Compile Data Set for Download or QSAR

Found 18 hits with Last Name = 'frugier' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100316 (CHEMBL3321809) Show SMILES Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(9.45,-34.75,;10.95,-35.07,;11.43,-36.54,;12.94,-36.86,;13.97,-35.71,;15.47,-36.03,;13.49,-34.25,;11.98,-33.93,;11.51,-32.46,;12.41,-31.22,;13.95,-31.22,;11.51,-29.97,;11.98,-28.51,;13.47,-28.11,;10.95,-27.36,;10.04,-30.45,;8.71,-29.68,;7.38,-30.45,;6.04,-29.68,;4.71,-30.45,;4.71,-31.99,;6.04,-32.76,;7.38,-31.99,;8.71,-32.76,;10.04,-31.99,)| Show InChI InChI=1S/C18H15N5O2/c1-9-6-7-10(24)8-13(9)23-16(19)14(17(20)25)15-18(23)22-12-5-3-2-4-11(12)21-15/h2-8,24H,19H2,1H3,(H2,20,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100326 (CHEMBL3321812) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(4.06,-42.16,;5.56,-42.48,;6.04,-43.95,;7.55,-44.27,;8.58,-43.13,;10.08,-43.45,;10.56,-44.91,;9.53,-46.05,;12.06,-45.23,;13.08,-44.09,;14.59,-44.4,;15.07,-45.87,;14.04,-47.02,;12.53,-46.7,;14.51,-48.48,;13.48,-49.63,;16.02,-48.8,;15.28,-49.81,;8.1,-41.66,;6.59,-41.34,;6.12,-39.88,;7.02,-38.63,;8.56,-38.63,;6.12,-37.38,;6.59,-35.92,;8.08,-35.52,;5.56,-34.77,;4.65,-37.86,;3.32,-37.09,;1.99,-37.86,;.65,-37.09,;-.69,-37.86,;-.69,-39.4,;.65,-40.17,;1.99,-39.4,;3.32,-40.17,;4.65,-39.4,)| Show InChI InChI=1S/C26H19F3N6O2/c1-13-9-10-16(32-25(37)14-5-4-6-15(11-14)26(27,28)29)12-19(13)35-22(30)20(23(31)36)21-24(35)34-18-8-3-2-7-17(18)33-21/h2-12H,30H2,1H3,(H2,31,36)(H,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100327 (CHEMBL3321813) Show SMILES NC(=O)c1c(N)n(-c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2F)c2nc3ccccc3nc12 |(24.7,-37.03,;23.21,-37.43,;22.18,-36.28,;22.74,-38.89,;23.64,-40.14,;25.18,-40.14,;22.74,-41.38,;23.21,-42.85,;24.72,-43.17,;25.2,-44.63,;26.7,-44.95,;27.18,-46.42,;26.15,-47.56,;28.69,-46.74,;29.71,-45.6,;31.21,-45.91,;31.69,-47.38,;30.66,-48.53,;29.16,-48.21,;31.14,-49.99,;30.1,-51.13,;32.64,-50.31,;31.9,-51.32,;24.17,-45.78,;22.66,-45.46,;22.18,-43.99,;20.68,-43.67,;21.27,-40.91,;19.94,-41.68,;18.61,-40.91,;17.27,-41.68,;15.94,-40.91,;15.94,-39.37,;17.27,-38.6,;18.61,-39.37,;19.94,-38.6,;21.27,-39.37,)| Show InChI InChI=1S/C25H16F4N6O2/c26-15-9-8-14(32-24(37)12-4-3-5-13(10-12)25(27,28)29)11-18(15)35-21(30)19(22(31)36)20-23(35)34-17-7-2-1-6-16(17)33-20/h1-11H,30H2,(H2,31,36)(H,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100340 (CHEMBL3321816) Show SMILES NC(=O)c1c(N)n(-c2cccc(c2)C(=O)Nc2cccc(c2)C(F)(F)F)c2nc3ccccc3nc12 Show InChI InChI=1S/C25H17F3N6O2/c26-25(27,28)14-6-4-7-15(12-14)31-24(36)13-5-3-8-16(11-13)34-21(29)19(22(30)35)20-23(34)33-18-10-2-1-9-17(18)32-20/h1-12H,29H2,(H2,30,35)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100325 (CHEMBL3321811) Show SMILES NC(=O)c1c(N)n(-c2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)c2nc3ccccc3nc12 Show InChI InChI=1S/C25H17F3N6O2/c26-25(27,28)14-6-3-5-13(11-14)24(36)31-15-7-4-8-16(12-15)34-21(29)19(22(30)35)20-23(34)33-18-10-2-1-9-17(18)32-20/h1-12H,29H2,(H2,30,35)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100382 (CHEMBL3321817) Show SMILES Cc1ccc(cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12)C(=O)Nc1cccc(c1)C(F)(F)F |(1.14,-21.09,;2.65,-21.41,;3.12,-22.87,;4.63,-23.19,;5.66,-22.05,;5.18,-20.58,;3.68,-20.26,;3.2,-18.8,;4.11,-17.55,;5.65,-17.55,;3.2,-16.31,;3.68,-14.84,;5.16,-14.44,;2.65,-13.7,;1.74,-16.78,;.4,-16.01,;-.94,-16.78,;-2.28,-16.01,;-3.6,-16.78,;-3.6,-18.32,;-2.28,-19.09,;-.94,-18.32,;.4,-19.09,;1.74,-18.32,;7.17,-22.37,;8.2,-21.22,;7.64,-23.83,;9.15,-24.15,;10.17,-23.01,;11.67,-23.32,;12.15,-24.79,;11.12,-25.94,;9.62,-25.62,;11.6,-27.4,;10.57,-28.55,;13.1,-27.72,;11.99,-28.89,)| Show InChI InChI=1S/C26H19F3N6O2/c1-13-9-10-14(25(37)32-16-6-4-5-15(12-16)26(27,28)29)11-19(13)35-22(30)20(23(31)36)21-24(35)34-18-8-3-2-7-17(18)33-21/h2-12H,30H2,1H3,(H2,31,36)(H,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100383 (CHEMBL3321818) Show SMILES NC(=O)c1c(N)n(-c2cc(ccc2F)C(=O)Nc2cccc(c2)C(F)(F)F)c2nc3ccccc3nc12 |(23.12,-14.22,;21.64,-14.62,;20.61,-13.47,;21.16,-16.08,;22.06,-17.33,;23.6,-17.33,;21.16,-18.57,;21.64,-20.04,;23.14,-20.36,;23.62,-21.82,;22.59,-22.97,;21.08,-22.65,;20.61,-21.18,;19.1,-20.86,;25.12,-22.14,;26.15,-21,;25.6,-23.61,;27.11,-23.93,;28.13,-22.78,;29.63,-23.1,;30.11,-24.57,;29.08,-25.71,;27.58,-25.39,;29.56,-27.18,;28.53,-28.32,;31.06,-27.5,;29.95,-28.66,;19.7,-18.1,;18.36,-18.87,;17.03,-18.1,;15.69,-18.87,;14.36,-18.1,;14.36,-16.56,;15.69,-15.79,;17.03,-16.56,;18.36,-15.79,;19.7,-16.56,)| Show InChI InChI=1S/C25H16F4N6O2/c26-15-9-8-12(24(37)32-14-5-3-4-13(11-14)25(27,28)29)10-18(15)35-21(30)19(22(31)36)20-23(35)34-17-7-2-1-6-16(17)33-20/h1-11H,30H2,(H2,31,36)(H,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100317 (CHEMBL3321822) Show SMILES NC(=O)c1c(N)n(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2nc3ccccc3nc12 Show InChI InChI=1S/C25H18F3N7O2/c26-25(27,28)13-4-3-5-15(12-13)32-24(37)31-14-8-10-16(11-9-14)35-21(29)19(22(30)36)20-23(35)34-18-7-2-1-6-17(18)33-20/h1-12H,29H2,(H2,30,36)(H2,31,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100324 (CHEMBL3321804) Show SMILES Cc1ccc(CO)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(17.1,-32.34,;18.6,-32.66,;19.08,-34.12,;20.58,-34.45,;21.62,-33.3,;23.13,-33.62,;23.61,-35.08,;21.14,-31.84,;19.63,-31.52,;19.16,-30.05,;20.06,-28.81,;21.6,-28.81,;19.16,-27.56,;19.63,-26.09,;21.12,-25.7,;18.6,-24.95,;17.69,-28.04,;16.36,-27.27,;15.02,-28.04,;13.69,-27.27,;12.36,-28.04,;12.36,-29.58,;13.69,-30.35,;15.02,-29.58,;16.36,-30.35,;17.69,-29.58,)| Show InChI InChI=1S/C19H17N5O2/c1-10-6-7-11(9-25)8-14(10)24-17(20)15(18(21)26)16-19(24)23-13-5-3-2-4-12(13)22-16/h2-8,25H,9,20H2,1H3,(H2,21,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100328 (CHEMBL3321814) Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(12.67,-33.82,;12.52,-35.36,;11.19,-36.13,;11.51,-37.64,;13.04,-37.79,;13.66,-36.38,;10.49,-38.79,;8.99,-38.47,;7.97,-39.61,;8.44,-41.08,;9.94,-41.4,;10.97,-40.26,;10.42,-42.87,;9.38,-44.01,;11.92,-43.19,;11.18,-44.19,;6.46,-39.29,;5.43,-40.44,;5.98,-37.83,;4.48,-37.51,;3.45,-38.65,;1.94,-38.33,;1.46,-36.87,;-.05,-36.55,;2.49,-35.72,;4,-36.04,;2.02,-34.26,;2.92,-33.01,;4.46,-33.01,;2.02,-31.77,;2.49,-30.3,;3.98,-29.91,;1.46,-29.16,;.55,-32.24,;-.79,-31.47,;-2.12,-32.24,;-3.46,-31.47,;-4.79,-32.24,;-4.79,-33.78,;-3.46,-34.55,;-2.12,-33.78,;-.79,-34.55,;.55,-33.78,)| Show InChI InChI=1S/C30H23F3N8O2/c1-15-7-8-19(37-29(43)17-9-18(30(31,32)33)11-20(10-17)40-13-16(2)36-14-40)12-23(15)41-26(34)24(27(35)42)25-28(41)39-22-6-4-3-5-21(22)38-25/h3-14H,34H2,1-2H3,(H2,35,42)(H,37,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100319 (CHEMBL3321800) Show SMILES Cc1ccccc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(9.69,-38.66,;11.2,-38.98,;11.68,-40.44,;13.18,-40.76,;14.22,-39.62,;13.73,-38.16,;12.23,-37.83,;11.75,-36.37,;12.66,-35.13,;14.2,-35.13,;11.75,-33.88,;12.23,-32.41,;11.2,-31.27,;13.72,-32.02,;10.29,-34.35,;8.95,-33.59,;7.62,-34.35,;6.29,-33.59,;4.96,-34.35,;4.96,-35.89,;6.29,-36.67,;7.62,-35.89,;8.95,-36.67,;10.29,-35.89,)| Show InChI InChI=1S/C18H15N5O/c1-10-6-2-5-9-13(10)23-16(19)14(17(20)24)15-18(23)22-12-8-4-3-7-11(12)21-15/h2-9H,19H2,1H3,(H2,20,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100384 (CHEMBL3321819) Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(c2)-n2c(N)c(C(N)=O)c3nc4ccccc4nc23)cc(c1)C(F)(F)F |(16.38,-35.15,;16.23,-36.68,;14.9,-37.45,;15.22,-38.96,;16.75,-39.11,;17.37,-37.7,;14.2,-40.11,;12.7,-39.79,;11.68,-40.94,;10.17,-40.62,;9.69,-39.15,;10.72,-38.01,;8.19,-38.83,;7.16,-39.98,;5.65,-39.66,;5.17,-38.19,;3.67,-37.87,;6.2,-37.05,;7.71,-37.37,;5.73,-35.58,;6.63,-34.34,;8.17,-34.34,;5.73,-33.09,;6.2,-31.63,;7.69,-31.23,;5.17,-30.48,;4.26,-33.57,;2.93,-32.8,;1.6,-33.57,;.26,-32.8,;-1.08,-33.57,;-1.08,-35.11,;.26,-35.88,;1.6,-35.11,;2.93,-35.88,;4.26,-35.11,;12.15,-42.4,;13.65,-42.72,;14.68,-41.58,;14.13,-44.19,;13.09,-45.33,;15.63,-44.51,;14.52,-45.67,)| Show InChI InChI=1S/C30H23F3N8O2/c1-15-7-8-17(29(43)37-19-10-18(30(31,32)33)11-20(12-19)40-13-16(2)36-14-40)9-23(15)41-26(34)24(27(35)42)25-28(41)39-22-6-4-3-5-21(22)38-25/h3-14H,34H2,1-2H3,(H2,35,42)(H,37,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100318 (CHEMBL3321823) Show SMILES NC(=O)c1c(N)n(-c2ccc(NC(=S)Nc3cccc(c3)C(F)(F)F)cc2)c2nc3ccccc3nc12 Show InChI InChI=1S/C25H18F3N7OS/c26-25(27,28)13-4-3-5-15(12-13)32-24(37)31-14-8-10-16(11-9-14)35-21(29)19(22(30)36)20-23(35)34-18-7-2-1-6-17(18)33-20/h1-12H,29H2,(H2,30,36)(H2,31,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100323 (CHEMBL3321803) Show SMILES COc1ccc(C)c(c1)-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(11.88,-35.21,;11.41,-33.74,;9.9,-33.43,;8.86,-34.57,;7.36,-34.25,;6.88,-32.78,;5.37,-32.46,;7.91,-31.64,;9.42,-31.96,;7.44,-30.18,;8.34,-28.94,;9.88,-28.94,;7.44,-27.68,;7.91,-26.22,;9.4,-25.82,;6.88,-25.07,;5.97,-28.16,;4.64,-27.39,;3.3,-28.16,;1.97,-27.39,;.64,-28.16,;.64,-29.7,;1.97,-30.48,;3.3,-29.7,;4.64,-30.48,;5.97,-29.7,)| Show InChI InChI=1S/C19H17N5O2/c1-10-7-8-11(26-2)9-14(10)24-17(20)15(18(21)25)16-19(24)23-13-6-4-3-5-12(13)22-16/h3-9H,20H2,1-2H3,(H2,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100322 (CHEMBL3321802) Show SMILES Cc1cccc(Cl)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(9.46,-36.08,;10.96,-36.4,;11.44,-37.87,;12.95,-38.19,;13.98,-37.04,;13.5,-35.58,;14.53,-34.43,;11.99,-35.26,;11.52,-33.79,;12.42,-32.55,;13.96,-32.55,;11.52,-31.3,;11.99,-29.84,;13.48,-29.44,;10.96,-28.69,;10.05,-31.78,;8.72,-31.01,;7.39,-31.78,;6.05,-31.01,;4.72,-31.78,;4.72,-33.32,;6.05,-34.09,;7.39,-33.32,;8.72,-34.09,;10.05,-33.32,)| Show InChI InChI=1S/C18H14ClN5O/c1-9-5-4-6-10(19)15(9)24-16(20)13(17(21)25)14-18(24)23-12-8-3-2-7-11(12)22-14/h2-8H,20H2,1H3,(H2,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50100321 (CHEMBL3321801) Show SMILES Cc1cccc(C)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(14.14,-36.13,;13.11,-37.27,;13.59,-38.74,;12.55,-39.88,;11.05,-39.56,;10.57,-38.1,;9.07,-37.78,;11.6,-36.95,;11.13,-35.49,;12.03,-34.25,;13.57,-34.25,;11.13,-33,;11.6,-31.53,;13.09,-31.13,;10.57,-30.39,;9.66,-33.47,;8.33,-32.7,;6.99,-33.47,;5.66,-32.7,;4.33,-33.47,;4.33,-35.01,;5.66,-35.79,;6.99,-35.01,;8.33,-35.79,;9.66,-35.01,)| Show InChI InChI=1S/C19H17N5O/c1-10-6-5-7-11(2)16(10)24-17(20)14(18(21)25)15-19(24)23-13-9-4-3-8-12(13)22-15/h3-9H,20H2,1-2H3,(H2,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISA				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 (Homo sapiens (Human))	BDBM50100317 (CHEMBL3321822) Show SMILES NC(=O)c1c(N)n(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2nc3ccccc3nc12 Show InChI InChI=1S/C25H18F3N7O2/c26-25(27,28)13-4-3-5-15(12-13)32-24(37)31-14-8-10-16(11-9-14)35-21(29)19(22(30)36)20-23(35)34-18-7-2-1-6-17(18)33-20/h1-12H,29H2,(H2,30,36)(H2,31,32,37)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	39.3	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Binding affinity to EphA3 (unknown origin) by surface plasmon resonance				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Ephrin type-A receptor 3 (Homo sapiens (Human))	BDBM50100316 (CHEMBL3321809) Show SMILES Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12 |(9.45,-34.75,;10.95,-35.07,;11.43,-36.54,;12.94,-36.86,;13.97,-35.71,;15.47,-36.03,;13.49,-34.25,;11.98,-33.93,;11.51,-32.46,;12.41,-31.22,;13.95,-31.22,;11.51,-29.97,;11.98,-28.51,;13.47,-28.11,;10.95,-27.36,;10.04,-30.45,;8.71,-29.68,;7.38,-30.45,;6.04,-29.68,;4.71,-30.45,;4.71,-31.99,;6.04,-32.76,;7.38,-31.99,;8.71,-32.76,;10.04,-31.99,)| Show InChI InChI=1S/C18H15N5O2/c1-9-6-7-10(24)8-13(9)23-16(19)14(17(20)25)15-18(23)22-12-5-3-2-4-11(12)21-15/h2-8,24H,19H2,1H3,(H2,20,25)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Binding affinity to EphA3 (unknown origin) by surface plasmon resonance				J Med Chem 57: 6834-44 (2014) Article DOI: 10.1021/jm5009242 BindingDB Entry DOI: 10.7270/Q2TQ638D
					More data for this Ligand-Target Pair