Reaction Details |
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Target | Muscarinic acetylcholine receptor M3 |
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Ligand | BDBM50343154 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745281 (CHEMBL1775313) |
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Ki | 0.397000±n/a nM |
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Citation | Jones, LH; Baldock, H; Bunnage, ME; Burrows, J; Clarke, N; Coghlan, M; Entwistle, D; Fairman, D; Feeder, N; Fulton, C; Hilton, L; James, K; Jones, RM; Kenyon, AS; Marshall, S; Newman, SD; Osborne, R; Patel, S; Selby, MD; Stuart, EF; Trevethick, MA; Wright, KN; Price, DA Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett21:2759-63 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M3 |
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Name: | Muscarinic acetylcholine receptor M3 |
Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
Type: | Enzyme |
Mol. Mass.: | 66151.03 |
Organism: | Homo sapiens (Human) |
Description: | P20309 |
Residue: | 590 |
Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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BDBM50343154 |
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n/a |
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Name | BDBM50343154 |
Synonyms: | 2-(3-((R)-2-((R)-2-(3,5-dihydroxyphenyl)-2-hydroxyethylamino)propyl)phenyl)-N-(3-(3-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)propyl)acetamide | CHEMBL1773198 |
Type | Small organic molecule |
Emp. Form. | C43H57N3O5 |
Mol. Mass. | 695.9298 |
SMILES | CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3cc(O)cc(O)c3)c2)ccc1O)C(C)C |r| |
Structure |
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