Compile Data Set for Download or QSAR

Found 51 hits with Last Name = 'giralt' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl endopeptidase-like (Human)	BDBM298372 ((S)-1-((S)-1-(4-(benzyloxy)-3-(trifluoromethyl)ben...) Show SMILES FC(F)(F)c1cc(ccc1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C25H22F5N3O3/c26-24(27)12-20(23(35)32-10-4-7-18(32)13-31)33(15-24)22(34)17-8-9-21(19(11-17)25(28,29)30)36-14-16-5-2-1-3-6-16/h1-3,5-6,8-9,11,18,20H,4,7,10,12,14-15H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298372 ((S)-1-((S)-1-(4-(benzyloxy)-3-(trifluoromethyl)ben...) Show SMILES FC(F)(F)c1cc(ccc1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C25H22F5N3O3/c26-24(27)12-20(23(35)32-10-4-7-18(32)13-31)33(15-24)22(34)17-8-9-21(19(11-17)25(28,29)30)36-14-16-5-2-1-3-6-16/h1-3,5-6,8-9,11,18,20H,4,7,10,12,14-15H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298373 ((S)-1-((S)-1-(4-(benzyloxy)-3-fluorobenzoyl)-4,4-d...) Show SMILES Fc1cc(ccc1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H22F3N3O3/c25-19-11-17(8-9-21(19)33-14-16-5-2-1-3-6-16)22(31)30-15-24(26,27)12-20(30)23(32)29-10-4-7-18(29)13-28/h1-3,5-6,8-9,11,18,20H,4,7,10,12,14-15H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298373 ((S)-1-((S)-1-(4-(benzyloxy)-3-fluorobenzoyl)-4,4-d...) Show SMILES Fc1cc(ccc1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H22F3N3O3/c25-19-11-17(8-9-21(19)33-14-16-5-2-1-3-6-16)22(31)30-15-24(26,27)12-20(30)23(32)29-10-4-7-18(29)13-28/h1-3,5-6,8-9,11,18,20H,4,7,10,12,14-15H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298357 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C27H31N3O5/c1-18-12-22(27(32)29-11-7-10-21(29)15-28)30(16-18)26(31)20-13-23(33-2)25(24(14-20)34-3)35-17-19-8-5-4-6-9-19/h4-6,8-9,13-14,18,21-22H,7,10-12,16-17H2,1-3H3/t18-,21-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298357 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C27H31N3O5/c1-18-12-22(27(32)29-11-7-10-21(29)15-28)30(16-18)26(31)20-13-23(33-2)25(24(14-20)34-3)35-17-19-8-5-4-6-9-19/h4-6,8-9,13-14,18,21-22H,7,10-12,16-17H2,1-3H3/t18-,21-,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298355 ((S)-1-((2S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H27F2N3O5/c1-34-21-11-18(12-22(35-2)23(21)36-15-17-7-4-3-5-8-17)24(32)31-16-26(27,28)13-20(31)25(33)30-10-6-9-19(30)14-29/h3-5,7-8,11-12,19-20H,6,9-10,13,15-16H2,1-2H3/t19-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.7	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298355 ((S)-1-((2S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H27F2N3O5/c1-34-21-11-18(12-22(35-2)23(21)36-15-17-7-4-3-5-8-17)24(32)31-16-26(27,28)13-20(31)25(33)30-10-6-9-19(30)14-29/h3-5,7-8,11-12,19-20H,6,9-10,13,15-16H2,1-2H3/t19-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.7	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298352 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H28FN3O5/c1-33-22-11-18(12-23(34-2)24(22)35-16-17-7-4-3-5-8-17)25(31)30-15-19(27)13-21(30)26(32)29-10-6-9-20(29)14-28/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20+,21+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.4	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298352 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H28FN3O5/c1-33-22-11-18(12-23(34-2)24(22)35-16-17-7-4-3-5-8-17)25(31)30-15-19(27)13-21(30)26(32)29-10-6-9-20(29)14-28/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20+,21+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.4	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298345 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1cc(OC)c(OCc2ccccc2)c(OC)c1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C27H31N3O6/c1-33-21-14-22(27(32)29-11-7-10-20(29)15-28)30(16-21)26(31)19-12-23(34-2)25(24(13-19)35-3)36-17-18-8-5-4-6-9-18/h4-6,8-9,12-13,20-22H,7,10-11,14,16-17H2,1-3H3/t20-,21+,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63.8	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298345 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1cc(OC)c(OCc2ccccc2)c(OC)c1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C27H31N3O6/c1-33-21-14-22(27(32)29-11-7-10-20(29)15-28)30(16-21)26(31)19-12-23(34-2)25(24(13-19)35-3)36-17-18-8-5-4-6-9-18/h4-6,8-9,12-13,20-22H,7,10-11,14,16-17H2,1-3H3/t20-,21+,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63.8	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298363 ((S)-1-((2S)-1-(4-benzoyloxy-3,5-dimethoxybenzoyl)-...) Show SMILES COc1cc(cc(OC)c1OC(=O)c1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H25F2N3O6/c1-35-20-11-17(12-21(36-2)22(20)37-25(34)16-7-4-3-5-8-16)23(32)31-15-26(27,28)13-19(31)24(33)30-10-6-9-18(30)14-29/h3-5,7-8,11-12,18-19H,6,9-10,13,15H2,1-2H3/t18-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298363 ((S)-1-((2S)-1-(4-benzoyloxy-3,5-dimethoxybenzoyl)-...) Show SMILES COc1cc(cc(OC)c1OC(=O)c1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C26H25F2N3O6/c1-35-20-11-17(12-21(36-2)22(20)37-25(34)16-7-4-3-5-8-16)23(32)31-15-26(27,28)13-19(31)24(33)30-10-6-9-18(30)14-29/h3-5,7-8,11-12,18-19H,6,9-10,13,15H2,1-2H3/t18-,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298356 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)SC |r| Show InChI InChI=1S/C27H31N3O5S/c1-33-23-12-19(13-24(34-2)25(23)35-17-18-8-5-4-6-9-18)26(31)30-16-21(36-3)14-22(30)27(32)29-11-7-10-20(29)15-28/h4-6,8-9,12-13,20-22H,7,10-11,14,16-17H2,1-3H3/t20-,21-,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298359 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F |r| Show InChI InChI=1S/C27H28F3N3O5/c1-36-22-11-18(12-23(37-2)24(22)38-16-17-7-4-3-5-8-17)25(34)33-15-19(27(28,29)30)13-21(33)26(35)32-10-6-9-20(32)14-31/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298359 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F |r| Show InChI InChI=1S/C27H28F3N3O5/c1-36-22-11-18(12-23(37-2)24(22)38-16-17-7-4-3-5-8-17)25(34)33-15-19(27(28,29)30)13-21(33)26(35)32-10-6-9-20(32)14-31/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298356 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)SC |r| Show InChI InChI=1S/C27H31N3O5S/c1-33-23-12-19(13-24(34-2)25(23)35-17-18-8-5-4-6-9-18)26(31)30-16-21(36-3)14-22(30)27(32)29-11-7-10-20(29)15-28/h4-6,8-9,12-13,20-22H,7,10-11,14,16-17H2,1-3H3/t20-,21-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298371 ((S)-1-((S)-1-(2-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1ccccc1OCc1ccccc1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-20(23(31)28-12-6-9-18(28)14-27)29(16-24)22(30)19-10-4-5-11-21(19)32-15-17-7-2-1-3-8-17/h1-5,7-8,10-11,18,20H,6,9,12-13,15-16H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	255	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298371 ((S)-1-((S)-1-(2-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1ccccc1OCc1ccccc1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-20(23(31)28-12-6-9-18(28)14-27)29(16-24)22(30)19-10-4-5-11-21(19)32-15-17-7-2-1-3-8-17/h1-5,7-8,10-11,18,20H,6,9,12-13,15-16H2/t18-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	255	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298368 ((S)-1-((S)-1-(4-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1ccc(OCc2ccccc2)cc1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-21(23(31)28-12-4-7-19(28)14-27)29(16-24)22(30)18-8-10-20(11-9-18)32-15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19,21H,4,7,12-13,15-16H2/t19-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	287	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298368 ((S)-1-((S)-1-(4-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1ccc(OCc2ccccc2)cc1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-21(23(31)28-12-4-7-19(28)14-27)29(16-24)22(30)18-8-10-20(11-9-18)32-15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19,21H,4,7,12-13,15-16H2/t19-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	287	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298364 ((S)-1-((2S)-1-(3,4-dibenzyloxy-5-methoxybenzoyl)-4...) Show SMILES COc1cc(cc(OCc2ccccc2)c1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCCC1C#N |r| Show InChI InChI=1S/C32H31F2N3O5/c1-40-27-15-24(30(38)37-21-32(33,34)17-26(37)31(39)36-14-8-13-25(36)18-35)16-28(41-19-22-9-4-2-5-10-22)29(27)42-20-23-11-6-3-7-12-23/h2-7,9-12,15-16,25-26H,8,13-14,17,19-21H2,1H3/t25?,26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM435747 ((S)-1-((2S)-1-(3,4-dibenzyloxy-5-methoxybenzoyl)-4...) Show SMILES COc1cc(cc(OCc2ccccc2)c1OCc1ccccc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C32H31F2N3O5/c1-40-27-15-24(30(38)37-21-32(33,34)17-26(37)31(39)36-14-8-13-25(36)18-35)16-28(41-19-22-9-4-2-5-10-22)29(27)42-20-23-11-6-3-7-12-23/h2-7,9-12,15-16,25-26H,8,13-14,17,19-21H2,1H3/t25-,26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298353 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)c1ccccc1 |r| Show InChI InChI=1S/C32H33N3O5/c1-38-28-17-24(18-29(39-2)30(28)40-21-22-10-5-3-6-11-22)31(36)35-20-25(23-12-7-4-8-13-23)16-27(35)32(37)34-15-9-14-26(34)19-33/h3-8,10-13,17-18,25-27H,9,14-16,20-21H2,1-2H3/t25-,26+,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	339	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298353 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)c1ccccc1 |r| Show InChI InChI=1S/C32H33N3O5/c1-38-28-17-24(18-29(39-2)30(28)40-21-22-10-5-3-6-11-22)31(36)35-20-25(23-12-7-4-8-13-23)16-27(35)32(37)34-15-9-14-26(34)19-33/h3-8,10-13,17-18,25-27H,9,14-16,20-21H2,1-2H3/t25-,26+,27+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	339	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298361 ((S)-1-((2S)-1-(4-acetoxy-3,5-dimethoxybenzoyl)-4,4...) Show SMILES COc1cc(cc(OC)c1OC(C)=O)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H23F2N3O6/c1-12(27)32-18-16(30-2)7-13(8-17(18)31-3)19(28)26-11-21(22,23)9-15(26)20(29)25-6-4-5-14(25)10-24/h7-8,14-15H,4-6,9,11H2,1-3H3/t14-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	352	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298361 ((S)-1-((2S)-1-(4-acetoxy-3,5-dimethoxybenzoyl)-4,4...) Show SMILES COc1cc(cc(OC)c1OC(C)=O)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H23F2N3O6/c1-12(27)32-18-16(30-2)7-13(8-17(18)31-3)19(28)26-11-21(22,23)9-15(26)20(29)25-6-4-5-14(25)10-24/h7-8,14-15H,4-6,9,11H2,1-3H3/t14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	352	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298369 ((S)-1-((S)-1-(3-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1cccc(OCc2ccccc2)c1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-21(23(31)28-11-5-9-19(28)14-27)29(16-24)22(30)18-8-4-10-20(12-18)32-15-17-6-2-1-3-7-17/h1-4,6-8,10,12,19,21H,5,9,11,13,15-16H2/t19-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	487	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298369 ((S)-1-((S)-1-(3-(benzyloxy)benzoyl)-4,4-difluoropy...) Show SMILES FC1(F)C[C@H](N(C1)C(=O)c1cccc(OCc2ccccc2)c1)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H23F2N3O3/c25-24(26)13-21(23(31)28-11-5-9-19(28)14-27)29(16-24)22(30)18-8-4-10-20(12-18)32-15-17-6-2-1-3-7-17/h1-4,6-8,10,12,19,21H,5,9,11,13,15-16H2/t19-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	487	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298360 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)OC(C)(C)C |r| Show InChI InChI=1S/C30H37N3O6/c1-30(2,3)39-23-16-24(29(35)32-13-9-12-22(32)17-31)33(18-23)28(34)21-14-25(36-4)27(26(15-21)37-5)38-19-20-10-7-6-8-11-20/h6-8,10-11,14-15,22-24H,9,12-13,16,18-19H2,1-5H3/t22-,23+,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	668	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298360 ((S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)OC(C)(C)C |r| Show InChI InChI=1S/C30H37N3O6/c1-30(2,3)39-23-16-24(29(35)32-13-9-12-22(32)17-31)33(18-23)28(34)21-14-25(36-4)27(26(15-21)37-5)38-19-20-10-7-6-8-11-20/h6-8,10-11,14-15,22-24H,9,12-13,16,18-19H2,1-5H3/t22-,23+,24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	668	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50090473 (Kalata B1) Show SMILES [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@]([H])(NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@]([H])(NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@]1([H])CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@]([H])(NC(=O)[C@H](CS)NC(=O)CNC2=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O |r| Show InChI InChI=1S/C18H19NO5/c1-4-12-9-14(5-6-15(12)20)24-16-10(2)7-13(8-11(16)3)19-17(21)18(22)23/h5-9,20H,4H2,1-3H3,(H,19,21)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Vienna Curated by ChEMBL					Assay Description Inhibition of human recombinant POP pre-incubated for 15 mins before Z-Gly-Pro-AMC substrate addition and further incubated for 1 hr by fluorimetry				J Nat Prod 78: 1073-82 (2015) Article DOI: 10.1021/np501061t BindingDB Entry DOI: 10.7270/Q2639RHR
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM435749 ((S)-1-((2S)-1-(3-pivaloyloxy-4,5-dimethoxybenzoyl)...) Show SMILES COc1cc(cc(CC(=O)C(C)(C)C)c1OC)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C25H31F2N3O5/c1-24(2,3)20(31)11-15-9-16(10-19(34-4)21(15)35-5)22(32)30-14-25(26,27)12-18(30)23(33)29-8-6-7-17(29)13-28/h9-10,17-18H,6-8,11-12,14H2,1-5H3/t17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298367 ((S)-1-((2S)-1-(3-pivaloyloxy-4,5-dimethoxybenzoyl)...) Show SMILES COc1cc(cc(OC(=O)C(C)(C)C)c1OC)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C24H29F2N3O6/c1-23(2,3)22(32)35-18-10-14(9-17(33-4)19(18)34-5)20(30)29-13-24(25,26)11-16(29)21(31)28-8-6-7-15(28)12-27/h9-10,15-16H,6-8,11,13H2,1-5H3/t15-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase-like (Human)	BDBM298366 ((S)-1-((2S)-1-(3-acetoxy-4,5-dimethoxybenzoyl)-4,4...) Show SMILES COc1cc(cc(OC(C)=O)c1OC)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H23F2N3O6/c1-12(27)32-17-8-13(7-16(30-2)18(17)31-3)19(28)26-11-21(22,23)9-15(26)20(29)25-6-4-5-14(25)10-24/h7-8,14-15H,4-6,9,11H2,1-3H3/t14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020) BindingDB Entry DOI: 10.7270/Q2377CQK
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298366 ((S)-1-((2S)-1-(3-acetoxy-4,5-dimethoxybenzoyl)-4,4...) Show SMILES COc1cc(cc(OC(C)=O)c1OC)C(=O)N1CC(F)(F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C21H23F2N3O6/c1-12(27)32-17-8-13(7-16(30-2)18(17)31-3)19(28)26-11-21(22,23)9-15(26)20(29)25-6-4-5-14(25)10-24/h7-8,14-15H,4-6,9,11H2,1-3H3/t14-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50090472 (CHEMBL3581703) Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@]4([H])CSSC[C@]([H])(NC(=O)CNC(=O)[C@]5([H])CCCN5C(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@@H](NC2=O)C(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@@]2([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N4)NC(=O)[C@@]([H])(NC(=O)CNC(=O)CNC(=O)[C@@H](NC3=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)[C@@H](C)O |r| Show InChI InChI=1S/C23H18F3NO5/c1-12-9-16(27-21(29)22(30)31)10-13(2)20(12)32-17-7-8-19(28)18(11-17)14-3-5-15(6-4-14)23(24,25)26/h3-11,28H,1-2H3,(H,27,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Vienna Curated by ChEMBL					Assay Description Inhibition of human recombinant POP pre-incubated for 15 mins before Z-Gly-Pro-AMC substrate addition and further incubated for 1 hr by fluorimetry				J Nat Prod 78: 1073-82 (2015) Article DOI: 10.1021/np501061t BindingDB Entry DOI: 10.7270/Q2639RHR
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50090472 (CHEMBL3581703) Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@]4([H])CSSC[C@]([H])(NC(=O)CNC(=O)[C@]5([H])CCCN5C(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@@H](NC2=O)C(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@@]2([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N4)NC(=O)[C@@]([H])(NC(=O)CNC(=O)CNC(=O)[C@@H](NC3=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)[C@@H](C)O |r| Show InChI InChI=1S/C23H18F3NO5/c1-12-9-16(27-21(29)22(30)31)10-13(2)20(12)32-17-7-8-19(28)18(11-17)14-3-5-15(6-4-14)23(24,25)26/h3-11,28H,1-2H3,(H,27,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Vienna Curated by ChEMBL					Assay Description Inhibition of human recombinant POP pre-incubated for 15 mins before Z-Gly-Pro-AMC substrate addition and further incubated for 1 hr by fluorimetry				J Nat Prod 78: 1073-82 (2015) Article DOI: 10.1021/np501061t BindingDB Entry DOI: 10.7270/Q2639RHR
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50242173 ((2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4...) Show SMILES O[C@H]1[C@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccccc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O |r| Show InChI InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM7460 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50009001 (5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...) Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1 Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM7460 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM7462 (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...) Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.32E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50273195 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S...) Show SMILES C[C@@H]1OC(OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26?,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50009001 (5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...) Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1 Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50273195 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S...) Show SMILES C[C@@H]1OC(OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26?,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM7462 (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...) Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM26660 (3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...) Show SMILES Oc1ccc2c(c1)oc(-c1ccccc1)c(O)c2=O Show InChI InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM26660 (3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...) Show SMILES Oc1ccc2c(c1)oc(-c1ccccc1)c(O)c2=O Show InChI InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recerca Biomèdica de Barcelona Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin)				Bioorg Med Chem 16: 7516-24 (2008) Article DOI: 10.1016/j.bmc.2008.04.067 BindingDB Entry DOI: 10.7270/Q2ZC82NG
					More data for this Ligand-Target Pair

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