Compile Data Set for Download or QSAR

Found 154 hits with Last Name = 'brian jones' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323836 (3-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(cnc23)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)10-3-4-14(28-8-10)30-12-5-7-27-17-16(12)29-9-13(31-17)15-11(19(23,24)25)2-1-6-26-15/h1-9H,(H,27,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191713 (CHEMBL214989 | N-(4-tert-butylphenyl)-4-[3-(N-meth...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2N(S(C)(=O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C24H27N3O5S2/c1-24(2,3)19-12-14-20(15-13-19)26-23(28)18-10-8-17(9-11-18)22-21(7-6-16-25-22)27(33(4,29)30)34(5,31)32/h6-16H,1-5H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323839 (5-(trifluoromethyl)-6-(8-(5-(trifluoromethyl)pyrid...) Show SMILES NC(=O)c1cnc(-c2cnc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c(c1)C(F)(F)F Show InChI InChI=1S/C20H11F6N7O/c21-19(22,23)10-1-2-14(29-7-10)32-12-3-4-28-18-16(12)31-8-13(33-18)15-11(20(24,25)26)5-9(6-30-15)17(27)34/h1-8H,(H2,27,34)(H,28,29,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191713 (CHEMBL214989 | N-(4-tert-butylphenyl)-4-[3-(N-meth...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2N(S(C)(=O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C24H27N3O5S2/c1-24(2,3)19-12-14-20(15-13-19)26-23(28)18-10-8-17(9-11-18)22-21(7-6-16-25-22)27(33(4,29)30)34(5,31)32/h6-16H,1-5H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191748 (CHEMBL214331 | N-(4-tert-butylphenyl)-4-(3-fluorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2F)cc1 Show InChI InChI=1S/C22H21FN2O/c1-22(2,3)17-10-12-18(13-11-17)25-21(26)16-8-6-15(7-9-16)20-19(23)5-4-14-24-20/h4-14H,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191726 ((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...) Show SMILES FC(F)(F)c1ccc(Nc2ncnc3cc(ccc23)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C21H12F6N4/c22-20(23,24)13-4-6-14(7-5-13)31-19-15-8-3-12(10-17(15)29-11-30-19)18-16(21(25,26)27)2-1-9-28-18/h1-11H,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50323839 (5-(trifluoromethyl)-6-(8-(5-(trifluoromethyl)pyrid...) Show SMILES NC(=O)c1cnc(-c2cnc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c(c1)C(F)(F)F Show InChI InChI=1S/C20H11F6N7O/c21-19(22,23)10-1-2-14(29-7-10)32-12-3-4-28-18-16(12)31-8-13(33-18)15-11(20(24,25)26)5-9(6-30-15)17(27)34/h1-8H,(H2,27,34)(H,28,29,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191726 ((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...) Show SMILES FC(F)(F)c1ccc(Nc2ncnc3cc(ccc23)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C21H12F6N4/c22-20(23,24)13-4-6-14(7-5-13)31-19-15-8-3-12(10-17(15)29-11-30-19)18-16(21(25,26)27)2-1-9-28-18/h1-11H,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50160039 (CHEMBL183752 | N-(4-tert-Butyl-phenyl)-4-(3-chloro...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2Cl)cc1 Show InChI InChI=1S/C22H21ClN2O/c1-22(2,3)17-10-12-18(13-11-17)25-21(26)16-8-6-15(7-9-16)20-19(23)5-4-14-24-20/h4-14H,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50315615 (7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C20H11F6N5/c21-19(22,23)11-3-6-16(29-10-11)30-14-7-9-28-18-12(14)4-5-15(31-18)17-13(20(24,25)26)2-1-8-27-17/h1-10H,(H,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191748 (CHEMBL214331 | N-(4-tert-butylphenyl)-4-(3-fluorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2F)cc1 Show InChI InChI=1S/C22H21FN2O/c1-22(2,3)17-10-12-18(13-11-17)25-21(26)16-8-6-15(7-9-16)20-19(23)5-4-14-24-20/h4-14H,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50323839 (5-(trifluoromethyl)-6-(8-(5-(trifluoromethyl)pyrid...) Show SMILES NC(=O)c1cnc(-c2cnc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c(c1)C(F)(F)F Show InChI InChI=1S/C20H11F6N7O/c21-19(22,23)10-1-2-14(29-7-10)32-12-3-4-28-18-16(12)31-8-13(33-18)15-11(20(24,25)26)5-9(6-30-15)17(27)34/h1-8H,(H2,27,34)(H,28,29,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50315615 (7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C20H11F6N5/c21-19(22,23)11-3-6-16(29-10-11)30-14-7-9-28-18-12(14)4-5-15(31-18)17-13(20(24,25)26)2-1-8-27-17/h1-10H,(H,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50160031 (CHEMBL180902 | N-(4-tert-Butyl-phenyl)-4-(3-triflu...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C23H21F3N2O/c1-22(2,3)17-10-12-18(13-11-17)28-21(29)16-8-6-15(7-9-16)20-19(23(24,25)26)5-4-14-27-20/h4-14H,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191708 (CHEMBL386251 | N-(4-tert-butylphenyl)-4-(3-(ethyls...) Show SMILES CCS(=O)(=O)Nc1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H27N3O3S/c1-5-31(29,30)27-21-7-6-16-25-22(21)17-8-10-18(11-9-17)23(28)26-20-14-12-19(13-15-20)24(2,3)4/h6-16,27H,5H2,1-4H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323824 (7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1cnc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)10-8-28-17(29-9-10)31-13-5-7-27-16-11(13)3-4-14(30-16)15-12(19(23,24)25)2-1-6-26-15/h1-9H,(H,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50323824 (7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1cnc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)10-8-28-17(29-9-10)31-13-5-7-27-16-11(13)3-4-14(30-16)15-12(19(23,24)25)2-1-6-26-15/h1-9H,(H,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160027 (CHEMBL183045 | N-(4-tert-Butyl-phenyl)-4-(3-nitro-...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2[N+]([O-])=O)cc1 Show InChI InChI=1S/C22H21N3O3/c1-22(2,3)17-10-12-18(13-11-17)24-21(26)16-8-6-15(7-9-16)20-19(25(27)28)5-4-14-23-20/h4-14H,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50160027 (CHEMBL183045 | N-(4-tert-Butyl-phenyl)-4-(3-nitro-...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2[N+]([O-])=O)cc1 Show InChI InChI=1S/C22H21N3O3/c1-22(2,3)17-10-12-18(13-11-17)24-21(26)16-8-6-15(7-9-16)20-19(25(27)28)5-4-14-23-20/h4-14H,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191705 (CHEMBL214628 | N-(4-tert-butylphenyl)-4-(3-(hydrox...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2NO)cc1 Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)17-10-12-18(13-11-17)24-21(26)16-8-6-15(7-9-16)20-19(25-27)5-4-14-23-20/h4-14,25,27H,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323823 (CHEMBL1214146 | N-(5-(trifluoromethyl)pyrazin-2-yl...) Show SMILES FC(F)(F)c1cnc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)cn1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)11-2-1-6-26-16(11)13-4-3-10-12(5-7-27-17(10)31-13)30-15-9-28-14(8-29-15)19(23,24)25/h1-9H,(H,27,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160031 (CHEMBL180902 | N-(4-tert-Butyl-phenyl)-4-(3-triflu...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C23H21F3N2O/c1-22(2,3)17-10-12-18(13-11-17)28-21(29)16-8-6-15(7-9-16)20-19(23(24,25)26)5-4-14-27-20/h4-14H,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50323823 (CHEMBL1214146 | N-(5-(trifluoromethyl)pyrazin-2-yl...) Show SMILES FC(F)(F)c1cnc(Nc2ccnc3nc(ccc23)-c2ncccc2C(F)(F)F)cn1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)11-2-1-6-26-16(11)13-4-3-10-12(5-7-27-17(10)31-13)30-15-9-28-14(8-29-15)19(23,24)25/h1-9H,(H,27,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50323831 (7-(4-(trifluoromethyl)pyridazin-3-yl)-N-(5-(triflu...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(ccc23)-c2nnccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)10-1-4-15(27-9-10)29-13-6-7-26-17-11(13)2-3-14(30-17)16-12(19(23,24)25)5-8-28-31-16/h1-9H,(H,26,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at Sprague-Dawley rat dorsal root ganglion TRPV1 assessed as inhibition of pH (5.0 to 5.5)-induced receptor activation				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160039 (CHEMBL183752 | N-(4-tert-Butyl-phenyl)-4-(3-chloro...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2Cl)cc1 Show InChI InChI=1S/C22H21ClN2O/c1-22(2,3)17-10-12-18(13-11-17)25-21(26)16-8-6-15(7-9-16)20-19(23)5-4-14-24-20/h4-14H,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50160036 (CHEMBL183121 | N-(4-tert-Butyl-phenyl)-4-pyridin-2...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H22N2O/c1-22(2,3)18-11-13-19(14-12-18)24-21(25)17-9-7-16(8-10-17)20-6-4-5-15-23-20/h4-15H,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323831 (7-(4-(trifluoromethyl)pyridazin-3-yl)-N-(5-(triflu...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(ccc23)-c2nnccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H10F6N6/c20-18(21,22)10-1-4-15(27-9-10)29-13-6-7-26-17-11(13)2-3-14(30-17)16-12(19(23,24)25)5-8-28-31-16/h1-9H,(H,26,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191728 (CHEMBL427052 | N-(4-tert-butylphenyl)-4-(3-(N-meth...) Show SMILES CN(c1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C)S(C)(=O)=O Show InChI InChI=1S/C24H27N3O3S/c1-24(2,3)19-12-14-20(15-13-19)26-23(28)18-10-8-17(9-11-18)22-21(7-6-16-25-22)27(4)31(5,29)30/h6-16H,1-5H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50160028 (CHEMBL180138 | N-(4-tert-Butyl-phenyl)-4-(3-methyl...) Show SMILES Cc1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C23H24N2O/c1-16-6-5-15-24-21(16)17-7-9-18(10-8-17)22(26)25-20-13-11-19(12-14-20)23(2,3)4/h5-15H,1-4H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160036 (CHEMBL183121 | N-(4-tert-Butyl-phenyl)-4-pyridin-2...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H22N2O/c1-22(2,3)18-11-13-19(14-12-18)24-21(25)17-9-7-16(8-10-17)20-6-4-5-15-23-20/h4-15H,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160028 (CHEMBL180138 | N-(4-tert-Butyl-phenyl)-4-(3-methyl...) Show SMILES Cc1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C23H24N2O/c1-16-6-5-15-24-21(16)17-7-9-18(10-8-17)22(26)25-20-13-11-19(12-14-20)23(2,3)4/h5-15H,1-4H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191704 ((R)-2-methyl-N-(4-(trifluoromethyl)phenyl)-4-(3-(t...) Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F Show InChI InChI=1S/C19H18F6N4O/c1-12-11-28(16-15(19(23,24)25)3-2-8-26-16)9-10-29(12)17(30)27-14-6-4-13(5-7-14)18(20,21)22/h2-8,12H,9-11H2,1H3,(H,27,30)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323835 (CHEMBL1214341 | N-(5-(trifluoromethyl)pyridin-2-yl...) Show SMILES FC(F)(F)c1scnc1-c1ccc2c(Nc3ccc(cn3)C(F)(F)F)ccnc2n1 Show InChI InChI=1S/C18H9F6N5S/c19-17(20,21)9-1-4-13(26-7-9)28-11-5-6-25-16-10(11)2-3-12(29-16)14-15(18(22,23)24)30-8-27-14/h1-8H,(H,25,26,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323833 (3-(trifluoromethyl)-2-(5-(5-(trifluoromethyl)pyrid...) Show SMILES NC(=O)c1ccnc(-c2ccc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c1C(F)(F)F Show InChI InChI=1S/C21H12F6N6O/c22-20(23,24)10-1-4-15(31-9-10)32-13-6-8-30-19-11(13)2-3-14(33-19)17-16(21(25,26)27)12(18(28)34)5-7-29-17/h1-9H,(H2,28,34)(H,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191744 (CHEMBL386040 | N-(4-tert-butylphenyl)-4-(3-cyanopy...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C#N)cc1 Show InChI InChI=1S/C23H21N3O/c1-23(2,3)19-10-12-20(13-11-19)26-22(27)17-8-6-16(7-9-17)21-18(15-24)5-4-14-25-21/h4-14H,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-9-15(10-8-14)28-18(29)13-5-3-12(4-6-13)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323838 (5-(trifluoromethyl)-6-(8-(5-(trifluoromethyl)pyrid...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(cnc23)-c2ncc(cc2C(F)(F)F)C#N)nc1 Show InChI InChI=1S/C20H9F6N7/c21-19(22,23)11-1-2-15(29-8-11)32-13-3-4-28-18-17(13)31-9-14(33-18)16-12(20(24,25)26)5-10(6-27)7-30-16/h1-5,7-9H,(H,28,29,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191704 ((R)-2-methyl-N-(4-(trifluoromethyl)phenyl)-4-(3-(t...) Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F Show InChI InChI=1S/C19H18F6N4O/c1-12-11-28(16-15(19(23,24)25)3-2-8-26-16)9-10-29(12)17(30)27-14-6-4-13(5-7-14)18(20,21)22/h2-8,12H,9-11H2,1H3,(H,27,30)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191715 (CHEMBL214274 | N-(4-tert-butylphenyl)-4-(3-propoxy...) Show SMILES CCCOc1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C25H28N2O2/c1-5-17-29-22-7-6-16-26-23(22)18-8-10-19(11-9-18)24(28)27-21-14-12-20(13-15-21)25(2,3)4/h6-16H,5,17H2,1-4H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191714 (4-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...) Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H11F6N3O/c20-18(21,22)13-7-8-15(27-10-13)28-17(29)12-5-3-11(4-6-12)16-14(19(23,24)25)2-1-9-26-16/h1-10H,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323826 (5-(trifluoromethyl)-2-(7-(3-(trifluoromethyl)pyrid...) Show SMILES FC(F)(F)c1cccnc1-c1ccc2c(Nc3ncc(c(n3)C#N)C(F)(F)F)ccnc2n1 Show InChI InChI=1S/C20H9F6N7/c21-19(22,23)11-2-1-6-28-16(11)14-4-3-10-13(5-7-29-17(10)31-14)32-18-30-9-12(20(24,25)26)15(8-27)33-18/h1-7,9H,(H,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50184737 (CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-9-15(10-8-14)28-18(29)13-5-3-12(4-6-13)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323840 (5-(trifluoromethyl)-6-(8-(5-(trifluoromethyl)pyrid...) Show SMILES OC(=O)c1cnc(-c2cnc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c(c1)C(F)(F)F Show InChI InChI=1S/C20H10F6N6O2/c21-19(22,23)10-1-2-14(28-7-10)31-12-3-4-27-17-16(12)30-8-13(32-17)15-11(20(24,25)26)5-9(6-29-15)18(33)34/h1-8H,(H,33,34)(H,27,28,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191744 (CHEMBL386040 | N-(4-tert-butylphenyl)-4-(3-cyanopy...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C#N)cc1 Show InChI InChI=1S/C23H21N3O/c1-23(2,3)19-10-12-20(13-11-19)26-22(27)17-8-6-16(7-9-17)21-18(15-24)5-4-14-25-21/h4-14H,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50323837 (3-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)-N-(5-(...) Show SMILES FC(F)(F)c1ccc(Nc2ccnc3nc(cnc23)-c2ncc(Br)cc2C(F)(F)F)nc1 Show InChI InChI=1S/C19H9BrF6N6/c20-10-5-11(19(24,25)26)15(29-7-10)13-8-30-16-12(3-4-27-17(16)32-13)31-14-2-1-9(6-28-14)18(21,22)23/h1-8H,(H,27,28,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assay				Bioorg Med Chem Lett 20: 4359-63 (2010) Article DOI: 10.1016/j.bmcl.2010.06.069 BindingDB Entry DOI: 10.7270/Q2959HRM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191718 (CHEMBL214658 | N-(4-tert-butylphenyl)-4-(3-(5-meth...) Show SMILES Cc1nnc(o1)-c1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C25H24N4O2/c1-16-28-29-24(31-16)21-6-5-15-26-22(21)17-7-9-18(10-8-17)23(30)27-20-13-11-19(12-14-20)25(2,3)4/h5-15H,1-4H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191724 (CHEMBL214510 | N-(4-tert-butylphenyl)-4-(3-(methyl...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2NS(C)(=O)=O)cc1 Show InChI InChI=1S/C23H25N3O3S/c1-23(2,3)18-11-13-19(14-12-18)25-22(27)17-9-7-16(8-10-17)21-20(6-5-15-24-21)26-30(4,28)29/h5-15,26H,1-4H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191719 (2-hydroxy-N-(4-(trifluoromethyl)phenyl)-4-(3-(trif...) Show SMILES Oc1cc(ccc1C(=O)Nc1ccc(cc1)C(F)(F)F)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H12F6N2O2/c21-19(22,23)12-4-6-13(7-5-12)28-18(30)14-8-3-11(10-16(14)29)17-15(20(24,25)26)2-1-9-27-17/h1-10,29H,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50191720 (CHEMBL217201 | N-(4-tert-butylphenyl)-4-(3-(propyl...) Show SMILES CCCNc1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C25H29N3O/c1-5-16-26-22-7-6-17-27-23(22)18-8-10-19(11-9-18)24(29)28-21-14-12-20(13-15-21)25(2,3)4/h6-15,17,26H,5,16H2,1-4H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50191728 (CHEMBL427052 | N-(4-tert-butylphenyl)-4-(3-(N-meth...) Show SMILES CN(c1cccnc1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C)S(C)(=O)=O Show InChI InChI=1S/C24H27N3O3S/c1-24(2,3)19-12-14-20(15-13-19)26-23(28)18-10-8-17(9-11-18)22-21(7-6-16-25-22)27(4)31(5,29)30/h6-16H,1-5H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
					More data for this Ligand-Target Pair

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