Compile Data Set for Download or QSAR

Found 167 hits with Last Name = 'hall' and Initial = 'be'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM154061 (US9012443, 57) Show SMILES FC(F)(F)c1ccc(cc1Cl)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C18H10ClF3N4O2S2/c19-15-8-11(1-4-14(15)18(20,21)22)16-13-3-2-12(7-10(13)5-6-23-16)30(27,28)26-17-24-9-25-29-17/h1-9H,(H,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533541 (CHEMBL4559824) Show SMILES CS(=O)(=O)NC(=O)c1ccc(cc1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H11Cl2NO3S/c1-21(19,20)17-14(18)10-4-2-9(3-5-10)11-6-7-12(15)13(16)8-11/h2-8H,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533554 (CHEMBL4470763) Show SMILES CC(C)COc1ncc(cc1Cl)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C17H17ClF2N2O4S/c1-9(2)8-26-17-13(18)4-10(7-21-17)11-5-15(20)12(6-14(11)19)16(23)22-27(3,24)25/h4-7,9H,8H2,1-3H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533546 (CHEMBL4462738) Show SMILES CC(C)COc1ncc(Oc2nccc3cc(ccc23)C(=O)NS(C)(=O)=O)cc1Cl Show InChI InChI=1S/C20H20ClN3O5S/c1-12(2)11-28-20-17(21)9-15(10-23-20)29-19-16-5-4-14(8-13(16)6-7-22-19)18(25)24-30(3,26)27/h4-10,12H,11H2,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533549 (CHEMBL4579742) Show SMILES CS(=O)(=O)NC(=O)c1ccc2c(Oc3ccc(Cl)c(c3)C(F)(F)F)nccc2c1 Show InChI InChI=1S/C18H12ClF3N2O4S/c1-29(26,27)24-16(25)11-2-4-13-10(8-11)6-7-23-17(13)28-12-3-5-15(19)14(9-12)18(20,21)22/h2-9H,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533553 (CHEMBL4445237) Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(cc1F)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H9Cl2F2NO3S/c1-23(21,22)19-14(20)9-6-12(17)8(5-13(9)18)7-2-3-10(15)11(16)4-7/h2-6H,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50272533 (CHEMBL4129030) Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C15H11Cl2F2NO4S/c1-25(22,23)20-15(21)10-6-13(18)8(4-14(10)19)7-24-9-2-3-11(16)12(17)5-9/h2-6H,7H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533547 (CHEMBL4537339) Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(Oc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C14H9Cl2F2NO4S/c1-24(21,22)19-14(20)8-5-12(18)13(6-11(8)17)23-7-2-3-9(15)10(16)4-7/h2-6H,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50533552 (CHEMBL4450471) Show SMILES CS(=O)(=O)NC(=O)c1ccc2c(nccc2c1)-c1ccc(c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C18H12ClF3N2O3S/c1-28(26,27)24-17(25)12-2-4-13-10(8-12)6-7-23-16(13)11-3-5-14(15(19)9-11)18(20,21)22/h2-9H,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154245 (US9012443, 261) Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -60 mV measured for 3 to 5 mins...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50201179 (CHEMBL2325007) Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1cn[nH]c1 Show InChI InChI=1S/C19H11F3N6O3S2/c20-19(21,22)13-1-3-17(15(6-13)12-8-25-26-9-12)31-16-4-2-14(5-11(16)7-23)33(29,30)28-18-24-10-27-32-18/h1-6,8-10H,(H,25,26)(H,24,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Displacement of [3H]-6,6-fused heteroaryl-sulfonamide derivative from human Nav1.7 expressed in HEK293 cell membranes preincubated for 30 mins follow...				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533564 (CHEMBL4576210) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(c1)C(F)(F)F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H15Cl2F3N2O5S/c1-32-18-6-11(19(29)28-34(2,30)31)3-4-16(18)12-5-17(21(24,25)26)20(27-10-12)33-15-8-13(22)7-14(23)9-15/h3-10H,1-2H3,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329015 (4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)-...) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C20H15Cl3N2O5S/c1-29-18-6-11(19(26)25-31(2,27)28)3-4-16(18)12-5-17(23)20(24-10-12)30-15-8-13(21)7-14(22)9-15/h3-10H,1-2H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50201185 (CHEMBL3942771) Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNCC1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1 |t:11| Show InChI InChI=1S/C24H19F3N4O2S2/c25-24(26,27)17-4-6-21(22(13-17)15-8-10-28-11-9-15)20-3-1-2-16-12-18(5-7-19(16)20)35(32,33)31-23-29-14-30-34-23/h1-8,12-14,28H,9-11H2,(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as use-dependent block at pulse 26 by ionworks quattro electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as tonic block at pulse 1 by ionworks quattro electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154018 (US9012443, 11) Show SMILES Cc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F Show InChI InChI=1S/C20H14F3N3O2S2/c1-12-9-14(20(21,22)23)5-7-16(12)18-4-2-3-13-10-15(6-8-17(13)18)30(27,28)26-19-24-11-25-29-19/h2-11H,1H3,(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current by manual whole cell patch clamp electrophysiology ...				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154019 (US9012443, 12) Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F Show InChI InChI=1S/C20H14F3N3O3S2/c1-29-18-10-13(20(21,22)23)5-7-17(18)16-4-2-3-12-9-14(6-8-15(12)16)31(27,28)26-19-24-11-25-30-19/h2-11H,1H3,(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 at 20% inactivated state expressed in HEK293 cells at -140 mV holding potential followed by channel inactivation by manual...				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329034 (4-(6-(3,5-dichlorophenoxy)-5- (difluoromethyl)-3-p...) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(c1)C(F)F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H16Cl2F2N2O5S/c1-31-18-6-11(20(28)27-33(2,29)30)3-4-16(18)12-5-17(19(24)25)21(26-10-12)32-15-8-13(22)7-14(23)9-15/h3-10,19H,1-2H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533561 (CHEMBL4459021) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OCC2(C)CC2)c(Cl)c1 Show InChI InChI=1S/C19H20ClFN2O5S/c1-19(4-5-19)10-28-18-14(20)6-11(9-22-18)12-7-15(21)13(8-16(12)27-2)17(24)23-29(3,25)26/h6-9H,4-5,10H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50272533 (CHEMBL4129030) Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C15H11Cl2F2NO4S/c1-25(22,23)20-15(21)10-6-13(18)8(4-14(10)19)7-24-9-2-3-11(16)12(17)5-9/h2-6H,7H2,1H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329062 (4-(5-cyano-6-(3,5- dichlorophenoxy)-3-pyridinyl)- ...) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(c1)C#N)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H15Cl2N3O5S/c1-30-19-6-12(20(27)26-32(2,28)29)3-4-18(19)14-5-13(10-24)21(25-11-14)31-17-8-15(22)7-16(23)9-17/h3-9,11H,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329017 (4-(5-chloro-6-((2S)-2-(1- methylethyl)-1-pyrrolidi...) Show SMILES COc1cc(ccc1-c1cnc(N2CCC[C@H]2C(C)C)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H26ClN3O4S/c1-13(2)18-6-5-9-25(18)20-17(22)10-15(12-23-20)16-8-7-14(11-19(16)29-3)21(26)24-30(4,27)28/h7-8,10-13,18H,5-6,9H2,1-4H3,(H,24,26)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329021 (4-(5-chloro-6-(2,5- difluorophenoxy)-3-pyridinyl)-...) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C20H15ClF2N2O5S/c1-29-17-8-11(19(26)25-31(2,27)28)3-5-14(17)12-7-15(21)20(24-10-12)30-18-9-13(22)4-6-16(18)23/h3-10H,1-2H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329075 (4-(5-Chloro-6-((4-Chlorobenzyl)Oxy)Pyridin-3-yl)-3...) Show SMILES COc1cc(ccc1-c1cnc(OCc2ccc(Cl)cc2)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H18Cl2N2O5S/c1-29-19-10-14(20(26)25-31(2,27)28)5-8-17(19)15-9-18(23)21(24-11-15)30-12-13-3-6-16(22)7-4-13/h3-11H,12H2,1-2H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM329200 (4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1 Show InChI InChI=1S/C18H18ClFN2O5S/c1-26-16-8-13(17(23)22-28(2,24)25)15(20)7-12(16)10-6-14(19)18(21-9-10)27-11-4-3-5-11/h6-9,11H,3-5H2,1-2H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Mus musculus)	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of mouse Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154008 (US9012443, 1) Show SMILES Cn1nccc1-c1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F Show InChI InChI=1S/C23H16F3N5O2S2/c1-31-21(9-10-28-31)20-12-15(23(24,25)26)5-7-19(20)18-4-2-3-14-11-16(6-8-17(14)18)35(32,33)30-22-27-13-29-34-22/h2-13H,1H3,(H,27,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM170177 (US9079902, 8) Show SMILES Cn1nccc1-c1cc(ccc1-c1cn(C)c2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F Show InChI InChI=1S/C22H17F3N6O2S2/c1-30-11-18(15-5-3-13(22(23,24)25)9-17(15)19-7-8-27-31(19)2)16-6-4-14(10-20(16)30)35(32,33)29-21-26-12-28-34-21/h3-12H,1-2H3,(H,26,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Mus musculus)	BDBM154245 (US9012443, 261) Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of 20% inactivated Nav1.7 in C57BL/6 mouse DRG neurons assessed as inhibition of sodium currents in presence of TTX by whole cell patch cl...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154245 (US9012443, 261) Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of 20% inactivated human Nav1.7 expressed in HEK293 cells assessed as inhibition of peak inward current by whole cell patch clamp method				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533540 (CHEMBL4539119) Show SMILES CC(C)COc1ncc(cc1Cl)-c1ccc(cc1OC(F)(F)F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C18H18ClF3N2O5S/c1-10(2)9-28-17-14(19)6-12(8-23-17)13-5-4-11(16(25)24-30(3,26)27)7-15(13)29-18(20,21)22/h4-8,10H,9H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154497 (US9012443, 293) Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533545 (CHEMBL4571566) Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cnc2OC)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C20H17Cl2N3O6S/c1-29-16-7-11(18(26)25-32(3,27)28)4-5-14(16)12-6-15(22)19(23-9-12)31-17-8-13(21)10-24-20(17)30-2/h4-10H,1-3H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154030 (US9012443, 23) Show SMILES FC(F)(F)c1ccc(c(Br)c1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C19H11BrF3N3O2S2/c20-17-9-12(19(21,22)23)4-6-16(17)15-3-1-2-11-8-13(5-7-14(11)15)30(27,28)26-18-24-10-25-29-18/h1-10H,(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533543 (CHEMBL4530399) Show SMILES COc1cc(ccc1-c1cnc(Sc2cccc(C)c2)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C21H19ClN2O4S2/c1-13-5-4-6-16(9-13)29-21-18(22)10-15(12-23-21)17-8-7-14(11-19(17)28-2)20(25)24-30(3,26)27/h4-12H,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154245 (US9012443, 261) Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Mus musculus)	BDBM154245 (US9012443, 261) Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of 20% inactivated mouse Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current measured for 3 to 5 mins by whole cell ...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533565 (CHEMBL4558539) Show SMILES COc1cc(ccc1-c1cnc(OCC2(C)CC2)c(Cl)c1)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C19H21ClN2O5S/c1-19(6-7-19)11-27-18-15(20)8-13(10-21-18)14-5-4-12(9-16(14)26-2)17(23)22-28(3,24)25/h4-5,8-10H,6-7,11H2,1-3H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533546 (CHEMBL4462738) Show SMILES CC(C)COc1ncc(Oc2nccc3cc(ccc23)C(=O)NS(C)(=O)=O)cc1Cl Show InChI InChI=1S/C20H20ClN3O5S/c1-12(2)11-28-20-17(21)9-15(10-23-20)29-19-16-5-4-14(8-13(16)6-7-22-19)18(25)24-30(3,26)27/h4-10,12H,11H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533557 (CHEMBL4517426) Show SMILES CC(C)COc1ncc(cc1Cl)-c1ccc(cc1C1=CCOC1)C(=O)NS(C)(=O)=O |t:20| Show InChI InChI=1S/C21H23ClN2O5S/c1-13(2)11-29-21-19(22)9-16(10-23-21)17-5-4-14(20(25)24-30(3,26)27)8-18(17)15-6-7-28-12-15/h4-6,8-10,13H,7,11-12H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Mus musculus)	BDBM329203 (4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...) Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1 Show InChI InChI=1S/C20H14ClF3N2O5S/c1-30-17-8-13(19(27)26-32(2,28)29)16(24)7-12(17)10-5-14(21)20(25-9-10)31-18-6-11(22)3-4-15(18)23/h3-9H,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of Nav1.7 in C57BL/6 mouse DRG neurons assessed as reduction in native TTX-S current amplitude by manual patch clamp electrophysiology ass...				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533551 (CHEMBL4459478) Show SMILES CC(C)COc1ncc(cc1Cl)-c1ccc(cc1C(F)(F)F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C18H18ClF3N2O4S/c1-10(2)9-28-17-15(19)7-12(8-23-17)13-5-4-11(6-14(13)18(20,21)22)16(25)24-29(3,26)27/h4-8,10H,9H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533549 (CHEMBL4579742) Show SMILES CS(=O)(=O)NC(=O)c1ccc2c(Oc3ccc(Cl)c(c3)C(F)(F)F)nccc2c1 Show InChI InChI=1S/C18H12ClF3N2O4S/c1-29(26,27)24-16(25)11-2-4-13-10(8-11)6-7-23-17(13)28-12-3-5-15(19)14(9-12)18(20,21)22/h2-9H,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50533544 (CHEMBL4444511) Show SMILES CC(C)COc1ncc(cc1Cl)-c1ccc(cc1Cl)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C17H18Cl2N2O4S/c1-10(2)9-25-17-15(19)7-12(8-20-17)13-5-4-11(6-14(13)18)16(22)21-26(3,23)24/h4-8,10H,9H2,1-3H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay				J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 BindingDB Entry DOI: 10.7270/Q25Q50KX
					More data for this Ligand-Target Pair

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