Found 97 hits with Last Name = 'fukuyama' and Initial = 't' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490579
(CHEMBL2337154)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H](CO)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C72H111N13O14/c1-37(87)74-51-25-3-14-40(51)64(91)78-53-27-5-16-42(53)63(90)75-38(36-86)35-61(88)76-52-26-4-15-41(52)65(92)79-55-29-7-18-44(55)67(94)81-57-31-9-20-46(57)69(96)83-59-33-11-22-48(59)71(98)85-60-34-12-23-49(60)72(99)84-58-32-10-21-47(58)70(97)82-56-30-8-19-45(56)68(95)80-54-28-6-17-43(54)66(93)77-50-24-2-13-39(50)62(73)89/h38-60,86H,2-36H2,1H3,(H2,73,89)(H,74,87)(H,75,90)(H,76,88)(H,77,93)(H,78,91)(H,79,92)(H,80,95)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.402 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490580
(CHEMBL2337153)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C73H112N14O14/c1-37(88)76-51-25-3-14-40(51)65(93)80-53-27-5-16-42(53)64(92)77-38(35-61(74)89)36-62(90)78-52-26-4-15-41(52)66(94)81-55-29-7-18-44(55)68(96)83-57-31-9-20-46(57)70(98)85-59-33-11-22-48(59)72(100)87-60-34-12-23-49(60)73(101)86-58-32-10-21-47(58)71(99)84-56-30-8-19-45(56)69(97)82-54-28-6-17-43(54)67(95)79-50-24-2-13-39(50)63(75)91/h38-60H,2-36H2,1H3,(H2,74,89)(H2,75,91)(H,76,88)(H,77,92)(H,78,90)(H,79,95)(H,80,93)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)(H,86,101)(H,87,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.555 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490579
(CHEMBL2337154)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H](CO)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C72H111N13O14/c1-37(87)74-51-25-3-14-40(51)64(91)78-53-27-5-16-42(53)63(90)75-38(36-86)35-61(88)76-52-26-4-15-41(52)65(92)79-55-29-7-18-44(55)67(94)81-57-31-9-20-46(57)69(96)83-59-33-11-22-48(59)71(98)85-60-34-12-23-49(60)72(99)84-58-32-10-21-47(58)70(97)82-56-30-8-19-45(56)68(95)80-54-28-6-17-43(54)66(93)77-50-24-2-13-39(50)62(73)89/h38-60,86H,2-36H2,1H3,(H2,73,89)(H,74,87)(H,75,90)(H,76,88)(H,77,93)(H,78,91)(H,79,92)(H,80,95)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490580
(CHEMBL2337153)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C73H112N14O14/c1-37(88)76-51-25-3-14-40(51)65(93)80-53-27-5-16-42(53)64(92)77-38(35-61(74)89)36-62(90)78-52-26-4-15-41(52)66(94)81-55-29-7-18-44(55)68(96)83-57-31-9-20-46(57)70(98)85-59-33-11-22-48(59)72(100)87-60-34-12-23-49(60)73(101)86-58-32-10-21-47(58)71(99)84-56-30-8-19-45(56)69(97)82-54-28-6-17-43(54)67(95)79-50-24-2-13-39(50)63(75)91/h38-60H,2-36H2,1H3,(H2,74,89)(H2,75,91)(H,76,88)(H,77,92)(H,78,90)(H,79,95)(H,80,93)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)(H,86,101)(H,87,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490588
(CHEMBL2336728)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)NCCC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C71H109N13O13/c1-37(85)74-50-25-4-15-40(50)63(89)77-52-27-3-14-39(52)62(88)73-36-35-60(86)75-51-26-5-16-41(51)64(90)78-54-29-7-18-43(54)66(92)80-56-31-9-20-45(56)68(94)82-58-33-11-22-47(58)70(96)84-59-34-12-23-48(59)71(97)83-57-32-10-21-46(57)69(95)81-55-30-8-19-44(55)67(93)79-53-28-6-17-42(53)65(91)76-49-24-2-13-38(49)61(72)87/h38-59H,2-36H2,1H3,(H2,72,87)(H,73,88)(H,74,85)(H,75,86)(H,76,91)(H,77,89)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189039
(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)Show SMILES CC(N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(cc1OCCCN1CCCC1)C(=O)c1ccc(COC(=O)NCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1 Show InChI InChI=1S/C51H61ClF2N6O8S2/c1-34(60(44-31-39(53)19-23-42(44)54)70(65,66)40-20-17-38(52)18-21-40)41-22-16-37(30-45(41)67-29-9-28-59-26-7-8-27-59)49(62)36-14-12-35(13-15-36)32-68-51(64)56-25-6-2-5-24-55-47(61)11-4-3-10-46-48-43(33-69-46)57-50(63)58-48/h12-23,30-31,34,43,46,48H,2-11,24-29,32-33H2,1H3,(H,55,61)(H,56,64)(H2,57,58,63)/t34?,43-,46-,48-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490580
(CHEMBL2337153)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C73H112N14O14/c1-37(88)76-51-25-3-14-40(51)65(93)80-53-27-5-16-42(53)64(92)77-38(35-61(74)89)36-62(90)78-52-26-4-15-41(52)66(94)81-55-29-7-18-44(55)68(96)83-57-31-9-20-46(57)70(98)85-59-33-11-22-48(59)72(100)87-60-34-12-23-49(60)73(101)86-58-32-10-21-47(58)71(99)84-56-30-8-19-45(56)69(97)82-54-28-6-17-43(54)67(95)79-50-24-2-13-39(50)63(75)91/h38-60H,2-36H2,1H3,(H2,74,89)(H2,75,91)(H,76,88)(H,77,92)(H,78,90)(H,79,95)(H,80,93)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)(H,86,101)(H,87,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189028
(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)Show SMILES CC(N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(cc1OCCCN1CCCC1)C(=O)c1ccc(COC(=O)NCCCCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1 Show InChI InChI=1S/C54H67ClF2N6O8S2/c1-37(63(47-34-42(56)22-26-45(47)57)73(68,69)43-23-20-41(55)21-24-43)44-25-19-40(33-48(44)70-32-12-31-62-29-10-11-30-62)52(65)39-17-15-38(16-18-39)35-71-54(67)59-28-9-5-3-2-4-8-27-58-50(64)14-7-6-13-49-51-46(36-72-49)60-53(66)61-51/h15-26,33-34,37,46,49,51H,2-14,27-32,35-36H2,1H3,(H,58,64)(H,59,67)(H2,60,61,66)/t37?,46-,49-,51-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490588
(CHEMBL2336728)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)NCCC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C71H109N13O13/c1-37(85)74-50-25-4-15-40(50)63(89)77-52-27-3-14-39(52)62(88)73-36-35-60(86)75-51-26-5-16-41(51)64(90)78-54-29-7-18-43(54)66(92)80-56-31-9-20-45(56)68(94)82-58-33-11-22-47(58)70(96)84-59-34-12-23-48(59)71(97)83-57-32-10-21-46(57)69(95)81-55-30-8-19-44(55)67(93)79-53-28-6-17-42(53)65(91)76-49-24-2-13-38(49)61(72)87/h38-59H,2-36H2,1H3,(H2,72,87)(H,73,88)(H,74,85)(H,75,86)(H,76,91)(H,77,89)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490578
(CHEMBL2337566)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C74H113N13O13/c1-38(88)76-52-27-3-15-40(52)64(90)78-54-29-5-17-42(54)66(92)80-56-31-7-19-44(56)68(94)82-58-33-9-21-46(58)70(96)84-60-35-11-23-48(60)72(98)86-62-37-13-25-50(62)74(100)87-61-36-12-24-49(61)73(99)85-59-34-10-22-47(59)71(97)83-57-32-8-20-45(57)69(95)81-55-30-6-18-43(55)67(93)79-53-28-4-16-41(53)65(91)77-51-26-2-14-39(51)63(75)89/h39-62H,2-37H2,1H3,(H2,75,89)(H,76,88)(H,77,91)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)(H,85,99)(H,86,98)(H,87,100)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490578
(CHEMBL2337566)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C74H113N13O13/c1-38(88)76-52-27-3-15-40(52)64(90)78-54-29-5-17-42(54)66(92)80-56-31-7-19-44(56)68(94)82-58-33-9-21-46(58)70(96)84-60-35-11-23-48(60)72(98)86-62-37-13-25-50(62)74(100)87-61-36-12-24-49(61)73(99)85-59-34-10-22-47(59)71(97)83-57-32-8-20-45(57)69(95)81-55-30-6-18-43(55)67(93)79-53-28-4-16-41(53)65(91)77-51-26-2-14-39(51)63(75)89/h39-62H,2-37H2,1H3,(H2,75,89)(H,76,88)(H,77,91)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)(H,85,99)(H,86,98)(H,87,100)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189036
(4-chloro-N-phenyl-N-(1-(2-(3-(pyrrolidin-1-yl)prop...)Show SMILES CC(N(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H31ClN2O3S/c1-22(26-12-5-6-13-27(26)33-21-9-20-29-18-7-8-19-29)30(24-10-3-2-4-11-24)34(31,32)25-16-14-23(28)15-17-25/h2-6,10-17,22H,7-9,18-21H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189041
(CHEMBL269580 | N-(5-(2-(4-(N-(1-(4-benzoyl-2-(3-(p...)Show SMILES CC(N(c1cc(F)c(OCC(=O)NCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(cc1OCCCN1CCCC1)C(=O)c1ccccc1 Show InChI InChI=1S/C51H61ClF2N6O8S2/c1-34(39-22-17-36(50(63)35-13-4-2-5-14-35)29-44(39)67-28-12-27-59-25-10-11-26-59)60(70(65,66)38-20-18-37(52)19-21-38)43-30-41(54)45(31-40(43)53)68-32-48(62)56-24-9-3-8-23-55-47(61)16-7-6-15-46-49-42(33-69-46)57-51(64)58-49/h2,4-5,13-14,17-22,29-31,34,42,46,49H,3,6-12,15-16,23-28,32-33H2,1H3,(H,55,61)(H,56,62)(H2,57,58,64)/t34?,42-,46-,49-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490578
(CHEMBL2337566)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C74H113N13O13/c1-38(88)76-52-27-3-15-40(52)64(90)78-54-29-5-17-42(54)66(92)80-56-31-7-19-44(56)68(94)82-58-33-9-21-46(58)70(96)84-60-35-11-23-48(60)72(98)86-62-37-13-25-50(62)74(100)87-61-36-12-24-49(61)73(99)85-59-34-10-22-47(59)71(97)83-57-32-8-20-45(57)69(95)81-55-30-6-18-43(55)67(93)79-53-28-4-16-41(53)65(91)77-51-26-2-14-39(51)63(75)89/h39-62H,2-37H2,1H3,(H2,75,89)(H,76,88)(H,77,91)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)(H,85,99)(H,86,98)(H,87,100)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189031
(CHEMBL266043 | N-(8-(2-(4-(N-(1-(4-benzoyl-2-(3-(p...)Show SMILES CC(N(c1cc(F)c(OCC(=O)NCCCCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(cc1OCCCN1CCCC1)C(=O)c1ccccc1 Show InChI InChI=1S/C54H67ClF2N6O8S2/c1-37(42-25-20-39(53(66)38-16-7-6-8-17-38)32-47(42)70-31-15-30-62-28-13-14-29-62)63(73(68,69)41-23-21-40(55)22-24-41)46-33-44(57)48(34-43(46)56)71-35-51(65)59-27-12-5-3-2-4-11-26-58-50(64)19-10-9-18-49-52-45(36-72-49)60-54(67)61-52/h6-8,16-17,20-25,32-34,37,45,49,52H,2-5,9-15,18-19,26-31,35-36H2,1H3,(H,58,64)(H,59,65)(H2,60,61,67)/t37?,45-,49-,52-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490579
(CHEMBL2337154)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H](CO)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C72H111N13O14/c1-37(87)74-51-25-3-14-40(51)64(91)78-53-27-5-16-42(53)63(90)75-38(36-86)35-61(88)76-52-26-4-15-41(52)65(92)79-55-29-7-18-44(55)67(94)81-57-31-9-20-46(57)69(96)83-59-33-11-22-48(59)71(98)85-60-34-12-23-49(60)72(99)84-58-32-10-21-47(58)70(97)82-56-30-8-19-45(56)68(95)80-54-28-6-17-43(54)66(93)77-50-24-2-13-39(50)62(73)89/h38-60,86H,2-36H2,1H3,(H2,73,89)(H,74,87)(H,75,90)(H,76,88)(H,77,93)(H,78,91)(H,79,92)(H,80,95)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit PEN-2
(Homo sapiens (Human)) | BDBM50143556
((S)-2-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]...)Show SMILES C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)(C)C Show InChI InChI=1S/C24H28F2N2O4/c1-15(27-21(29)13-17-10-18(25)14-19(26)11-17)22(30)28-20(23(31)32-24(2,3)4)12-16-8-6-5-7-9-16/h5-11,14-15,20H,12-13H2,1-4H3,(H,27,29)(H,28,30)/t15-,20-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against gamma-secretase |
Bioorg Med Chem Lett 14: 1983-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.067 BindingDB Entry DOI: 10.7270/Q2R78DPT |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490580
(CHEMBL2337153)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C73H112N14O14/c1-37(88)76-51-25-3-14-40(51)65(93)80-53-27-5-16-42(53)64(92)77-38(35-61(74)89)36-62(90)78-52-26-4-15-41(52)66(94)81-55-29-7-18-44(55)68(96)83-57-31-9-20-46(57)70(98)85-59-33-11-22-48(59)72(100)87-60-34-12-23-49(60)73(101)86-58-32-10-21-47(58)71(99)84-56-30-8-19-45(56)69(97)82-54-28-6-17-43(54)67(95)79-50-24-2-13-39(50)63(75)91/h38-60H,2-36H2,1H3,(H2,74,89)(H2,75,91)(H,76,88)(H,77,92)(H,78,90)(H,79,95)(H,80,93)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)(H,86,101)(H,87,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490579
(CHEMBL2337154)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H](CO)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C72H111N13O14/c1-37(87)74-51-25-3-14-40(51)64(91)78-53-27-5-16-42(53)63(90)75-38(36-86)35-61(88)76-52-26-4-15-41(52)65(92)79-55-29-7-18-44(55)67(94)81-57-31-9-20-46(57)69(96)83-59-33-11-22-48(59)71(98)85-60-34-12-23-49(60)72(99)84-58-32-10-21-47(58)70(97)82-56-30-8-19-45(56)68(95)80-54-28-6-17-43(54)66(93)77-50-24-2-13-39(50)62(73)89/h38-60,86H,2-36H2,1H3,(H2,73,89)(H,74,87)(H,75,90)(H,76,88)(H,77,93)(H,78,91)(H,79,92)(H,80,95)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490580
(CHEMBL2337153)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C73H112N14O14/c1-37(88)76-51-25-3-14-40(51)65(93)80-53-27-5-16-42(53)64(92)77-38(35-61(74)89)36-62(90)78-52-26-4-15-41(52)66(94)81-55-29-7-18-44(55)68(96)83-57-31-9-20-46(57)70(98)85-59-33-11-22-48(59)72(100)87-60-34-12-23-49(60)73(101)86-58-32-10-21-47(58)71(99)84-56-30-8-19-45(56)69(97)82-54-28-6-17-43(54)67(95)79-50-24-2-13-39(50)63(75)91/h38-60H,2-36H2,1H3,(H2,74,89)(H2,75,91)(H,76,88)(H,77,92)(H,78,90)(H,79,95)(H,80,93)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)(H,86,101)(H,87,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490579
(CHEMBL2337154)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H](CO)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C72H111N13O14/c1-37(87)74-51-25-3-14-40(51)64(91)78-53-27-5-16-42(53)63(90)75-38(36-86)35-61(88)76-52-26-4-15-41(52)65(92)79-55-29-7-18-44(55)67(94)81-57-31-9-20-46(57)69(96)83-59-33-11-22-48(59)71(98)85-60-34-12-23-49(60)72(99)84-58-32-10-21-47(58)70(97)82-56-30-8-19-45(56)68(95)80-54-28-6-17-43(54)66(93)77-50-24-2-13-39(50)62(73)89/h38-60,86H,2-36H2,1H3,(H2,73,89)(H,74,87)(H,75,90)(H,76,88)(H,77,93)(H,78,91)(H,79,92)(H,80,95)(H,81,94)(H,82,97)(H,83,96)(H,84,99)(H,85,98)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189045
(CHEMBL373983 | N-(1-(4-benzoyl-2-(3-(pyrrolidin-1-...)Show SMILES CC(N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(cc1OCCCN1CCCC1)C(=O)c1ccccc1 Show InChI InChI=1S/C34H33ClF2N2O4S/c1-24(39(32-23-28(36)13-17-31(32)37)44(41,42)29-14-11-27(35)12-15-29)30-16-10-26(34(40)25-8-3-2-4-9-25)22-33(30)43-21-7-20-38-18-5-6-19-38/h2-4,8-17,22-24H,5-7,18-21H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM28922
((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)Show SMILES OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 203 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490586
(CHEMBL2337559)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C68H104N12O12/c1-35(81)70-48-25-3-14-37(48)59(83)72-50-27-5-16-39(50)61(85)74-52-29-7-18-41(52)63(87)76-54-31-9-20-43(54)65(89)78-56-33-11-22-45(56)67(91)80-57-34-12-23-46(57)68(92)79-55-32-10-21-44(55)66(90)77-53-30-8-19-42(53)64(88)75-51-28-6-17-40(51)62(86)73-49-26-4-15-38(49)60(84)71-47-24-2-13-36(47)58(69)82/h36-57H,2-34H2,1H3,(H2,69,82)(H,70,81)(H,71,84)(H,72,83)(H,73,86)(H,74,85)(H,75,88)(H,76,87)(H,77,90)(H,78,89)(H,79,92)(H,80,91)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490586
(CHEMBL2337559)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C68H104N12O12/c1-35(81)70-48-25-3-14-37(48)59(83)72-50-27-5-16-39(50)61(85)74-52-29-7-18-41(52)63(87)76-54-31-9-20-43(54)65(89)78-56-33-11-22-45(56)67(91)80-57-34-12-23-46(57)68(92)79-55-32-10-21-44(55)66(90)77-53-30-8-19-42(53)64(88)75-51-28-6-17-40(51)62(86)73-49-26-4-15-38(49)60(84)71-47-24-2-13-36(47)58(69)82/h36-57H,2-34H2,1H3,(H2,69,82)(H,70,81)(H,71,84)(H,72,83)(H,73,86)(H,74,85)(H,75,88)(H,76,87)(H,77,90)(H,78,89)(H,79,92)(H,80,91)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189043
(4-fluoro-N-phenyl-N-(1-(2-(3-(pyrrolidin-1-yl)prop...)Show SMILES CC(N(c1ccccc1)S(=O)(=O)c1ccc(F)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H31FN2O3S/c1-22(26-12-5-6-13-27(26)33-21-9-20-29-18-7-8-19-29)30(24-10-3-2-4-11-24)34(31,32)25-16-14-23(28)15-17-25/h2-6,10-17,22H,7-9,18-21H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189048
(CHEMBL385166 | N-phenyl-N-(1-(2-(3-(pyrrolidin-1-y...)Show SMILES CC(N(c1ccccc1)S(=O)(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C28H31F3N2O3S/c1-22(26-12-5-6-13-27(26)36-21-9-20-32-18-7-8-19-32)33(24-10-3-2-4-11-24)37(34,35)25-16-14-23(15-17-25)28(29,30)31/h2-6,10-17,22H,7-9,18-21H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM28922
((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)Show SMILES OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 414 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189029
(4-chloro-N-(2-methoxyphenyl)-N-(1-(2-(3-(pyrrolidi...)Show SMILES COc1ccccc1N(C(C)c1ccccc1OCCCN1CCCC1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H33ClN2O4S/c1-22(25-10-3-5-12-27(25)35-21-9-20-30-18-7-8-19-30)31(26-11-4-6-13-28(26)34-2)36(32,33)24-16-14-23(29)15-17-24/h3-6,10-17,22H,7-9,18-21H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189044
(4-chloro-N-(2-chlorophenyl)-N-(1-(2-(3-(pyrrolidin...)Show SMILES CC(N(c1ccccc1Cl)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H30Cl2N2O3S/c1-21(24-9-2-5-12-27(24)34-20-8-19-30-17-6-7-18-30)31(26-11-4-3-10-25(26)29)35(32,33)23-15-13-22(28)14-16-23/h2-5,9-16,21H,6-8,17-20H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186512
(CHEMBL377810 | benzyl 6-benzyl-2-hydroxy-5-oxo-5,6...)Show SMILES OC1C=CC(=O)C(Cc2ccccc2)N1C(=O)OCc1ccccc1 |c:2| Show InChI InChI=1S/C20H19NO4/c22-18-11-12-19(23)21(17(18)13-15-7-3-1-4-8-15)20(24)25-14-16-9-5-2-6-10-16/h1-12,17,19,23H,13-14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189037
(4-chloro-N-(3-chlorophenyl)-N-(1-(2-(3-(pyrrolidin...)Show SMILES CC(N(c1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H30Cl2N2O3S/c1-21(26-10-2-3-11-27(26)34-19-7-18-30-16-4-5-17-30)31(24-9-6-8-23(29)20-24)35(32,33)25-14-12-22(28)13-15-25/h2-3,6,8-15,20-21H,4-5,7,16-19H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189046
(4-chloro-N-(3-methoxyphenyl)-N-(1-(2-(3-(pyrrolidi...)Show SMILES COc1cccc(c1)N(C(C)c1ccccc1OCCCN1CCCC1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H33ClN2O4S/c1-22(27-11-3-4-12-28(27)35-20-8-19-30-17-5-6-18-30)31(24-9-7-10-25(21-24)34-2)36(32,33)26-15-13-23(29)14-16-26/h3-4,7,9-16,21-22H,5-6,8,17-20H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490578
(CHEMBL2337566)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C74H113N13O13/c1-38(88)76-52-27-3-15-40(52)64(90)78-54-29-5-17-42(54)66(92)80-56-31-7-19-44(56)68(94)82-58-33-9-21-46(58)70(96)84-60-35-11-23-48(60)72(98)86-62-37-13-25-50(62)74(100)87-61-36-12-24-49(61)73(99)85-59-34-10-22-47(59)71(97)83-57-32-8-20-45(57)69(95)81-55-30-6-18-43(55)67(93)79-53-28-4-16-41(53)65(91)77-51-26-2-14-39(51)63(75)89/h39-62H,2-37H2,1H3,(H2,75,89)(H,76,88)(H,77,91)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)(H,85,99)(H,86,98)(H,87,100)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 626 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189026
(CHEMBL211428 | N-phenyl-N-(1-(2-(3-(pyrrolidin-1-y...)Show SMILES CC(N(c1ccccc1)S(=O)(=O)c1ccccc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H32N2O3S/c1-23(26-17-8-9-18-27(26)32-22-12-21-28-19-10-11-20-28)29(24-13-4-2-5-14-24)33(30,31)25-15-6-3-7-16-25/h2-9,13-18,23H,10-12,19-22H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186512
(CHEMBL377810 | benzyl 6-benzyl-2-hydroxy-5-oxo-5,6...)Show SMILES OC1C=CC(=O)C(Cc2ccccc2)N1C(=O)OCc1ccccc1 |c:2| Show InChI InChI=1S/C20H19NO4/c22-18-11-12-19(23)21(17(18)13-15-7-3-1-4-8-15)20(24)25-14-16-9-5-2-6-10-16/h1-12,17,19,23H,13-14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 42 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186500
(1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one | ...)Show InChI InChI=1S/C19H17NO2/c21-18-12-7-13-20(19(22)16-10-5-2-6-11-16)17(18)14-15-8-3-1-4-9-15/h1-12,17H,13-14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189032
(4-chloro-N-(1-(2-(3-(diethylamino)propoxy)phenyl)e...)Show SMILES CCN(CC)CCCOc1ccccc1C(C)N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C27H31ClF2N2O3S/c1-4-31(5-2)17-8-18-35-27-10-7-6-9-24(27)20(3)32(26-19-22(29)13-16-25(26)30)36(33,34)23-14-11-21(28)12-15-23/h6-7,9-16,19-20H,4-5,8,17-18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186507
((5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone | CHEMB...)Show SMILES O=C1C=CC[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 |c:2| Show InChI InChI=1S/C20H20O3/c21-18-12-7-13-19(22-14-16-8-3-1-4-9-16)20(18)23-15-17-10-5-2-6-11-17/h1-12,19-20H,13-15H2/t19-,20-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 42 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189047
(4-chloro-N-(4-methoxyphenyl)-N-(1-(2-(3-(pyrrolidi...)Show SMILES COc1ccc(cc1)N(C(C)c1ccccc1OCCCN1CCCC1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H33ClN2O4S/c1-22(27-8-3-4-9-28(27)35-21-7-20-30-18-5-6-19-30)31(24-12-14-25(34-2)15-13-24)36(32,33)26-16-10-23(29)11-17-26/h3-4,8-17,22H,5-7,18-21H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490578
(CHEMBL2337566)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C74H113N13O13/c1-38(88)76-52-27-3-15-40(52)64(90)78-54-29-5-17-42(54)66(92)80-56-31-7-19-44(56)68(94)82-58-33-9-21-46(58)70(96)84-60-35-11-23-48(60)72(98)86-62-37-13-25-50(62)74(100)87-61-36-12-24-49(61)73(99)85-59-34-10-22-47(59)71(97)83-57-32-8-20-45(57)69(95)81-55-30-6-18-43(55)67(93)79-53-28-4-16-41(53)65(91)77-51-26-2-14-39(51)63(75)89/h39-62H,2-37H2,1H3,(H2,75,89)(H,76,88)(H,77,91)(H,78,90)(H,79,93)(H,80,92)(H,81,95)(H,82,94)(H,83,97)(H,84,96)(H,85,99)(H,86,98)(H,87,100)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189034
(CHEMBL211955 | N-(2-benzoylphenyl)-4-chloro-N-(1-(...)Show SMILES CC(N(c1ccccc1C(=O)c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C34H35ClN2O4S/c1-26(30-14-6-8-17-33(30)41-25-11-24-36-22-9-10-23-36)37(42(39,40)29-20-18-28(35)19-21-29)32-16-7-5-15-31(32)34(38)27-12-3-2-4-13-27/h2-8,12-21,26H,9-11,22-25H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189040
(4-chloro-N-(4-chlorophenyl)-N-(1-(2-(3-(pyrrolidin...)Show SMILES CC(N(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H30Cl2N2O3S/c1-21(26-7-2-3-8-27(26)34-20-6-19-30-17-4-5-18-30)31(24-13-9-22(28)10-14-24)35(32,33)25-15-11-23(29)12-16-25/h2-3,7-16,21H,4-6,17-20H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186507
((5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone | CHEMB...)Show SMILES O=C1C=CC[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 |c:2| Show InChI InChI=1S/C20H20O3/c21-18-12-7-13-19(22-14-16-8-3-1-4-9-16)20(18)23-15-17-10-5-2-6-11-17/h1-12,19-20H,13-15H2/t19-,20-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189027
(4-bromo-N-phenyl-N-(1-(2-(3-(pyrrolidin-1-yl)propo...)Show SMILES CC(N(c1ccccc1)S(=O)(=O)c1ccc(Br)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H31BrN2O3S/c1-22(26-12-5-6-13-27(26)33-21-9-20-29-18-7-8-19-29)30(24-10-3-2-4-11-24)34(31,32)25-16-14-23(28)15-17-25/h2-6,10-17,22H,7-9,18-21H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189035
(4-chloro-N-(2,5-difluorophenyl)-N-(1-(2-(3-(pyrrol...)Show SMILES CC(N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C27H29ClF2N2O3S/c1-20(24-7-2-3-8-27(24)35-18-6-17-31-15-4-5-16-31)32(26-19-22(29)11-14-25(26)30)36(33,34)23-12-9-21(28)10-13-23/h2-3,7-14,19-20H,4-6,15-18H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189030
(4-chloro-N-(2,5-difluorophenyl)-N-(1-(2-(3-(piperi...)Show SMILES CC(N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCCC1 Show InChI InChI=1S/C28H31ClF2N2O3S/c1-21(25-8-3-4-9-28(25)36-19-7-18-32-16-5-2-6-17-32)33(27-20-23(30)12-15-26(27)31)37(34,35)24-13-10-22(29)11-14-24/h3-4,8-15,20-21H,2,5-7,16-19H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50186500
(1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one | ...)Show InChI InChI=1S/C19H17NO2/c21-18-12-7-13-20(19(22)16-10-5-2-6-11-16)17(18)14-15-8-3-1-4-9-15/h1-12,17H,13-14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 42 |
Bioorg Med Chem Lett 16: 3813-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.025 BindingDB Entry DOI: 10.7270/Q2VM4BVF |
More data for this Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50490581
(CHEMBL2337560)Show SMILES CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(N)=O |r| Show InChI InChI=1S/C62H95N11O11/c1-32(74)64-44-23-3-13-34(44)54(76)66-46-25-5-15-36(46)56(78)68-48-27-7-17-38(48)58(80)70-50-29-9-19-40(50)60(82)72-52-31-11-21-42(52)62(84)73-51-30-10-20-41(51)61(83)71-49-28-8-18-39(49)59(81)69-47-26-6-16-37(47)57(79)67-45-24-4-14-35(45)55(77)65-43-22-2-12-33(43)53(63)75/h33-52H,2-31H2,1H3,(H2,63,75)(H,64,74)(H,65,77)(H,66,76)(H,67,79)(H,68,78)(H,69,81)(H,70,80)(H,71,83)(H,72,82)(H,73,84)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL... |
J Med Chem 56: 1443-54 (2013)
Article DOI: 10.1021/jm301306c BindingDB Entry DOI: 10.7270/Q2251N3J |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50189038
(CHEMBL378664 | N-(3-benzoylphenyl)-4-chloro-N-(1-(...)Show SMILES CC(N(c1cccc(c1)C(=O)c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1OCCCN1CCCC1 Show InChI InChI=1S/C34H35ClN2O4S/c1-26(32-15-5-6-16-33(32)41-24-10-23-36-21-7-8-22-36)37(42(39,40)31-19-17-29(35)18-20-31)30-14-9-13-28(25-30)34(38)27-11-3-2-4-12-27/h2-6,9,11-20,25-26H,7-8,10,21-24H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of beta amyloid protein 40 production |
Bioorg Med Chem Lett 16: 4184-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.091 BindingDB Entry DOI: 10.7270/Q2RF5TN8 |
More data for this Ligand-Target Pair | |