Found 70 hits with Last Name = 'hussoin' and Initial = 'ms' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408421
(CHEMBL2113725)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H38F4N2O8S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(47-23)19-15-26(43-3)31(45-5)27(16-19)44-4)14-25(42-2)30(22)46-11-12-48-32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50002823
(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)Show SMILES CCCOc1c(OC)cc(cc1S(=O)(=O)CCO)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C25H34O9S/c1-6-10-33-25-22(31-4)14-17(15-23(25)35(27,28)11-9-26)19-8-7-18(34-19)16-12-20(29-2)24(32-5)21(13-16)30-3/h12-15,18-19,26H,6-11H2,1-5H3/t18-,19-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286666
(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C26H36N2O8/c1-7-11-35-24-18(27-26(29)28(30)8-2)12-16(13-21(24)31-3)19-9-10-20(36-19)17-14-22(32-4)25(34-6)23(15-17)33-5/h12-15,19-20,30H,7-11H2,1-6H3,(H,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286666
(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C26H36N2O8/c1-7-11-35-24-18(27-26(29)28(30)8-2)12-16(13-21(24)31-3)19-9-10-20(36-19)17-14-22(32-4)25(34-6)23(15-17)33-5/h12-15,19-20,30H,7-11H2,1-6H3,(H,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408414
(CHEMBL2113720)Show SMILES COc1cc(cc(CNC(=O)N(C)O)c1OCCSc1ccc(Cl)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C31H37ClN2O8S/c1-34(36)31(35)33-18-21-14-19(15-26(37-2)29(21)41-12-13-43-23-8-6-22(32)7-9-23)24-10-11-25(42-24)20-16-27(38-3)30(40-5)28(17-20)39-4/h6-9,14-17,24-25,36H,10-13,18H2,1-5H3,(H,33,35)/t24-,25-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286665
(CHEMBL160692 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C25H34N2O8/c1-7-10-34-23-17(26-25(28)27(2)29)11-15(12-20(23)30-3)18-8-9-19(35-18)16-13-21(31-4)24(33-6)22(14-16)32-5/h11-14,18-19,29H,7-10H2,1-6H3,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286665
(CHEMBL160692 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(C)O)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C25H34N2O8/c1-7-10-34-23-17(26-25(28)27(2)29)11-15(12-20(23)30-3)18-8-9-19(35-18)16-13-21(31-4)24(33-6)22(14-16)32-5/h11-14,18-19,29H,7-10H2,1-6H3,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408417
(CHEMBL2113724)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Cl)c(Cl)c1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H40Cl2N2O8S/c1-6-7-12-37(39)33(38)36-25-15-20(16-28(40-2)31(25)44-13-14-46-22-8-9-23(34)24(35)19-22)26-10-11-27(45-26)21-17-29(41-3)32(43-5)30(18-21)42-4/h8-9,15-19,26-27,39H,6-7,10-14H2,1-5H3,(H,36,38)/t26-,27-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286669
(5-lipoxygenase inhibitor | CHEMBL348609)Show SMILES CCCOc1cc(cc(N(CC)C(=O)N(O)CC)c1OCCC)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C30H44N2O8/c1-8-14-38-27-19-20(16-22(28(27)39-15-9-2)31(10-3)30(33)32(34)11-4)23-12-13-24(40-23)21-17-25(35-5)29(37-7)26(18-21)36-6/h16-19,23-24,34H,8-15H2,1-7H3/t23-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408419
(CHEMBL2113723)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Br)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-14-36(38)33(37)35-25-17-21(18-28(39-2)31(25)43-15-16-45-24-10-8-23(34)9-11-24)26-12-13-27(44-26)22-19-29(40-3)32(42-5)30(20-22)41-4/h8-11,17-20,26-27,38H,6-7,12-16H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408413
(CHEMBL2113727)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Cl)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41ClN2O8S/c1-6-7-14-36(38)33(37)35-25-17-21(18-28(39-2)31(25)43-15-16-45-24-10-8-23(34)9-11-24)26-12-13-27(44-26)22-19-29(40-3)32(42-5)30(20-22)41-4/h8-11,17-20,26-27,38H,6-7,12-16H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408419
(CHEMBL2113723)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Br)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-14-36(38)33(37)35-25-17-21(18-28(39-2)31(25)43-15-16-45-24-10-8-23(34)9-11-24)26-12-13-27(44-26)22-19-29(40-3)32(42-5)30(20-22)41-4/h8-11,17-20,26-27,38H,6-7,12-16H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408418
(CHEMBL2113722)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1cccc(Br)c1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-13-36(38)33(37)35-25-16-21(17-28(39-2)31(25)43-14-15-45-24-10-8-9-23(34)20-24)26-11-12-27(44-26)22-18-29(40-3)32(42-5)30(19-22)41-4/h8-10,16-20,26-27,38H,6-7,11-15H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408422
(CHEMBL2113721)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccccc1Br)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-14-36(38)33(37)35-24-17-21(18-27(39-2)31(24)43-15-16-45-30-11-9-8-10-23(30)34)25-12-13-26(44-25)22-19-28(40-3)32(42-5)29(20-22)41-4/h8-11,17-20,25-26,38H,6-7,12-16H2,1-5H3,(H,35,37)/t25-,26-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408424
(CHEMBL2113733)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCS(=O)(=O)c1ccccc1Br)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O10S/c1-6-7-14-36(38)33(37)35-24-17-21(25-12-13-26(46-25)22-19-28(42-3)32(44-5)29(20-22)43-4)18-27(41-2)31(24)45-15-16-47(39,40)30-11-9-8-10-23(30)34/h8-11,17-20,25-26,38H,6-7,12-16H2,1-5H3,(H,35,37)/t25-,26-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286661
(CHEMBL160290 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)C(C)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-8-12-37-26-20(29-28(31)30(32)17(3)9-2)13-18(14-23(26)33-4)21-10-11-22(38-21)19-15-24(34-5)27(36-7)25(16-19)35-6/h13-17,21-22,32H,8-12H2,1-7H3,(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286661
(CHEMBL160290 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)C(C)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-8-12-37-26-20(29-28(31)30(32)17(3)9-2)13-18(14-23(26)33-4)21-10-11-22(38-21)19-15-24(34-5)27(36-7)25(16-19)35-6/h13-17,21-22,32H,8-12H2,1-7H3,(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286667
(CHEMBL155851 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-9-12-37-25-19(29-27(31)30(32)28(2,3)4)13-17(14-22(25)33-5)20-10-11-21(38-20)18-15-23(34-6)26(36-8)24(16-18)35-7/h13-16,20-21,32H,9-12H2,1-8H3,(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286667
(CHEMBL155851 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-9-12-37-25-19(29-27(31)30(32)28(2,3)4)13-17(14-22(25)33-5)20-10-11-21(38-20)18-15-23(34-6)26(36-8)24(16-18)35-7/h13-16,20-21,32H,9-12H2,1-8H3,(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286668
(CHEMBL160218 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)NO)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C24H32N2O8/c1-6-9-33-22-16(25-24(27)26-28)10-14(11-19(22)29-2)17-7-8-18(34-17)15-12-20(30-3)23(32-5)21(13-15)31-4/h10-13,17-18,28H,6-9H2,1-5H3,(H2,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286668
(CHEMBL160218 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)NO)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C24H32N2O8/c1-6-9-33-22-16(25-24(27)26-28)10-14(11-19(22)29-2)17-7-8-18(34-17)15-12-20(30-3)23(32-5)21(13-15)31-4/h10-13,17-18,28H,6-9H2,1-5H3,(H2,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408422
(CHEMBL2113721)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccccc1Br)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-14-36(38)33(37)35-24-17-21(18-27(39-2)31(24)43-15-16-45-30-11-9-8-10-23(30)34)25-12-13-26(44-25)22-19-28(40-3)32(42-5)29(20-22)41-4/h8-11,17-20,25-26,38H,6-7,12-16H2,1-5H3,(H,35,37)/t25-,26-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408423
(CHEMBL2113726)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCS(=O)(=O)c1ccc(Br)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O10S/c1-6-7-14-36(38)33(37)35-25-17-21(26-12-13-27(46-26)22-19-29(42-3)32(44-5)30(20-22)43-4)18-28(41-2)31(25)45-15-16-47(39,40)24-10-8-23(34)9-11-24/h8-11,17-20,26-27,38H,6-7,12-16H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408415
(CHEMBL2113730)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(OC)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C34H44N2O9S/c1-7-8-15-36(38)34(37)35-26-18-22(19-29(40-3)32(26)44-16-17-46-25-11-9-24(39-2)10-12-25)27-13-14-28(45-27)23-20-30(41-4)33(43-6)31(21-23)42-5/h9-12,18-21,27-28,38H,7-8,13-17H2,1-6H3,(H,35,37)/t27-,28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408418
(CHEMBL2113722)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1cccc(Br)c1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O8S/c1-6-7-13-36(38)33(37)35-25-16-21(17-28(39-2)31(25)43-14-15-45-24-10-8-9-23(34)20-24)26-11-12-27(44-26)22-18-29(40-3)32(42-5)30(19-22)41-4/h8-10,16-20,26-27,38H,6-7,11-15H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408417
(CHEMBL2113724)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Cl)c(Cl)c1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H40Cl2N2O8S/c1-6-7-12-37(39)33(38)36-25-15-20(16-28(40-2)31(25)44-13-14-46-22-8-9-23(34)24(35)19-22)26-10-11-27(45-26)21-17-29(41-3)32(43-5)30(18-21)42-4/h8-9,15-19,26-27,39H,6-7,10-14H2,1-5H3,(H,36,38)/t26-,27-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286658
(5-lipoxygenase inhibitor | CHEMBL155760)Show SMILES CCCOc1cc(cc(N(CC)C(=O)N(O)CCC)c1OCCC)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C31H46N2O8/c1-8-14-33(35)31(34)32(11-4)23-17-21(20-28(39-15-9-2)29(23)40-16-10-3)24-12-13-25(41-24)22-18-26(36-5)30(38-7)27(19-22)37-6/h17-20,24-25,35H,8-16H2,1-7H3/t24-,25-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408413
(CHEMBL2113727)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Cl)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41ClN2O8S/c1-6-7-14-36(38)33(37)35-25-17-21(18-28(39-2)31(25)43-15-16-45-24-10-8-23(34)9-11-24)26-12-13-27(44-26)22-19-29(40-3)32(42-5)30(20-22)41-4/h8-11,17-20,26-27,38H,6-7,12-16H2,1-5H3,(H,35,37)/t26-,27-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description 5-lipoxygenase inhibitory activity determined by measuring the conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cell using thin-layer ... |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286660
(5-lipoxygenase inhibitor | CHEMBL160839)Show SMILES CCCOc1cc(cc(N(O)C(=O)NCC)c1OCCC)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-12-36-25-17-18(14-20(26(25)37-13-8-2)30(32)28(31)29-9-3)21-10-11-22(38-21)19-15-23(33-4)27(35-6)24(16-19)34-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286659
(5-lipoxygenase inhibitor | CHEMBL434090)Show SMILES CCCOc1cc(cc(N(CC)C(=O)N(C)O)c1OCCC)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C29H42N2O8/c1-8-13-37-26-18-19(15-21(27(26)38-14-9-2)31(10-3)29(32)30(4)33)22-11-12-23(39-22)20-16-24(34-5)28(36-7)25(17-20)35-6/h15-18,22-23,33H,8-14H2,1-7H3/t22-,23-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408415
(CHEMBL2113730)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(OC)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C34H44N2O9S/c1-7-8-15-36(38)34(37)35-26-18-22(19-29(40-3)32(26)44-16-17-46-25-11-9-24(39-2)10-12-25)27-13-14-28(45-27)23-20-30(41-4)33(43-6)31(21-23)42-5/h9-12,18-21,27-28,38H,7-8,13-17H2,1-6H3,(H,35,37)/t27-,28-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286656
(5-lipoxygenase inhibitor | CHEMBL160571)Show SMILES CCCNC(=O)N(O)c1cc(cc(OCCC)c1OCCC)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C29H42N2O8/c1-7-12-30-29(32)31(33)21-15-19(18-26(37-13-8-2)27(21)38-14-9-3)22-10-11-23(39-22)20-16-24(34-4)28(36-6)25(17-20)35-5/h15-18,22-23,33H,7-14H2,1-6H3,(H,30,32)/t22-,23-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50000714
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl |c:6| Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408414
(CHEMBL2113720)Show SMILES COc1cc(cc(CNC(=O)N(C)O)c1OCCSc1ccc(Cl)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C31H37ClN2O8S/c1-34(36)31(35)33-18-21-14-19(15-26(37-2)29(21)41-12-13-43-23-8-6-22(32)7-9-23)24-10-11-25(42-24)20-16-27(38-3)30(40-5)28(17-20)39-4/h6-9,14-17,24-25,36H,10-13,18H2,1-5H3,(H,33,35)/t24-,25-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408421
(CHEMBL2113725)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H38F4N2O8S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(47-23)19-15-26(43-3)31(45-5)27(16-19)44-4)14-25(42-2)30(22)46-11-12-48-32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50286666
(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C26H36N2O8/c1-7-11-35-24-18(27-26(29)28(30)8-2)12-16(13-21(24)31-3)19-9-10-20(36-19)17-14-22(32-4)25(34-6)23(15-17)33-5/h12-15,19-20,30H,7-11H2,1-6H3,(H,27,29) | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50286666
(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)CC)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C26H36N2O8/c1-7-11-35-24-18(27-26(29)28(30)8-2)12-16(13-21(24)31-3)19-9-10-20(36-19)17-14-22(32-4)25(34-6)23(15-17)33-5/h12-15,19-20,30H,7-11H2,1-6H3,(H,27,29) | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408424
(CHEMBL2113733)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCS(=O)(=O)c1ccccc1Br)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H41BrN2O10S/c1-6-7-14-36(38)33(37)35-24-17-21(25-12-13-26(46-25)22-19-28(42-3)32(44-5)29(20-22)43-4)18-27(41-2)31(24)45-15-16-47(39,40)30-11-9-8-10-23(30)34/h8-11,17-20,25-26,38H,6-7,12-16H2,1-5H3,(H,35,37)/t25-,26-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408420
(CHEMBL2113731)Show SMILES CCCCN(O)C(=O)NCc1cc(cc(OC)c1OCCSc1ccc(Cl)cc1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C34H43ClN2O8S/c1-6-7-14-37(39)34(38)36-21-24-17-22(18-29(40-2)32(24)44-15-16-46-26-10-8-25(35)9-11-26)27-12-13-28(45-27)23-19-30(41-3)33(43-5)31(20-23)42-4/h8-11,17-20,27-28,39H,6-7,12-16,21H2,1-5H3,(H,36,38)/t27-,28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50408416
(CHEMBL2113732)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCS(=O)(=O)c1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H38F4N2O10S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(49-23)19-15-26(45-3)31(47-5)27(16-19)46-4)14-25(44-2)30(22)48-11-12-50(42,43)32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 285 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50029775
((R)-(+)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-met...)Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19) | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 298 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286662
(CHEMBL160148 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C31H38N2O8/c1-6-14-40-29-23(32-31(34)33(35)19-20-10-8-7-9-11-20)15-21(16-26(29)36-2)24-12-13-25(41-24)22-17-27(37-3)30(39-5)28(18-22)38-4/h7-11,15-18,24-25,35H,6,12-14,19H2,1-5H3,(H,32,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 423 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50286662
(CHEMBL160148 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)Show SMILES CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C31H38N2O8/c1-6-14-40-29-23(32-31(34)33(35)19-20-10-8-7-9-11-20)15-21(16-26(29)36-2)24-12-13-25(41-24)22-17-27(37-3)30(39-5)28(18-22)38-4/h7-11,15-18,24-25,35H,6,12-14,19H2,1-5H3,(H,32,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 423 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. |
Bioorg Med Chem Lett 5: 643-648 (1995)
Article DOI: 10.1016/0960-894X(95)00088-B BindingDB Entry DOI: 10.7270/Q23778QB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50064506
(1-Butyl-3-{3-methoxy-2-propoxy-5-[5-(3,4,5-trimeth...)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C28H40N2O8/c1-7-9-12-30(32)28(31)29-20-14-18(15-23(33-3)26(20)37-13-8-2)21-10-11-22(38-21)19-16-24(34-4)27(36-6)25(17-19)35-5/h14-17,21-22,32H,7-13H2,1-6H3,(H,29,31)/t21-,22-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 424 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50408416
(CHEMBL2113732)Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCS(=O)(=O)c1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C33H38F4N2O10S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(49-23)19-15-26(45-3)31(47-5)27(16-19)46-4)14-25(44-2)30(22)48-11-12-50(42,43)32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells |
J Med Chem 41: 1970-9 (1998)
Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 |
More data for this Ligand-Target Pair | |