Compile Data Set for Download or QSAR

Found 231 hits with Last Name = 'lafrance, iii' and Initial = 'lv'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259330 (US9505745, 7) Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259356 (US9505745, 33 | US9790212, Example 33) Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259339 (US9505745, 16 | US9790212, Example 16) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259341 (US9505745, 18 | US9790212, Example 18) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439129 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES C[C@H](C1CCN(CC(C)(C)C)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439130 ((R)-2-(1-(1-(Cyclobutylmethyl)piperidin-4-yl)ethyl...) Show SMILES C[C@H](C1CCN(CC2CCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439132 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES CC(C)CN1CCC(CC1)[C@@H](C)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439133 ((R)-2-(1-(1-(Cyclopentylmethyl)piperidin-4-yl)ethy...) Show SMILES C[C@H](C1CCN(CC2CCCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439163 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES CCC(C)(C)CN1CCC(CC1)[C@@H](C)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439164 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES C[C@H](C1CCN(CC(C)(C)F)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439165 ((R)-2-(1-(1-(Cyclopropylmethyl)piperidin-4-yl)ethy...) Show SMILES C[C@H](C1CCN(CC2CC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439169 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES C[C@H](C1CCN(CC2(C)CCCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439190 ((R)-2-(1-(1-(Bicyclo[2.2.2]octan-1-ylmethyl)piperi...) Show SMILES C[C@H](C1CCN(CC23CCC(CC2)CC3)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439192 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES C[C@H](C1CCN(CC2(C)CCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM439197 ((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...) Show SMILES C[C@H](C1CCN(CC2(C)CC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED US Patent					Assay Description 1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...				US Patent US10604531 (2020) BindingDB Entry DOI: 10.7270/Q23X89N4
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259371 (US9505745, 48 | US9790212, Example 48) Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1 |(1.29,-4.65,;.52,-3.32,;-1.02,-3.32,;-1.79,-1.98,;-3.33,-1.98,;-3.81,-.52,;-2.56,.39,;-2.56,1.93,;-3.9,2.7,;-1.23,2.7,;-1.23,4.24,;.1,5.01,;.1,6.55,;-1.23,7.32,;1.44,7.32,;2.77,6.55,;4.1,7.32,;2.77,5.01,;1.44,4.24,;1.44,2.7,;-1.32,-.52,;.02,.25,;-1.79,-4.65,;-3.33,-4.65,;-4.1,-5.98,;-3.33,-7.32,;-1.79,-7.32,;-1.02,-5.98,)| Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259331 (US9505745, 8) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259335 (US9505745, 12 | US9790212, Example 12) Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259339 (US9505745, 16 | US9790212, Example 16) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259341 (US9505745, 18 | US9790212, Example 18) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259342 (US9505745, 19 | US9790212, Example 19) Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259355 (US9505745, 32 | US9790212, Example 32) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259359 (US9505745, 36 | US9790212, Example 36) Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.71,-2.37,;6.62,-1.28,;5.14,-1.67,;4.74,-3.16,;3.25,-3.56,;2.85,-5.05,;3.94,-6.14,;5.43,-5.74,;5.83,-4.25,;3.54,-7.62,;4.63,-8.71,;2.05,-8.02,;4.05,-.59,;2.51,-.59,;2.03,.88,;3.28,1.78,;3.28,3.32,;1.94,4.09,;4.61,4.09,;4.61,5.63,;5.94,6.4,;5.94,7.94,;4.61,8.71,;7.28,8.71,;8.61,7.94,;9.94,8.71,;8.61,6.4,;7.28,5.63,;7.28,4.09,;4.52,.88,;5.86,1.65,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259367 (US9505745, 44 | US9505745, 45 | US9790212, Example...) Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259371 (US9505745, 48 | US9790212, Example 48) Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1 |(1.29,-4.65,;.52,-3.32,;-1.02,-3.32,;-1.79,-1.98,;-3.33,-1.98,;-3.81,-.52,;-2.56,.39,;-2.56,1.93,;-3.9,2.7,;-1.23,2.7,;-1.23,4.24,;.1,5.01,;.1,6.55,;-1.23,7.32,;1.44,7.32,;2.77,6.55,;4.1,7.32,;2.77,5.01,;1.44,4.24,;1.44,2.7,;-1.32,-.52,;.02,.25,;-1.79,-4.65,;-3.33,-4.65,;-4.1,-5.98,;-3.33,-7.32,;-1.79,-7.32,;-1.02,-5.98,)| Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259335 (US9505745, 12 | US9790212, Example 12) Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259342 (US9505745, 19 | US9790212, Example 19) Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259355 (US9505745, 32 | US9790212, Example 32) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259356 (US9505745, 33 | US9790212, Example 33) Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259359 (US9505745, 36 | US9790212, Example 36) Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.71,-2.37,;6.62,-1.28,;5.14,-1.67,;4.74,-3.16,;3.25,-3.56,;2.85,-5.05,;3.94,-6.14,;5.43,-5.74,;5.83,-4.25,;3.54,-7.62,;4.63,-8.71,;2.05,-8.02,;4.05,-.59,;2.51,-.59,;2.03,.88,;3.28,1.78,;3.28,3.32,;1.94,4.09,;4.61,4.09,;4.61,5.63,;5.94,6.4,;5.94,7.94,;4.61,8.71,;7.28,8.71,;8.61,7.94,;9.94,8.71,;8.61,6.4,;7.28,5.63,;7.28,4.09,;4.52,.88,;5.86,1.65,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259367 (US9505745, 44 | US9505745, 45 | US9790212, Example...) Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259369 (US9505745, 46 | US9505745, 47 | US9790212, Example...) Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259331 (US9505745, 8) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259341 (US9505745, 18 | US9790212, Example 18) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259358 (US9505745, 35) Show SMILES C\C=C(/[C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.6,wD:3.2,(7.69,-1.28,;6.6,-.19,;5.12,-.59,;4.72,-2.07,;3.23,-2.47,;2.83,-3.96,;3.92,-5.05,;3.52,-6.54,;5.41,-4.65,;5.81,-3.16,;4.03,.5,;2.49,.5,;2.01,1.97,;3.26,2.87,;3.26,4.41,;1.92,5.18,;4.59,5.18,;4.59,6.72,;5.93,7.49,;5.93,9.03,;4.59,9.8,;7.26,9.8,;8.59,9.03,;9.93,9.8,;8.59,7.49,;7.26,6.72,;7.26,5.18,;4.5,1.97,;5.84,2.74,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259341 (US9505745, 18 | US9790212, Example 18) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259357 (US9505745, 34 | US9790212, Example 35) Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.06,-1.28,;3.97,-.19,;2.48,-.59,;2.09,-2.07,;3.17,-3.16,;2.78,-4.65,;1.29,-5.05,;.2,-3.96,;.6,-2.47,;.89,-6.54,;1.98,-7.62,;1.58,-9.11,;3.47,-7.23,;4.56,-8.32,;6.04,-7.92,;4.16,-9.8,;5.64,-9.4,;1.4,.5,;-.14,.5,;-.62,1.97,;.63,2.87,;.63,4.41,;1.96,5.18,;-.71,5.18,;-.71,6.72,;-2.04,7.49,;-2.04,9.03,;-.71,9.8,;-3.38,9.8,;-4.71,9.03,;-6.04,9.8,;-4.71,7.49,;-3.38,6.72,;-3.38,5.18,;1.87,1.97,;3.21,2.74,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259369 (US9505745, 46 | US9505745, 47 | US9790212, Example...) Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259329 (US9505745, 6 | US9790212, Example 6) Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259334 (US9505745, 11 | US9790212, Example 11) Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259366 (US9505745, 43 | US9790212, Example 43) Show SMILES CCC([C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.6,wD:3.2,(1.29,-3.98,;.52,-2.65,;-1.02,-2.65,;-1.79,-3.98,;-3.33,-3.98,;-4.1,-5.32,;-3.33,-6.65,;-4.1,-7.98,;-1.79,-6.65,;-1.02,-5.32,;-1.79,-1.32,;-3.33,-1.32,;-3.81,.15,;-2.56,1.05,;-2.56,2.59,;-3.9,3.36,;-1.23,3.36,;-1.23,4.9,;.1,5.67,;.1,7.21,;-1.23,7.98,;1.44,7.98,;2.77,7.21,;4.1,7.98,;2.77,5.67,;1.44,4.9,;1.44,3.36,;-1.32,.15,;.02,.92,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259327 (US9505745, 4 | US9790212, Example 4) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.26,-3.32,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;2.95,-4.65,;2.18,-5.98,;.64,-5.98,;-.13,-4.65,;.64,-3.32,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259329 (US9505745, 6 | US9790212, Example 6) Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259334 (US9505745, 11 | US9790212, Example 11) Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259366 (US9505745, 43 | US9790212, Example 43) Show SMILES CCC([C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.6,wD:3.2,(1.29,-3.98,;.52,-2.65,;-1.02,-2.65,;-1.79,-3.98,;-3.33,-3.98,;-4.1,-5.32,;-3.33,-6.65,;-4.1,-7.98,;-1.79,-6.65,;-1.02,-5.32,;-1.79,-1.32,;-3.33,-1.32,;-3.81,.15,;-2.56,1.05,;-2.56,2.59,;-3.9,3.36,;-1.23,3.36,;-1.23,4.9,;.1,5.67,;.1,7.21,;-1.23,7.98,;1.44,7.98,;2.77,7.21,;4.1,7.98,;2.77,5.67,;1.44,4.9,;1.44,3.36,;-1.32,.15,;.02,.92,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259376 (US9505745, 53 | US9790212, Example 53) Show SMILES CCN(C1CCOCC1)c1sc(Cl)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM259387 (US9505745, 64 | US9790212, Example 64) Show SMILES CCN(C)[C@H]1CC[C@@H](CC1)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:4.3,wD:7.10,(4.62,-7.16,;3.14,-7.56,;2.05,-6.47,;.56,-6.87,;2.45,-4.98,;1.36,-3.89,;1.76,-2.41,;3.24,-2.01,;4.33,-3.1,;3.93,-4.58,;3.64,-.52,;5.13,-.12,;6.22,-1.21,;2.55,.57,;1.01,.57,;.54,2.03,;1.78,2.94,;1.78,4.48,;3.12,5.25,;.45,5.25,;-.88,4.48,;-2.22,5.25,;-3.55,4.48,;-3.55,2.94,;-4.89,5.25,;-4.89,6.79,;-6.22,7.56,;-3.55,7.56,;-2.22,6.79,;-.88,7.56,;3.03,2.03,;4.36,2.8,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent					Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...				US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T
					More data for this Ligand-Target Pair

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