(27)18-11-14-25(15-12-18)13-1-2-21(26)16-5-9-20(24)10-6-16/h3-10,18,22,27H,1-2,11-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474709
(CHEMBL147829)Show SMILES OC1(Cc2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-3-17(4-8-19)16-22(27)11-14-25(15-12-22)13-1-2-21(26)18-5-9-20(24)10-6-18/h3-10,27H,1-2,11-16H2 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 7.23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
Reactome pathway
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Article
PubMed
| 7.27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474701
(CHEMBL147830)Show InChI InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2 | PDB
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 7.34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474708
(CHEMBL149877)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(15-25)11-13-24(14-21)12-1-2-20(26)16-3-9-19(23)10-4-16/h3-10,25H,1-2,11-15H2 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 7.36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50185474
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 7.48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474702
(CHEMBL358190)Show SMILES OCCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(12-15-26)11-14-25(16-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474706
(CHEMBL148626)Show InChI InChI=1S/C21H25ClFNO2/c1-24(14-2-4-20(25)16-6-10-18(22)11-7-16)15-3-5-21(26)17-8-12-19(23)13-9-17/h6-13,20,25H,2-5,14-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474701
(CHEMBL147830)Show InChI InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474705
(CHEMBL357956)Show SMILES OC(C1CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-3-17(4-8-19)22(27)18-11-14-25(15-12-18)13-1-2-21(26)16-5-9-20(24)10-6-16/h3-10,18,22,27H,1-2,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474708
(CHEMBL149877)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(15-25)11-13-24(14-21)12-1-2-20(26)16-3-9-19(23)10-4-16/h3-10,25H,1-2,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474702
(CHEMBL358190)Show SMILES OCCC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(12-15-26)11-14-25(16-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474701
(CHEMBL147830)Show InChI InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474707
(CHEMBL148627)Show InChI InChI=1S/C20H21ClFNO/c21-18-7-3-15(4-8-18)17-11-13-23(14-17)12-1-2-20(24)16-5-9-19(22)10-6-16/h3-10,17H,1-2,11-14H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50474700
(CHEMBL149721)Show SMILES OCC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-5-18(6-8-19)22(16-26)11-14-25(15-12-22)13-1-2-21(27)17-3-9-20(24)10-4-17/h3-10,26H,1-2,11-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D2 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50474707
(CHEMBL148627)Show InChI InChI=1S/C20H21ClFNO/c21-18-7-3-15(4-8-18)17-11-13-23(14-17)12-1-2-20(24)16-5-9-19(22)10-6-16/h3-10,17H,1-2,11-14H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 7.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 7.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50185474
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human Dopamine receptor D4 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22566
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells after 90 mins by scintillation counting technique |
Bioorg Med Chem Lett 21: 6591-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.114
BindingDB Entry DOI: 10.7270/Q2DF6RNQ |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474707
(CHEMBL148627)Show InChI InChI=1S/C20H21ClFNO/c21-18-7-3-15(4-8-18)17-11-13-23(14-17)12-1-2-20(24)16-5-9-19(22)10-6-16/h3-10,17H,1-2,11-14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50474709
(CHEMBL147829)Show SMILES OC1(Cc2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H25ClFNO2/c23-19-7-3-17(4-8-19)16-22(27)11-14-25(15-12-22)13-1-2-21(26)18-5-9-20(24)10-6-18/h3-10,27H,1-2,11-16H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 8.05 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A and M University
Curated by ChEMBL
| Assay Description
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3 |
J Med Chem 47: 497-508 (2004)
Article DOI: 10.1021/jm0301033
BindingDB Entry DOI: 10.7270/Q2445Q6H |
More data for this
Ligand-Target Pair | |
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