Found 7 hits with Last Name = 'caccamo' and Initial = 'n' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM12578
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273714
(CHEMBL446734 | [2-(Imidazol-1-yl)ethyl]-bisphospho...)Show InChI InChI=1S/C5H10N2O6P2/c8-14(9,10)5(15(11,12)13)3-7-2-1-6-4-7/h1-2,4-5H,3H2,(H2,8,9,10)(H2,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273716
(CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...)Show InChI InChI=1S/C9H12N2O6P2/c12-18(13,14)9(19(15,16)17)5-11-6-10-7-3-1-2-4-8(7)11/h1-4,6,9H,5H2,(H2,12,13,14)(H2,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273717
(CHEMBL504429 | [2-(Imidazol-2-yl-thio)ethyl]-bisph...)Show InChI InChI=1S/C5H10N2O6P2S/c8-14(9,10)4(15(11,12)13)3-16-5-6-1-2-7-5/h1-2,4H,3H2,(H,6,7)(H2,8,9,10)(H2,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273718
(CHEMBL457424 | [2-(Purin-9-yl)ethyl]-bisphosphonic...)Show InChI InChI=1S/C7H10N4O6P2/c12-18(13,14)6(19(15,16)17)2-11-4-10-5-1-8-3-9-7(5)11/h1,3-4,6H,2H2,(H2,12,13,14)(H2,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273799
(CHEMBL452354 | [2-(6-Chloro-purin-9-yl)ethyl]-bisp...)Show InChI InChI=1S/C7H9ClN4O6P2/c8-6-5-7(10-2-9-6)12(3-11-5)1-4(19(13,14)15)20(16,17)18/h2-4H,1H2,(H2,13,14,15)(H2,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 883 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50273715
(CHEMBL457069 | [2-(Pyrazol-1-yl)ethyl]-bisphosphon...)Show InChI InChI=1S/C5H10N2O6P2/c8-14(9,10)5(15(11,12)13)4-7-3-1-2-6-7/h1-3,5H,4H2,(H2,8,9,10)(H2,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 3.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara
Curated by ChEMBL
| Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) |
J Med Chem 51: 6800-7 (2008)
Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 |
More data for this Ligand-Target Pair | |