Found 14 hits with Last Name = 'bright' and Initial = 'sa' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Estrogen receptor
(Homo sapiens (Human)) | BDBM17292
((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)Show SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] Show InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 | PDB
UniProtKB/SwissProt
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PC sid
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| PDB
Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-alpha (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Estrogen receptor beta
(Homo sapiens (Human)) | BDBM17292
((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)Show SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] Show InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 | PDB
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MCE
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PC cid
PC sid
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| PDB
Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-beta (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50010859
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 | PDB
KEGG
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| DrugBank
PDB
Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Estrogen receptor beta
(Homo sapiens (Human)) | BDBM50186728
(CHEMBL3823426)Show SMILES Cc1c(-c2ccc(O)cc2)n(CCCCn2c(c(C)c3cc(O)ccc23)-c2ccc(O)cc2)c2ccc(O)cc12 Show InChI InChI=1S/C34H32N2O4/c1-21-29-19-27(39)13-15-31(29)35(33(21)23-5-9-25(37)10-6-23)17-3-4-18-36-32-16-14-28(40)20-30(32)22(2)34(36)24-7-11-26(38)12-8-24/h5-16,19-20,37-40H,3-4,17-18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-beta (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Estrogen receptor beta
(Homo sapiens (Human)) | BDBM50186729
(CHEMBL3823192)Show SMILES COc1ccc(\C=C(\C(=O)N(C)CCCCCCCCCCCCn2c(c(C)c3cc(O)ccc23)-c2ccc(O)cc2)c2cc(OC)c(OC)c(OC)c2)cc1O Show InChI InChI=1S/C47H58N2O8/c1-32-38-31-37(51)22-23-40(38)49(45(32)34-18-20-36(50)21-19-34)26-16-14-12-10-8-7-9-11-13-15-25-48(2)47(53)39(27-33-17-24-42(54-3)41(52)28-33)35-29-43(55-4)46(57-6)44(30-35)56-5/h17-24,27-31,50-52H,7-16,25-26H2,1-6H3/b39-27+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-beta (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50186727
(CHEMBL3823498)Show SMILES CNCCCCCCCCCCCCn1c(c(C)c2cc(O)ccc12)-c1ccc(O)cc1 Show InChI InChI=1S/C28H40N2O2/c1-22-26-21-25(32)17-18-27(26)30(28(22)23-13-15-24(31)16-14-23)20-12-10-8-6-4-3-5-7-9-11-19-29-2/h13-18,21,29,31-32H,3-12,19-20H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-alpha (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50186728
(CHEMBL3823426)Show SMILES Cc1c(-c2ccc(O)cc2)n(CCCCn2c(c(C)c3cc(O)ccc23)-c2ccc(O)cc2)c2ccc(O)cc12 Show InChI InChI=1S/C34H32N2O4/c1-21-29-19-27(39)13-15-31(29)35(33(21)23-5-9-25(37)10-6-23)17-3-4-18-36-32-16-14-28(40)20-30(32)22(2)34(36)24-7-11-26(38)12-8-24/h5-16,19-20,37-40H,3-4,17-18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 436 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-alpha (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | PDB
KEGG
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PC cid
PC sid
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| DrugBank
Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM50186729
(CHEMBL3823192)Show SMILES COc1ccc(\C=C(\C(=O)N(C)CCCCCCCCCCCCn2c(c(C)c3cc(O)ccc23)-c2ccc(O)cc2)c2cc(OC)c(OC)c(OC)c2)cc1O Show InChI InChI=1S/C47H58N2O8/c1-32-38-31-37(51)22-23-40(38)49(45(32)34-18-20-36(50)21-19-34)26-16-14-12-10-8-7-9-11-13-15-25-48(2)47(53)39(27-33-17-24-42(54-3)41(52)28-33)35-29-43(55-4)46(57-6)44(30-35)56-5/h17-24,27-31,50-52H,7-16,25-26H2,1-6H3/b39-27+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 574 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-alpha (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Estrogen receptor beta
(Homo sapiens (Human)) | BDBM50186727
(CHEMBL3823498)Show SMILES CNCCCCCCCCCCCCn1c(c(C)c2cc(O)ccc12)-c1ccc(O)cc1 Show InChI InChI=1S/C28H40N2O2/c1-22-26-21-25(32)17-18-27(26)30(28(22)23-13-15-24(31)16-14-23)20-12-10-8-6-4-3-5-7-9-11-19-29-2/h13-18,21,29,31-32H,3-12,19-20H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of ER-beta (unknown origin) by Lanthascreen-FRET assay |
Bioorg Med Chem 24: 4075-4099 (2016)
Article DOI: 10.1016/j.bmc.2016.06.050
BindingDB Entry DOI: 10.7270/Q2T43W1S |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50429853
(CHEMBL2332389)Show SMILES CN(CCCN1c2ccccc2CCc2ccccc12)CCOCCOCCN(C)CCCN1c2ccccc2CCc2ccccc12 Show InChI InChI=1S/C42H54N4O2/c1-43(25-11-27-45-39-17-7-3-13-35(39)21-22-36-14-4-8-18-40(36)45)29-31-47-33-34-48-32-30-44(2)26-12-28-46-41-19-9-5-15-37(41)23-24-38-16-6-10-20-42(38)46/h3-10,13-20H,11-12,21-34H2,1-2H3 | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50429852
(CHEMBL2332390)Show SMILES CN(CCCN1c2ccccc2CCc2ccccc12)CCOCCOCCOCCN(C)CCCN1c2ccccc2CCc2ccccc12 Show InChI InChI=1S/C44H58N4O3/c1-45(25-11-27-47-41-17-7-3-13-37(41)21-22-38-14-4-8-18-42(38)47)29-31-49-33-35-51-36-34-50-32-30-46(2)26-12-28-48-43-19-9-5-15-39(43)23-24-40-16-6-10-20-44(40)48/h3-10,13-20H,11-12,21-36H2,1-2H3 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50429854
(CHEMBL2332388)Show SMILES CN(CCCN1c2ccccc2CCc2ccccc12)CCOCCN(C)CCCN1c2ccccc2CCc2ccccc12 Show InChI InChI=1S/C40H50N4O/c1-41(25-11-27-43-37-17-7-3-13-33(37)21-22-34-14-4-8-18-38(34)43)29-31-45-32-30-42(2)26-12-28-44-39-19-9-5-15-35(39)23-24-36-16-6-10-20-40(36)44/h3-10,13-20H,11-12,21-32H2,1-2H3 | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50429851
(CHEMBL2332391)Show SMILES CN(CCCN1c2ccccc2CCc2ccccc12)C(=O)COCCOCC(=O)N(C)CCCN1c2ccccc2CCc2ccccc12 Show InChI InChI=1S/C42H50N4O4/c1-43(25-11-27-45-37-17-7-3-13-33(37)21-22-34-14-4-8-18-38(34)45)41(47)31-49-29-30-50-32-42(48)44(2)26-12-28-46-39-19-9-5-15-35(39)23-24-36-16-6-10-20-40(36)46/h3-10,13-20H,11-12,21-32H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay |
Bioorg Med Chem Lett 23: 1220-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.020
BindingDB Entry DOI: 10.7270/Q2BK1DQB |
More data for this
Ligand-Target Pair | |
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