Reaction Details |
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Target | Toll-like receptor 4 |
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Ligand | BDBM50255625 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1687455 (CHEMBL4037934) |
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IC50 | 1700±n/a nM |
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Citation | Facchini, FA; Zaffaroni, L; Minotti, A; Rapisarda, S; Calabrese, V; Forcella, M; Fusi, P; Airoldi, C; Ciaramelli, C; Billod, JM; Schromm, AB; Braun, H; Palmer, C; Beyaert, R; Lapenta, F; Jerala, R; Pirianov, G; Martin-Santamaria, S; Peri, F Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists. J Med Chem61:2895-2909 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Toll-like receptor 4 |
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Name: | Toll-like receptor 4 |
Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 95675.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1436169 |
Residue: | 839 |
Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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BDBM50255625 |
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n/a |
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Name | BDBM50255625 |
Synonyms: | CHEMBL4070714 |
Type | Small organic molecule |
Emp. Form. | C30H57NNa2O13P2 |
Mol. Mass. | 747.6995 |
SMILES | [Na+].[Na+].CCCCCCCCCCCC(=O)N[C@H]1[C@@H](OP(O)([O-])=O)O[C@H](CO)[C@@H](OP(O)([O-])=O)[C@@H]1OC(=O)CCCCCCCCCCC |r| |
Structure |
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