Found 295 hits with Last Name = 'kukral' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50184807
((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)Show SMILES C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C Show InChI InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGFR2 |
J Med Chem 49: 2143-6 (2006)
Article DOI: 10.1021/jm051106d BindingDB Entry DOI: 10.7270/Q2WW7H7N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50184807
((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)Show SMILES C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C Show InChI InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGFR2 |
J Med Chem 49: 2143-6 (2006)
Article DOI: 10.1021/jm051106d BindingDB Entry DOI: 10.7270/Q2WW7H7N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Mus musculus) | BDBM50184807
((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)Show SMILES C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C Show InChI InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against Flk1 |
J Med Chem 49: 2143-6 (2006)
Article DOI: 10.1021/jm051106d BindingDB Entry DOI: 10.7270/Q2WW7H7N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50184807
((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)Show SMILES C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C Show InChI InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGFR1 |
J Med Chem 49: 2143-6 (2006)
Article DOI: 10.1021/jm051106d BindingDB Entry DOI: 10.7270/Q2WW7H7N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168389
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168394
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533649
(CHEMBL4467132)Show SMILES Cc1c(cccc1-n1cnc2cc(F)ccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H25FN4O3/c1-16-19(5-4-6-26(16)36-15-34-24-14-18(32)8-10-22(24)30(36)38)20-11-12-23(29(33)37)28-27(20)21-9-7-17(31(2,3)39)13-25(21)35-28/h4-15,35,39H,1-3H3,(H2,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533652
(CHEMBL4543505)Show SMILES Cc1c(cccc1-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O)N1Cc2ccc(F)cc2C1=O Show InChI InChI=1S/C31H26FN3O3/c1-16-20(5-4-6-26(16)35-15-17-7-9-19(32)14-24(17)30(35)37)21-11-12-23(29(33)36)28-27(21)22-10-8-18(31(2,3)38)13-25(22)34-28/h4-14,34,38H,15H2,1-3H3,(H2,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533641
(CHEMBL4460221)Show SMILES Cc1c(cccc1-n1cnc2c(F)cccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H25FN4O3/c1-16-18(6-5-9-25(16)36-15-34-27-22(30(36)38)7-4-8-23(27)32)19-12-13-21(29(33)37)28-26(19)20-11-10-17(31(2,3)39)14-24(20)35-28/h4-15,35,39H,1-3H3,(H2,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533650
(CHEMBL4550390)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(CO)ccc3c12 Show InChI InChI=1S/C29H22N4O3/c1-16-18(6-4-8-25(16)33-15-31-23-7-3-2-5-21(23)29(33)36)19-11-12-22(28(30)35)27-26(19)20-10-9-17(14-34)13-24(20)32-27/h2-13,15,32,34H,14H2,1H3,(H2,30,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533645
(CHEMBL4465380)Show SMILES Cc1c(cccc1-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O)N1CCc2ccccc2C1=O Show InChI InChI=1S/C32H29N3O3/c1-18-21(9-6-10-27(18)35-16-15-19-7-4-5-8-22(19)31(35)37)23-13-14-25(30(33)36)29-28(23)24-12-11-20(32(2,3)38)17-26(24)34-29/h4-14,17,34,38H,15-16H2,1-3H3,(H2,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50194715
(CHEMBL3918580)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50194726
(CHEMBL3977725)Show SMILES CC(C)(O)c1ccc2c(c1)[nH]c1c(ccc(-c3cccc(c3F)-n3cnc4ccccc4c3=O)c21)C(N)=O Show InChI InChI=1S/C30H23FN4O3/c1-30(2,38)16-10-11-19-23(14-16)34-27-21(28(32)36)13-12-17(25(19)27)18-7-5-9-24(26(18)31)35-15-33-22-8-4-3-6-20(22)29(35)37/h3-15,34,38H,1-2H3,(H2,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533651
(CHEMBL4473176)Show SMILES Cc1c(cccc1-n1cnc2cccc(F)c2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H25FN4O3/c1-16-18(6-4-9-25(16)36-15-34-23-8-5-7-22(32)27(23)30(36)38)19-12-13-21(29(33)37)28-26(19)20-11-10-17(31(2,3)39)14-24(20)35-28/h4-15,35,39H,1-3H3,(H2,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533648
(CHEMBL4439761)Show SMILES Cc1c(cccc1-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O)N1Cc2ccccc2C1=O Show InChI InChI=1S/C31H27N3O3/c1-17-20(9-6-10-26(17)34-16-18-7-4-5-8-21(18)30(34)36)22-13-14-24(29(32)35)28-27(22)23-12-11-19(31(2,3)37)15-25(23)33-28/h4-15,33,37H,16H2,1-3H3,(H2,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533646
(CHEMBL4554269)Show SMILES Cc1c(cccc1-n1ccc2ccccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C32H27N3O3/c1-18-21(9-6-10-27(18)35-16-15-19-7-4-5-8-22(19)31(35)37)23-13-14-25(30(33)36)29-28(23)24-12-11-20(32(2,3)38)17-26(24)34-29/h4-17,34,38H,1-3H3,(H2,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50123553
(CHEMBL3622189)Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(ccc(-c3cccc(NC(=O)c4ccc(F)cc4)c3C)c21)C(N)=O Show InChI InChI=1S/C33H30FN5O3/c1-19-23(4-3-5-27(19)37-32(41)20-6-9-22(34)10-7-20)24-12-13-26(31(35)40)30-29(24)25-11-8-21(18-28(25)36-30)33(42)39-16-14-38(2)15-17-39/h3-13,18,36H,14-17H2,1-2H3,(H2,35,40)(H,37,41) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533644
(CHEMBL4567605)Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(ccc(-c3cccc(N4Cc5ccccc5C4=O)c3C)c21)C(N)=O Show InChI InChI=1S/C34H31N5O3/c1-20-23(8-5-9-29(20)39-19-22-6-3-4-7-24(22)34(39)42)25-12-13-27(32(35)40)31-30(25)26-11-10-21(18-28(26)36-31)33(41)38-16-14-37(2)15-17-38/h3-13,18,36H,14-17,19H2,1-2H3,(H2,35,40) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168400
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533647
(CHEMBL4513599)Show SMILES Cc1c(cccc1-n1cnc2ccc(F)cc2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H25FN4O3/c1-16-19(5-4-6-26(16)36-15-34-24-12-8-18(32)14-23(24)30(36)38)20-10-11-22(29(33)37)28-27(20)21-9-7-17(31(2,3)39)13-25(21)35-28/h4-15,35,39H,1-3H3,(H2,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168400
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50194715
(CHEMBL3918580)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of BTK in human peripheral B cells assessed as suppression of BCR/anti-IgM/IgG stimulated CD69 surface expression after 18 hrs by FACS ana... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50194715
(CHEMBL3918580)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of BTK in human tonsillar B cells assessed as suppression of BCR/anti-IgM/IgG stimulated cell proliferation |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533642
(CHEMBL4466870)Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(ccc(-c3cccc(NC(=O)c4ccc(F)cn4)c3C)c21)C(N)=O Show InChI InChI=1S/C32H29FN6O3/c1-18-21(4-3-5-25(18)37-31(41)26-11-7-20(33)17-35-26)22-9-10-24(30(34)40)29-28(22)23-8-6-19(16-27(23)36-29)32(42)39-14-12-38(2)13-15-39/h3-11,16-17,36H,12-15H2,1-2H3,(H2,34,40)(H,37,41) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50533643
(CHEMBL4466400)Show SMILES CC(C)Nc1ccc2c(c1)[nH]c1c(ccc(-c3cccc(NC(=O)c4ccc(F)cc4)c3C)c21)C(N)=O Show InChI InChI=1S/C30H27FN4O2/c1-16(2)33-20-11-12-23-26(15-20)34-28-24(29(32)36)14-13-22(27(23)28)21-5-4-6-25(17(21)3)35-30(37)18-7-9-19(31)10-8-18/h4-16,33-34H,1-3H3,(H2,32,36)(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc... |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Tec
(Homo sapiens (Human)) | BDBM50194715
(CHEMBL3918580)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of partial length human TEC expressed in bacterial system |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168421
(4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-...)Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C20H21F2N5O4/c1-5-31-20(29)12-8-27-17(16(12)10(2)3)18(23-9-24-27)25-15-6-11(19(28)26-30-4)13(21)7-14(15)22/h6-10H,5H2,1-4H3,(H,26,28)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189609
(CHEMBL209555 | N-cyclopropyl-4-fluoro-3-(2-(2-(pyr...)Show InChI InChI=1S/C20H19FN4OS/c21-17-9-5-14(19(26)24-15-6-7-15)11-13(17)4-8-16-12-23-20(27-16)25-18-3-1-2-10-22-18/h1-3,5,9-12,15H,4,6-8H2,(H,24,26)(H,22,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FLK1 |
J Med Chem 49: 3766-9 (2006)
Article DOI: 10.1021/jm060347y BindingDB Entry DOI: 10.7270/Q2PG1RBM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50194715
(CHEMBL3918580)Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O Show InChI InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of BTK in human PBMC assessed as suppression of FCgamma2aR/FCgamma3R stimulated TNFalpha production after 7 hrs by ELISA |
J Med Chem 59: 7915-35 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00722 BindingDB Entry DOI: 10.7270/Q24Q7ZGM |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |