Compile Data Set for Download or QSAR

Found 491 hits with Last Name = 'buckheit' and Initial = 'rw'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480836 (CHEMBL574823) Show SMILES COc1c(C)cc(cc1C(=O)SC)C(=C/CCCc1nnc(C)o1)\c1cc(C)c2oc(=O)n(C)c2c1 Show InChI InChI=1S/C27H29N3O5S/c1-15-11-18(13-21(24(15)33-5)26(31)36-6)20(9-7-8-10-23-29-28-17(3)34-23)19-12-16(2)25-22(14-19)30(4)27(32)35-25/h9,11-14H,7-8,10H2,1-6H3/b20-9+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rC)-oligo)dG) as template				J Med Chem 52: 6467-73 (2009) Article DOI: 10.1021/jm901167t BindingDB Entry DOI: 10.7270/Q2MC92T0
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480612 (CHEMBL550916) Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O Show InChI InChI=1S/C19H24N2O2S/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S] (Human immunodeficiency virus type 1)	BDBM17667 (2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...) Show SMILES COc1cccc2n(Cc3c(F)cccc3F)c(nc12)-c1c(F)cccc1F |(1.21,7.81,;1.21,6.27,;-.12,5.5,;-1.46,6.27,;-2.79,5.5,;-2.79,3.95,;-1.46,3.18,;-1.14,1.68,;-1.91,.34,;-3.45,.39,;-4.22,1.72,;-3.45,3.05,;-5.76,1.72,;-6.53,.39,;-5.76,-.95,;-4.22,-.95,;-3.45,-2.28,;.39,1.52,;1.02,2.92,;-.12,3.95,;1.16,.18,;2.7,.18,;3.47,1.52,;3.47,-1.15,;2.7,-2.48,;1.16,-2.48,;.39,-1.15,;-1.15,-1.15,)| Show InChI InChI=1S/C21H14F4N2O/c1-28-18-10-4-9-17-20(18)26-21(19-15(24)7-3-8-16(19)25)27(17)11-12-13(22)5-2-6-14(12)23/h2-10H,11H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	8.0	37
NCI-FCRDC					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 50: 4003-4015 (2007) Article DOI: 10.1021/jm060103d BindingDB Entry DOI: 10.7270/Q25M6409
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480595 (CHEMBL560576) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CCCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C23H30N2O3/c1-14(2)19-20(21(26)18-11-15(3)10-16(4)12-18)25(23(28)24-22(19)27)13-17-8-6-5-7-9-17/h10-12,14,17H,5-9,13H2,1-4H3,(H,24,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480599 (CHEMBL550163) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O Show InChI InChI=1S/C23H24N2O3/c1-14(2)19-20(21(26)18-11-15(3)10-16(4)12-18)25(23(28)24-22(19)27)13-17-8-6-5-7-9-17/h5-12,14H,13H2,1-4H3,(H,24,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480643 (CHEMBL549900) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CC=CC2)c(=O)[nH]c1=O |c:21| Show InChI InChI=1S/C23H28N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h5-6,11-14,17H,7-10H2,1-4H3,(H,24,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480613 (CHEMBL564867) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O Show InChI InChI=1S/C19H24N2O3/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480645 (CHEMBL553470) Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O Show InChI InChI=1S/C18H22N2O3/c1-4-15-16(21)19-18(22)20(10-13-5-6-13)17(15)23-14-8-11(2)7-12(3)9-14/h7-9,13H,4-6,10H2,1-3H3,(H,19,21,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM2797 (4-(N-Ethoxycarbonyl)amino-3,3-dimethyl-4,4-dimetho...) Show SMILES [#6]-[#6]-[#8]-[#6](=O)-[#7]-[#6]-[#6]\[#6]=[#6](/c1cc(-[#6])c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6])-c1cc(-[#6])c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6] Show InChI InChI=1S/C27H33NO8/c1-8-36-27(31)28-11-9-10-20(18-12-16(2)23(32-4)21(14-18)25(29)34-6)19-13-17(3)24(33-5)22(15-19)26(30)35-7/h10,12-15H,8-9,11H2,1-7H3,(H,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 44: 4092-113 (2001) Article DOI: 10.1021/jm010212m BindingDB Entry DOI: 10.7270/Q2XG9PB0
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480642 (CHEMBL561923) Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CC=CC2)c(=O)[nH]c1=O |c:20| Show InChI InChI=1S/C22H26N2O3/c1-4-18-19(20(25)17-12-14(2)11-15(3)13-17)24(22(27)23-21(18)26)10-9-16-7-5-6-8-16/h5-6,11-13,16H,4,7-10H2,1-3H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480644 (CHEMBL560783) Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O Show InChI InChI=1S/C18H22N2O2S/c1-4-15-16(21)19-18(22)20(10-13-5-6-13)17(15)23-14-8-11(2)7-12(3)9-14/h7-9,13H,4-6,10H2,1-3H3,(H,19,21,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480615 (CHEMBL539429) Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C19H24N2O2S/c1-4-16-17(22)20-19(23)21(11-14-6-5-7-14)18(16)24-15-9-12(2)8-13(3)10-15/h8-10,14H,4-7,11H2,1-3H3,(H,20,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50476397 (CHEMBL226735) Show SMILES COC(=O)CCC\C=C(/c1cc(C)c(OC)c(c1)C(=O)OC)c1cc(C)c2oc(=O)n(C)c2c1 Show InChI InChI=1S/C26H29NO7/c1-15-11-17(13-20(23(15)32-5)25(29)33-6)19(9-7-8-10-22(28)31-4)18-12-16(2)24-21(14-18)27(3)26(30)34-24/h9,11-14H,7-8,10H2,1-6H3/b19-9+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase				J Med Chem 50: 4854-67 (2007) Article DOI: 10.1021/jm070382k BindingDB Entry DOI: 10.7270/Q2N58Q4R
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50193526 (CHEMBL212448 | methyl 5-(1-(3,7-dimethyl-2-oxo-2,3...) Show SMILES COC(=O)CCC\C=C(\c1cc(C)c(OC)c(c1)C(=O)OC)c1cc(C)c2oc(=O)n(C)c2c1 Show InChI InChI=1S/C26H29NO7/c1-15-11-17(13-20(23(15)32-5)25(29)33-6)19(9-7-8-10-22(28)31-4)18-12-16(2)24-21(14-18)27(3)26(30)34-24/h9,11-14H,7-8,10H2,1-6H3/b19-9-	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant HIV1 reverse transcriptase measured as inhibition of incorporation of [32P]GTP in rCDG primer				J Med Chem 49: 5316-23 (2006) Article DOI: 10.1021/jm060449o BindingDB Entry DOI: 10.7270/Q2QV3M5K
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50476397 (CHEMBL226735) Show SMILES COC(=O)CCC\C=C(/c1cc(C)c(OC)c(c1)C(=O)OC)c1cc(C)c2oc(=O)n(C)c2c1 Show InChI InChI=1S/C26H29NO7/c1-15-11-17(13-20(23(15)32-5)25(29)33-6)19(9-7-8-10-22(28)31-4)18-12-16(2)24-21(14-18)27(3)26(30)34-24/h9,11-14H,7-8,10H2,1-6H3/b19-9+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase				J Med Chem 50: 3314-21 (2007) Article DOI: 10.1021/jm070236e BindingDB Entry DOI: 10.7270/Q2MC92SJ
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480646 (CHEMBL562588) Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C20H26N2O2S/c1-12(2)17-18(23)21-20(24)22(11-15-6-5-7-15)19(17)25-16-9-13(3)8-14(4)10-16/h8-10,12,15H,5-7,11H2,1-4H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480601 (CHEMBL559924) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:18| Show InChI InChI=1S/C22H26N2O3/c1-13(2)18-19(20(25)17-10-14(3)9-15(4)11-17)24(22(27)23-21(18)26)12-16-7-5-6-8-16/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50476397 (CHEMBL226735) Show SMILES COC(=O)CCC\C=C(/c1cc(C)c(OC)c(c1)C(=O)OC)c1cc(C)c2oc(=O)n(C)c2c1 Show InChI InChI=1S/C26H29NO7/c1-15-11-17(13-20(23(15)32-5)25(29)33-6)19(9-7-8-10-22(28)31-4)18-12-16(2)24-21(14-18)27(3)26(30)34-24/h9,11-14H,7-8,10H2,1-6H3/b19-9+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rC)-oligo)dG) as template				J Med Chem 52: 6467-73 (2009) Article DOI: 10.1021/jm901167t BindingDB Entry DOI: 10.7270/Q2MC92T0
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50127511 (4-hydroxy-2-(methoxymethyl)-5-(6-oxo-1-prop-2-ynyl...) Show SMILES COC[C@H]1O[C@H](C(O)[C@H]1OP(C)([O-])=O)n1cnc2c1ncn(CC#C)c2=O Show InChI InChI=1S/C15H19N4O7P/c1-4-5-18-7-17-13-10(14(18)21)16-8-19(13)15-11(20)12(26-27(3,22)23)9(25-15)6-24-2/h1,7-9,11-12,15,20H,5-6H2,2-3H3,(H,22,23)/p-1/t9-,11?,12+,15-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibitory activity of compound against reverse transcriptase (RT) in cell free RT.				J Med Chem 46: 1878-85 (2003) Article DOI: 10.1021/jm0203276 BindingDB Entry DOI: 10.7270/Q25X29NG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480664 (CHEMBL560180) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:22| Show InChI InChI=1S/C23H28N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h5,7,11-14,17H,6,8-10H2,1-4H3,(H,24,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480598 (CHEMBL552192) Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N2O3/c1-4-18-19(20(25)17-11-14(2)10-15(3)12-17)24(22(27)23-21(18)26)13-16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480651 (CHEMBL559788) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:21| Show InChI InChI=1S/C22H28N2O3/c1-14(2)19-20(25)23-22(26)24(10-9-17-7-5-6-8-17)21(19)27-18-12-15(3)11-16(4)13-18/h5,7,11-14,17H,6,8-10H2,1-4H3,(H,23,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480627 (CHEMBL558404) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17| Show InChI InChI=1S/C21H26N2O3/c1-13(2)18-19(24)22-21(25)23(12-16-7-5-6-8-16)20(18)26-17-10-14(3)9-15(4)11-17/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50127517 (O-[5-(1-allyl-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-m...) Show SMILES COC[C@H]1O[C@H](C(OC)[C@H]1OP(C)([O-])=S)n1cnc2c1ncn(CC=C)c2=O Show InChI InChI=1S/C16H23N4O6PS/c1-5-6-19-8-18-14-11(15(19)21)17-9-20(14)16-13(24-3)12(26-27(4,22)28)10(25-16)7-23-2/h5,8-10,12-13,16H,1,6-7H2,2-4H3,(H,22,28)/p-1/t10-,12+,13?,16-,27?/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibitory activity of compound against reverse transcriptase (RT) in cell free RT.				J Med Chem 46: 1878-85 (2003) Article DOI: 10.1021/jm0203276 BindingDB Entry DOI: 10.7270/Q25X29NG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480634 (CHEMBL550386) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C23H30N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h11-14,17H,5-10H2,1-4H3,(H,24,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase protein (Human immunodeficiency virus 1)	BDBM50480613 (CHEMBL564867) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O Show InChI InChI=1S/C19H24N2O3/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase K103N mutant assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480618 (CHEMBL562879) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C21H26N2O3/c1-12(2)17-18(19(24)16-9-13(3)8-14(4)10-16)23(11-15-6-5-7-15)21(26)22-20(17)25/h8-10,12,15H,5-7,11H2,1-4H3,(H,22,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM2809 (Alkenyldiarylmethanes (ADAM) 6b | CHEMBL105859 | M...) Show SMILES COC(=O)CCC\C=C(\c1ccc(OC)c(OC)c1)c1cc(C)c(OC)c(c1)C(=O)OC Show InChI InChI=1S/C25H30O7/c1-16-13-18(14-20(24(16)31-5)25(27)32-6)19(9-7-8-10-23(26)30-4)17-11-12-21(28-2)22(15-17)29-3/h9,11-15H,7-8,10H2,1-6H3/b19-9-	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant HIV-1 reverse transcriptase activity				J Med Chem 48: 6140-55 (2005) Article DOI: 10.1021/jm050452s BindingDB Entry DOI: 10.7270/Q2TB16F6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147] (Human immunodeficiency virus type 1)	BDBM2809 (Alkenyldiarylmethanes (ADAM) 6b | CHEMBL105859 | M...) Show SMILES COC(=O)CCC\C=C(\c1ccc(OC)c(OC)c1)c1cc(C)c(OC)c(c1)C(=O)OC Show InChI InChI=1S/C25H30O7/c1-16-13-18(14-20(24(16)31-5)25(27)32-6)19(9-7-8-10-23(26)30-4)17-11-12-21(28-2)22(15-17)29-3/h9,11-15H,7-8,10H2,1-6H3/b19-9-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	7.9	n/a
Purdue University					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				Bioorg Med Chem 10: 283-90 (2002) Article DOI: 10.1016/s0968-0896(01)00282-6 BindingDB Entry DOI: 10.7270/Q2SQ8XM8
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480639 (CHEMBL549428) Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:21| Show InChI InChI=1S/C22H26N2O3/c1-4-18-19(20(25)17-12-14(2)11-15(3)13-17)24(22(27)23-21(18)26)10-9-16-7-5-6-8-16/h5,7,11-13,16H,4,6,8-10H2,1-3H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480626 (CHEMBL539400) Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17| Show InChI InChI=1S/C21H26N2O2S/c1-13(2)18-19(24)22-21(25)23(12-16-7-5-6-8-16)20(18)26-17-10-14(3)9-15(4)11-17/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM1434 (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...) Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12 Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase				Bioorg Med Chem Lett 18: 469-73 (2008) Article DOI: 10.1016/j.bmcl.2007.11.114 BindingDB Entry DOI: 10.7270/Q2X63QRR
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480656 (CHEMBL559205) Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17| Show InChI InChI=1S/C21H24N2O3/c1-4-17-18(19(24)16-10-13(2)9-14(3)11-16)23(21(26)22-20(17)25)12-15-7-5-6-8-15/h7,9-11H,4-6,8,12H2,1-3H3,(H,22,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480597 (CHEMBL559529) Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O Show InChI InChI=1S/C21H22N2O3/c1-4-18-19(24)22-21(25)23(13-16-8-6-5-7-9-16)20(18)26-17-11-14(2)10-15(3)12-17/h5-12H,4,13H2,1-3H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of PDE4B2 expressed in COS7 cells assessed as cAMP hydrolysis				Bioorg Med Chem Lett 18: 1530-3 (2008) Article DOI: 10.1016/j.bmcl.2007.12.015 BindingDB Entry DOI: 10.7270/Q26Q1Z31
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S] (Human immunodeficiency virus type 1)	BDBM17666 (2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...) Show SMILES Fc1cccc(F)c1Cn1c(nc2ccccc12)-c1c(F)cccc1F |(-3.45,3.05,;-4.22,1.72,;-5.76,1.72,;-6.53,.39,;-5.76,-.95,;-4.22,-.95,;-3.45,-2.28,;-3.45,.39,;-1.91,.34,;-1.14,1.68,;.39,1.52,;1.02,2.92,;-.12,3.95,;-.12,5.5,;-1.46,6.27,;-2.79,5.5,;-2.79,3.95,;-1.46,3.18,;1.16,.18,;2.7,.18,;3.47,1.52,;3.47,-1.15,;2.7,-2.48,;1.16,-2.48,;.39,-1.15,;-1.15,-1.15,)| Show InChI InChI=1S/C20H12F4N2/c21-13-5-3-6-14(22)12(13)11-26-18-10-2-1-9-17(18)25-20(26)19-15(23)7-4-8-16(19)24/h1-10H,11H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	8.0	37
NCI-FCRDC					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 50: 4003-4015 (2007) Article DOI: 10.1021/jm060103d BindingDB Entry DOI: 10.7270/Q25M6409
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480625 (CHEMBL562570) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H24N2O3/c1-14(2)19-20(25)23-22(26)24(13-17-8-6-5-7-9-17)21(19)27-18-11-15(3)10-16(4)12-18/h5-12,14H,13H2,1-4H3,(H,23,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480633 (CHEMBL562602) Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H28N2O3/c1-4-18-19(20(25)17-12-14(2)11-15(3)13-17)24(22(27)23-21(18)26)10-9-16-7-5-6-8-16/h11-13,16H,4-10H2,1-3H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480616 (CHEMBL551257) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C20H26N2O3/c1-12(2)17-18(23)21-20(24)22(11-15-6-5-7-15)19(17)25-16-9-13(3)8-14(4)10-16/h8-10,12,15H,5-7,11H2,1-4H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480661 (CHEMBL565097) Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:16| Show InChI InChI=1S/C20H24N2O3/c1-4-17-18(23)21-20(24)22(12-15-7-5-6-8-15)19(17)25-16-10-13(2)9-14(3)11-16/h7,9-11H,4-6,8,12H2,1-3H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480654 (CHEMBL556182) Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C20H26N2O2S/c1-4-17-18(23)21-20(24)22(12-15-7-5-6-8-15)19(17)25-16-10-13(2)9-14(3)11-16/h9-11,15H,4-8,12H2,1-3H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480638 (CHEMBL555876) Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:20| Show InChI InChI=1S/C21H26N2O2S/c1-4-18-19(24)22-21(25)23(10-9-16-7-5-6-8-16)20(18)26-17-12-14(2)11-15(3)13-17/h5,7,11-13,16H,4,6,8-10H2,1-3H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480655 (CHEMBL562061) Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C21H28N2O2S/c1-13(2)18-19(24)22-21(25)23(12-16-7-5-6-8-16)20(18)26-17-10-14(3)9-15(4)11-17/h9-11,13,16H,5-8,12H2,1-4H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480666 (CHEMBL551922) Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(CC2CCCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C21H28N2O3/c1-4-18-19(24)22-21(25)23(13-16-8-6-5-7-9-16)20(18)26-17-11-14(2)10-15(3)12-17/h10-12,16H,4-9,13H2,1-3H3,(H,22,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480624 (CHEMBL564915) Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H24N2O2S/c1-14(2)19-20(25)23-22(26)24(13-17-8-6-5-7-9-17)21(19)27-18-11-15(3)10-16(4)12-18/h5-12,14H,13H2,1-4H3,(H,23,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480619 (CHEMBL551459) Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(CC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C20H26N2O3/c1-4-17-18(23)21-20(24)22(12-15-7-5-6-8-15)19(17)25-16-10-13(2)9-14(3)11-16/h9-11,15H,4-8,12H2,1-3H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480600 (CHEMBL550507) Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:16| Show InChI InChI=1S/C20H24N2O2S/c1-4-17-18(23)21-20(24)22(12-15-7-5-6-8-15)19(17)25-16-10-13(2)9-14(3)11-16/h7,9-11H,4-6,8,12H2,1-3H3,(H,21,23,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480594 (CHEMBL556699) Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CCCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H30N2O3/c1-14(2)19-20(25)23-22(26)24(13-17-8-6-5-7-9-17)21(19)27-18-11-15(3)10-16(4)12-18/h10-12,14,17H,5-9,13H2,1-4H3,(H,23,25,26)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50480621 (CHEMBL557439) Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CCCC2)c(=O)[nH]c1=O Show InChI InChI=1S/C22H28N2O3/c1-13(2)18-19(20(25)17-10-14(3)9-15(4)11-17)24(22(27)23-21(18)26)12-16-7-5-6-8-16/h9-11,13,16H,5-8,12H2,1-4H3,(H,23,26,27)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
ImQuest BioSciences, Inc. Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand				Antimicrob Agents Chemother 52: 225-36 (2008) Article DOI: 10.1128/aac.00972-07 BindingDB Entry DOI: 10.7270/Q2JM2DFB
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50127514 (4-methoxy-2-(methoxymethyl)-5-(6-oxo-1-prop-2-ynyl...) Show SMILES COC[C@H]1O[C@H](C(OC)[C@H]1OP(C)([O-])=O)n1cnc2c1ncn(CC#C)c2=O Show InChI InChI=1S/C16H21N4O7P/c1-5-6-19-8-18-14-11(15(19)21)17-9-20(14)16-13(25-3)12(27-28(4,22)23)10(26-16)7-24-2/h1,8-10,12-13,16H,6-7H2,2-4H3,(H,22,23)/p-1/t10-,12+,13?,16-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibitory activity of compound against reverse transcriptase (RT) in cell free RT.				J Med Chem 46: 1878-85 (2003) Article DOI: 10.1021/jm0203276 BindingDB Entry DOI: 10.7270/Q25X29NG
					More data for this Ligand-Target Pair

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