Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sialidase-2 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sialidase-2 (Homo sapiens (Human)) | BDBM4706 ((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sialidase-2 (Homo sapiens (Human)) | BDBM5024 ((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 3.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sialidase-2 (Homo sapiens (Human)) | BDBM50314987 ((2S,3R,4R)-3-acetamido-4-hydroxy-2-(3-hydroxypropo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-2 (Homo sapiens (Human)) | BDBM50314988 ((2S,3R,4R)-3-acetamido-4-hydroxy-2-isobutoxy-3,4-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-2 (Homo sapiens (Human)) | BDBM50314986 ((2S,3R,4R)-3-acetamido-2-(2,3-dihydroxypropoxy)-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan. Curated by ChEMBL | Assay Description Inhibition of human neuraminidase 2 | J Med Chem 53: 2998-3002 (2010) Article DOI: 10.1021/jm100078r BindingDB Entry DOI: 10.7270/Q2N58NBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan-Bicocca Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry | J Med Chem 55: 2112-24 (2012) Article DOI: 10.1021/jm201344a BindingDB Entry DOI: 10.7270/Q2MK6GR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50485110 (CHEMBL2032213) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan-Bicocca Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry | J Med Chem 55: 2112-24 (2012) Article DOI: 10.1021/jm201344a BindingDB Entry DOI: 10.7270/Q2MK6GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50485110 (CHEMBL2032213) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan-Bicocca Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry | J Med Chem 55: 2112-24 (2012) Article DOI: 10.1021/jm201344a BindingDB Entry DOI: 10.7270/Q2MK6GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50485109 (CHEMBL2032319) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan-Bicocca Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry | J Med Chem 55: 2112-24 (2012) Article DOI: 10.1021/jm201344a BindingDB Entry DOI: 10.7270/Q2MK6GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50485109 (CHEMBL2032319) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan-Bicocca Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry | J Med Chem 55: 2112-24 (2012) Article DOI: 10.1021/jm201344a BindingDB Entry DOI: 10.7270/Q2MK6GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255633 (CHEMBL4091601) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair |