Compile Data Set for Download or QSAR

Found 299 hits with Last Name = 'farah' and Initial = 'mm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398017 (CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398017 (CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47287 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1-propyl-1H...) Show SMILES CCCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-4-12-26-14-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(2)13-16(3)27(21)25-19/h5-9,13-14H,4,10-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47287 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1-propyl-1H...) Show SMILES CCCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-4-12-26-14-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(2)13-16(3)27(21)25-19/h5-9,13-14H,4,10-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156359 (US9018217, 8-Ethyl-5-methyl-2-[2-(1-methyl-4-pheny...) Show SMILES CCc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)12-13-20-22-18(14-25(20)3)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156359 (US9018217, 8-Ethyl-5-methyl-2-[2-(1-methyl-4-pheny...) Show SMILES CCc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)12-13-20-22-18(14-25(20)3)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47296 (US9018217, 8-Ethyl-5-methyl-2-(2-(1-methyl-4-pheny...) Show SMILES CCc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H22N6/c1-4-15-12-21-14(2)26-20(15)23-18(24-26)10-11-19-22-17(13-25(19)3)16-8-6-5-7-9-16/h5-9,12-13H,4,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47296 (US9018217, 8-Ethyl-5-methyl-2-(2-(1-methyl-4-pheny...) Show SMILES CCc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H22N6/c1-4-15-12-21-14(2)26-20(15)23-18(24-26)10-11-19-22-17(13-25(19)3)16-8-6-5-7-9-16/h5-9,12-13H,4,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156347 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N6/c1-15(2)13-27-14-19(18-8-6-5-7-9-18)24-21(27)11-10-20-25-22-23-16(3)12-17(4)28(22)26-20/h5-9,12,14-15H,10-11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156347 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N6/c1-15(2)13-27-14-19(18-8-6-5-7-9-18)24-21(27)11-10-20-25-22-23-16(3)12-17(4)28(22)26-20/h5-9,12,14-15H,10-11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47283 (US9018217, 5-Methyl-2-(2-[4-phenyl-1-(2-piperidin-...) Show SMILES Cc1cccc2nc(CCc3nc(cn3CCC3CCCCN3)-c3ccccc3)nn12 Show InChI InChI=1S/C25H30N6/c1-19-8-7-12-25-28-23(29-31(19)25)13-14-24-27-22(20-9-3-2-4-10-20)18-30(24)17-15-21-11-5-6-16-26-21/h2-4,7-10,12,18,21,26H,5-6,11,13-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM299447 (US9592230, 5-Methyl-2-{2-[4-phenyl-1-(2-piperidin-...) Show SMILES Cc1cccc2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nn12 Show InChI InChI=1S/C25H30N6/c1-20-9-8-12-25-27-23(28-31(20)25)13-14-24-26-22(21-10-4-2-5-11-21)19-30(24)18-17-29-15-6-3-7-16-29/h2,4-5,8-12,19H,3,6-7,13-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156350 (US9018217, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H29N7O/c1-18-16-19(2)31-24(25-18)27-22(28-31)8-9-23-26-21(20-6-4-3-5-7-20)17-30(23)11-10-29-12-14-32-15-13-29/h3-7,16-17H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156350 (US9018217, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H29N7O/c1-18-16-19(2)31-24(25-18)27-22(28-31)8-9-23-26-21(20-6-4-3-5-7-20)17-30(23)11-10-29-12-14-32-15-13-29/h3-7,16-17H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156337 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-16(2)14-26-15-19(18-9-5-4-6-10-18)23-21(26)13-12-20-24-22-11-7-8-17(3)27(22)25-20/h4-11,15-16H,12-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156337 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-16(2)14-26-15-19(18-9-5-4-6-10-18)23-21(26)13-12-20-24-22-11-7-8-17(3)27(22)25-20/h4-11,15-16H,12-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398014 (CHEMBL2180414 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)19-22-17(23-25(13)19)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398014 (CHEMBL2180414 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)19-22-17(23-25(13)19)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156352 (US9018217, 8-methoxy-5-methyl-2-(2-(1-methyl-4-phe...) Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5O/c1-14-9-10-17(26-3)20-22-18(23-25(14)20)11-12-19-21-16(13-24(19)2)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156352 (US9018217, 8-methoxy-5-methyl-2-(2-(1-methyl-4-phe...) Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5O/c1-14-9-10-17(26-3)20-22-18(23-25(14)20)11-12-19-21-16(13-24(19)2)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM31592 (PF-2545920 | US9138494, MP-10 | substituted pyraz...) Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1 Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Inhibition of PDE10A				Bioorg Med Chem Lett 21: 3738-42 (2011) Article DOI: 10.1016/j.bmcl.2011.04.067 BindingDB Entry DOI: 10.7270/Q24B31PT
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156346 (US9018217, 5,7-Dimethyl-2-{2-[4-phenyl-1-(2-piperi...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C25H31N7/c1-19-17-20(2)32-25(26-19)28-23(29-32)11-12-24-27-22(21-9-5-3-6-10-21)18-31(24)16-15-30-13-7-4-8-14-30/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156346 (US9018217, 5,7-Dimethyl-2-{2-[4-phenyl-1-(2-piperi...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C25H31N7/c1-19-17-20(2)32-25(26-19)28-23(29-32)11-12-24-27-22(21-9-5-3-6-10-21)18-31(24)16-15-30-13-7-4-8-14-30/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156342 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156333 (US9018217, 5-Methyl-2-[2-(4-phenyl-1H-imidazol-2-y...) Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H17N5/c1-13-6-5-9-18-21-17(22-23(13)18)11-10-16-19-12-15(20-16)14-7-3-2-4-8-14/h2-9,12H,10-11H2,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156342 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47278 (US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3cccc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H27N7O/c1-18-7-6-10-23-26-21(27-31(18)23)11-12-22-25-20(19-8-4-3-5-9-19)17-30(22)16-15-29-14-13-28(2)24(29)32/h3-10,17H,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156333 (US9018217, 5-Methyl-2-[2-(4-phenyl-1H-imidazol-2-y...) Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H17N5/c1-13-6-5-9-18-21-17(22-23(13)18)11-10-16-19-12-15(20-16)14-7-3-2-4-8-14/h2-9,12H,10-11H2,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47278 (US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3cccc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H27N7O/c1-18-7-6-10-23-26-21(27-31(18)23)11-12-22-25-20(19-8-4-3-5-9-19)17-30(22)16-15-29-14-13-28(2)24(29)32/h3-10,17H,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156348 (US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...) Show SMILES CC(C)n1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-14(2)26-13-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(3)12-16(4)27(21)25-19/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156348 (US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...) Show SMILES CC(C)n1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-14(2)26-13-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(3)12-16(4)27(21)25-19/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156354 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES CCCc1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-4-8-17-13-15(2)22-21-24-19(25-27(17)21)11-12-20-23-18(14-26(20)3)16-9-6-5-7-10-16/h5-7,9-10,13-14H,4,8,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156354 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES CCCc1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-4-8-17-13-15(2)22-21-24-19(25-27(17)21)11-12-20-23-18(14-26(20)3)16-9-6-5-7-10-16/h5-7,9-10,13-14H,4,8,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156334 (US9018217, 2-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl...) Show SMILES CC(C)Cn1cc(nc1SCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6S/c1-14(2)11-26-12-18(17-8-6-5-7-9-17)23-21(26)28-13-19-24-20-22-15(3)10-16(4)27(20)25-19/h5-10,12,14H,11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156334 (US9018217, 2-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl...) Show SMILES CC(C)Cn1cc(nc1SCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6S/c1-14(2)11-26-12-18(17-8-6-5-7-9-17)23-21(26)28-13-19-24-20-22-15(3)10-16(4)27(20)25-19/h5-10,12,14H,11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47285 (US9018217, 1-(2-[2-[2-(5,7-Dimethyl-[1,2,4]triazol...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3nc(C)cc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H28N8O/c1-17-15-18(2)32-23(25-17)27-21(28-32)9-10-22-26-20(19-7-5-4-6-8-19)16-31(22)14-13-30-12-11-29(3)24(30)33/h4-8,15-16H,9-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47285 (US9018217, 1-(2-[2-[2-(5,7-Dimethyl-[1,2,4]triazol...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3nc(C)cc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H28N8O/c1-17-15-18(2)32-23(25-17)27-21(28-32)9-10-22-26-20(19-7-5-4-6-8-19)16-31(22)14-13-30-12-11-29(3)24(30)33/h4-8,15-16H,9-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156356 (US9018217, 7-Isopropyl-5-methyl-2-[2-(1-methyl-4-p...) Show SMILES CC(C)c1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-14(2)18-12-15(3)22-21-24-19(25-27(18)21)10-11-20-23-17(13-26(20)4)16-8-6-5-7-9-16/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156356 (US9018217, 7-Isopropyl-5-methyl-2-[2-(1-methyl-4-p...) Show SMILES CC(C)c1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-14(2)18-12-15(3)22-21-24-19(25-27(18)21)10-11-20-23-17(13-26(20)4)16-8-6-5-7-9-16/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156335 (US9018217, 5,7-Dimethyl-2-[1-(2-morpholin-4-yl-eth...) Show SMILES Cc1cc(C)n2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C23H27N7OS/c1-17-14-18(2)30-22(24-17)26-21(27-30)16-32-23-25-20(19-6-4-3-5-7-19)15-29(23)9-8-28-10-12-31-13-11-28/h3-7,14-15H,8-13,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156335 (US9018217, 5,7-Dimethyl-2-[1-(2-morpholin-4-yl-eth...) Show SMILES Cc1cc(C)n2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C23H27N7OS/c1-17-14-18(2)30-22(24-17)26-21(27-30)16-32-23-25-20(19-6-4-3-5-7-19)15-29(23)9-8-28-10-12-31-13-11-28/h3-7,14-15H,8-13,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156330 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1H-imidazol...) Show SMILES Cc1cc(C)n2nc(CCc3nc(c[nH]3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C18H18N6/c1-12-10-13(2)24-18(20-12)22-17(23-24)9-8-16-19-11-15(21-16)14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156330 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1H-imidazol...) Show SMILES Cc1cc(C)n2nc(CCc3nc(c[nH]3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C18H18N6/c1-12-10-13(2)24-18(20-12)22-17(23-24)9-8-16-19-11-15(21-16)14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156255 (US9018217, 5,7-Dimethyl-2-[1-(3-methyl-butyl)-4-ph...) Show SMILES CC(C)CCn1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1 Show InChI InChI=1S/C23H27N5S/c1-16(2)10-11-27-14-21(19-8-6-5-7-9-19)26-23(27)29-15-20-13-28-18(4)12-17(3)24-22(28)25-20/h5-9,12-14,16H,10-11,15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156255 (US9018217, 5,7-Dimethyl-2-[1-(3-methyl-butyl)-4-ph...) Show SMILES CC(C)CCn1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1 Show InChI InChI=1S/C23H27N5S/c1-16(2)10-11-27-14-21(19-8-6-5-7-9-19)26-23(27)29-15-20-13-28-18(4)12-17(3)24-22(28)25-20/h5-9,12-14,16H,10-11,15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156351 (US9018217, (S)-1-{2-[2-(5,7-Dimethyl-[1,2,4]triazo...) Show SMILES C[C@H](O)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6O/c1-14-11-15(2)27-21(22-14)24-19(25-27)9-10-20-23-18(13-26(20)12-16(3)28)17-7-5-4-6-8-17/h4-8,11,13,16,28H,9-10,12H2,1-3H3/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156351 (US9018217, (S)-1-{2-[2-(5,7-Dimethyl-[1,2,4]triazo...) Show SMILES C[C@H](O)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6O/c1-14-11-15(2)27-21(22-14)24-19(25-27)9-10-20-23-18(13-26(20)12-16(3)28)17-7-5-4-6-8-17/h4-8,11,13,16,28H,9-10,12H2,1-3H3/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156324 (US9018217, 4-(2-(2-(2-(5,7-dimethyl-[1,2,4]triazol...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2c1 Show InChI InChI=1S/C25H30N6O/c1-19-16-20(2)31-25(17-19)27-23(28-31)8-9-24-26-22(21-6-4-3-5-7-21)18-30(24)11-10-29-12-14-32-15-13-29/h3-7,16-18H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156324 (US9018217, 4-(2-(2-(2-(5,7-dimethyl-[1,2,4]triazol...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2c1 Show InChI InChI=1S/C25H30N6O/c1-19-16-20(2)31-25(17-19)27-23(28-31)8-9-24-26-22(21-6-4-3-5-7-21)18-30(24)11-10-29-12-14-32-15-13-29/h3-7,16-18H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156336 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES Cc1cc(N2CCOCC2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1 Show InChI InChI=1S/C22H25N7O/c1-16-14-21(28-10-12-30-13-11-28)29-22(23-16)25-19(26-29)8-9-20-24-18(15-27(20)2)17-6-4-3-5-7-17/h3-7,14-15H,8-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair

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