Compile Data Set for Download or QSAR

Found 153 hits with Last Name = 'kang' and Initial = 'sh'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473585 (US10844062, Example 21) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473613 (US10844062, Example 49) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-20(28)21(12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473640 (US10844062, Example 76) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H17F4N7O/c26-18-7-6-16(11-19(18)36-20(37)10-14-3-1-4-15(9-14)25(27,28)29)35-23-17(5-2-8-30-23)21-22-24(33-12-31-21)34-13-32-22/h1-9,11-13H,10H2,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473190 (US10844062, Example 1) Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C24H14F5N7O/c25-15-6-7-16(35-23(37)12-3-1-4-13(9-12)24(27,28)29)17(26)19(15)36-21-14(5-2-8-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473594 (US10844062, Example 30) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473600 (US10844062, Example 36) Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F Show InChI InChI=1S/C24H14F5N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473573 (US10844062, Example 9) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(11-16)26(38)36-19-9-8-18(28)22(20(19)29)37-24-17(7-4-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,37)(H,36,38)(H,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473593 (US10844062, Example 29) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-7-3-6-16(12-17)26(37)36-20-10-4-9-19(21(20)28)35-24-18(8-5-11-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473587 (US10844062, Example 23) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 Show InChI InChI=1S/C27H22N8O/c1-27(2,14-28)18-7-3-6-17(12-18)26(36)35-20-9-4-8-19(13-20)34-24-21(10-5-11-29-24)22-23-25(32-15-30-22)33-16-31-23/h3-13,15-16H,1-2H3,(H,29,34)(H,35,36)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473648 (US10844062, Example 84) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)c(F)cc1F Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(11-17)27(38)37-23-13-22(20(29)12-21(23)30)36-26-18(7-4-9-32-26)24-19-8-10-33-25(19)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473629 (US10844062, Example 65) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C25H14F7N7O/c26-17-4-3-15(38-21-16(2-1-5-33-21)19-20-22(36-10-34-19)37-11-35-20)9-18(17)39-23(40)12-6-13(24(27,28)29)8-14(7-12)25(30,31)32/h1-11H,(H,33,38)(H,39,40)(H,34,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	26.2	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	26.2	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical& Health Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Prostaglandin G/H synthase 2 from freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 14: 2195-8 (2004) BindingDB Entry DOI: 10.7270/Q2K939PT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473642 (US10844062, Example 78) Show SMILES Fc1cc(NC(=O)c2ccc(CC#N)cc2)ccc1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C25H17FN8O/c26-19-12-17(33-25(35)16-5-3-15(4-6-16)9-10-27)7-8-20(19)34-23-18(2-1-11-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-8,11-14H,9H2,(H,28,34)(H,33,35)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473596 (US10844062, Example 32) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)cc1F Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(9-16)26(38)37-21-11-20(18(28)10-19(21)29)36-24-17(7-4-8-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473641 (US10844062, Example 77) Show SMILES Fc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(CC#N)c1 Show InChI InChI=1S/C25H17FN8O/c26-19-7-6-16(25(35)33-17-4-1-3-15(11-17)8-9-27)12-20(19)34-23-18(5-2-10-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-7,10-14H,8H2,(H,28,34)(H,33,35)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473631 (US10844062, Example 67) Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl Show InChI InChI=1S/C24H14ClF4N7O/c25-17-4-3-15(9-18(17)36-23(37)12-6-13(24(27,28)29)8-14(26)7-12)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473638 (US10844062, Example 74) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C24H15ClF4N8O/c25-16-5-3-12(8-15(16)24(27,28)29)36-23(38)37-18-9-13(4-6-17(18)26)35-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H2,36,37,38)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473637 (US10844062, Example 73) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H15F4N7O/c25-18-7-6-15(10-17(18)23(36)35-14-4-1-3-13(9-14)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422587 (CHEMBL423892) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=S)c1-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FO3S2/c1-28(24,25)17-12-8-15(9-13-17)21-20(14-6-10-16(23)11-7-14)22(27)18-4-2-3-5-19(18)26-21/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	73.1	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473592 (US10844062, Example 28) Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C24H13F6N7O/c25-13-7-11(6-12(8-13)24(28,29)30)23(38)36-16-4-3-15(26)19(17(16)27)37-21-14(2-1-5-31-21)18-20-22(34-9-32-18)35-10-33-20/h1-10H,(H,31,37)(H,36,38)(H,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473653 (US10844062, Example 91) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F Show InChI InChI=1S/C28H22FN7O/c1-28(2,15-30)18-6-3-5-17(13-18)27(37)36-23-14-19(8-9-22(23)29)35-26-20(7-4-11-31-26)24-21-10-12-32-25(21)34-16-33-24/h3-14,16H,1-2H3,(H,31,35)(H,36,37)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422584 (CHEMBL69026) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccccc1F |(6.09,-11.72,;6.07,-10.18,;5.68,-8.7,;7.4,-9.41,;4.74,-9.41,;4.74,-7.87,;3.41,-7.1,;2.08,-7.89,;2.08,-9.43,;3.41,-10.18,;.75,-7.12,;-.6,-7.89,;-1.93,-7.12,;-3.26,-7.89,;-4.59,-7.12,;-4.59,-5.58,;-3.26,-4.81,;-1.93,-5.58,;-.6,-4.79,;-.6,-3.25,;.75,-5.56,;2.08,-4.78,;3.41,-5.55,;4.74,-4.77,;4.72,-3.23,;3.37,-2.46,;2.05,-3.25,;.71,-2.48,)| Show InChI InChI=1S/C22H15FO4S/c1-28(25,26)15-12-10-14(11-13-15)22-20(16-6-2-4-8-18(16)23)21(24)17-7-3-5-9-19(17)27-22/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	76.1	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422584 (CHEMBL69026) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccccc1F |(6.09,-11.72,;6.07,-10.18,;5.68,-8.7,;7.4,-9.41,;4.74,-9.41,;4.74,-7.87,;3.41,-7.1,;2.08,-7.89,;2.08,-9.43,;3.41,-10.18,;.75,-7.12,;-.6,-7.89,;-1.93,-7.12,;-3.26,-7.89,;-4.59,-7.12,;-4.59,-5.58,;-3.26,-4.81,;-1.93,-5.58,;-.6,-4.79,;-.6,-3.25,;.75,-5.56,;2.08,-4.78,;3.41,-5.55,;4.74,-4.77,;4.72,-3.23,;3.37,-2.46,;2.05,-3.25,;.71,-2.48,)| Show InChI InChI=1S/C22H15FO4S/c1-28(25,26)15-12-10-14(11-13-15)22-20(16-6-2-4-8-18(16)23)21(24)17-7-3-5-9-19(17)27-22/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	76.1	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical& Health Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Prostaglandin G/H synthase 2 from freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 14: 2195-8 (2004) BindingDB Entry DOI: 10.7270/Q2K939PT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473605 (US10844062, Example 41) Show SMILES CC(C)(C#N)c1cc(ccc1Cl)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C27H19ClF2N8O/c1-27(2,11-31)16-10-14(5-6-17(16)28)26(39)37-19-8-7-18(29)22(20(19)30)38-24-15(4-3-9-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473654 (US10844062, Example 92) Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-10-16(11-18(29)12-17)27(38)37-23-13-19(5-6-22(23)30)36-26-20(4-3-8-32-26)24-21-7-9-33-25(21)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50410060 (CHEMBL308692) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1occ(Cl)c(=O)c1-c1ccc(c(F)c1)-c1ccccc1 Show InChI InChI=1S/C24H16ClFO4S/c1-31(28,29)18-10-7-16(8-11-18)24-22(23(27)20(25)14-30-24)17-9-12-19(21(26)13-17)15-5-3-2-4-6-15/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	87.9	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical& Health Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Prostaglandin G/H synthase 2 from freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 14: 2195-8 (2004) BindingDB Entry DOI: 10.7270/Q2K939PT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473630 (US10844062, Example 66) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl Show InChI InChI=1S/C24H15ClF3N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473649 (US10844062, Example 85) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(13-17)27(38)36-21-9-8-20(29)24(22(21)30)37-26-18(7-4-11-32-26)23-19-10-12-33-25(19)35-15-34-23/h3-13,15H,1-2H3,(H,32,37)(H,36,38)(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473614 (US10844062, Example 50) Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(34-23(36)13-3-1-4-14(9-13)24(26,27)28)10-18(17)35-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,35)(H,34,36)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50220685 (CHEMBL410891) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1occ(Cl)c(=O)c1-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C24H17ClO4S/c1-30(27,28)20-13-11-19(12-14-20)24-22(23(26)21(25)15-29-24)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	91.6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical& Health Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Prostaglandin G/H synthase 2 from freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 14: 2195-8 (2004) BindingDB Entry DOI: 10.7270/Q2K939PT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473604 (US10844062, Example 40) Show SMILES [O-][N+](=O)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C24H13F5N8O3/c25-15-3-4-16(35-23(38)11-6-12(24(27,28)29)8-13(7-11)37(39)40)17(26)19(15)36-21-14(2-1-5-30-21)18-20-22(33-9-31-18)34-10-32-20/h1-10H,(H,30,36)(H,35,38)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422578 (CHEMBL422623) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=S)c1-c1ccccc1 Show InChI InChI=1S/C22H16O3S2/c1-27(23,24)17-13-11-16(12-14-17)21-20(15-7-3-2-4-8-15)22(26)18-9-5-6-10-19(18)25-21/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422570 (CHEMBL435189) Show SMILES NS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccccc1 Show InChI InChI=1S/C21H15NO4S/c22-27(24,25)16-12-10-15(11-13-16)21-19(14-6-2-1-3-7-14)20(23)17-8-4-5-9-18(17)26-21/h1-13H,(H2,22,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473652 (US10844062, Example 88) Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F Show InChI InChI=1S/C25H15F5N6O/c26-15-9-13(8-14(10-15)25(28,29)30)24(37)36-20-11-16(3-4-19(20)27)35-23-17(2-1-6-31-23)21-18-5-7-32-22(18)34-12-33-21/h1-12H,(H,31,35)(H,36,37)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473611 (US10844062, Example 47) Show SMILES Cc1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C24H17F2N7O/c1-13-4-2-5-14(10-13)24(34)32-17-8-7-16(25)20(18(17)26)33-22-15(6-3-9-27-22)19-21-23(30-11-28-19)31-12-29-21/h2-12H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473645 (US10844062, Example 81) Show SMILES Fc1ccc(cc1)N1CCN(C(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)C1=O Show InChI InChI=1S/C26H18F3N9O2/c27-14-3-5-15(6-4-14)37-10-11-38(26(37)40)25(39)35-18-8-7-17(28)21(19(18)29)36-23-16(2-1-9-30-23)20-22-24(33-12-31-20)34-13-32-22/h1-9,12-13H,10-11H2,(H,30,36)(H,35,39)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473597 (US10844062, Example 33) Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-8-15(9-17(28)10-16)26(38)37-21-11-18(5-6-20(21)29)36-24-19(4-3-7-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473656 (US10844062, Example 139) Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F Show InChI InChI=1S/C25H17F4N7O/c1-13-7-14(9-15(8-13)25(27,28)29)24(37)36-19-10-16(4-5-18(19)26)35-22-17(3-2-6-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422577 (CHEMBL133065) Show SMILES NS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccc(F)cc1 Show InChI InChI=1S/C21H14FNO4S/c22-15-9-5-13(6-10-15)19-20(24)17-3-1-2-4-18(17)27-21(19)14-7-11-16(12-8-14)28(23,25)26/h1-12H,(H2,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473607 (US10844062, Example 43) Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C27H19F3N8O/c1-27(2,11-31)15-8-14(9-16(28)10-15)26(39)37-19-6-5-18(29)22(20(19)30)38-24-17(4-3-7-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422591 (CHEMBL133507) Show SMILES COc1ccc(cc1)-c1c(oc2ccccc2c1=S)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C23H18O4S2/c1-26-17-11-7-15(8-12-17)21-22(16-9-13-18(14-10-16)29(2,24)25)27-20-6-4-3-5-19(20)23(21)28/h3-14H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473609 (US10844062, Example 45) Show SMILES Fc1ccc(NC(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C23H14ClF2N7O/c24-13-4-1-3-12(9-13)23(34)32-16-7-6-15(25)19(17(16)26)33-21-14(5-2-8-27-21)18-20-22(30-10-28-18)31-11-29-20/h1-11H,(H,27,33)(H,32,34)(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422586 (CHEMBL132721) Show SMILES NS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccccc1F |(11.98,-6.38,;10.62,-5.61,;9.85,-6.96,;11.41,-4.25,;9.27,-4.83,;7.93,-5.6,;6.6,-4.83,;6.6,-3.29,;7.94,-2.5,;9.27,-3.27,;5.27,-2.5,;3.93,-3.27,;2.6,-2.5,;1.27,-3.27,;-.06,-2.5,;-.06,-.98,;1.27,-.19,;2.6,-.96,;3.93,-.19,;3.93,1.35,;5.27,-.96,;6.6,-.19,;7.93,-.98,;9.27,-.21,;9.27,1.33,;7.92,2.1,;6.6,1.33,;5.26,2.1,)| Show InChI InChI=1S/C21H14FNO4S/c22-17-7-3-1-5-15(17)19-20(24)16-6-2-4-8-18(16)27-21(19)13-9-11-14(12-10-13)28(23,25)26/h1-12H,(H2,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473615 (US10844062, Example 51) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 Show InChI InChI=1S/C24H16F3N7O/c25-24(26,27)15-5-1-4-14(10-15)23(35)34-17-7-2-6-16(11-17)33-21-18(8-3-9-28-21)19-20-22(31-12-29-19)32-13-30-20/h1-13H,(H,28,33)(H,34,35)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473655 (US10844062, Example 135) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(Cl)cc(c1)C(F)(F)F Show InChI InChI=1S/C24H14ClF4N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473588 (US10844062, Example 24) Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl Show InChI InChI=1S/C27H21ClN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	191	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422590 (CHEMBL132190) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=S)c1-c1ccccc1F |(11.98,-6.38,;10.62,-5.61,;9.85,-6.96,;11.41,-4.25,;9.27,-4.83,;9.27,-3.27,;7.94,-2.5,;6.6,-3.29,;6.6,-4.83,;7.93,-5.6,;5.27,-2.5,;3.93,-3.27,;2.6,-2.5,;1.27,-3.27,;-.06,-2.5,;-.06,-.98,;1.27,-.19,;2.6,-.96,;3.93,-.19,;3.93,1.35,;5.27,-.96,;6.6,-.19,;7.93,-.98,;9.27,-.21,;9.27,1.33,;7.92,2.1,;6.6,1.33,;5.26,2.1,)| Show InChI InChI=1S/C22H15FO3S2/c1-28(24,25)15-12-10-14(11-13-15)21-20(16-6-2-4-8-18(16)23)22(27)17-7-3-5-9-19(17)26-21/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Mus musculus (Mouse))	BDBM50422589 (CHEMBL134512) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ccccc2c(=O)c1-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FO4S/c1-28(25,26)17-12-8-15(9-13-17)22-20(14-6-10-16(23)11-7-14)21(24)18-4-2-3-5-19(18)27-22/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	202	n/a	n/a	n/a	n/a	n/a	n/a
AmorePacific Corporation R&D Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration against prostaglandin G/H synthase 2 using freshly harvested mouse peritoneal macrophages				Bioorg Med Chem Lett 13: 413-7 (2003) BindingDB Entry DOI: 10.7270/Q29Z973Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473651 (US10844062, Example 87) Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]ccc23)cc1NC(=O)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H16F4N6O/c26-19-7-6-16(12-20(19)35-24(36)14-3-1-4-15(11-14)25(27,28)29)34-23-17(5-2-9-30-23)21-18-8-10-31-22(18)33-13-32-21/h1-13H,(H,30,34)(H,35,36)(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd. US Patent					Assay Description The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...				US Patent US10844062 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TRN
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 153 total )  |  Next  |  Last  >>

Jump to: