Compile Data Set for Download or QSAR

Found 91 hits with Last Name = 'finn' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051408 (CHEMBL3337527 | US11071729, Compound 2) Show SMILES CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O Show InChI InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cells				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50383332 (CHEMBL2029786) Show SMILES CC(C)CCn1ccc(-c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C17H18N2O/c1-13(2)8-10-19-11-9-15(16(12-18)17(19)20)14-6-4-3-5-7-14/h3-7,9,11,13H,8,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.51E+3	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051414 (CHEMBL3337498) Show SMILES CC(C)CCn1ccc(CCc2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C19H22N2O/c1-15(2)10-12-21-13-11-17(18(14-20)19(21)22)9-8-16-6-4-3-5-7-16/h3-7,11,13,15H,8-10,12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	361	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051418 (CHEMBL3337499) Show SMILES CC(C)CCn1ccc(OCc2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C18H20N2O2/c1-14(2)8-10-20-11-9-17(16(12-19)18(20)21)22-13-15-6-4-3-5-7-15/h3-7,9,11,14H,8,10,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051420 (CHEMBL3337500) Show SMILES CC(C)CCn1ccc(N(C)Cc2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C19H23N3O/c1-15(2)9-11-22-12-10-18(17(13-20)19(22)23)21(3)14-16-7-5-4-6-8-16/h4-8,10,12,15H,9,11,14H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051421 (CHEMBL3337501) Show SMILES CC(C)CCn1ccc(N2CCc3ccccc3C2)c(C#N)c1=O Show InChI InChI=1S/C20H23N3O/c1-15(2)7-10-22-12-9-19(18(13-21)20(22)24)23-11-8-16-5-3-4-6-17(16)14-23/h3-6,9,12,15H,7-8,10-11,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	871	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051428 (CHEMBL3337502) Show SMILES CC(C)CCn1ccc(N2CCC(CC2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C22H27N3O/c1-17(2)8-12-25-15-11-21(20(16-23)22(25)26)24-13-9-19(10-14-24)18-6-4-3-5-7-18/h3-7,11,15,17,19H,8-10,12-14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051490 (CHEMBL3337503) Show SMILES CC(C)CCn1ccc(N2CCCC(C2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C22H27N3O/c1-17(2)10-13-24-14-11-21(20(15-23)22(24)26)25-12-6-9-19(16-25)18-7-4-3-5-8-18/h3-5,7-8,11,14,17,19H,6,9-10,12-13,16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.31E+3	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051519 (CHEMBL3337504) Show SMILES CC(C)CCn1ccc(N2CCCCC2)c(C#N)c1=O Show InChI InChI=1S/C16H23N3O/c1-13(2)6-10-19-11-7-15(14(12-17)16(19)20)18-8-4-3-5-9-18/h7,11,13H,3-6,8-10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051557 (CHEMBL3337505) Show SMILES CC(C)CCn1ccc(N2CCN(CC2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C21H26N4O/c1-17(2)8-10-25-11-9-20(19(16-22)21(25)26)24-14-12-23(13-15-24)18-6-4-3-5-7-18/h3-7,9,11,17H,8,10,12-15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	661	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051558 (CHEMBL3337506) Show SMILES CC(C)CCn1ccc(N2CCN(CC2)c2ccccn2)c(C#N)c1=O Show InChI InChI=1S/C20H25N5O/c1-16(2)6-9-25-10-7-18(17(15-21)20(25)26)23-11-13-24(14-12-23)19-5-3-4-8-22-19/h3-5,7-8,10,16H,6,9,11-14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051559 (CHEMBL3337507) Show SMILES CC(C)CCn1ccc(N2CCN(Cc3ccccc3)CC2)c(C#N)c1=O Show InChI InChI=1S/C22H28N4O/c1-18(2)8-10-26-11-9-21(20(16-23)22(26)27)25-14-12-24(13-15-25)17-19-6-4-3-5-7-19/h3-7,9,11,18H,8,10,12-15,17H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.68E+3	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051566 (CHEMBL3337508) Show SMILES CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C21H25N3O/c1-2-3-12-24-15-11-20(19(16-22)21(24)25)23-13-9-18(10-14-23)17-7-5-4-6-8-17/h4-8,11,15,18H,2-3,9-10,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	95	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051569 (CHEMBL3337509) Show SMILES CC(C)Cn1ccc(N2CCC(CC2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C21H25N3O/c1-16(2)15-24-13-10-20(19(14-22)21(24)25)23-11-8-18(9-12-23)17-6-4-3-5-7-17/h3-7,10,13,16,18H,8-9,11-12,15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	282	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051570 (CHEMBL3337456) Show SMILES O=c1c(C#N)c(ccn1CC1CCC1)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H25N3O/c23-15-20-21(11-14-25(22(20)26)16-17-5-4-6-17)24-12-9-19(10-13-24)18-7-2-1-3-8-18/h1-3,7-8,11,14,17,19H,4-6,9-10,12-13,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051571 (CHEMBL3337510) Show SMILES O=c1c(C#N)c(ccn1CC1CC1)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N3O/c22-14-19-20(10-13-24(21(19)25)15-16-6-7-16)23-11-8-18(9-12-23)17-4-2-1-3-5-17/h1-5,10,13,16,18H,6-9,11-12,15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	151	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051572 (CHEMBL3337511) Show SMILES O=c1c(C#N)c(ccn1CCC1CC1)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H25N3O/c23-16-20-21(11-15-25(22(20)26)12-8-17-6-7-17)24-13-9-19(10-14-24)18-4-2-1-3-5-18/h1-5,11,15,17,19H,6-10,12-14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	178	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051574 (CHEMBL3337512) Show SMILES FC(F)(F)CCCn1ccc(N2CCC(CC2)c2ccccc2)c(C#N)c1=O Show InChI InChI=1S/C21H22F3N3O/c22-21(23,24)10-4-11-27-14-9-19(18(15-25)20(27)28)26-12-7-17(8-13-26)16-5-2-1-3-6-16/h1-3,5-6,9,14,17H,4,7-8,10-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	355	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051575 (CHEMBL3337513) Show SMILES Fc1ccccc1C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H22FN3O/c22-19-4-2-1-3-17(19)16-7-10-24(11-8-16)20-9-12-25(14-15-5-6-15)21(26)18(20)13-23/h1-4,9,12,15-16H,5-8,10-11,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051576 (CHEMBL3337514) Show SMILES Fc1cccc(c1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H22FN3O/c22-18-3-1-2-17(12-18)16-6-9-24(10-7-16)20-8-11-25(14-15-4-5-15)21(26)19(20)13-23/h1-3,8,11-12,15-16H,4-7,9-10,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	141	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051577 (CHEMBL3337515) Show SMILES Fc1ccc(cc1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H22FN3O/c22-18-5-3-16(4-6-18)17-7-10-24(11-8-17)20-9-12-25(14-15-1-2-15)21(26)19(20)13-23/h3-6,9,12,15,17H,1-2,7-8,10-11,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	89	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051579 (CHEMBL3337516) Show SMILES Clc1ccccc1C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H22ClN3O/c22-19-4-2-1-3-17(19)16-7-10-24(11-8-16)20-9-12-25(14-15-5-6-15)21(26)18(20)13-23/h1-4,9,12,15-16H,5-8,10-11,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051580 (CHEMBL3337517) Show SMILES Clc1ccc(cc1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H22ClN3O/c22-18-5-3-16(4-6-18)17-7-10-24(11-8-17)20-9-12-25(14-15-1-2-15)21(26)19(20)13-23/h3-6,9,12,15,17H,1-2,7-8,10-11,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051581 (CHEMBL3337518) Show SMILES FC(F)(F)c1cccc(c1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C22H22F3N3O/c23-22(24,25)18-3-1-2-17(12-18)16-6-9-27(10-7-16)20-8-11-28(14-15-4-5-15)21(29)19(20)13-26/h1-3,8,11-12,15-16H,4-7,9-10,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051582 (CHEMBL3337519) Show SMILES COc1ccccc1C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C22H25N3O2/c1-27-21-5-3-2-4-18(21)17-8-11-24(12-9-17)20-10-13-25(15-16-6-7-16)22(26)19(20)14-23/h2-5,10,13,16-17H,6-9,11-12,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051583 (CHEMBL3337520) Show SMILES COc1ccc(cc1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C22H25N3O2/c1-27-19-6-4-17(5-7-19)18-8-11-24(12-9-18)21-10-13-25(15-16-2-3-16)22(26)20(21)14-23/h4-7,10,13,16,18H,2-3,8-9,11-12,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	98	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051584 (CHEMBL3337521) Show SMILES Fc1ccc(C2CCN(CC2)c2ccn(CC3CC3)c(=O)c2C#N)c(F)c1 Show InChI InChI=1S/C21H21F2N3O/c22-16-3-4-17(19(23)11-16)15-5-8-25(9-6-15)20-7-10-26(13-14-1-2-14)21(27)18(20)12-24/h3-4,7,10-11,14-15H,1-2,5-6,8-9,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	68	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051587 (CHEMBL3337522) Show SMILES Fc1cccc(F)c1C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H21F2N3O/c22-17-2-1-3-18(23)20(17)15-6-9-25(10-7-15)19-8-11-26(13-14-4-5-14)21(27)16(19)12-24/h1-3,8,11,14-15H,4-7,9-10,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051589 (CHEMBL3337523) Show SMILES Fc1cc(F)cc(c1)C1CCN(CC1)c1ccn(CC2CC2)c(=O)c1C#N Show InChI InChI=1S/C21H21F2N3O/c22-17-9-16(10-18(23)11-17)15-3-6-25(7-4-15)20-5-8-26(13-14-1-2-14)21(27)19(20)12-24/h5,8-11,14-15H,1-4,6-7,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	151	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051590 (CHEMBL3337524 | US11071729, Compound 1) Show SMILES Clc1c(ccn(CC2CC2)c1=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C20H23ClN2O/c21-19-18(10-13-23(20(19)24)14-15-6-7-15)22-11-8-17(9-12-22)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051591 (CHEMBL3337525 | US11071729, Compound 4) Show SMILES FC(F)(F)c1c(ccn(CC2CC2)c1=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C21H23F3N2O/c22-21(23,24)19-18(10-13-26(20(19)27)14-15-6-7-15)25-11-8-17(9-12-25)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051607 (CHEMBL3337526 | US11071729, Compound 19) Show SMILES CC(C)Cn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O Show InChI InChI=1S/C20H25ClN2O/c1-15(2)14-23-13-10-18(19(21)20(23)24)22-11-8-17(9-12-22)16-6-4-3-5-7-16/h3-7,10,13,15,17H,8-9,11-12,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	195	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50051408 (CHEMBL3337527 | US11071729, Compound 2) Show SMILES CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O Show InChI InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	147	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...				J Med Chem 57: 6495-512 (2014) Article DOI: 10.1021/jm500496m BindingDB Entry DOI: 10.7270/Q2DJ5H8J
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417815 (CHEMBL1669391) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1cnc(OC)c(F)c1 Show InChI InChI=1S/C18H16ClFN2O2/c1-3-5-22-6-4-11-7-12(8-14(19)16(11)18(22)23)13-9-15(20)17(24-2)21-10-13/h4,6-10H,3,5H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417816 (CHEMBL1669392) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccccc2)nc1 Show InChI InChI=1S/C23H19ClN2O2/c1-2-11-26-12-10-16-13-18(14-20(24)22(16)23(26)27)17-8-9-21(25-15-17)28-19-6-4-3-5-7-19/h3-10,12-15H,2,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	501	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417817 (CHEMBL1669393) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCCc2ccccc2)nc1 Show InChI InChI=1S/C25H23ClN2O2/c1-2-12-28-13-10-19-15-21(16-22(26)24(19)25(28)29)20-8-9-23(27-17-20)30-14-11-18-6-4-3-5-7-18/h3-10,13,15-17H,2,11-12,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417818 (CHEMBL1669394) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2cccnc2)nc1 Show InChI InChI=1S/C23H20ClN3O2/c1-2-9-27-10-7-17-11-19(12-20(24)22(17)23(27)28)18-5-6-21(26-14-18)29-15-16-4-3-8-25-13-16/h3-8,10-14H,2,9,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417819 (CHEMBL1669395) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OC)cc1 Show InChI InChI=1S/C19H18ClNO2/c1-3-9-21-10-8-14-11-15(12-17(20)18(14)19(21)22)13-4-6-16(23-2)7-5-13/h4-8,10-12H,3,9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417820 (CHEMBL1669396) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C24H20ClNO2/c1-2-13-26-14-12-18-15-19(16-22(25)23(18)24(26)27)17-8-10-21(11-9-17)28-20-6-4-3-5-7-20/h3-12,14-16H,2,13H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417821 (CHEMBL1669397) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccncc2)cc1 Show InChI InChI=1S/C23H19ClN2O2/c1-2-12-26-13-9-17-14-18(15-21(24)22(17)23(26)27)16-3-5-19(6-4-16)28-20-7-10-25-11-8-20/h3-11,13-15H,2,12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417822 (CHEMBL1669398) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2cccnc2)cc1 Show InChI InChI=1S/C24H21ClN2O2/c1-2-11-27-12-9-19-13-20(14-22(25)23(19)24(27)28)18-5-7-21(8-6-18)29-16-17-4-3-10-26-15-17/h3-10,12-15H,2,11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417823 (CHEMBL1669399) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2ccc(Cl)nc2)cc1 Show InChI InChI=1S/C24H20Cl2N2O2/c1-2-10-28-11-9-18-12-19(13-21(25)23(18)24(28)29)17-4-6-20(7-5-17)30-15-16-3-8-22(26)27-14-16/h3-9,11-14H,2,10,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417824 (CHEMBL1669400) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2ccc(nc2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H20ClF3N2O2/c1-2-10-31-11-9-18-12-19(13-21(26)23(18)24(31)32)17-4-6-20(7-5-17)33-15-16-3-8-22(30-14-16)25(27,28)29/h3-9,11-14H,2,10,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417825 (CHEMBL1669401) Show SMILES CCCn1ccc2cc(ccc2c1=O)N1CCOCC1 Show InChI InChI=1S/C16H20N2O2/c1-2-6-18-7-5-13-12-14(3-4-15(13)16(18)19)17-8-10-20-11-9-17/h3-5,7,12H,2,6,8-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417826 (CHEMBL1669402) Show SMILES CCCn1ccc2cc(ccc2c1=O)-c1cccnc1 Show InChI InChI=1S/C17H16N2O/c1-2-9-19-10-7-14-11-13(5-6-16(14)17(19)20)15-4-3-8-18-12-15/h3-8,10-12H,2,9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417827 (CHEMBL1669403) Show SMILES CCCn1ccc2cc(cc(C#N)c2c1=O)-c1cccnc1 Show InChI InChI=1S/C18H15N3O/c1-2-7-21-8-5-13-9-15(14-4-3-6-20-12-14)10-16(11-19)17(13)18(21)22/h3-6,8-10,12H,2,7H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>5.01E+4	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417828 (CHEMBL1669377) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)N1CCOCC1 Show InChI InChI=1S/C16H19ClN2O2/c1-2-4-19-5-3-12-10-13(18-6-8-21-9-7-18)11-14(17)15(12)16(19)20/h3,5,10-11H,2,4,6-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in HEK293 cells assessed as induction of calcium release by FLIPR assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417828 (CHEMBL1669377) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)N1CCOCC1 Show InChI InChI=1S/C16H19ClN2O2/c1-2-4-19-5-3-12-10-13(18-6-8-21-9-7-18)11-14(17)15(12)16(19)20/h3,5,10-11H,2,4,6-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50417829 (CHEMBL1669378) Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)N1CCC(O)CC1 Show InChI InChI=1S/C17H21ClN2O2/c1-2-6-20-7-3-12-10-13(11-15(18)16(12)17(20)22)19-8-4-14(21)5-9-19/h3,7,10-11,14,21H,2,4-6,8-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
Janssen-Cilag SA Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay				Bioorg Med Chem Lett 21: 971-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18
					More data for this Ligand-Target Pair

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