Found 22 hits with Last Name = 'fulcher' and Initial = 'eh' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374555
(REGRELOR DISODIUM)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])([O-])=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C22H25N6O8P/c1-2-23-22(29)27-19-16-20(25-11-24-19)28(12-26-16)21-18-17(14(34-21)10-33-37(30,31)32)35-15(36-18)9-8-13-6-4-3-5-7-13/h3-9,11-12,14-15,17-18,21H,2,10H2,1H3,(H2,30,31,32)(H2,23,24,25,27,29)/p-2/b9-8+/t14-,15+,17-,18-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374558
(CHEMBL255350)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCc2ccccc2C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C30H30N6O7/c1-2-31-30(39)35-26-23-27(33-16-32-26)36(17-34-23)28-25-24(42-22(43-25)13-12-18-8-4-3-5-9-18)21(41-28)15-40-14-19-10-6-7-11-20(19)29(37)38/h3-13,16-17,21-22,24-25,28H,2,14-15H2,1H3,(H,37,38)(H2,31,32,33,35,39)/b13-12+/t21-,22+,24-,25-,28-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374572
(CHEMBL403010)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1)C(O)=O Show InChI InChI=1S/C22H22N6O6/c1-2-23-22(31)27-18-14-19(25-10-24-18)28(11-26-14)20-16-15(17(34-20)21(29)30)32-13(33-16)9-8-12-6-4-3-5-7-12/h3-11,13,15-17,20H,2H2,1H3,(H,29,30)(H2,23,24,25,27,31)/b9-8+/t13-,15-,16+,17-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 201 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374559
(CHEMBL255349)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H26N6O7/c1-2-25-24(33)29-21-18-22(27-12-26-21)30(13-28-18)23-20-19(15(35-23)10-34-11-16(31)32)36-17(37-20)9-8-14-6-4-3-5-7-14/h3-9,12-13,15,17,19-20,23H,2,10-11H2,1H3,(H,31,32)(H2,25,26,27,29,33)/b9-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 243 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374571
(CHEMBL272113)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CCC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H26N6O6/c1-2-25-24(33)29-21-18-22(27-12-26-21)30(13-28-18)23-20-19(15(34-23)9-10-16(31)32)35-17(36-20)11-8-14-6-4-3-5-7-14/h3-8,11-13,15,17,19-20,23H,2,9-10H2,1H3,(H,31,32)(H2,25,26,27,29,33)/b11-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 495 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374566
(CHEMBL272975)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H27N7O6/c1-2-26-24(34)30-21-18-22(28-12-27-21)31(13-29-18)23-20-19(15(35-23)10-25-11-16(32)33)36-17(37-20)9-8-14-6-4-3-5-7-14/h3-9,12-13,15,17,19-20,23,25H,2,10-11H2,1H3,(H,32,33)(H2,26,27,28,30,34)/b9-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 513 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374568
(CHEMBL401780)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CN(CC2CC2C(O)=O)CC2CC2C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:23.26,30.34,28.30,21.22| Show InChI InChI=1S/C32H37N7O8/c1-2-33-32(44)37-27-24-28(35-15-34-27)39(16-36-24)29-26-25(46-23(47-26)9-8-17-6-4-3-5-7-17)22(45-29)14-38(12-18-10-20(18)30(40)41)13-19-11-21(19)31(42)43/h3-9,15-16,18-23,25-26,29H,2,10-14H2,1H3,(H,40,41)(H,42,43)(H2,33,34,35,37,44)/b9-8+/t18?,19?,20?,21?,22-,23+,25-,26-,29-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374557
(CHEMBL267283)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCc2cccc(c2)C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C30H30N6O7/c1-2-31-30(39)35-26-23-27(33-16-32-26)36(17-34-23)28-25-24(42-22(43-25)12-11-18-7-4-3-5-8-18)21(41-28)15-40-14-19-9-6-10-20(13-19)29(37)38/h3-13,16-17,21-22,24-25,28H,2,14-15H2,1H3,(H,37,38)(H2,31,32,33,35,39)/b12-11+/t21-,22+,24-,25-,28-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 616 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374560
(CHEMBL256251)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C23H24N6O6/c1-2-24-23(32)28-20-17-21(26-11-25-20)29(12-27-17)22-19-18(14(33-22)10-15(30)31)34-16(35-19)9-8-13-6-4-3-5-7-13/h3-9,11-12,14,16,18-19,22H,2,10H2,1H3,(H,30,31)(H2,24,25,26,28,32)/b9-8+/t14-,16+,18-,19-,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 663 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374574
(CHEMBL265707)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C22H24N6O5/c1-2-23-22(30)27-19-16-20(25-11-24-19)28(12-26-16)21-18-17(14(10-29)31-21)32-15(33-18)9-8-13-6-4-3-5-7-13/h3-9,11-12,14-15,17-18,21,29H,2,10H2,1H3,(H2,23,24,25,27,30)/b9-8+/t14-,15+,17-,18-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374556
(CHEMBL412171)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCc2ccc(cc2)C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C30H30N6O7/c1-2-31-30(39)35-26-23-27(33-16-32-26)36(17-34-23)28-25-24(42-22(43-25)13-10-18-6-4-3-5-7-18)21(41-28)15-40-14-19-8-11-20(12-9-19)29(37)38/h3-13,16-17,21-22,24-25,28H,2,14-15H2,1H3,(H,37,38)(H2,31,32,33,35,39)/b13-10+/t21-,22+,24-,25-,28-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374565
(CHEMBL403011)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNC(=O)c2cccs2)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C27H27N7O5S/c1-2-28-27(36)33-23-20-24(31-14-30-23)34(15-32-20)26-22-21(17(37-26)13-29-25(35)18-9-6-12-40-18)38-19(39-22)11-10-16-7-4-3-5-8-16/h3-12,14-15,17,19,21-22,26H,2,13H2,1H3,(H,29,35)(H2,28,30,31,33,36)/b11-10+/t17-,19+,21-,22-,26-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374561
(CHEMBL427723)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CS(=O)(=O)CC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H26N6O8S/c1-2-25-24(33)29-21-18-22(27-12-26-21)30(13-28-18)23-20-19(15(36-23)10-39(34,35)11-16(31)32)37-17(38-20)9-8-14-6-4-3-5-7-14/h3-9,12-13,15,17,19-20,23H,2,10-11H2,1H3,(H,31,32)(H2,25,26,27,29,33)/b9-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374564
(CHEMBL255553)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CS(=O)(=O)CC(C)O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:23.26| Show InChI InChI=1S/C25H30N6O7S/c1-3-26-25(33)30-22-19-23(28-13-27-22)31(14-29-19)24-21-20(17(36-24)12-39(34,35)11-15(2)32)37-18(38-21)10-9-16-7-5-4-6-8-16/h4-10,13-15,17-18,20-21,24,32H,3,11-12H2,1-2H3,(H2,26,27,28,30,33)/b10-9+/t15?,17-,18+,20-,21-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374567
(CHEMBL269934)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCc2ccccc2F)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C29H30FN7O4/c1-2-32-29(38)36-26-23-27(34-16-33-26)37(17-35-23)28-25-24(40-22(41-25)13-12-18-8-4-3-5-9-18)21(39-28)15-31-14-19-10-6-7-11-20(19)30/h3-13,16-17,21-22,24-25,28,31H,2,14-15H2,1H3,(H2,32,33,34,36,38)/b13-12+/t21-,22+,24-,25-,28-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374569
(CHEMBL271643)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCC2CC2C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:23.26,21.22| Show InChI InChI=1S/C27H31N7O6/c1-2-29-27(37)33-23-20-24(31-13-30-23)34(14-32-20)25-22-21(18(38-25)12-28-11-16-10-17(16)26(35)36)39-19(40-22)9-8-15-6-4-3-5-7-15/h3-9,13-14,16-19,21-22,25,28H,2,10-12H2,1H3,(H,35,36)(H2,29,30,31,33,37)/b9-8+/t16?,17?,18-,19+,21-,22-,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374575
(CHEMBL403928)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNC(=O)CO)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H27N7O6/c1-2-25-24(34)30-21-18-22(28-12-27-21)31(13-29-18)23-20-19(15(35-23)10-26-16(33)11-32)36-17(37-20)9-8-14-6-4-3-5-7-14/h3-9,12-13,15,17,19-20,23,32H,2,10-11H2,1H3,(H,26,33)(H2,25,27,28,30,34)/b9-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374562
(CHEMBL402401)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCC(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C24H26N6O6S/c1-2-25-24(33)29-21-18-22(27-12-26-21)30(13-28-18)23-20-19(15(34-23)10-37-11-16(31)32)35-17(36-20)9-8-14-6-4-3-5-7-14/h3-9,12-13,15,17,19-20,23H,2,10-11H2,1H3,(H,31,32)(H2,25,26,27,29,33)/b9-8+/t15-,17+,19-,20-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374570
(CHEMBL402592)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCC2CC2C(=O)OCC)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:23.26,21.22| Show InChI InChI=1S/C29H35N7O6/c1-3-31-29(38)35-25-22-26(33-15-32-25)36(16-34-22)27-24-23(41-21(42-24)11-10-17-8-6-5-7-9-17)20(40-27)14-30-13-18-12-19(18)28(37)39-4-2/h5-11,15-16,18-21,23-24,27,30H,3-4,12-14H2,1-2H3,(H2,31,32,33,35,38)/b11-10+/t18?,19?,20-,21+,23-,24-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374573
(CHEMBL260602)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CN)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C22H25N7O4/c1-2-24-22(30)28-19-16-20(26-11-25-19)29(12-27-16)21-18-17(14(10-23)31-21)32-15(33-18)9-8-13-6-4-3-5-7-13/h3-9,11-12,14-15,17-18,21H,2,10,23H2,1H3,(H2,24,25,26,28,30)/b9-8+/t14-,15+,17-,18-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374576
(CHEMBL402800)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNC(=O)c2ccco2)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 Show InChI InChI=1S/C27H27N7O6/c1-2-28-27(36)33-23-20-24(31-14-30-23)34(15-32-20)26-22-21(18(38-26)13-29-25(35)17-9-6-12-37-17)39-19(40-22)11-10-16-7-4-3-5-8-16/h3-12,14-15,18-19,21-22,26H,2,13H2,1H3,(H,29,35)(H2,28,30,31,33,36)/b11-10+/t18-,19+,21-,22-,26-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
P2Y purinoceptor 12
(Homo sapiens (Human)) | BDBM50374563
(CHEMBL257651)Show SMILES CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCC(O)CO)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:21.23| Show InChI InChI=1S/C25H30N6O6S/c1-2-26-25(34)30-22-19-23(28-13-27-22)31(14-29-19)24-21-20(17(35-24)12-38-11-16(33)10-32)36-18(37-21)9-8-15-6-4-3-5-7-15/h3-9,13-14,16-18,20-21,24,32-33H,2,10-12H2,1H3,(H2,26,27,28,30,34)/b9-8+/t16?,17-,18+,20-,21-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Inspire Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assay |
Bioorg Med Chem Lett 18: 2167-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.038
BindingDB Entry DOI: 10.7270/Q2GM885R |
More data for this
Ligand-Target Pair | |
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