Compile Data Set for Download or QSAR

Found 274 hits with Last Name = 'freeman' and Initial = 'jl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257123 (CHEMBL4072279) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC2=NCCS2)c(=O)c2cc(Cl)ccc12 |t:19| Show InChI InChI=1S/C22H19ClN4O3S/c1-30-13-10-16-18(26-11-13)19-17(20(16)28)14-4-3-12(23)9-15(14)21(29)27(19)7-2-5-24-22-25-6-8-31-22/h3-4,9-11H,2,5-8H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257089 (CHEMBL4083140) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(O)CC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C24H24ClN3O4/c1-32-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-14(25)11-18(17)24(31)28(22)8-2-7-27-9-5-15(29)6-10-27/h3-4,11-13,15,29H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257106 (CHEMBL4077196) Show SMILES CNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(Cl)cc2c1=O Show InChI InChI=1S/C20H18ClN3O3/c1-22-6-3-7-24-18-16(13-5-4-11(21)8-14(13)20(24)26)19(25)15-9-12(27-2)10-23-17(15)18/h4-5,8-10,22H,3,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257102 (CHEMBL4090922) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCNCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H23ClN4O3/c1-31-15-12-18-20(26-13-15)21-19(22(18)29)16-4-3-14(24)11-17(16)23(30)28(21)8-2-7-27-9-5-25-6-10-27/h3-4,11-13,25H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257107 (CHEMBL4079315) Show SMILES CCNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(Cl)cc2c1=O Show InChI InChI=1S/C21H20ClN3O3/c1-3-23-7-4-8-25-19-17(14-6-5-12(22)9-15(14)21(25)27)20(26)16-10-13(28-2)11-24-18(16)19/h5-6,9-11,23H,3-4,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257120 (CHEMBL4072940) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H22ClN3O3/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-6-5-14(24)11-17(16)23(29)27(21)10-4-9-26-7-2-3-8-26/h5-6,11-13H,2-4,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257123 (CHEMBL4072279) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC2=NCCS2)c(=O)c2cc(Cl)ccc12 |t:19| Show InChI InChI=1S/C22H19ClN4O3S/c1-30-13-10-16-18(26-11-13)19-17(20(16)28)14-4-3-12(23)9-15(14)21(29)27(19)7-2-5-24-22-25-6-8-31-22/h3-4,9-11H,2,5-8H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257105 (CHEMBL4064072) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC(C)C)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H22ClN3O3/c1-12(2)24-7-4-8-26-20-18(15-6-5-13(23)9-16(15)22(26)28)21(27)17-10-14(29-3)11-25-19(17)20/h5-6,9-12,24H,4,7-8H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257101 (CHEMBL4063586) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC2=NCCS2)c(=O)c2cc(F)ccc12 |t:19| Show InChI InChI=1S/C22H19FN4O3S/c1-30-13-10-16-18(26-11-13)19-17(20(16)28)14-4-3-12(23)9-15(14)21(29)27(19)7-2-5-24-22-25-6-8-31-22/h3-4,9-11H,2,5-8H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257119 (CHEMBL4076362) Show SMILES CCNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(F)cc2c1=O Show InChI InChI=1S/C21H20FN3O3/c1-3-23-7-4-8-25-19-17(14-6-5-12(22)9-15(14)21(25)27)20(26)16-10-13(28-2)11-24-18(16)19/h5-6,9-11,23H,3-4,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.04E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257104 (CHEMBL4063011) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCNCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H23FN4O3/c1-31-15-12-18-20(26-13-15)21-19(22(18)29)16-4-3-14(24)11-17(16)23(30)28(21)8-2-7-27-9-5-25-6-10-27/h3-4,11-13,25H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257124 (CHEMBL4070873) Show SMILES CNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(F)cc2c1=O Show InChI InChI=1S/C20H18FN3O3/c1-22-6-3-7-24-18-16(13-5-4-11(21)8-14(13)20(24)26)19(25)15-9-12(27-2)10-23-17(15)18/h4-5,8-10,22H,3,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257126 (CHEMBL4101133) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(O)CC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C24H24FN3O4/c1-32-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-14(25)11-18(17)24(31)28(22)8-2-7-27-9-5-15(29)6-10-27/h3-4,11-13,15,29H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257127 (CHEMBL4085641) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC(C)C)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C22H22FN3O3/c1-12(2)24-7-4-8-26-20-18(15-6-5-13(23)9-16(15)22(26)28)21(27)17-10-14(29-3)11-25-19(17)20/h5-6,9-12,24H,4,7-8H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257124 (CHEMBL4070873) Show SMILES CNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(F)cc2c1=O Show InChI InChI=1S/C20H18FN3O3/c1-22-6-3-7-24-18-16(13-5-4-11(21)8-14(13)20(24)26)19(25)15-9-12(27-2)10-23-17(15)18/h4-5,8-10,22H,3,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257125 (CHEMBL4094373) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H22FN3O3/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-6-5-14(24)11-17(16)23(29)27(21)10-4-9-26-7-2-3-8-26/h5-6,11-13H,2-4,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257099 (CHEMBL4103520) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCn2ccnc2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H17ClN4O3/c1-30-14-10-17-19(25-11-14)20-18(21(17)28)15-4-3-13(23)9-16(15)22(29)27(20)7-2-6-26-8-5-24-12-26/h3-5,8-12H,2,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257126 (CHEMBL4101133) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(O)CC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C24H24FN3O4/c1-32-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-14(25)11-18(17)24(31)28(22)8-2-7-27-9-5-15(29)6-10-27/h3-4,11-13,15,29H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257127 (CHEMBL4085641) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC(C)C)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C22H22FN3O3/c1-12(2)24-7-4-8-26-20-18(15-6-5-13(23)9-16(15)22(26)28)21(27)17-10-14(29-3)11-25-19(17)20/h5-6,9-12,24H,4,7-8H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50008923 ((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r| Show InChI InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257089 (CHEMBL4083140) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(O)CC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C24H24ClN3O4/c1-32-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-14(25)11-18(17)24(31)28(22)8-2-7-27-9-5-15(29)6-10-27/h3-4,11-13,15,29H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257090 (CHEMBL4072994) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCOCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H22FN3O4/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-4-3-14(24)11-17(16)23(29)27(21)6-2-5-26-7-9-31-10-8-26/h3-4,11-13H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257099 (CHEMBL4103520) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCn2ccnc2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H17ClN4O3/c1-30-14-10-17-19(25-11-14)20-18(21(17)28)15-4-3-13(23)9-16(15)22(29)27(20)7-2-6-26-8-5-24-12-26/h3-5,8-12H,2,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257100 (CHEMBL4079995) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCn2ccnc2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C22H17FN4O3/c1-30-14-10-17-19(25-11-14)20-18(21(17)28)15-4-3-13(23)9-16(15)22(29)27(20)7-2-6-26-8-5-24-12-26/h3-5,8-12H,2,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257101 (CHEMBL4063586) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC2=NCCS2)c(=O)c2cc(F)ccc12 |t:19| Show InChI InChI=1S/C22H19FN4O3S/c1-30-13-10-16-18(26-11-13)19-17(20(16)28)14-4-3-12(23)9-15(14)21(29)27(19)7-2-5-24-22-25-6-8-31-22/h3-4,9-11H,2,5-8H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257104 (CHEMBL4063011) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCNCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H23FN4O3/c1-31-15-12-18-20(26-13-15)21-19(22(18)29)16-4-3-14(24)11-17(16)23(30)28(21)8-2-7-27-9-5-25-6-10-27/h3-4,11-13,25H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257119 (CHEMBL4076362) Show SMILES CCNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(F)cc2c1=O Show InChI InChI=1S/C21H20FN3O3/c1-3-23-7-4-8-25-19-17(14-6-5-12(22)9-15(14)21(25)27)20(26)16-10-13(28-2)11-24-18(16)19/h5-6,9-11,23H,3-4,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257122 (CHEMBL4099136) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCOCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H22ClN3O4/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-4-3-14(24)11-17(16)23(29)27(21)6-2-5-26-7-9-31-10-8-26/h3-4,11-13H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50008923 ((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r| Show InChI InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257121 (CHEMBL4068761) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCN(C)CC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C24H25FN4O3/c1-27-8-10-28(11-9-27)6-3-7-29-22-20(17-5-4-15(25)12-18(17)24(29)31)23(30)19-13-16(32-2)14-26-21(19)22/h4-5,12-14H,3,6-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257125 (CHEMBL4094373) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H22FN3O3/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-6-5-14(24)11-17(16)23(29)27(21)10-4-9-26-7-2-3-8-26/h5-6,11-13H,2-4,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257120 (CHEMBL4072940) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H22ClN3O3/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-6-5-14(24)11-17(16)23(29)27(21)10-4-9-26-7-2-3-8-26/h5-6,11-13H,2-4,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257107 (CHEMBL4079315) Show SMILES CCNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(Cl)cc2c1=O Show InChI InChI=1S/C21H20ClN3O3/c1-3-23-7-4-8-25-19-17(14-6-5-12(22)9-15(14)21(25)27)20(26)16-10-13(28-2)11-24-18(16)19/h5-6,9-11,23H,3-4,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257106 (CHEMBL4077196) Show SMILES CNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(Cl)cc2c1=O Show InChI InChI=1S/C20H18ClN3O3/c1-22-6-3-7-24-18-16(13-5-4-11(21)8-14(13)20(24)26)19(25)15-9-12(27-2)10-23-17(15)18/h4-5,8-10,22H,3,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257105 (CHEMBL4064072) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC(C)C)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H22ClN3O3/c1-12(2)24-7-4-8-26-20-18(15-6-5-13(23)9-16(15)22(26)28)21(27)17-10-14(29-3)11-25-19(17)20/h5-6,9-12,24H,4,7-8H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257102 (CHEMBL4090922) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCNCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H23ClN4O3/c1-31-15-12-18-20(26-13-15)21-19(22(18)29)16-4-3-14(24)11-17(16)23(30)28(21)8-2-7-27-9-5-25-6-10-27/h3-4,11-13,25H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257100 (CHEMBL4079995) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCn2ccnc2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C22H17FN4O3/c1-30-14-10-17-19(25-11-14)20-18(21(17)28)15-4-3-13(23)9-16(15)22(29)27(20)7-2-6-26-8-5-24-12-26/h3-5,8-12H,2,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50257121 (CHEMBL4068761) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCN(C)CC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C24H25FN4O3/c1-27-8-10-28(11-9-27)6-3-7-29-22-20(17-5-4-15(25)12-18(17)24(29)31)23(30)19-13-16(32-2)14-26-21(19)22/h4-5,12-14H,3,6-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded DNA containing a 3'-phosphotyrosine as substrate after 15 mins...				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257122 (CHEMBL4099136) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCOCC2)c(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H22ClN3O4/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-4-3-14(24)11-17(16)23(29)27(21)6-2-5-26-7-9-31-10-8-26/h3-4,11-13H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50257090 (CHEMBL4072994) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCOCC2)c(=O)c2cc(F)ccc12 Show InChI InChI=1S/C23H22FN3O4/c1-30-15-12-18-20(25-13-15)21-19(22(18)28)16-4-3-14(24)11-17(16)23(29)27(21)6-2-5-26-7-9-31-10-8-26/h3-4,11-13H,2,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using 3'-labeled alpha-[32P]-cordycepin as substrate after 15 mins				J Med Chem 60: 5364-5376 (2017) Article DOI: 10.1021/acs.jmedchem.6b01870 BindingDB Entry DOI: 10.7270/Q290266B
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189942 (US9175003, 27) Show SMILES OC(=O)[C@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)NC(=O)[C@@H]1Cc2cc3OCC(Oc3cc2CN1C(=O)c1ccoc1)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C46H35Cl2N3O8/c47-37-14-5-29(17-38(37)48)24-57-36-12-10-32(11-13-36)43-26-58-41-20-34-19-40(51(23-35(34)21-42(41)59-43)45(53)33-15-16-56-25-33)44(52)50-39(46(54)55)18-27-1-6-30(7-2-27)31-8-3-28(22-49)4-9-31/h1-17,20-21,25,39-40,43H,18-19,23-24,26H2,(H,50,52)(H,54,55)/t39-,40-,43?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	843	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189943 (US9175003, 31) Show SMILES OC(=O)[C@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)NC(=O)[C@@H]1Cc2cc3OCC(Oc3cc2CN1Cc1ccccc1C#N)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C49H38Cl2N4O6/c50-41-18-9-32(19-42(41)51)28-59-40-16-14-35(15-17-40)47-29-60-45-22-38-21-44(55(27-39(38)23-46(45)61-47)26-37-4-2-1-3-36(37)25-53)48(56)54-43(49(57)58)20-30-5-10-33(11-6-30)34-12-7-31(24-52)8-13-34/h1-19,22-23,43-44,47H,20-21,26-29H2,(H,54,56)(H,57,58)/t43-,44-,47?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	657	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189944 (US9175003, 40) Show SMILES Cn1ccnc1CN1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C46H39Cl2N5O6/c1-52-17-16-50-44(52)25-53-24-35-22-42-41(58-27-43(59-42)33-11-13-36(14-12-33)57-26-30-6-15-37(47)38(48)18-30)21-34(35)20-40(53)45(54)51-39(46(55)56)19-28-2-7-31(8-3-28)32-9-4-29(23-49)5-10-32/h2-18,21-22,39-40,43H,19-20,24-27H2,1H3,(H,51,54)(H,55,56)/t39-,40-,43?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189945 (US9175003, 51) Show SMILES OC(=O)[C@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)NC(=O)[C@@H]1Cc2cc3NCC(Oc3cc2CN1C(=O)c1ccccc1)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C48H38Cl2N4O6/c49-39-19-10-31(20-40(39)50)28-59-38-17-15-34(16-18-38)45-26-52-41-22-36-23-43(54(27-37(36)24-44(41)60-45)47(56)35-4-2-1-3-5-35)46(55)53-42(48(57)58)21-29-6-11-32(12-7-29)33-13-8-30(25-51)9-14-33/h1-20,22,24,42-43,45,52H,21,23,26-28H2,(H,53,55)(H,57,58)/t42-,43-,45?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	410	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189946 (US9175003, 53) Show SMILES CC(=O)N1CC(Oc2cc3CN([C@@H](Cc3cc12)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)C(=O)c1ccccc1)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C50H40Cl2N4O7/c1-30(57)55-28-47(36-16-18-40(19-17-36)62-29-33-11-20-41(51)42(52)21-33)63-46-25-39-27-56(49(59)37-5-3-2-4-6-37)45(24-38(39)23-44(46)55)48(58)54-43(50(60)61)22-31-7-12-34(13-8-31)35-14-9-32(26-53)10-15-35/h2-21,23,25,43,45,47H,22,24,27-29H2,1H3,(H,54,58)(H,60,61)/t43-,45-,47?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189947 (US9175003, 55) Show SMILES Cc1nc(NC(=O)C2CCC2)sc1S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C50H43Cl2N5O9S2/c1-28-49(67-50(54-28)56-46(58)35-3-2-4-35)68(62,63)57-25-37-23-44-43(65-27-45(66-44)34-14-16-38(17-15-34)64-26-31-9-18-39(51)40(52)19-31)22-36(37)21-42(57)47(59)55-41(48(60)61)20-29-5-10-32(11-6-29)33-12-7-30(24-53)8-13-33/h5-19,22-23,35,41-42,45H,2-4,20-21,25-27H2,1H3,(H,55,59)(H,60,61)(H,54,56,58)/t41-,42-,45?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189948 (US9175003, 60) Show SMILES Cc1nc(N)sc1S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C45H37Cl2N5O8S2/c1-25-44(61-45(49)50-25)62(56,57)52-22-33-20-40-39(59-24-41(60-40)31-11-13-34(14-12-31)58-23-28-6-15-35(46)36(47)16-28)19-32(33)18-38(52)42(53)51-37(43(54)55)17-26-2-7-29(8-3-26)30-9-4-27(21-48)5-10-30/h2-16,19-20,37-38,41H,17-18,22-24H2,1H3,(H2,49,50)(H,51,53)(H,54,55)/t37-,38-,41-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	109	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189949 (US9175003, 61) Show SMILES CNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C46H39Cl2N5O8S2/c1-26-45(62-46(50-2)51-26)63(57,58)53-23-34-21-41-40(60-25-42(61-41)32-12-14-35(15-13-32)59-24-29-7-16-36(47)37(48)17-29)20-33(34)19-39(53)43(54)52-38(44(55)56)18-27-3-8-30(9-4-27)31-10-5-28(22-49)6-11-31/h3-17,20-21,38-39,42H,18-19,23-25H2,1-2H3,(H,50,51)(H,52,54)(H,55,56)/t38-,39-,42-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189950 (US9175003, 62) Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C47H41Cl2N5O8S2/c1-3-51-47-52-27(2)46(63-47)64(58,59)54-24-35-22-42-41(61-26-43(62-42)33-13-15-36(16-14-33)60-25-30-8-17-37(48)38(49)18-30)21-34(35)20-40(54)44(55)53-39(45(56)57)19-28-4-9-31(10-5-28)32-11-6-29(23-50)7-12-32/h4-18,21-22,39-40,43H,3,19-20,24-26H2,1-2H3,(H,51,52)(H,53,55)(H,56,57)/t39-,40-,43-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	328	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM189951 (US9175003, 63) Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(C)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C48H44ClN5O8S2/c1-4-51-48-52-29(3)47(63-48)64(58,59)54-25-37-23-43-42(61-27-44(62-43)35-15-17-38(18-16-35)60-26-32-6-5-28(2)39(49)19-32)22-36(37)21-41(54)45(55)53-40(46(56)57)20-30-7-11-33(12-8-30)34-13-9-31(24-50)10-14-34/h5-19,22-23,40-41,44H,4,20-21,25-27H2,1-3H3,(H,51,52)(H,53,55)(H,56,57)/t40-,41-,44?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	277	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...				US Patent US9175003 (2015) BindingDB Entry DOI: 10.7270/Q27943FG
					More data for this Ligand-Target Pair

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