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Compile Data Set for Download or QSAR

Found 77 hits with Last Name = 'fisher' and Initial = 'le'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228703
PNG
(CHEMBL155823)
Show SMILES Clc1cccc2CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)CCc12
Show InChI InChI=1S/C23H31ClN2O2/c24-20-7-5-6-18-8-14-25(15-9-19(18)20)12-3-4-13-26-21(27)16-23(17-22(26)28)10-1-2-11-23/h5-7H,1-4,8-17H2
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5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228680
PNG
(CHEMBL345810)
Show SMILES [H][C@@]12CCCc3ccc(Cl)c(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228679
PNG
(CHEMBL160918)
Show SMILES Clc1ccc2CCCC3CN(CCCCN4C(=O)CC5(CCCC5)CC4=O)CCc1c23
Show InChI InChI=1S/C26H35ClN2O2/c27-22-9-8-19-6-5-7-20-18-28(15-10-21(22)25(19)20)13-3-4-14-29-23(30)16-26(17-24(29)31)11-1-2-12-26/h8-9,20H,1-7,10-18H2
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7.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228685
PNG
(CHEMBL1202289)
Show SMILES Br.CN1CCc2c3C(CCc3ccc2Cl)C1
Show InChI InChI=1S/C13H16ClN.BrH/c1-15-7-6-11-12(14)5-4-9-2-3-10(8-15)13(9)11;/h4-5,10H,2-3,6-8H2,1H3;1H
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7.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228695
PNG
(CHEMBL156585)
Show SMILES Clc1ccc2CCCC3CN(CC=C)CCc1c23
Show InChI InChI=1S/C16H20ClN/c1-2-9-18-10-8-14-15(17)7-6-12-4-3-5-13(11-18)16(12)14/h2,6-7,13H,1,3-5,8-11H2
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7.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM66983
PNG
(6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazep...)
Show SMILES CN1CCc2cccc(Cl)c2CC1
Show InChI InChI=1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3
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7.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228699
PNG
(CHEMBL345214)
Show SMILES CN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3
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10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228684
PNG
(CHEMBL1203597)
Show SMILES Cl.COc1ccc2CCCC3CN(CC=C)CCc1c23
Show InChI InChI=1S/C17H23NO.ClH/c1-3-10-18-11-9-15-16(19-2)8-7-13-5-4-6-14(12-18)17(13)15;/h3,7-8,14H,1,4-6,9-12H2,2H3;1H
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13n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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13n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228700
PNG
(CHEMBL1202288)
Show SMILES Br.CN1CCc2cccc3CCC(C1)c23
Show InChI InChI=1S/C13H17N.BrH/c1-14-8-7-11-4-2-3-10-5-6-12(9-14)13(10)11;/h2-4,12H,5-9H2,1H3;1H
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16n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228690
PNG
(CHEMBL346122)
Show SMILES CCN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C15H20ClN/c1-2-17-9-8-13-14(16)7-6-11-4-3-5-12(10-17)15(11)13/h6-7,12H,2-5,8-10H2,1H3
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16n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228706
PNG
(CHEMBL1203631)
Show SMILES Cl.C=CCN1CCc2cccc3CCCC(C1)c23
Show InChI InChI=1S/C16H21N.ClH/c1-2-10-17-11-9-14-7-3-5-13-6-4-8-15(12-17)16(13)14;/h2-3,5,7,15H,1,4,6,8-12H2;1H
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20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228686
PNG
(CHEMBL160607)
Show SMILES [H][C@]12CCCc3ccc(Cl)c(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m0/s1
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20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228696
PNG
(CHEMBL1203603)
Show SMILES Cl.COc1ccc2CCCC3CN(C)CCc1c23
Show InChI InChI=1S/C15H21NO.ClH/c1-16-9-8-13-14(17-2)7-6-11-4-3-5-12(10-16)15(11)13;/h6-7,12H,3-5,8-10H2,1-2H3;1H
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25n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228685
PNG
(CHEMBL1202289)
Show SMILES Br.CN1CCc2c3C(CCc3ccc2Cl)C1
Show InChI InChI=1S/C13H16ClN.BrH/c1-15-7-6-11-12(14)5-4-9-2-3-10(8-15)13(9)11;/h4-5,10H,2-3,6-8H2,1H3;1H
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25n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228709
PNG
(CHEMBL1203625)
Show SMILES Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCc2ccccc2CC1
Show InChI InChI=1S/C23H32N2O2/c26-21-17-23(11-3-4-12-23)18-22(27)25(21)14-6-5-13-24-15-9-19-7-1-2-8-20(19)10-16-24/h1-2,7-8H,3-6,9-18H2
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25n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228689
PNG
(CHEMBL156229)
Show SMILES CN1CCc2ccc(Cl)c3CCC(C1)c23
Show InChI InChI=1S/C13H16ClN/c1-15-7-6-9-3-5-12(14)11-4-2-10(8-15)13(9)11/h3,5,10H,2,4,6-8H2,1H3
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25n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228683
PNG
(CHEMBL348058)
Show SMILES CCCN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C16H22ClN/c1-2-9-18-10-8-14-15(17)7-6-12-4-3-5-13(11-18)16(12)14/h6-7,13H,2-5,8-11H2,1H3
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32n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228691
PNG
(CHEMBL1203624)
Show SMILES Cl.[H][C@@]12CCCc3cccc(CCN(C)C1)c23 |r|
Show InChI InChI=1S/C14H19N.ClH/c1-15-9-8-12-6-2-4-11-5-3-7-13(10-15)14(11)12;/h2,4,6,13H,3,5,7-10H2,1H3;1H/t13-;/m1./s1
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32n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228701
PNG
(CHEMBL1202291)
Show SMILES Br.CN1CCc2c(Cl)ccc3[nH]cc(C1)c23
Show InChI InChI=1S/C12H13ClN2/c1-15-5-4-9-10(13)2-3-11-12(9)8(7-15)6-14-11/h2-3,6,14H,4-5,7H2,1H3
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32n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228694
PNG
(CHEMBL1203601)
Show SMILES Cl.CN1CCc2c(OCC=C)ccc3CCCC(C1)c23
Show InChI InChI=1S/C17H23NO.ClH/c1-3-11-19-16-8-7-13-5-4-6-14-12-18(2)10-9-15(16)17(13)14;/h3,7-8,14H,1,4-6,9-12H2,2H3;1H
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32n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228675
PNG
(CHEMBL1203595)
Show SMILES Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCc2cccc3CCCC(C1)c23
Show InChI InChI=1S/C26H36N2O2.ClH/c29-23-17-26(12-1-2-13-26)18-24(30)28(23)15-4-3-14-27-16-11-21-9-5-7-20-8-6-10-22(19-27)25(20)21;/h5,7,9,22H,1-4,6,8,10-19H2;1H
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40n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228702
PNG
(CHEMBL346276)
Show SMILES [H][C@@]12CCCc3c(Cl)ccc(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-10-5-6-13(15)12-4-2-3-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m1/s1
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50n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228705
PNG
(CHEMBL1203598)
Show SMILES Cl.CCCN1CCc2cccc3CCCC(C1)c23
Show InChI InChI=1S/C16H23N.ClH/c1-2-10-17-11-9-14-7-3-5-13-6-4-8-15(12-17)16(13)14;/h3,5,7,15H,2,4,6,8-12H2,1H3;1H
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50n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228681
PNG
(CHEMBL1203600)
Show SMILES Cl.CCN1CCc2cccc3CCCC(C1)c23
Show InChI InChI=1S/C15H21N.ClH/c1-2-16-10-9-13-7-3-5-12-6-4-8-14(11-16)15(12)13;/h3,5,7,14H,2,4,6,8-11H2,1H3;1H
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50n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228682
PNG
(CHEMBL1203623)
Show SMILES Cl.CN1CCc2cccc3CCCC(C1)c23
Show InChI InChI=1S/C14H19N.ClH/c1-15-9-8-12-6-2-4-11-5-3-7-13(10-15)14(11)12;/h2,4,6,13H,3,5,7-10H2,1H3;1H
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50n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228693
PNG
(CHEMBL1203644)
Show SMILES Cl.[H][C@]12CCCc3cccc(CCN(C)C1)c23 |r|
Show InChI InChI=1S/C14H19N.ClH/c1-15-9-8-12-6-2-4-11-5-3-7-13(10-15)14(11)12;/h2,4,6,13H,3,5,7-10H2,1H3;1H/t13-;/m0./s1
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63n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228642
PNG
(CHEMBL158505)
Show SMILES CN1CCc2c(Cl)ccc3CCCCC(C1)c23
Show InChI InChI=1S/C15H20ClN/c1-17-9-8-13-14(16)7-6-11-4-2-3-5-12(10-17)15(11)13/h6-7,12H,2-5,8-10H2,1H3
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79n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228688
PNG
(CHEMBL348273)
Show SMILES CN1CCc2ccc(Cl)c3CCCC(C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-10-5-6-13(15)12-4-2-3-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3
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79n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228692
PNG
(CHEMBL1202290)
Show SMILES Br.COc1ccc2CCC3CN(C)CCc1c23
Show InChI InChI=1S/C14H19NO.BrH/c1-15-8-7-12-13(16-2)6-5-10-3-4-11(9-15)14(10)12;/h5-6,11H,3-4,7-9H2,1-2H3;1H
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100n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50069022
PNG
(4-Methyl-3,4,5,6-tetrahydro-1H-azepino[3,4,5-cd]in...)
Show SMILES CN1CCc2cccc3[nH]cc(C1)c23
Show InChI InChI=1S/C12H14N2/c1-14-6-5-9-3-2-4-11-12(9)10(8-14)7-13-11/h2-4,7,13H,5-6,8H2,1H3
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100n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM66983
PNG
(6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazep...)
Show SMILES CN1CCc2cccc(Cl)c2CC1
Show InChI InChI=1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3
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100n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228686
PNG
(CHEMBL160607)
Show SMILES [H][C@]12CCCc3ccc(Cl)c(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m0/s1
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100n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228699
PNG
(CHEMBL345214)
Show SMILES CN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3
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126n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228692
PNG
(CHEMBL1202290)
Show SMILES Br.COc1ccc2CCC3CN(C)CCc1c23
Show InChI InChI=1S/C14H19NO.BrH/c1-15-8-7-12-13(16-2)6-5-10-3-4-11(9-15)14(10)12;/h5-6,11H,3-4,7-9H2,1-2H3;1H
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126n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228708
PNG
(CHEMBL160186)
Show SMILES [H][C@]12CCCc3c(Cl)ccc(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-10-5-6-13(15)12-4-2-3-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m0/s1
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126n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228701
PNG
(CHEMBL1202291)
Show SMILES Br.CN1CCc2c(Cl)ccc3[nH]cc(C1)c23
Show InChI InChI=1S/C12H13ClN2/c1-15-5-4-9-10(13)2-3-11-12(9)8(7-15)6-14-11/h2-3,6,14H,4-5,7H2,1H3
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158n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228689
PNG
(CHEMBL156229)
Show SMILES CN1CCc2ccc(Cl)c3CCC(C1)c23
Show InChI InChI=1S/C13H16ClN/c1-15-7-6-9-3-5-12(14)11-4-2-10(8-15)13(9)11/h3,5,10H,2,4,6-8H2,1H3
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158n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228696
PNG
(CHEMBL1203603)
Show SMILES Cl.COc1ccc2CCCC3CN(C)CCc1c23
Show InChI InChI=1S/C15H21NO.ClH/c1-16-9-8-13-14(17-2)7-6-11-4-3-5-12(10-16)15(11)13;/h6-7,12H,3-5,8-10H2,1-2H3;1H
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158n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228678
PNG
(CHEMBL1203611)
Show SMILES Cl.COc1ccc2CCCC3CN(C)Cc1c23
Show InChI InChI=1S/C14H19NO.ClH/c1-15-8-11-5-3-4-10-6-7-13(16-2)12(9-15)14(10)11;/h6-7,11H,3-5,8-9H2,1-2H3;1H
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158n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228678
PNG
(CHEMBL1203611)
Show SMILES Cl.COc1ccc2CCCC3CN(C)Cc1c23
Show InChI InChI=1S/C14H19NO.ClH/c1-15-8-11-5-3-4-10-6-7-13(16-2)12(9-15)14(10)11;/h6-7,11H,3-5,8-9H2,1-2H3;1H
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200n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228643
PNG
(CHEMBL1203645)
Show SMILES Cl.C1CC2CNCCc3cccc(C1)c23
Show InChI InChI=1S/C13H17N.ClH/c1-3-10-4-2-6-12-9-14-8-7-11(5-1)13(10)12;/h1,3,5,12,14H,2,4,6-9H2;1H
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200n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228700
PNG
(CHEMBL1202288)
Show SMILES Br.CN1CCc2cccc3CCC(C1)c23
Show InChI InChI=1S/C13H17N.BrH/c1-14-8-7-11-4-2-3-10-5-6-12(9-14)13(10)11;/h2-4,12H,5-9H2,1H3;1H
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251n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228680
PNG
(CHEMBL345810)
Show SMILES [H][C@@]12CCCc3ccc(Cl)c(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-12-13(15)6-5-10-3-2-4-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m1/s1
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251n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228642
PNG
(CHEMBL158505)
Show SMILES CN1CCc2c(Cl)ccc3CCCCC(C1)c23
Show InChI InChI=1S/C15H20ClN/c1-17-9-8-13-14(16)7-6-11-4-2-3-5-12(10-17)15(11)13/h6-7,12H,2-5,8-10H2,1H3
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316n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50228697
PNG
(CHEMBL1203602)
Show SMILES Cl.CN1CCc2c(O)ccc3CCCC(C1)c23
Show InChI InChI=1S/C14H19NO.ClH/c1-15-8-7-12-13(16)6-5-10-3-2-4-11(9-15)14(10)12;/h5-6,11,16H,2-4,7-9H2,1H3;1H
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316n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228690
PNG
(CHEMBL346122)
Show SMILES CCN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C15H20ClN/c1-2-17-9-8-13-14(16)7-6-11-4-3-5-12(10-17)15(11)13/h6-7,12H,2-5,8-10H2,1H3
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316n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228683
PNG
(CHEMBL348058)
Show SMILES CCCN1CCc2c(Cl)ccc3CCCC(C1)c23
Show InChI InChI=1S/C16H22ClN/c1-2-9-18-10-8-14-15(17)7-6-12-4-3-5-13(11-18)16(12)14/h6-7,13H,2-5,8-11H2,1H3
PDB

UniProtKB/SwissProt

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CHEMBL
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PC sid
UniChem

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PubMed
398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228708
PNG
(CHEMBL160186)
Show SMILES [H][C@]12CCCc3c(Cl)ccc(CCN(C)C1)c23
Show InChI InChI=1S/C14H18ClN/c1-16-8-7-10-5-6-13(15)12-4-2-3-11(9-16)14(10)12/h5-6,11H,2-4,7-9H2,1H3/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228693
PNG
(CHEMBL1203644)
Show SMILES Cl.[H][C@]12CCCc3cccc(CCN(C)C1)c23 |r|
Show InChI InChI=1S/C14H19N.ClH/c1-15-9-8-12-6-2-4-11-5-3-7-13(10-15)14(11)12;/h2,4,6,13H,3,5,7-10H2,1H3;1H/t13-;/m0./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane using [3H]yohimbine as radioligand.


J Med Chem 33: 633-41 (1990)


BindingDB Entry DOI: 10.7270/Q26T0PV7
More data for this
Ligand-Target Pair
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